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WO2004070008A8 - Methods and compositions for using suramin, pentosan polysulfate, telomerase antisense, and telomerase inhibitors - Google Patents

Methods and compositions for using suramin, pentosan polysulfate, telomerase antisense, and telomerase inhibitors

Info

Publication number
WO2004070008A8
WO2004070008A8 PCT/US2004/002609 US2004002609W WO2004070008A8 WO 2004070008 A8 WO2004070008 A8 WO 2004070008A8 US 2004002609 W US2004002609 W US 2004002609W WO 2004070008 A8 WO2004070008 A8 WO 2004070008A8
Authority
WO
WIPO (PCT)
Prior art keywords
telomerase
compositions
methods
suramin
antisense
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/002609
Other languages
French (fr)
Other versions
WO2004070008A2 (en
WO2004070008A3 (en
Inventor
Jessie L-S Au
M Guillaume Wientjes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CA002515000A priority Critical patent/CA2515000A1/en
Priority to EP04706977A priority patent/EP1606302A4/en
Priority to AU2004209428A priority patent/AU2004209428A1/en
Priority to JP2006503176A priority patent/JP2007525414A/en
Publication of WO2004070008A2 publication Critical patent/WO2004070008A2/en
Publication of WO2004070008A3 publication Critical patent/WO2004070008A3/en
Priority to US11/193,883 priority patent/US20050282893A1/en
Anticipated expiration legal-status Critical
Publication of WO2004070008A8 publication Critical patent/WO2004070008A8/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/07049—RNA-directed DNA polymerase (2.7.7.49), i.e. telomerase or reverse-transcriptase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention provides methods and compositions for inhibiting telomerase activity and treatment of telomerase mediated conditions or diseases. The methods, compounds, and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents, surgery, or radiation in the treatment of conditions or diseases mediated by telomerase activity, such as in the treatment of cancer.
PCT/US2004/002609 2003-01-31 2004-01-30 Methods and compositions for using suramin, pentosan polysulfate, telomerase antisense, and telomerase inhibitors Ceased WO2004070008A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002515000A CA2515000A1 (en) 2003-01-31 2004-01-30 Methods and compositions for using suramin, pentosan polysulfate, telomerase antisense, and telomerase inhibitors
EP04706977A EP1606302A4 (en) 2003-01-31 2004-01-30 Methods and compositions for using suramin, pentosan polysulfate, telomerase antisense, and telomerase inhibitors
AU2004209428A AU2004209428A1 (en) 2003-01-31 2004-01-30 Methods and compositions for using suramin, pentosan polysulfate, telomerase antisense, and telomerase inhibitors
JP2006503176A JP2007525414A (en) 2003-01-31 2004-01-30 Methods and ingredients for using suramin, pentosan polysulfate, telomerase antisense, and telomerase inhibitors
US11/193,883 US20050282893A1 (en) 2004-01-30 2005-07-29 Methods and compositions for using suramin, pentosan, polysulfate, telomerase antisense and telomerase inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44406103P 2003-01-31 2003-01-31
US60/444,061 2003-01-31

Publications (3)

Publication Number Publication Date
WO2004070008A2 WO2004070008A2 (en) 2004-08-19
WO2004070008A3 WO2004070008A3 (en) 2005-05-26
WO2004070008A8 true WO2004070008A8 (en) 2005-09-29

Family

ID=32850822

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/002609 Ceased WO2004070008A2 (en) 2003-01-31 2004-01-30 Methods and compositions for using suramin, pentosan polysulfate, telomerase antisense, and telomerase inhibitors

Country Status (6)

Country Link
EP (1) EP1606302A4 (en)
JP (1) JP2007525414A (en)
CN (1) CN1768075A (en)
AU (1) AU2004209428A1 (en)
CA (1) CA2515000A1 (en)
WO (1) WO2004070008A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SMT202000328T1 (en) * 2012-12-07 2020-07-08 Geron Corp Use of the telomerase inhibitor imetelstat for the treatment of myelodysplastic syndrome
US11787783B2 (en) 2016-12-13 2023-10-17 Beta Therapeutics Pty Ltd Heparanase inhibitors and use thereof
AU2017377659A1 (en) * 2016-12-13 2019-07-11 Beta Therapeutics Pty. Ltd. Methods of treating ocular disorders
JP2020503377A (en) 2016-12-13 2020-01-30 ベータ セラピューティクス プロプライアタリー リミティド Heparanase inhibitors and uses thereof
JPWO2022114111A1 (en) * 2020-11-27 2022-06-02
CN119770468B (en) * 2025-01-03 2025-10-31 中国人民解放军军事科学院军事医学研究院 Application of suramin sodium in the prevention and/or treatment of radiation-induced intestinal injury

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5882893A (en) * 1997-12-04 1999-03-16 Millennium Pharmaceuticals, Inc. Nucleic acids encoding muscarinic receptors and uses therefor

Also Published As

Publication number Publication date
WO2004070008A2 (en) 2004-08-19
JP2007525414A (en) 2007-09-06
CA2515000A1 (en) 2004-08-19
EP1606302A4 (en) 2009-02-18
WO2004070008A3 (en) 2005-05-26
EP1606302A2 (en) 2005-12-21
AU2004209428A1 (en) 2004-08-19
CN1768075A (en) 2006-05-03

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