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WO2004071267A3 - Diagnosis of colorectal cancer by detection of nicotinamide n-methyltransferase in a stool sample - Google Patents

Diagnosis of colorectal cancer by detection of nicotinamide n-methyltransferase in a stool sample Download PDF

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Publication number
WO2004071267A3
WO2004071267A3 PCT/EP2004/001152 EP2004001152W WO2004071267A3 WO 2004071267 A3 WO2004071267 A3 WO 2004071267A3 EP 2004001152 W EP2004001152 W EP 2004001152W WO 2004071267 A3 WO2004071267 A3 WO 2004071267A3
Authority
WO
WIPO (PCT)
Prior art keywords
diagnosis
colorectal cancer
nicotinamide
methyltransferase
detection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2004/001152
Other languages
French (fr)
Other versions
WO2004071267A2 (en
Inventor
Peter Berndt
Marie-Luise Hagmann
Hanno Langen
Stefan Palme
Markus Roessler
Wolfgang Rollinger
Michael Tacke
Werner Zolg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Roche Diagnostics GmbH
Original Assignee
F Hoffmann La Roche AG
Roche Diagnostics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG, Roche Diagnostics GmbH filed Critical F Hoffmann La Roche AG
Publication of WO2004071267A2 publication Critical patent/WO2004071267A2/en
Publication of WO2004071267A3 publication Critical patent/WO2004071267A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57419—Specifically defined cancers of colon

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention relates to the diagnosis of colorectal cancer. It discloses the use of nicotinamide N­methyltransferase NNMT in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a stool sample, derived from an individual by measuring NNMT in said sample. Measurement of NNMT can, e.g., be used in the early detection or diagnosis of colorectal cancer.
PCT/EP2004/001152 2003-02-11 2004-02-09 Diagnosis of colorectal cancer by detection of nicotinamide n-methyltransferase in a stool sample Ceased WO2004071267A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03002651.2 2003-02-11
EP03002651 2003-02-11

Publications (2)

Publication Number Publication Date
WO2004071267A2 WO2004071267A2 (en) 2004-08-26
WO2004071267A3 true WO2004071267A3 (en) 2004-10-21

Family

ID=32864921

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/001152 Ceased WO2004071267A2 (en) 2003-02-11 2004-02-09 Diagnosis of colorectal cancer by detection of nicotinamide n-methyltransferase in a stool sample

Country Status (1)

Country Link
WO (1) WO2004071267A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006044680A1 (en) * 2004-10-14 2006-04-27 The Cleveland Clinic Foundation Methods of detecting colorectal cancer
JP2009520957A (en) * 2005-12-21 2009-05-28 エフ．ホフマン−ラ ロシュ アーゲー Method for evaluating colorectal cancer by measuring hemoglobin and M2-PK in stool samples
US10087449B2 (en) 2014-04-07 2018-10-02 Shionogi & Co., Ltd. Pharmaceutical composition for treating chronic kidney disease
CN106248946A (en) * 2016-08-19 2016-12-21 浙江大学 A kind of enzyme-linked immunologic detecting kit and application thereof
ES2785682T3 (en) 2017-07-17 2020-10-07 Univ Masarykova Colorectal Cancer Diagnostic Method

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002070742A1 (en) * 2001-03-01 2002-09-12 Epigenomics Ag Method for the development of gene panels for diagnostic and therapeutic purposes based on the expression and methylatoin status of the genes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002070742A1 (en) * 2001-03-01 2002-09-12 Epigenomics Ag Method for the development of gene panels for diagnostic and therapeutic purposes based on the expression and methylatoin status of the genes

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
AHLQUIST D A: "FECAL OCCULT BLOOD TESTING FOR COLORECTAL CANCER CAN WE AFFORD TO DO THIS?", GASTROENTEROLOGY CLINICS OF NORTH AMERICA, XX, XX, vol. 26, no. 1, March 1997 (1997-03-01), pages 41 - 55, XP008021412 *
AOYAMA K ET AL: "Nicotinamide-N-methyltransferase is higher in the lumbar cerebrospinal fluid of patients with Parkinson's disease.", NEUROSCIENCE LETTERS. 26 JAN 2001, vol. 298, no. 1, 26 January 2001 (2001-01-26), pages 78 - 80, XP002237184, ISSN: 0304-3940 *
OKAMURA A ET AL: "INCREASED HEPATIC NICOTINAMIDE N-METHYLTRANSFERASE ACTIVITY AS A MARKER OF CANCER CACHEXIA IN MICE BEARING COLON 26 ADENOCARCINOMA", JAPANESE JOURNAL OF CANCER RESEARCH, JAPANESE CANCER ASSOCIATION, TOKYO, JP, vol. 89, no. 6, June 1998 (1998-06-01), pages 649 - 656, XP009008878, ISSN: 0910-5050 *
PARSONS RICHARD B ET AL: "Expression of nicotinamide N-methyltransferase (E.C. 2.1.1.1) in the Parkinsonian brain", JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, vol. 61, no. 2, February 2002 (2002-02-01), pages 111 - 124, XP009033873, ISSN: 0022-3069 *
SIEG ANDREAS ET AL: "Detection of colorectal neoplasms by the highly sensitive hemoglobin-haptoglobin complex in feces", INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, vol. 14, no. 6, December 1999 (1999-12-01), pages 267 - 271, XP002288706, ISSN: 0179-1958 *

Also Published As

Publication number Publication date
WO2004071267A2 (en) 2004-08-26

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