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WO2004060347A3 - Pharmaceutical propylene glycol solvate compositions - Google Patents

Pharmaceutical propylene glycol solvate compositions Download PDF

Info

Publication number
WO2004060347A3
WO2004060347A3 PCT/US2003/041642 US0341642W WO2004060347A3 WO 2004060347 A3 WO2004060347 A3 WO 2004060347A3 US 0341642 W US0341642 W US 0341642W WO 2004060347 A3 WO2004060347 A3 WO 2004060347A3
Authority
WO
WIPO (PCT)
Prior art keywords
propylene glycol
pharmaceutical
glycol solvate
compositions
solvate compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/041642
Other languages
French (fr)
Other versions
WO2004060347A2 (en
Inventor
Mark Tawa
Oern Almarsson
Julius Remenar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Transform Pharmaceuticals Inc
Original Assignee
Transform Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/232,589 external-priority patent/US6559293B1/en
Priority claimed from PCT/US2003/019574 external-priority patent/WO2004000284A1/en
Priority claimed from PCT/US2003/028982 external-priority patent/WO2004026235A2/en
Priority claimed from PCT/US2003/041273 external-priority patent/WO2004061433A1/en
Application filed by Transform Pharmaceuticals Inc filed Critical Transform Pharmaceuticals Inc
Priority to AU2003300452A priority Critical patent/AU2003300452A1/en
Priority to US10/551,014 priority patent/US20060223794A1/en
Priority to PCT/US2004/009947 priority patent/WO2004089313A2/en
Publication of WO2004060347A2 publication Critical patent/WO2004060347A2/en
Publication of WO2004060347A3 publication Critical patent/WO2004060347A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to pharmaceutical compositions comprising propylene glycol solvates of active pharmaceutical ingredients (APIs).
PCT/US2003/041642 2002-02-15 2003-12-29 Pharmaceutical propylene glycol solvate compositions Ceased WO2004060347A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2003300452A AU2003300452A1 (en) 2002-12-30 2003-12-29 Pharmaceutical propylene glycol solvate compositions
US10/551,014 US20060223794A1 (en) 2002-02-15 2004-03-31 Novel olanzapine forms and related methods of treatment
PCT/US2004/009947 WO2004089313A2 (en) 2003-04-01 2004-03-31 Novel olanzapine forms and related methods of treatment

Applications Claiming Priority (21)

Application Number Priority Date Filing Date Title
US10/232,589 US6559293B1 (en) 2002-02-15 2002-09-03 Topiramate sodium trihydrate
US43751602P 2002-12-30 2002-12-30
US60/437,516 2002-12-30
US44133503P 2003-01-21 2003-01-21
US60/441,335 2003-01-21
US45602703P 2003-03-18 2003-03-18
US60/456,027 2003-03-18
US45660803P 2003-03-21 2003-03-21
US60/456,608 2003-03-21
US45950103P 2003-04-01 2003-04-01
US60/459,501 2003-04-01
USPCT/US03/19574 2003-06-20
PCT/US2003/019574 WO2004000284A1 (en) 2002-06-21 2003-06-20 Pharmaceutical compositions with improved dissolution
US10/601,092 2003-06-20
US10/601,092 US20050025791A1 (en) 2002-06-21 2003-06-20 Pharmaceutical compositions with improved dissolution
US48671303P 2003-07-11 2003-07-11
US60/486,713 2003-07-11
USPCT/US03/28982 2003-09-16
PCT/US2003/028982 WO2004026235A2 (en) 2002-09-20 2003-09-16 Pharmaceutical compositions with improved dissolution
PCT/US2003/041273 WO2004061433A1 (en) 2002-12-30 2003-12-24 Pharmaceutical compositions with improved dissolution
USPCT/US03/41273 2003-12-24

Publications (2)

Publication Number Publication Date
WO2004060347A2 WO2004060347A2 (en) 2004-07-22
WO2004060347A3 true WO2004060347A3 (en) 2004-11-04

Family

ID=56290517

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/041642 Ceased WO2004060347A2 (en) 2002-02-15 2003-12-29 Pharmaceutical propylene glycol solvate compositions

Country Status (1)

Country Link
WO (1) WO2004060347A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8555875B2 (en) 2008-12-23 2013-10-15 Map Pharmaceuticals, Inc. Inhalation devices and related methods for administration of sedative hypnotic compounds
US9101596B2 (en) 2004-07-19 2015-08-11 Biocon Limited Cation complexes of insulin compound conjugates, formulations and uses thereof
US9241908B2 (en) 2007-10-16 2016-01-26 Biocon Limited Orally administrable solid pharmaceutical composition and a process thereof

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4906233B2 (en) 2002-03-01 2012-03-28 ユニバーシティー オブ サウス フロリダ Multi-component solid phase containing at least one active pharmaceutical ingredient
AU2003243699B2 (en) 2002-06-21 2009-01-15 Transform Pharmaceuticals, Inc. Pharmaceutical compositions with improved dissolution
US8183290B2 (en) 2002-12-30 2012-05-22 Mcneil-Ppc, Inc. Pharmaceutically acceptable propylene glycol solvate of naproxen
US7507823B2 (en) 2004-05-06 2009-03-24 Bristol-Myers Squibb Company Process of making aripiprazole particles
WO2007070563A2 (en) * 2005-12-13 2007-06-21 Harkness Pharmaceuticals, Inc. Stable solid forms of enterostatin
WO2007070562A2 (en) * 2005-12-13 2007-06-21 Harkness Pharmaceuticals, Inc. Non-hygroscopic compositions of enterostatin
US7919598B2 (en) 2006-06-28 2011-04-05 Bristol-Myers Squibb Company Crystal structures of SGLT2 inhibitors and processes for preparing same
CA2570949A1 (en) 2006-12-12 2008-06-12 Apotex Pharmachem Inc. Ibandronate sodium propylene glycol solvate and processes for the preparation thereof
US7834195B2 (en) * 2007-01-24 2010-11-16 Apotex Pharmachem Inc. Atorvastatin calcium propylene glycol solvates
TW200904405A (en) 2007-03-22 2009-02-01 Bristol Myers Squibb Co Pharmaceutical formulations containing an SGLT2 inhibitor
ITMI20071616A1 (en) 2007-08-03 2009-02-04 Cosmo Spa ENZYMATIC PROCESS FOR THE OBTAINING OF 17-ALFA MONOESTERS OF CORTEXOLONE AND / OR ITS 9,11-DEIDRODERIVATI.
WO2010002675A2 (en) 2008-06-30 2010-01-07 Mutual Pharmaceutical Company, Inc. Quinine sulfate/bisulfate solid complex; methods of making; and methods of use thereof
EP2456868A4 (en) 2009-07-22 2013-11-06 Puretech Ventures Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation
US10265311B2 (en) 2009-07-22 2019-04-23 PureTech Health LLC Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation
US9624258B2 (en) * 2013-05-30 2017-04-18 Biophore India Pharmaceuticals Pvt. Ltd. Polymorph of regadenoson
EP3108879A1 (en) 2015-06-25 2016-12-28 Cassiopea S.p.A. High concentration formulation
JP7096441B2 (en) 2018-09-28 2022-07-05 カルナ セラピューティックス，インコーポレイテッド Compositions and Methods for Treating Disorders Ameliorated by Muscarinic Receptor Activation

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4008321A (en) * 1974-12-20 1977-02-15 Toko Yakuhin Kogyo Kabushiki Kaisha Composition for a topical preparation and a process for producing the same
JPS5495589A (en) * 1977-12-30 1979-07-28 Sumitomo Chem Co Ltd Production of cephalosporin derivative
US4853379A (en) * 1982-12-09 1989-08-01 Societe Anonyme Dite: L'oreal Stable hydrocortisone-based composition for use in local corticotherapy
WO1995023596A1 (en) * 1994-03-05 1995-09-08 The Boots Company Plc Adhesive free topical pharmaceutical formulations
US5641512A (en) * 1995-03-29 1997-06-24 The Procter & Gamble Company Soft gelatin capsule compositions
US6420394B1 (en) * 1997-04-10 2002-07-16 Roche Consumer Health (Worldwide) Sa Topically applied pharmaceutical formulation

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4008321A (en) * 1974-12-20 1977-02-15 Toko Yakuhin Kogyo Kabushiki Kaisha Composition for a topical preparation and a process for producing the same
JPS5495589A (en) * 1977-12-30 1979-07-28 Sumitomo Chem Co Ltd Production of cephalosporin derivative
US4853379A (en) * 1982-12-09 1989-08-01 Societe Anonyme Dite: L'oreal Stable hydrocortisone-based composition for use in local corticotherapy
WO1995023596A1 (en) * 1994-03-05 1995-09-08 The Boots Company Plc Adhesive free topical pharmaceutical formulations
US5641512A (en) * 1995-03-29 1997-06-24 The Procter & Gamble Company Soft gelatin capsule compositions
US6420394B1 (en) * 1997-04-10 2002-07-16 Roche Consumer Health (Worldwide) Sa Topically applied pharmaceutical formulation

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 197936, Derwent World Patents Index; Class B02, AN 1979-65538B, XP002282989 *
FUNG H L ET AL: "Solvent effects on comparative dissolution of pharmaceutical solvates", CHEMICAL AND PHARMACEUTICAL BULLETIN 1974, vol. 22, no. 2, 1974, pages 454 - 458, XP009031785 *
RUBINO J T ET AL: "INFLUENCE OF SOLVENT COMPOSITION OF THE SOLUBILITIES AND SOLID-STATE PROPERTIES OF THE SODIUM SALTS OF SOME DRUGS", INTERNATIONAL JOURNAL OF PHARMACEUTICS (KIDLINGTON), vol. 65, no. 1-2, 1990, pages 141 - 145, XP002282988, ISSN: 0378-5173 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9101596B2 (en) 2004-07-19 2015-08-11 Biocon Limited Cation complexes of insulin compound conjugates, formulations and uses thereof
US9102758B2 (en) 2004-07-19 2015-08-11 Biocon Limited Insulin-oligomer conjugates, formulations and uses thereof
US9241908B2 (en) 2007-10-16 2016-01-26 Biocon Limited Orally administrable solid pharmaceutical composition and a process thereof
US8555875B2 (en) 2008-12-23 2013-10-15 Map Pharmaceuticals, Inc. Inhalation devices and related methods for administration of sedative hypnotic compounds
US9161912B2 (en) 2008-12-23 2015-10-20 Map Pharmaceuticals, Inc. Inhalation devices and related methods for administration of sedative hypnotic compounds

Also Published As

Publication number Publication date
WO2004060347A2 (en) 2004-07-22

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