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WO2004065383A3 - Nouvelle synthese d'irbesartan - Google Patents

Nouvelle synthese d'irbesartan Download PDF

Info

Publication number
WO2004065383A3
WO2004065383A3 PCT/US2004/001135 US2004001135W WO2004065383A3 WO 2004065383 A3 WO2004065383 A3 WO 2004065383A3 US 2004001135 W US2004001135 W US 2004001135W WO 2004065383 A3 WO2004065383 A3 WO 2004065383A3
Authority
WO
WIPO (PCT)
Prior art keywords
irbesartan
novel synthesis
novel
imidazolephenylboronic
diazaspiro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/001135
Other languages
English (en)
Other versions
WO2004065383A2 (fr
Inventor
Gennady Nisnevich
Igor Rukhman
Boris Pertsikov
Julia Kaftanov
Ben-Zion Dolitzky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Teva Pharmaceuticals USA Inc
Original Assignee
Teva Pharmaceutical Industries Ltd
Teva Pharmaceuticals USA Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd, Teva Pharmaceuticals USA Inc filed Critical Teva Pharmaceutical Industries Ltd
Priority to SI200430833T priority Critical patent/SI1509517T1/sl
Priority to EP04702955A priority patent/EP1509517B1/fr
Priority to DE602004014321T priority patent/DE602004014321D1/de
Priority to CA002513373A priority patent/CA2513373A1/fr
Publication of WO2004065383A2 publication Critical patent/WO2004065383A2/fr
Publication of WO2004065383A3 publication Critical patent/WO2004065383A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Catalysts (AREA)

Abstract

L'invention concerne un procédé de préparation d'irbésartan par réaction de couplage de Suzuki et un nouveau produit intermédiaire, le 2-butyl-3-(4'-bromobenzyle)-1,3-diazaspiro[4.4]none-1-ène-4-one, approprié pour ledit processus. Ce nouveau processus comprend l'étape de la réaction d'un tel produit intermédiaire avec un acide imidazolephénylboronique protégé.
PCT/US2004/001135 2003-01-16 2004-01-16 Nouvelle synthese d'irbesartan Ceased WO2004065383A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
SI200430833T SI1509517T1 (sl) 2003-01-16 2004-01-16 Nova sinteza irbesartana
EP04702955A EP1509517B1 (fr) 2003-01-16 2004-01-16 Nouvelle synthese d'irbesartan
DE602004014321T DE602004014321D1 (de) 2003-01-16 2004-01-16 Neue synthese von irbesartan
CA002513373A CA2513373A1 (fr) 2003-01-16 2004-01-16 Nouvelle synthese d'irbesartan

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44099703P 2003-01-16 2003-01-16
US60/440,997 2003-01-16

Publications (2)

Publication Number Publication Date
WO2004065383A2 WO2004065383A2 (fr) 2004-08-05
WO2004065383A3 true WO2004065383A3 (fr) 2004-12-16

Family

ID=32771889

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/001135 Ceased WO2004065383A2 (fr) 2003-01-16 2004-01-16 Nouvelle synthese d'irbesartan

Country Status (10)

Country Link
US (6) US7019148B2 (fr)
EP (3) EP1509517B1 (fr)
CN (2) CN1759113A (fr)
AT (1) ATE398121T1 (fr)
CA (1) CA2513373A1 (fr)
DE (1) DE602004014321D1 (fr)
ES (1) ES2281312T3 (fr)
PT (1) PT1509517E (fr)
SI (1) SI1509517T1 (fr)
WO (1) WO2004065383A2 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7957356B2 (en) 2002-05-13 2011-06-07 Misomino Chi Acquisitions L.L.C. Scalable media access control for multi-hop high bandwidth communications
US7941149B2 (en) 2002-05-13 2011-05-10 Misonimo Chi Acquistion L.L.C. Multi-hop ultra wide band wireless network communication
US8780770B2 (en) * 2002-05-13 2014-07-15 Misonimo Chi Acquisition L.L.C. Systems and methods for voice and video communication over a wireless network
CN1759113A (zh) * 2003-01-16 2006-04-12 特瓦制药工业有限公司 伊贝沙坦的新合成方法
PT1590343E (pt) * 2003-02-05 2008-09-11 Teva Pharma Síntese de 2-butil-3-(2¿-(1-tritil-1h-tetrazol-5-il)bifenil-4-il)-1,3-diazaspiro-4,4-non-en-4-ona
US20090286990A1 (en) * 2004-05-20 2009-11-19 Reguri Buchi Reddy Process for preparing irbesartan
TWI346108B (en) * 2004-08-23 2011-08-01 Bristol Myers Squibb Co A method for preparing irbesartan and intermediates thereof
DE102004060699A1 (de) * 2004-12-16 2006-06-22 Ratiopharm Gmbh Verfahren zur Herstellung von Candesartan
ES2308591T3 (es) * 2004-12-22 2008-12-01 Algry Quimica, S.L Intermedios para la preparacion de antagonistas de los receptores de la angiotensina ii.
SI21965A (sl) * 2005-01-05 2006-08-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Priprava tetrazolskega derivata
ES2259909B1 (es) * 2005-02-28 2007-06-16 Inke, S.A. Procedimiento para la obtencion de un compuesto farmaceuticamente activo y de su intermedio de sintesis.
WO2006125592A2 (fr) * 2005-05-24 2006-11-30 Lek Pharmaceuticals D.D. Procede de preparation de derives de 2-alkyl-1-((2'-substitue-biphenyl-4-yl)methyl)-imidazole, dihydroimidazole ou benzimidazole
EP1749828A1 (fr) 2005-08-04 2007-02-07 Farmaprojects S.L. Procédé pour la préparation d'un récepteur de l'angiotensine II
EP1764365A1 (fr) * 2005-09-20 2007-03-21 KRKA, D.D., Novo Mesto Méthode de préparation de dérivés de sartan et des intermédiaires servant à un tel procédé
WO2007049293A1 (fr) 2005-10-28 2007-05-03 Alembic Limited Meilleur procédé pour la préparation d'irbésartan
ES2300175B1 (es) * 2006-02-14 2009-06-08 Inke, S.A. Procedimiento para la obtencion de intermedios utiles en la obtencion de un compuesto farmaceuticamente activo.
EP2016073B1 (fr) 2006-04-07 2011-07-27 LEK Pharmaceuticals d.d. Procede de preparation d'irbesartan pur
US8175613B2 (en) 2006-08-04 2012-05-08 Misonimo Chi Acquisitions L.L.C. Systems and methods for determining location of devices within a wireless network
US20080103312A1 (en) * 2006-08-29 2008-05-01 Kansal Vinod K Processes for the synthesis of 5-phenyl-1-trityl-1H-tetrazole
JP4861484B2 (ja) * 2006-12-07 2012-01-25 ミソニモ チ アクイジションズ エル．エル．シー． タイムスロット及びチャネルを割り当てるシステム及び方法
KR101676512B1 (ko) 2009-04-28 2016-11-15 다이이찌 산쿄 가부시키가이샤 올메살탄메독소밀의 제조 방법
CN106608886A (zh) * 2015-11-22 2017-05-03 宁夏际华环境安全科技有限公司 一种苯基硼酸生产工艺

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0508393A1 (fr) * 1991-04-05 1992-10-14 G.D. Searle & Co. Composés de N-arylhétéroarylalkyl imidazol-2-one dans le traitement de troubles circulatoires
US5310929A (en) * 1992-08-06 1994-05-10 E. I. Du Pont De Nemours And Company Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists
WO1994011012A1 (fr) * 1992-11-06 1994-05-26 Merck & Co., Inc. Analogues dipeptidiques substitues favorisant la liberation de l'hormone de croissance
GB2281072A (en) * 1991-08-19 1995-02-22 Du Pont Angiotensin II receptor blocking imidazoline derivatives
US5541209A (en) * 1994-08-22 1996-07-30 Bristol-Myers Squibb Company Method of treating or preventing cardiac arrhythmia employing an N-substituted heterocyclic derivative
EP0782996A1 (fr) * 1994-09-20 1997-07-09 Wakunaga Seiyaku Kabushiki Kaisha Procede de production d'un derive de n-biphenylmethylthiadiazoline ou un sel de celui-ci et son intermediaire de production
FR2780403A1 (fr) * 1998-06-24 1999-12-31 Sanofi Sa Nouvelle forme de l'irbesartan, procedes pour obtenir ladite forme et compositions pharmaceutiques en contenant
WO2004007482A2 (fr) * 2002-07-16 2004-01-22 Teva Pharmaceutical Industries Ltd. Nouveau procede de synthese d'irbesartan

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US531929A (en) * 1895-01-01 harden
GB8910547D0 (en) * 1989-05-08 1989-06-21 Ici America Inc Substituted ketones
US5270317A (en) * 1990-03-20 1993-12-14 Elf Sanofi N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present
FR2725987B1 (fr) 1994-10-19 1997-01-10 Sanofi Sa Procede pour la preparation d'un derive de tetrazole sous deux formes cristallines et nouvelle forme cristalline de ce derive
US5541204A (en) * 1994-12-02 1996-07-30 Bristol-Myers Squibb Company Aryloxypropanolamine β 3 adrenergic agonists
IT1292437B1 (it) * 1997-06-30 1999-02-08 Zambon Spa Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti
CN1759113A (zh) * 2003-01-16 2006-04-12 特瓦制药工业有限公司 伊贝沙坦的新合成方法

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0508393A1 (fr) * 1991-04-05 1992-10-14 G.D. Searle & Co. Composés de N-arylhétéroarylalkyl imidazol-2-one dans le traitement de troubles circulatoires
GB2281072A (en) * 1991-08-19 1995-02-22 Du Pont Angiotensin II receptor blocking imidazoline derivatives
US5310929A (en) * 1992-08-06 1994-05-10 E. I. Du Pont De Nemours And Company Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists
WO1994011012A1 (fr) * 1992-11-06 1994-05-26 Merck & Co., Inc. Analogues dipeptidiques substitues favorisant la liberation de l'hormone de croissance
US5541209A (en) * 1994-08-22 1996-07-30 Bristol-Myers Squibb Company Method of treating or preventing cardiac arrhythmia employing an N-substituted heterocyclic derivative
EP0782996A1 (fr) * 1994-09-20 1997-07-09 Wakunaga Seiyaku Kabushiki Kaisha Procede de production d'un derive de n-biphenylmethylthiadiazoline ou un sel de celui-ci et son intermediaire de production
FR2780403A1 (fr) * 1998-06-24 1999-12-31 Sanofi Sa Nouvelle forme de l'irbesartan, procedes pour obtenir ladite forme et compositions pharmaceutiques en contenant
WO2004007482A2 (fr) * 2002-07-16 2004-01-22 Teva Pharmaceutical Industries Ltd. Nouveau procede de synthese d'irbesartan

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BERNHART G A ET AL: "A NEW SERIES OF IMIDAZOLONES: HIGHLY SPECIFIC AND POTENT NONPEPTIDEAT1 ANTIOTENSIN II RECEPTOR ANTAGONISTS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 36, no. 22, 1993, pages 3371 - 3380, XP002064391, ISSN: 0022-2623 *
MURUGESAN, NATESAN ET AL: "Discovery of N-isoxazolyl biphenylsulfonamides as potent dual angiotensin II and endothelin A receptor antagonists", JOURNAL OF MEDICINAL CHEMISTRY (2002), 45(18), 3829-3835, 2002, XP002281023 *

Also Published As

Publication number Publication date
US20040192713A1 (en) 2004-09-30
US7227026B2 (en) 2007-06-05
US7217825B2 (en) 2007-05-15
US7301035B2 (en) 2007-11-27
ATE398121T1 (de) 2008-07-15
WO2004065383A2 (fr) 2004-08-05
DE602004014321D1 (de) 2008-07-24
EP2039693A3 (fr) 2009-06-17
US7019148B2 (en) 2006-03-28
ES2281312T1 (es) 2007-10-01
US7838683B2 (en) 2010-11-23
EP1509517B1 (fr) 2008-06-11
ES2281312T3 (es) 2008-08-01
US20090216026A1 (en) 2009-08-27
CA2513373A1 (fr) 2004-08-05
US20060135544A1 (en) 2006-06-22
US20060128968A1 (en) 2006-06-15
EP2039693A2 (fr) 2009-03-25
EP2189457A1 (fr) 2010-05-26
PT1509517E (pt) 2008-08-05
EP1509517A2 (fr) 2005-03-02
CN1759113A (zh) 2006-04-12
SI1509517T1 (sl) 2008-10-31
CN101165062A (zh) 2008-04-23
US20070213539A1 (en) 2007-09-13
US20060135780A1 (en) 2006-06-22

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