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WO2004066950A3 - Derives de quinoleine en tant qu'antagonistes du recepteur nk-2 et nk-3 - Google Patents

Derives de quinoleine en tant qu'antagonistes du recepteur nk-2 et nk-3 Download PDF

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Publication number
WO2004066950A3
WO2004066950A3 PCT/US2004/002366 US2004002366W WO2004066950A3 WO 2004066950 A3 WO2004066950 A3 WO 2004066950A3 US 2004002366 W US2004002366 W US 2004002366W WO 2004066950 A3 WO2004066950 A3 WO 2004066950A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptor antagonists
quinoline derivatives
compounds
useful
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/002366
Other languages
English (en)
Other versions
WO2004066950A2 (fr
Inventor
Jeffrey Kerns
Qi Jin
Zehong Wan
Hong Nie
Chongjie Zhu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Priority to EP04706434A priority Critical patent/EP1601360A2/fr
Priority to US10/542,870 priority patent/US20060135771A1/en
Priority to JP2006503104A priority patent/JP2006517226A/ja
Publication of WO2004066950A2 publication Critical patent/WO2004066950A2/fr
Publication of WO2004066950A3 publication Critical patent/WO2004066950A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Abstract

La présente invention a trait à des composés de formule (I) qui sont des antagonistes du récepteur de NK2 et NK3 et sont utiles dans le traitement de maladies respiratoires, ou un sel pharmaceutiquement acceptable de desdits composés.
PCT/US2004/002366 2003-01-30 2004-01-29 Derives de quinoleine en tant qu'antagonistes du recepteur nk-2 et nk-3 Ceased WO2004066950A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP04706434A EP1601360A2 (fr) 2003-01-30 2004-01-29 Derives de quinoleine en tant qu'antagonistes du recepteur nk-2 et nk-3
US10/542,870 US20060135771A1 (en) 2003-01-30 2004-01-29 Quinoline derivatives as nk-2 and nk-3 receptor antagonists
JP2006503104A JP2006517226A (ja) 2003-01-30 2004-01-29 Ｎｋ−２およびｎｋ−３受容体アンタゴニストとしてのキノリン誘導体

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44365003P 2003-01-30 2003-01-30
US60/443,650 2003-01-30

Publications (2)

Publication Number Publication Date
WO2004066950A2 WO2004066950A2 (fr) 2004-08-12
WO2004066950A3 true WO2004066950A3 (fr) 2004-11-04

Family

ID=32825355

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/002366 Ceased WO2004066950A2 (fr) 2003-01-30 2004-01-29 Derives de quinoleine en tant qu'antagonistes du recepteur nk-2 et nk-3

Country Status (4)

Country Link
US (1) US20060135771A1 (fr)
EP (1) EP1601360A2 (fr)
JP (1) JP2006517226A (fr)
WO (1) WO2004066950A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070060593A1 (en) * 2003-06-25 2007-03-15 Kerns Jeffrey K 4-Carboxamido quinoline derivatives for use as nk-2 and nk-3
GB0515580D0 (en) 2005-07-29 2005-09-07 Merck Sharp & Dohme Therapeutic compounds

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002044165A1 (fr) * 2000-11-28 2002-06-06 Glaxosmithkline Spa Derives de quinoline utilises comme antagonistes de nk-3

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002044165A1 (fr) * 2000-11-28 2002-06-06 Glaxosmithkline Spa Derives de quinoline utilises comme antagonistes de nk-3

Also Published As

Publication number Publication date
EP1601360A2 (fr) 2005-12-07
US20060135771A1 (en) 2006-06-22
WO2004066950A2 (fr) 2004-08-12
JP2006517226A (ja) 2006-07-20

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