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WO2004070680A1 - Simulateur de systeme vasculaire - Google Patents

Simulateur de systeme vasculaire Download PDF

Info

Publication number
WO2004070680A1
WO2004070680A1 PCT/GB2004/000495 GB2004000495W WO2004070680A1 WO 2004070680 A1 WO2004070680 A1 WO 2004070680A1 GB 2004000495 W GB2004000495 W GB 2004000495W WO 2004070680 A1 WO2004070680 A1 WO 2004070680A1
Authority
WO
WIPO (PCT)
Prior art keywords
test system
conduit
pump
fluid
test
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2004/000495
Other languages
English (en)
Inventor
Robert Gordon Hood
Craig Mcleod Duff
Peter Arno Stonebridge
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tayside Flow Technologies Ltd
Original Assignee
Tayside Flow Technologies Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tayside Flow Technologies Ltd filed Critical Tayside Flow Technologies Ltd
Publication of WO2004070680A1 publication Critical patent/WO2004070680A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
    • G09B23/00—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes
    • G09B23/28—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine
    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
    • G09B23/00—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes
    • G09B23/28—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine
    • G09B23/30—Anatomical models

Definitions

  • the invention relates to a test system for simulating a conduit system, and especially for simulating a compliant conduit system.
  • the compliance refers to the elastic expansion of the vascular system, and especially the blood vessels, that occurs when there is a pressure pulse through the vascular system, for example, when the heart beats. Subsequent contraction of the vascular system following the pressure pulse produces a secondary pulse in the vascular system as the vascular system reverts back to its original state.
  • the compliance can vary from subject to subject depending on age and fitness of the subject, as well as other factors. A healthy subject would typically have greater compliance and this would normally improve blood flow by the secondary pulse helping to push blood through the vascular system. However, a non-healthy subject would typically have less compliance, and this would normally produce more backflow in the vascular system. This backflow is detrimental as it opposes the normal blood flow in the vascular system.
  • test system for simulating a conduit system, the test system comprising a fluid reservoir, conduit, a pump to pump fluid from the fluid reservoir through the conduit and back to the reservoir, mounting means to mount a section of test conduit in the test system, the test system being substantially non-expansible, and a backflow control means to control the amount of fluid backflow within the test system.
  • substantially non-expansible means non-expansible at the operating pressures of the conduit system being simulated.
  • the backflow control means comprises a variable backflow control means.
  • the variable back flow control means comprises a valving system.
  • the valving system may comprises at least one variable flow valve in parallel with a unidirectional valve, which permits flow in the direction of fluid flow from the pump to the reservoir.
  • the unidirectional valve is also variable.
  • both valves are unidirectional.
  • the fluid reservoir may be pressurised to the pressure of the conduit system being simulated.
  • the conduit is substantially rigid, and may be metal tubing, such as stainless steel tubing.
  • the test system is for simulating the flow of a liquid in a cpnduit system.
  • the test system may be for simulating flow of a gas in a conduit system.
  • the test system simulates a compliant conduit system, such as a vascular system for the human or animal body.
  • the pump simulates the heart.
  • the pump simulates fluid flow velocity and pressure in a blood vessel.
  • the pump may comprise a four piston pump.
  • a four piston pump has the advantage of providing a greater flow volume through the test system compared to a two piston or single piston pump.
  • Figure 1 is a schematic diagram showing a test system
  • Figure 2 is a schematic diagram of an electrically controlled compliance control means
  • Figure 3 is a schematic diagram of a manually controlled compliance control means.
  • Figure 1 shows a test system 1 for simulating a vascular system of a human or animal body.
  • the test system 1 comprises a fluid reservoir 2 that is pressurisable by a source of pressurised gas 3 and tubing 4 extends from the source of pressurised gas 3 to the reservoir 2.
  • Tubing 5 couples the reservoir 2 to a control valve 6.
  • the control valve 6 is coupled by tube 25 to a sample test bath 26, in which a device to be tested (not shown) is mounted.
  • a pump 50 pumps fluid in the reservoir 2 around the test system 1 and to the sample test bath 26.
  • the pump 50 comprises an electric motor 7 that rotates a driveshaft 8 by means of a drive belt 9 and pulleys 10, 11.
  • the driveshaft 8 is threaded so that as it rotates, it moves cross member 12 in the direction of either arrow 13 or arrow 14, depending on the direction of rotation of the driveshaft 8.
  • the cross-member 12 is connected to pistons 15, 16, 17, 18 mounted within piston cylinders 19, 20, 21 , 22, respectively.
  • Each piston cylinder 19 - 22 has two ports 23, 24 at opposite ends of the respective piston cylinder 19 - 22.
  • the ports 23 are coupled to a valve 27 via a tubing 28 and the ports 24 are coupled to a valve 29 via tubing 30.
  • the valves 27, 29 are two-way valves that are switchable to couple the tubing 28, 30 to either tubing 31 coupled to the reservoir 2 or to tubing 32 coupled to the valve 6, which couples the tubing 32 to tubing 25 and the sample test bath 26.
  • the sample test bath 26 also has tubing 33 exiting from the sample test bath that is coupled to a compliance control means in the form of a variable backflow control valve system 34.
  • the variable backflow control valve system 34 may be either manually operated or electrically operated via a control system, such as a computer.
  • An electrically operated variable backflow valve system 34a is shown in
  • the electrically operated variable backflow control valve system 34a includes two electrically operated variable one-way valves 35, 36.
  • Valve 35 permits flow only in the direction of arrows 37 and the valve 36 permits flow only in the direction of arrows 38. Therefore, this enables both the forward flow and the back flow through the valve 34a to be adjusted independently of each other to simulate the compliance of an actual vascular system.
  • the manually operated variable backflow control valve system 34b operates in the same way as the electrically operated variable backflow control valve system 34a, except that one way valves 40, 41 are operated manually instead of electrically. As with the valves 35, 36, the valves 40, 41 only permit flow in the direction of the arrows 37, 38 respectively. As with the electrically operated variable backflow control valve system 34a, this permits both the forward flow and the back flow through the valve 34b to be adjusted independently of each other to simulate the compliance of an actual vascular system.
  • the valve 34 is coupled to the reservoir 2 by tubing 45.
  • All the tubing 4, 5, 25, 28, 30, 31 , 32, 33, 45 is stainless steel so that it is substantially rigid at the operating pressures of the test system 1.
  • the operating pressures are anatomical pressures, which are typically, in the region of 60mmHg to 200mmHg.
  • a patient's heart output and vascular responses are recorded and stored.
  • the stored data is then downloaded on to a computer 50.
  • a device to be tested is mounted in the sample test bath 26 and coupled by tubing between inlet 46 and outlet 47.
  • the cross member 12 is driven in the direction of the arrow 13 or the arrow 14.
  • the valve 27 is switched to couple the tubing 28 to the tubing 31 , and thereby to the reservoir 2.
  • this causes fluid in the reservoir 2 to be drawn through the tubing 31, the valve 27, the tubing 28 and into the piston cylinders 19 - 22 through the ports 23.
  • the valve 29 is switched to couple the tubing 30 to the tubing 32.
  • the fluid will then pass through the device being tested and pass out of the mounting tray 26 through outlet 47 and the tubing 33 to the variable backflow control valve system 34. The fluid then passes back to the fluid reservoir 2 through the tubing 45.
  • the motor 7 is controlled by the computer 50 using the stored data of a patient's heart output and vascular responses to simulate the pulse flow in the patient's vascular system. Hence, the motor 7 is driven in pulses so that the fluid pushed out of the ports 24 is pushed out in a manner that simulates fluid flow in the blood vessel system being modelled.
  • the pulsed operation of the motor 7 produce a pressure pulse in the system 1 and by varying the forward flow and back flow through the variable backflow control valve system 34, it is possible to vary the compliance of the test system to reproduce the compliance of the vascular system being simulated. If the variable backflow control valve system 34 is electrically operated, it can be controlled by the computer 50 using the stored data with the movement of the motor 7 and the operation of the valves 27, 29.
  • the tubing 5 enables draining of the device being tested to the reservoir 2 by gravity when the valve 6 is operated to couple the tubing 25 to the tubing 5.
  • test system 1 is particularly useful for the ex vivo testing of vascular prosthetic devices, such as vascular grafts, stents, filters and valves.
  • An advantage of the invention is that by having a substantially rigid (or non- expansible) test system 1 , it is possible to pressurise the system to the operating pressure of the conduit system being simulated. It is also possible to control back flow within the system 1 to simulate back flow conditions, such as those caused by compliance within the conduit system being simulated.

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  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Computational Mathematics (AREA)
  • Mathematical Analysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Algebra (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medical Informatics (AREA)
  • Mathematical Optimization (AREA)
  • Mathematical Physics (AREA)
  • Pure & Applied Mathematics (AREA)
  • Business, Economics & Management (AREA)
  • Educational Administration (AREA)
  • Educational Technology (AREA)
  • Theoretical Computer Science (AREA)
  • Instructional Devices (AREA)

Abstract

L'invention concerne un système d'essai (1) destiné à simuler un système de conduit. Le système d'essai (1) comprend un réservoir de fluide (2), un conduit (5, 25, 28, 30, 31, 33, 45), une pompe (50) destinée à pomper le fluide du réservoir de fluide (2) par le conduit (5, 25, 28, 30, 31, 33, 45) et en retour au réservoir (2). Est également prévu un moyen de montage (26) pour monter une section du conduit d'essai dans le système d'essai (1). Le système d'essai (1) est sensiblement non extensible et un moyen de commande de refoulement (34) commande la quantité de refoulement de fluide à l'intérieur du système d'essai (1).
PCT/GB2004/000495 2003-02-08 2004-02-09 Simulateur de systeme vasculaire Ceased WO2004070680A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0302932.9 2003-02-08
GB0302932A GB0302932D0 (en) 2003-02-08 2003-02-08 A test system for simulating a conduit system

Publications (1)

Publication Number Publication Date
WO2004070680A1 true WO2004070680A1 (fr) 2004-08-19

Family

ID=9952692

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2004/000495 Ceased WO2004070680A1 (fr) 2003-02-08 2004-02-09 Simulateur de systeme vasculaire

Country Status (2)

Country Link
GB (1) GB0302932D0 (fr)
WO (1) WO2004070680A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0624861A2 (fr) * 1993-05-13 1994-11-17 Gerhard Szinicz Appareil et procédé d'entraînement chirurgical
EP0825582A1 (fr) * 1996-07-26 1998-02-25 Peter Lyon Harris Système de simulation
GB2338582A (en) * 1998-06-19 1999-12-22 Simutech Limited Surgical simulators
US20020042701A1 (en) * 2000-10-06 2002-04-11 Dancu Michael B. System and method to simulate hemodynamics
WO2002041285A2 (fr) * 2000-11-17 2002-05-23 David Levy Appareil medical de simulation et procedes apparentes

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0624861A2 (fr) * 1993-05-13 1994-11-17 Gerhard Szinicz Appareil et procédé d'entraînement chirurgical
EP0825582A1 (fr) * 1996-07-26 1998-02-25 Peter Lyon Harris Système de simulation
GB2338582A (en) * 1998-06-19 1999-12-22 Simutech Limited Surgical simulators
US20020042701A1 (en) * 2000-10-06 2002-04-11 Dancu Michael B. System and method to simulate hemodynamics
WO2002041285A2 (fr) * 2000-11-17 2002-05-23 David Levy Appareil medical de simulation et procedes apparentes

Also Published As

Publication number Publication date
GB0302932D0 (en) 2003-03-12

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