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WO2004063214A3 - Anticorps qui reconnaissent de maniere specifique des proteines sumo conjuguees - Google Patents

Anticorps qui reconnaissent de maniere specifique des proteines sumo conjuguees Download PDF

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Publication number
WO2004063214A3
WO2004063214A3 PCT/US2004/000562 US2004000562W WO2004063214A3 WO 2004063214 A3 WO2004063214 A3 WO 2004063214A3 US 2004000562 W US2004000562 W US 2004000562W WO 2004063214 A3 WO2004063214 A3 WO 2004063214A3
Authority
WO
WIPO (PCT)
Prior art keywords
sumo
antibodies
proteins
conjugation
specifically recognize
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/000562
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English (en)
Other versions
WO2004063214A2 (fr
Inventor
Mary Dasso
Byrn Booth Quimby
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Institutes of Health NIH
Original Assignee
National Institutes of Health NIH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Institutes of Health NIH filed Critical National Institutes of Health NIH
Publication of WO2004063214A2 publication Critical patent/WO2004063214A2/fr
Anticipated expiration legal-status Critical
Publication of WO2004063214A3 publication Critical patent/WO2004063214A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des peptides ramifiés contenant au moins 11 résidus d'acides aminés correspondant à la structure au niveau du point de conjugaison de conjugués de protéines SUMO, telles que SUMO-1, avec des protéines qui sont des cibles de conjugaison avec les protéines SUMO. Lesdits peptides peuvent être utilisés afin de générer des anticorps qui réagissent de manière spécifique avec les conjugués de protéines cibles SUMO et pas avec la protéine SUMO non conjuguée ou la protéine cible non conjuguée. Lesdits anticorps peuvent être utilisés afin de détecter des maladies et afin de cribler des effecteurs qui activent ou inhibent la conjugaison ou la déconjugaison.
PCT/US2004/000562 2003-01-08 2004-01-08 Anticorps qui reconnaissent de maniere specifique des proteines sumo conjuguees Ceased WO2004063214A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43868503P 2003-01-08 2003-01-08
US60/438,685 2003-01-08

Publications (2)

Publication Number Publication Date
WO2004063214A2 WO2004063214A2 (fr) 2004-07-29
WO2004063214A3 true WO2004063214A3 (fr) 2007-06-07

Family

ID=32713367

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/000562 Ceased WO2004063214A2 (fr) 2003-01-08 2004-01-08 Anticorps qui reconnaissent de maniere specifique des proteines sumo conjuguees

Country Status (1)

Country Link
WO (1) WO2004063214A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011006249A1 (fr) * 2009-07-13 2011-01-20 Université de Montréal Isoformes mutées de la protéine sumo et leurs utilisations
WO2012061732A1 (fr) 2010-11-05 2012-05-10 Cell Signaling Technology, Inc. Anticorps spécifiques de motif et indépendants du contexte qui se lient à un motif caspase clivé ou à un motif contenant une lysine sumoylée

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002090495A2 (fr) * 2001-05-04 2002-11-14 Cornell Research Foundation, Inc. Systeme d'expression de proteine sumo a scission rapide pour proteines difficiles a exprimer

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002090495A2 (fr) * 2001-05-04 2002-11-14 Cornell Research Foundation, Inc. Systeme d'expression de proteine sumo a scission rapide pour proteines difficiles a exprimer

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SEELER J.-S. ET AL.: "SUMO: of branched proteins and nuclear bodies", ONCOGENE, vol. 20, 2001, pages 7243 - 7249, XP003013459 *

Also Published As

Publication number Publication date
WO2004063214A2 (fr) 2004-07-29

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