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WO2004067721A3 - Tkts as modifiers of the beta-catenin pathway and methods of use - Google Patents

Tkts as modifiers of the beta-catenin pathway and methods of use Download PDF

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Publication number
WO2004067721A3
WO2004067721A3 PCT/US2004/002321 US2004002321W WO2004067721A3 WO 2004067721 A3 WO2004067721 A3 WO 2004067721A3 US 2004002321 W US2004002321 W US 2004002321W WO 2004067721 A3 WO2004067721 A3 WO 2004067721A3
Authority
WO
WIPO (PCT)
Prior art keywords
beta
methods
tkts
modifiers
catenin pathway
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/002321
Other languages
French (fr)
Other versions
WO2004067721A2 (en
Inventor
Helen Francis-Lang
Christopher G Winter
Richard Benn Abegania Ventura
Kim Lickteig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Exelixis Inc
Original Assignee
Exelixis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exelixis Inc filed Critical Exelixis Inc
Priority to JP2006503093A priority Critical patent/JP2007524355A/en
Priority to AU2004207272A priority patent/AU2004207272A1/en
Priority to CA002513601A priority patent/CA2513601A1/en
Priority to EP04706014A priority patent/EP1587911A4/en
Priority to US10/543,639 priority patent/US20070020628A1/en
Publication of WO2004067721A2 publication Critical patent/WO2004067721A2/en
Anticipated expiration legal-status Critical
Publication of WO2004067721A3 publication Critical patent/WO2004067721A3/en
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1022—Transferases (2.) transferring aldehyde or ketonic groups (2.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y202/00—Transferases transferring aldehyde or ketonic groups (2.2)
    • C12Y202/01—Transketolases and transaldolases (2.2.1)
    • C12Y202/01001—Transketolase (2.2.1.1)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Human TKT genes are identified as modulators of the beta-catenin pathway, and thus are therapeutic targets for disorders associated with defective beta-catenin function. Methods for identifying modulators of beta-catenin, comprising screening for agents that modulate the activity of TKT are provided.
PCT/US2004/002321 2003-01-29 2004-01-28 Tkts as modifiers of the beta-catenin pathway and methods of use Ceased WO2004067721A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2006503093A JP2007524355A (en) 2003-01-29 2004-01-28 TKTs as modifiers of the β-catenin pathway and methods of use
AU2004207272A AU2004207272A1 (en) 2003-01-29 2004-01-28 TKTS as modifiers of the beta-catenin pathway and methods of use
CA002513601A CA2513601A1 (en) 2003-01-29 2004-01-28 Tkts as modifiers of the beta-catenin pathway and methods of use
EP04706014A EP1587911A4 (en) 2003-01-29 2004-01-28 Tkts as modifiers of the beta-catenin pathway and methods of use
US10/543,639 US20070020628A1 (en) 2004-01-28 2004-01-28 Tkts as mondifiers of the beta-catenin pathway and methods of use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44347803P 2003-01-29 2003-01-29
US60/443,478 2003-01-29

Publications (2)

Publication Number Publication Date
WO2004067721A2 WO2004067721A2 (en) 2004-08-12
WO2004067721A3 true WO2004067721A3 (en) 2006-12-14

Family

ID=32825336

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/002321 Ceased WO2004067721A2 (en) 2003-01-29 2004-01-28 Tkts as modifiers of the beta-catenin pathway and methods of use

Country Status (5)

Country Link
EP (1) EP1587911A4 (en)
JP (1) JP2007524355A (en)
AU (1) AU2004207272A1 (en)
CA (1) CA2513601A1 (en)
WO (1) WO2004067721A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002099122A1 (en) * 2001-06-05 2002-12-12 Exelixis, Inc. Modifiers of the p53 pathway and methods of use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002099122A1 (en) * 2001-06-05 2002-12-12 Exelixis, Inc. Modifiers of the p53 pathway and methods of use

Also Published As

Publication number Publication date
EP1587911A4 (en) 2007-09-12
EP1587911A2 (en) 2005-10-26
WO2004067721A2 (en) 2004-08-12
AU2004207272A1 (en) 2004-08-12
CA2513601A1 (en) 2004-08-12
JP2007524355A (en) 2007-08-30

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