[go: up one dir, main page]

WO2004064728A3 - Composes de tetracycline possedant des activites therapeutiques ciblees - Google Patents

Composes de tetracycline possedant des activites therapeutiques ciblees Download PDF

Info

Publication number
WO2004064728A3
WO2004064728A3 PCT/US2004/001036 US2004001036W WO2004064728A3 WO 2004064728 A3 WO2004064728 A3 WO 2004064728A3 US 2004001036 W US2004001036 W US 2004001036W WO 2004064728 A3 WO2004064728 A3 WO 2004064728A3
Authority
WO
WIPO (PCT)
Prior art keywords
therapy
tetracycline compounds
specific tetracycline
specific
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/001036
Other languages
English (en)
Other versions
WO2004064728A2 (fr
Inventor
Stuart B Levy
Michael Draper
Mark L Nelson
Graham Jones
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Paratek Pharmaceuticals Inc
Original Assignee
Paratek Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paratek Pharmaceuticals Inc filed Critical Paratek Pharmaceuticals Inc
Publication of WO2004064728A2 publication Critical patent/WO2004064728A2/fr
Publication of WO2004064728A3 publication Critical patent/WO2004064728A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des méthodes et des composés de traitement de maladies avec des composés de tétracycline possédant une activité thérapeutique ciblée.
PCT/US2004/001036 2003-01-16 2004-01-16 Composes de tetracycline possedant des activites therapeutiques ciblees Ceased WO2004064728A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44114103P 2003-01-16 2003-01-16
US60/441,141 2003-01-16

Publications (2)

Publication Number Publication Date
WO2004064728A2 WO2004064728A2 (fr) 2004-08-05
WO2004064728A3 true WO2004064728A3 (fr) 2004-12-16

Family

ID=32771908

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/001036 Ceased WO2004064728A2 (fr) 2003-01-16 2004-01-16 Composes de tetracycline possedant des activites therapeutiques ciblees

Country Status (1)

Country Link
WO (1) WO2004064728A2 (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002250331A1 (en) * 2001-03-13 2002-09-24 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
JP4416652B2 (ja) 2002-07-12 2010-02-17 パラテック ファーマシューティカルズ インコーポレイテッド ３、１０、および１２ａ置換されたテトラサイクリン化合物
WO2005070878A1 (fr) * 2004-01-15 2005-08-04 Paratek Pharmaceuticals, Inc. Derives a cycle aromatique a provenant de composes de tetracycline
SI1753713T1 (sl) * 2004-05-21 2017-01-31 President And Fellows Of Harvard College Sinteza tetraciklinov in njihovih analogov
EP1778252A4 (fr) * 2004-08-11 2010-01-27 Williamsburg Holdings Llc Composes pharmaceutiques non cardiotoxiques
US8466132B2 (en) * 2004-10-25 2013-06-18 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
AU2005299294B2 (en) * 2004-10-25 2012-06-07 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
AU2006214543A1 (en) * 2005-02-15 2006-08-24 Wyeth 9-substituted tetracyclines
EP1910273A2 (fr) * 2005-07-21 2008-04-16 Paratek Pharmaceuticals, Inc. Tetracyclines 10-substituees et leurs procedes d'utilisation
KR20080041722A (ko) * 2005-08-31 2008-05-13 와이어쓰 글리실사이클린의 9-아미노카르보닐 치환된 유도체
CN100516067C (zh) * 2006-01-10 2009-07-22 上海恒瑞医药有限公司 具有抗肿瘤活性的紫杉酚衍生物
CA2648668C (fr) 2006-04-07 2015-06-23 The President And Fellows Of Harvard College Synthese de tetracyclines et d'analogues de celles-ci
WO2008045507A2 (fr) 2006-10-11 2008-04-17 Paratek Pharmaceuticals, Inc. Composés de tétracycline substitués utilisés pour le traitement d'infections à bacillus anthracis
US7763735B2 (en) 2006-10-11 2010-07-27 President And Fellows Of Harvard College Synthesis of enone intermediate
EP2455367B1 (fr) * 2006-12-21 2015-12-16 Paratek Pharmaceuticals, Inc. Dérivés de tétracycline pour le traitement d'infections bactériennes, virales et parasites
PL2120963T3 (pl) * 2006-12-21 2019-05-31 Paratek Pharm Innc Podstawione związki tetracyklinowe do leczenia zaburzeń zapalnych skóry
GB2446652A (en) * 2007-02-16 2008-08-20 Inion Ltd Osteogenic compounds
GB0708507D0 (en) 2007-05-02 2007-06-13 Queen Mary & Westfield College Substituted phosphonates and their use
PT2271348T (pt) * 2008-03-28 2018-04-16 Paratek Pharm Innc Formulação de comprimido oral de composto de tetraciclina
EP2307027A4 (fr) 2008-07-11 2012-08-15 Neumedics Dérivés de tétracycline présentant une activité antibiotique réduite et des bénéfices neuroprotecteurs
AU2009292986A1 (en) * 2008-09-19 2010-03-25 Paratek Pharmaceuticals, Inc. Tetracycline compounds for the treatment of rheumatoid arthritis and related methods of treatment
EP2424834B1 (fr) 2009-04-30 2018-07-11 President and Fellows of Harvard College Synthèse de tétracyclines et intermédiaires de celles-ci
US20120329761A1 (en) * 2010-03-10 2012-12-27 University Health Network Use of tigecycline for treatment of cancer
CN102204921B (zh) * 2011-04-14 2012-12-26 苏州大学 一种四环素类衍生物在制备放疗增敏药物中的应用
CN103717571B8 (zh) * 2011-07-26 2017-05-17 山东亨利医药科技有限责任公司 9‑氨基甲基取代的四环素类化合物
CN104797429B (zh) 2012-11-21 2017-04-19 日本曹达株式会社 使用非酚类化合物的记录材料、记录片和将非酚类化合物用于显色剂的方法
CN103142624A (zh) * 2013-03-01 2013-06-12 西南大学 抗生素替加环素在制备抗癌药物中的应用
KR102237887B1 (ko) 2013-03-15 2021-04-07 멜린타 서브시디어리 코프. 항생제를 사용하여 과체중 및 비만 환자에서 감염을 치료하는 방법
JP6783777B2 (ja) * 2015-02-09 2020-11-11 イェダ リサーチ アンド ディベロップメント カンパニー リミテッドＹｅｄａ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｄｅｖｅｌｏｐｍｅｎｔ Ｃｏ．Ｌｔｄ． 二次感染の予防方法
US10633337B2 (en) * 2016-06-22 2020-04-28 Kbp Biosciences Co., Ltd. Crystal forms of a 9-aminomethyl substituted tetracycline compound and a preparation method thereof
WO2019241490A1 (fr) * 2018-06-13 2019-12-19 Texas Tech University System Nouvelles tétracyclines modifiées pour le traitement de troubles d'utilisation d'alcool, de la douleur et d'autres troubles impliquant des processus inflammatoires potentiels
WO2021021951A1 (fr) 2019-07-29 2021-02-04 Vanderbilt University Inhibiteurs de wdr5-myc
WO2022079204A1 (fr) 2020-10-14 2022-04-21 Institut Du Cerveau Et De La Moelle Epiniere Dérivés de tétracycline pour le traitement de maladies neurodégénératives ou neuroinflammatoires
BR112023015520A2 (pt) * 2021-02-03 2023-10-24 Consejo Nacional De Investigaciones Cientificas Y Tecn Conicet Transportador quimicamente acoplado para fármacos bioativos de baixa hidrofobicidade no sistema nervoso central
EP4551552A1 (fr) 2022-07-08 2025-05-14 ICM (Institut du Cerveau et de la Moelle Épinière) Dérivés de tétracycline

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998052575A1 (fr) * 1997-05-20 1998-11-26 The Trustees Of Columbia University In The City Of New York Utilisation d'inhibiteurs de la proteinase pour le traitement de l'emphyseme pulmonaire
WO2000016783A1 (fr) * 1998-09-21 2000-03-30 The Research Foundation Of State University Of New York Methode de prevention des lesions pulmonaires aiguës
WO2001062261A1 (fr) * 2000-02-25 2001-08-30 Arakis Ltd. Inhibiteurs de metalloproteinase utilises dans le traitement des maladies respiratoires
WO2002072031A2 (fr) * 2001-03-14 2002-09-19 Paratek Pharmaceuticals, Inc. Composes de tetracycline substitue utilises en tant qu'antifongiques synergiques
WO2002072022A2 (fr) * 2001-03-14 2002-09-19 Paratek Pharmaceuticals, Inc. Composes de tetracycline substitues, en tant qu'agents antifongiques
WO2003061767A1 (fr) * 2002-01-25 2003-07-31 Atopic Pty Ltd Techniques et compositions destines au traitement de l'asthme et de troubles associes

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998052575A1 (fr) * 1997-05-20 1998-11-26 The Trustees Of Columbia University In The City Of New York Utilisation d'inhibiteurs de la proteinase pour le traitement de l'emphyseme pulmonaire
WO2000016783A1 (fr) * 1998-09-21 2000-03-30 The Research Foundation Of State University Of New York Methode de prevention des lesions pulmonaires aiguës
WO2001062261A1 (fr) * 2000-02-25 2001-08-30 Arakis Ltd. Inhibiteurs de metalloproteinase utilises dans le traitement des maladies respiratoires
WO2002072031A2 (fr) * 2001-03-14 2002-09-19 Paratek Pharmaceuticals, Inc. Composes de tetracycline substitue utilises en tant qu'antifongiques synergiques
WO2002072022A2 (fr) * 2001-03-14 2002-09-19 Paratek Pharmaceuticals, Inc. Composes de tetracycline substitues, en tant qu'agents antifongiques
WO2003061767A1 (fr) * 2002-01-25 2003-07-31 Atopic Pty Ltd Techniques et compositions destines au traitement de l'asthme et de troubles associes

Also Published As

Publication number Publication date
WO2004064728A2 (fr) 2004-08-05

Similar Documents

Publication Publication Date Title
WO2004064728A3 (fr) Composes de tetracycline possedant des activites therapeutiques ciblees
WO2003005971A3 (fr) Composes de tetracycline a activites therapeutiques cibles
AU2003239568A1 (en) Pyrrolotriazinone compounds and their use to treat diseases
AU2003278775A8 (en) Porifera-based therapeutic compositions for treating and preventing skin diseases
IL173123A0 (en) System and method for the photodynamic treatment of burns, wounds, and related skin disorders
WO2005097119A3 (fr) Inhibiteurs de pten
AU2003300791A1 (en) Combination therapy for the treatment of pain
AU2003300200A1 (en) Valve treatment catheter and methods
WO2006113802A3 (fr) Dispositif pour l'administration de stimulation par electrodes des muscles dorsaux et abdominaux
WO2005037323A3 (fr) Methode pour inhiber une signalisation de nf-kappa b et son utilisation pour traiter et pour prevenir des maladies humaines
EP1636160A4 (fr) Nouveaux agents therapeutiques permettant de traiter le cancer, les maladies metaboliques et les affections cutanees
AU2003263628A1 (en) Medical treatment system for stimulating spots on the body suitable for acupuncture
AU2003299378A1 (en) Method and compounds for inhibiting hec1 activity for the treatment of proliferative diseases
IL166016A0 (en) Topical treatment of skin diseases
AU2003209150A1 (en) Combination for the treatment of immunoinflammatory disorders and proliferative skin diseases
AU2003246592A1 (en) Tumour marker and the use thereof for the diagnosis and treatment of tumour diseases
PL375629A1 (en) 1-phenyl-2-dimethylaminomethyl cyclohexane compounds used for the therapy of depressive symptoms, pain, and incontinence
AU2003240545A1 (en) Use of ramoplanin to treat diseases associated with the use of antibiotics
WO2003079748A3 (fr) Renforcement de therapies cancereuses par inhibition de znf217
AU2003245858A1 (en) Uses of ngal-binding substances in the diagnosis and treatment of cancer diseases
AU2003219664A1 (en) Methods and therapeutic compositions in the treatment of advanced cancer
AU2003274649A1 (en) Diagnostic markers for therapeutic treatment
AU2003297570A1 (en) Treatment of skin diseases
WO2004093919A3 (fr) Cible pour la therapie du cancer et la decouverte de medicaments
AU2003247810A1 (en) Novel therapeutic target for treating vascular diseases, dyslipidemias and related disorders

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase