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WO2004065288A1 - Connecteurs microfluidiques - Google Patents

Connecteurs microfluidiques Download PDF

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Publication number
WO2004065288A1
WO2004065288A1 PCT/AU2004/000077 AU2004000077W WO2004065288A1 WO 2004065288 A1 WO2004065288 A1 WO 2004065288A1 AU 2004000077 W AU2004000077 W AU 2004000077W WO 2004065288 A1 WO2004065288 A1 WO 2004065288A1
Authority
WO
WIPO (PCT)
Prior art keywords
tube
recess
connector
microfluidic
hole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/AU2004/000077
Other languages
English (en)
Inventor
Sebastiaan Garst
Tony Liu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microtechnology Centre Management Ltd
Original Assignee
Microtechnology Centre Management Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microtechnology Centre Management Ltd filed Critical Microtechnology Centre Management Ltd
Publication of WO2004065288A1 publication Critical patent/WO2004065288A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B1/00—Devices without movable or flexible elements, e.g. microcapillary devices
    • B81B1/006—Microdevices formed as a single homogeneous piece, i.e. wherein the mechanical function is obtained by the use of the device, e.g. cutters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N3/00—Investigating strength properties of solid materials by application of mechanical stress
    • G01N3/08—Investigating strength properties of solid materials by application of mechanical stress by applying steady tensile or compressive forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B2201/00—Specific applications of microelectromechanical systems
    • B81B2201/13—Mechanical connectors, i.e. not functioning as an electrical connector
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2203/00—Investigating strength properties of solid materials by application of mechanical stress
    • G01N2203/0014—Type of force applied
    • G01N2203/0016—Tensile or compressive
    • G01N2203/0017—Tensile

Definitions

  • This invention relates to a means and devices for establishing a connection to a microfluidic channel.
  • Microfluidic connectors are required for external connection to a reservoir, interconnecting two microfluidic devices by tubing or interconnecting modular parts by using a fluidic bus. Connections are required between microfluidic wafers and between fixed and disposable devices from micro to macro connections for single and multi channel devices. The results obtained by research groups are still not meeting all the requirements for these targets.
  • the design of fluidic interconnects is influenced by the intended application of the device the types of manipulations on fluids to be performed and the performance criteria.
  • the ideal interconnect design is one that has the least possible effect on fluid flow.
  • the performance criteria can be split into different elements:
  • USA patent 6319476 discloses a connector that urges the tube and a seal against the microfluidic device.
  • the clamping member is a screw threaded adaptor holding the tube.
  • This device is reconnectable.
  • USA patent 6209928 uses a screw threaded arrangement to provide a reconnectable connector while patent 6273478 covers simpler arrangements. Both patents disclose arrangements in which the tube tips to be inserted need to be micromachined to have a narrower tip with projections or recesses.
  • WO01/86155 discloses an adaptor facilitating microfluidic connections. The device has a large footprint and a relatively complicated rig without eliminating dead volume.
  • USA patent 6605472 discloses a method of connecting a capillary tube to a micro chip device by drilling into the edge of the micro chip to create a flat bottomed hole to communicate with the capillary channel. This enables the microchip device to be used with a mass spectrometer.
  • a commonly used tubing material in microfluidic connections is made of polyethylethyleneketone(PEEK).
  • connection device and method that meets the desirable criteria.
  • the present invention provides a micro fluidic connection port in which a) a microfluidic channel is formed in one surface of a substrate b) a microfluidic through hole extends from the second face of the substrate into said microfluidic channel c) a larger diameter recess is formed about the through hole in the opposite face d) a support is bonded to the second surface about said recess e) said support having a through hole of diameter equal to the diameter of said recess f) the diameter of said recess and support through hole accommodating the external diameter of a connection tube for connecting the microfluidic device to an external device.
  • Connector does not have influence on minimal thickness device.
  • connection assembly adapted to connect a tube to a micro fluidic channel which includes a) a connector base that consists of a tube recess adapted to receive the end of a connector tube b) the micro fluidic channel terminates in said recess c) a clamping recess at least partially surrounding said tube recess and spaced from said tube recess d) a connecting tube optionally incorporating a gasket on its end face which is adapted to seat in said tube recess e) a wedging clamp fitted to said tube which has an inclined face to the wall of the clamping recess so that the tube is fastened to the connector base by pressing down on the wedging clamp.
  • the advantage of this connector is that expensive micro machining of the tubes and the base are avoided and connection is achieved by pressing.
  • the tube is of PEEK and the microfluidic device is preferably formed of poly methylmethacrylate (PMMA).
  • the gasket is preferably made of polydimethylsiloxane (PDMS).
  • Figure 1 is a schematic representation of a first embodiment of this invention
  • Figure 2 is a graph illustrating the pulling force required for the device of figure 1;
  • Figure 3 is a schematic representation of a second embodiment of the invention.
  • Figure 4 is a cross sectional view of the figure 3 embodiment for general use and; Figure 5 illustrates the details of the connector of figure 3 used for applications where dead volume is an issue.
  • This invention is based on the commonly used standard PEEK (polyethylethylene ketone) tube to connect a microfluidic device to supply the micro to macro connection.
  • This invention provides a connector for microfluidic systems useful in the medical and biomedical field, that optimizes performance in terms of fluidic volume, dead volume, size, connection time and reliability.
  • the connector is made for a PEEK tube connecting to a microfluidic device. In the embodiment shown in figure 1 it consists of a PEEK tubel 1, a wedge fitting 13, a gasket seal 15 and connector base 17.
  • a tube recess 12 is formed on the connector base 17 to leave a desired thickness of wall 14 on the outside of the recess 12.
  • a circular clamping slot 16 of the same depth as the tube recess 12 is cut around the tube recess 12.
  • the wedge fitting 13 is machined to a have an internal conical recess so that the rim 19 is of suitable dimensions to match the tube size, the depth of the clamp recess 16 and the diameter of the clamp recess 16.
  • the angle of the internal cone 19 is determined by calculation to reach a suitable lock angle.
  • the assembly steps are a) push and hold down the PEEK tube b) then push down the fitting.
  • the disconnection steps are a) lifting the fitting b) and then lifting the PEEK tube.
  • This connector has been designed to keep the liquid volume in the micro-scale with no dead volume in the design principle as the pressed gasket internal diameter is of the same size as the PEEK tube internal. diameter and the internal diameter of the microfluidic channel.
  • the connector base of this invention can be pre-formed on the microfluidic device directly if the microfluidic device has a sufficient free area and the required thickness. Otherwise, the connector base can be made as additional layer or base and bonded onto the microfluidic device.
  • the wedge fitting and connector base may be fabricated using PMMA (polymethylmethacrylate) or polycarbonate.
  • the connector bases are machined by micro milling a 2 mm PMMA or polycarbonate sheet and the fittings are machined on a lathe machine.
  • the PEEK tube is 1.6 mm outer diameter with 0.5 mm inner diameter.
  • the gaskets were cut by AVIA laser on 0.15 mm thickness PDMS (polydimethylsiloxane).
  • the circular clamping slot may vary with the recess wall having a thickness of 0.2, 0.3 and 0.4 mm thickness and 0.8 ⁇ 1.5 mm depth with 1.6 mm diameter 0.8 ⁇ 1.5 mm deep tube recess and 0.5 mm diameter micro fluidic channel in the centre.
  • Three wedge fittings were machined to match the three tube recess wall thicknesses in the connector base. The cone angle of the wedge fitting was selected to be 5 degree as lock angle based testing results.
  • Connectors were assembled for liquid pressure testing by connecting the PEEK tube to a syringe pump with colour liquid while blocking other end of the connector. The pressure reached over 75 Psi without any leakage.
  • the Pulling force on PEEK tube was tested on a ZWICK testing machine.
  • the fittings were pushed in by hand and then the PEEK tube was pulled by the machine. Then the machine was set up for applying a pushing force to let the machine push fittings in. Forces of 20, 30, 40, and 50 Newtons were used which are within the range of a hand pushing force.
  • the pulling force tests were done by repeating on same connector and with different fittings. The pulling force on the tube was over 20 Newtons.
  • Fig. 2 is a graph illustrating the pulling testing force against distance. From the above it can be seen that this invention provides a connection that meets the requirements for microfluidic systems and laboratory products.
  • the connector size, fitting tolerance, PEEK tube surface and shape can be modified to suit various applications.
  • the connector of this invention is functional at high pressure, has a better lock angle and bigger pulling force than comparable fitting systems. It was found in trials that the polycarbonate fitting performed better than the PMMA device. In polycarbonate the pulling force reached 40 newtons without moving and without the sealing gasket could withstand 1.64 MPa without leaking.
  • the polycarbonate fitting was easier to connect and disconnect and had a reuse ability of 20 times.
  • a second embodiment is illustrated in figures 3-5.
  • the surface connector consists of 4 parts, as illustrated in figure 3.
  • the base part 21 contains the holes 23 to align the standard PEEK tubing .
  • a microchannel in the base connects these holes, or ports of the device. After machining the channel needs to be isolated by laminating a layer 22 to the bottom of the base part 21 containing the microchannel.
  • the moulded connector 25 ensures a reliable and firm connection of the tubing with the ports in the base part 21.
  • a rubbery sealing/gasket 26 is applied.
  • the dimensions of the microchannel 24 in the base part are dependent on the application of the device. A typical dimension would be 200 ⁇ m x 250 ⁇ m.
  • This cross-sectional area corresponds to an inner diameter of 250 ⁇ m in the PEEK tubing to create a homogeneous flow.
  • the standard outer diameter of this PEEK tubing is 1/16", thus the alignment holes 23 in the base need to have the same dimension to mate accurately.
  • the design of the connector 25, in figures 4 & 5 has a hole at the top for alignment of the PEEK tubing.
  • a cylindrical shaped cut-away under the hole provides room for moulding the rubbery sealing 26.
  • the bottom part of the connector has a 10 x 15 mm footprint.
  • the flange is not essential and the foot print can be reduced to the area of the cylindrical tubing part.
  • the connector acts as a generic connector. Dead volume is not an issue and the connector 25 functions as a clamp to hold the tubing 20 in place without leaking.
  • the device is adapted for applications where dead volume is to be avoided.
  • the tubing 20 will align with the via that connects to a microfluidic channel 24.
  • an accurate connection will be realised.
  • the inner diameter of the tubing will align with the via of the microfluidic channel.
  • the hole at the top of the connector is 1.5 mm.
  • a steel wire with a diameter of 1.5 mm is inserted into this hole, to protect it from clogging and more important, align the hole in the rubbery sealing that is moulded into the cut-away of the connector.
  • the material used for the sealing is polydimethylsiloxane (PDMS). This two compound silicon rubber was moulded into the connector and the heat cured in a 100 Celsius heated oven for six hours. After curing the steel wire is pulled out of the connector and the top hole was drilled to meet the outer diameter of the tubing. The inner diameter of the moulded sealing is still 1.5 mm, giving the connector good sealing and clamping properties.
  • PDMS polydimethylsiloxane
  • a very important feature of the moulding procedure is the bubble left on top of the cut-away in the connector as shown in figure 5.
  • This bubble shaped part of the sealing material will be compressed when the connector is attached to the device, providing a pre-loaded sealing between the polycarbonate device and the ABS connector. Also, the diameter of the sealing at that part of the connector will decrease slightly, so improved clamping and sealing properties is achieved between the connector and the PEEK tubing.
  • the final part in this embodiment is the lamination of the polycarbonate base part. After excimer laser micromachining of the channels in polymer substrates, the devices are sealed using a PET/PE (polyethylene terephthalate / polyethylene) laminate.
  • the device can be assembled. After machining all the necessary features in the polycarbonate base part, it can be laminated.
  • the connector and sealing part are integrated in one final part during fabrication. The last assembly step is the most important one, namely the mating of the hole in the connector with the hole in the device and also, the leakage free bonding of the connector with a preload in the sealing.
  • a piece of tubing is inserted into the connector, while the end is sticking out about 2 mm.
  • adhesive 27 (Loctite 406) is applied on the connector 25 and the whole put on the device.
  • the tubing sticking out of the connector will secure the alignment, while the connector is pushed firmly on the polycarbonate base part.
  • the adhesive 27 has enough bonding strength to resist the preload in the sealing and connector, and the tubing may be released from the connector so that the device is ready.
  • a double sided adhesive ring 27 having a thickness of 200 ⁇ m and may be applied on the footprint of the connector.
  • a protective layer can be peeled off to expose the adhesive.
  • this connector will have the sealing pre assembled and the double sided adhesive ring is applied to the connector.
  • the protective layer is peeled off to expose the adhesive and the connector can be bonded to the micro device.
  • the alignment will be accomplished by fitting a tube into the connector. The tip of the tube will protrude from the side with the adhesive. One now can put the tip in the micro device until it touches the bottom with the channel. By sliding the connector over the tube towards the device, an accurate alignment will be achieved. Once the connector reaches the surface of the device, the adhesive layer will secure the position of the connector.
  • the devices were pressurised by blocking one of the in/outlets while the other one was connected to a computer controlled syringe pump.
  • a pressure sensor registered the pressure in the tubing between the pump and the microdevice.
  • a computer was used to acquire the data generated by this sensor.
  • the first test showed a pressure running off scale at the display without any leakages observed. After multiple tests and reconnections no leakage could be observed at the surface connector, proving the durability to be very high for this type of connector. After multiple tests and reconnections no leakage could be observed at the surface connector, proving the durability to be very high for this type of connector.
  • the present invention provides a reusable connection system for microfluidic devices that uses commonly used materials without expensive manufacturing steps.

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Computer Hardware Design (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micromachines (AREA)

Abstract

L'invention concerne des ensembles de connexion conçus pour raccorder un tube à un canal microfluidique. Un premier connecteur comporte un élément de serrage à coins logé dans un évidement annulaire de calage entourant l'orifice microfluidique. Un deuxième connecteur comprend un boîtier de connecteur préajusté et doté d'un matériau d'étanchéité disposé sur l'orifice microfluidique.
PCT/AU2004/000077 2003-01-24 2004-01-23 Connecteurs microfluidiques Ceased WO2004065288A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2003900329A AU2003900329A0 (en) 2003-01-24 2003-01-24 Microfluidic connector
AU2003900329 2003-01-24

Publications (1)

Publication Number Publication Date
WO2004065288A1 true WO2004065288A1 (fr) 2004-08-05

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PCT/AU2004/000077 Ceased WO2004065288A1 (fr) 2003-01-24 2004-01-23 Connecteurs microfluidiques

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AU (1) AU2003900329A0 (fr)
WO (1) WO2004065288A1 (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007037788A1 (de) * 2007-08-10 2008-09-11 Gesellschaft zur Förderung der Analytischen Wissenschaften e.V. Vorrichtung zum Ankoppeln von Leitungen an einen mikrofluidischen Chip
KR101070311B1 (ko) 2009-01-29 2011-10-06 한국표준과학연구원 마이크로플루이딕스 칩을 위한 플랫폼 장치
US8911689B2 (en) 2010-07-27 2014-12-16 General Electric Company Interfacing caps for microfluidic devices and methods of making and using the same
CN104226386A (zh) * 2013-06-14 2014-12-24 中国科学院大连化学物理研究所 一种通用型微流控芯片接口
US8961906B2 (en) 2010-07-27 2015-02-24 General Electric Company Fluid connector devices and methods of making and using the same
EP2982440A4 (fr) * 2014-04-08 2017-01-04 NOK Corporation Accessoire pour injection de liquide et procédé d'injection de liquide
RU185769U1 (ru) * 2018-05-29 2018-12-18 Общество с ограниченной ответственностью Научно-технический центр "БиоКлиникум" Многоканальный коннектор для подключения устройства подачи рабочей среды к микрофлюидному чипу
NL2029067B1 (en) * 2021-08-27 2023-03-15 Univ Delft Tech Fluidic interface
JPWO2024004380A1 (fr) * 2022-06-28 2024-01-04

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000022409A2 (fr) * 1998-10-09 2000-04-20 University Of Alberta Dispositifs microfluidiques connectes a des capillaires en minimisant le volume inutilise
US6248053B1 (en) * 1995-07-25 2001-06-19 Ehnstroem Lars Centrifugal separator comprising tubular elements
US6273478B1 (en) * 1999-03-30 2001-08-14 The Regents Of The University Of California Microfluidic interconnects
WO2002070942A1 (fr) * 2001-03-01 2002-09-12 Commissariat A L'energie Atomique Dispositif pour la connexion de capillaires a un composant de micro-fluidique
US20040017078A1 (en) * 2002-04-02 2004-01-29 Karp Christoph D. Connectors for microfluidic devices

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6248053B1 (en) * 1995-07-25 2001-06-19 Ehnstroem Lars Centrifugal separator comprising tubular elements
WO2000022409A2 (fr) * 1998-10-09 2000-04-20 University Of Alberta Dispositifs microfluidiques connectes a des capillaires en minimisant le volume inutilise
US6273478B1 (en) * 1999-03-30 2001-08-14 The Regents Of The University Of California Microfluidic interconnects
WO2002070942A1 (fr) * 2001-03-01 2002-09-12 Commissariat A L'energie Atomique Dispositif pour la connexion de capillaires a un composant de micro-fluidique
US20040017078A1 (en) * 2002-04-02 2004-01-29 Karp Christoph D. Connectors for microfluidic devices

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007037788A1 (de) * 2007-08-10 2008-09-11 Gesellschaft zur Förderung der Analytischen Wissenschaften e.V. Vorrichtung zum Ankoppeln von Leitungen an einen mikrofluidischen Chip
DE102007037788B4 (de) * 2007-08-10 2010-11-04 Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V. Vorrichtung zum Ankoppeln von Leitungen an einen mikrofluidischen Chip
KR101070311B1 (ko) 2009-01-29 2011-10-06 한국표준과학연구원 마이크로플루이딕스 칩을 위한 플랫폼 장치
US8911689B2 (en) 2010-07-27 2014-12-16 General Electric Company Interfacing caps for microfluidic devices and methods of making and using the same
US8961906B2 (en) 2010-07-27 2015-02-24 General Electric Company Fluid connector devices and methods of making and using the same
CN104226386A (zh) * 2013-06-14 2014-12-24 中国科学院大连化学物理研究所 一种通用型微流控芯片接口
EP2982440A4 (fr) * 2014-04-08 2017-01-04 NOK Corporation Accessoire pour injection de liquide et procédé d'injection de liquide
RU185769U1 (ru) * 2018-05-29 2018-12-18 Общество с ограниченной ответственностью Научно-технический центр "БиоКлиникум" Многоканальный коннектор для подключения устройства подачи рабочей среды к микрофлюидному чипу
NL2029067B1 (en) * 2021-08-27 2023-03-15 Univ Delft Tech Fluidic interface
JPWO2024004380A1 (fr) * 2022-06-28 2024-01-04
WO2024004380A1 (fr) * 2022-06-28 2024-01-04 Nok株式会社 Raccord et structure de raccordement pour dispositif microfluidique

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