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WO2004078118A3 - Protein kinase c inhibitor, related composition, and method of use - Google Patents

Protein kinase c inhibitor, related composition, and method of use Download PDF

Info

Publication number
WO2004078118A3
WO2004078118A3 PCT/US2004/005855 US2004005855W WO2004078118A3 WO 2004078118 A3 WO2004078118 A3 WO 2004078118A3 US 2004005855 W US2004005855 W US 2004005855W WO 2004078118 A3 WO2004078118 A3 WO 2004078118A3
Authority
WO
WIPO (PCT)
Prior art keywords
inhibitor
protein kinase
related composition
moiety
dag
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/005855
Other languages
French (fr)
Other versions
WO2004078118A2 (en
Inventor
Shaomeng Wang
Peter M Blumberg
Nancy Lewin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Georgetown University
University of Michigan System
University of Michigan Ann Arbor
US Department of Health and Human Services
Original Assignee
Georgetown University
University of Michigan System
University of Michigan Ann Arbor
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Georgetown University, University of Michigan System, University of Michigan Ann Arbor, US Department of Health and Human Services filed Critical Georgetown University
Publication of WO2004078118A2 publication Critical patent/WO2004078118A2/en
Anticipated expiration legal-status Critical
Publication of WO2004078118A3 publication Critical patent/WO2004078118A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds of the formula (1), (2), (3), (4), (5) or (6) or a pharmaceutically acceptable salt thereof, wherein A is a DAG receptor-binding moiety, L is a linker moiety, and B is a zinc finger reactive moiety, and, a pharmaceutical composition comprising an above compound, and methods of use.
PCT/US2004/005855 2003-02-28 2004-02-26 Protein kinase c inhibitor, related composition, and method of use Ceased WO2004078118A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45121403P 2003-02-28 2003-02-28
US60/451,214 2003-02-28

Publications (2)

Publication Number Publication Date
WO2004078118A2 WO2004078118A2 (en) 2004-09-16
WO2004078118A3 true WO2004078118A3 (en) 2006-03-02

Family

ID=32962570

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/005855 Ceased WO2004078118A2 (en) 2003-02-28 2004-02-26 Protein kinase c inhibitor, related composition, and method of use

Country Status (1)

Country Link
WO (1) WO2004078118A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120208750A1 (en) 2009-09-29 2012-08-16 Joslin Diabetes Center, Inc. Use of protein kinase c delta (pkcd) inhibitors to treat diabetes, obesity, and hepatic steatosis

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816450A (en) * 1986-09-15 1989-03-28 Duke University Inhibition of protein kinase C by long-chain bases
US5145842A (en) * 1986-06-11 1992-09-08 Alder Research Center Limited Partnership Protein kinase c. modulators. d.
US5750568A (en) * 1986-06-11 1998-05-12 Procyon Pharmaceuticals, Inc. Protein kinase C Modulators. L.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5145842A (en) * 1986-06-11 1992-09-08 Alder Research Center Limited Partnership Protein kinase c. modulators. d.
US5750568A (en) * 1986-06-11 1998-05-12 Procyon Pharmaceuticals, Inc. Protein kinase C Modulators. L.
US4816450A (en) * 1986-09-15 1989-03-28 Duke University Inhibition of protein kinase C by long-chain bases

Also Published As

Publication number Publication date
WO2004078118A2 (en) 2004-09-16

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