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WO2004060341B1 - Increasing skin cell renewal with water-soluble vitamin e - Google Patents

Increasing skin cell renewal with water-soluble vitamin e

Info

Publication number
WO2004060341B1
WO2004060341B1 PCT/US2003/039275 US0339275W WO2004060341B1 WO 2004060341 B1 WO2004060341 B1 WO 2004060341B1 US 0339275 W US0339275 W US 0339275W WO 2004060341 B1 WO2004060341 B1 WO 2004060341B1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
water
vitamin
soluble vitamin
skin exfoliation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/039275
Other languages
French (fr)
Other versions
WO2004060341A2 (en
WO2004060341A3 (en
Inventor
Louise M Schneider
Melissa L Hundey
John V Scimeca
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Access Business Group International LLC
Original Assignee
Access Business Group International LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/325,326 external-priority patent/US6645514B1/en
Application filed by Access Business Group International LLC filed Critical Access Business Group International LLC
Priority to JP2004565335A priority Critical patent/JP2006514047A/en
Priority to EP03814700A priority patent/EP1583514A2/en
Priority to AU2003296454A priority patent/AU2003296454A1/en
Publication of WO2004060341A2 publication Critical patent/WO2004060341A2/en
Publication of WO2004060341A3 publication Critical patent/WO2004060341A3/en
Publication of WO2004060341B1 publication Critical patent/WO2004060341B1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/678—Tocopherol, i.e. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

The present invention relates to a method of enhancing the rate of skin exfoliation by incorporating a water-soluble Vitamin E derivative into a cosmetic composition that contains water and is suitable for application to mammalian skin. The composition has a pH from about 4.5 to 9 and can increase the rate of natural skin exfoliation by at least 10%.

Claims

AMENDED CLAIMS[received by the International Bureau on 19 October 2004 (19.10.04);]What is claimed is:
1. A topical composition for enhancing the rate of mammalian skin exfoliation comprising: a. from 0.05% to 30% of a water-soluble Vitamin E derivative selected from the group consisting of Sodium Vitamin E Phosphate, Lauryl Imino Dipropionic Acid Tocopheryl Phosphate, Tocopheryl Glucoside, Tocopheryl Succinate, Tocophersolan (Tocopheryl Polyethylene Glycol 1000 Succinate), Vitamin E derivatives having beta-alanine functionality, Tocophereth-5,10,12,18, and 50, and mixtures thereof; and b. a carrier comprising water; wherein the composition has a pH from about 4.5 to 9 and the water-soluble Vitamin E derivative is substantially in the water and the composition is effective to enhance the natural rate of mammalian skin exfoliation by at least 10%.
2. The composition of claim 1 , where the water-soluble Vitamin E derivative is selected from the group consisting of Sodium Vitamin E Phosphate, Lauryl Imino Dipropionic Acid Tocopheryl Phosphate, Vitamin E derivatives having beta-alanine functionality, and mixtures thereof.
3. The composition of claim 1 , where the composition does not comprise squalene or squalane.
4. The composition of claim 1 , where the water-soluble Vitamin E derivative includes a Sodium Vitamin E Phosphate.
5. The composition of claim 1 , where the water-soluble Vitamin E derivative includes a Disodium Lauriminodipropionate Tocopheryl Phosphate.
6. The composition of claim 1 , where the composition comprises from 0.1 % to about 15% of the water-soluble Vitamin E derivative.
7. The composition of claim 1 , where the composition comprises from 0.4% to about 5% of the water-soluble Vitamin E derivative.
20
8. The composition of claim 1 , where the carrier further comprises a cosmetic ingredient.
9. The composition of claim 1 , where the composition has a pH from 4.8 to 8.2,
10. The composition of claim 1 , where the composition has a pH from 5.6 to 7.9.
11. Use of the composition of any one of the preceding claims for preparing a pharmaceutical, dermatological, topical, or cosmetic composition for enhancing the natural rate of mammalian skin exfoliation.
12. The use of the composition of claim 11 , where the natural rate of mammalian skin exfoliation is accelerated by at least 10%.
13. The use of the composition of claim 11 , where the natural rate of mammalian skin exfoliation is accelerated by at least 15%.
14. The use of the composition of claim 11 , where sting % is reduced by at least 25% in relation to that achieved with an exfoliating acid having a pKa of 4.0 and below.
15. The use of the composition of claim 11 , where sting % is reduced by at least 50% in relation to that achieved with an exfoliating acid having a pKa of 4.0 and below.
16. The use of the composition of claim 11 , where the natural rate of skin exfoliation is accelerated by at least 10% and sting % is reduced by at least 25% in relation to that achieved with an exfoliating acid having a pKa of 4.0 and below.
17. The use of the composition of claim 11 , where the natural rate of skin exfoliation is accelerated by at least 20% and sting % is reduced by at least 50% in relation to that achieved with an exfoliating acid having a pKa of 4.0 and below.
18. The use of the composition of claim 11 , where the pharmaceutical, dermatological, topical, or cosmetic composition is prepared as a solution, gel, lotion, cream, or ointment.
19. The use of the composition of claim 11 , where the enhanced rate of skin exfoliation improves the texture of mammalian skin.
20. The use of the composition of claim 11 , where the enhanced rate of skin exfoliation refinishes the mammalian skin.
22
PCT/US2003/039275 2002-12-19 2003-12-10 Increasing skin cell renewal with water-soluble vitamin e Ceased WO2004060341A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2004565335A JP2006514047A (en) 2002-12-19 2003-12-10 Promotion of skin cell regeneration by water-soluble vitamin E
EP03814700A EP1583514A2 (en) 2002-12-19 2003-12-10 Increasing skin cell renewal with water-soluble vitamin e
AU2003296454A AU2003296454A1 (en) 2002-12-19 2003-12-10 Increasing skin cell renewal with water-soluble vitamin e

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10/325,326 2002-12-19
US10/325,326 US6645514B1 (en) 2002-12-19 2002-12-19 Increasing skin cell renewal with water-soluble Vitamin E
US10/684,140 2003-10-10
US10/684,140 US20040131569A1 (en) 2002-12-19 2003-10-10 Increasing skin cell renewal with water-soluble vitamin E

Publications (3)

Publication Number Publication Date
WO2004060341A2 WO2004060341A2 (en) 2004-07-22
WO2004060341A3 WO2004060341A3 (en) 2005-03-03
WO2004060341B1 true WO2004060341B1 (en) 2005-04-14

Family

ID=32716851

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/039275 Ceased WO2004060341A2 (en) 2002-12-19 2003-12-10 Increasing skin cell renewal with water-soluble vitamin e

Country Status (5)

Country Link
EP (1) EP1583514A2 (en)
JP (1) JP2006514047A (en)
KR (1) KR20050089045A (en)
AU (1) AU2003296454A1 (en)
WO (1) WO2004060341A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005053785A (en) * 2003-05-20 2005-03-03 Nippon Menaade Keshohin Kk External preparation
JP2014084308A (en) * 2012-10-25 2014-05-12 Fancl Corp Liquid crystal composition

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2657526B1 (en) * 1990-01-31 1994-10-28 Lvmh Rech USE OF AN ALPHA-TOCOPHEROL PHOSPHATE, OR ONE OF ITS DERIVATIVES, FOR THE PREPARATION OF COSMETIC, DERMATOLOGICAL, OR PHARMACEUTICAL COMPOSITIONS; COMPOSITIONS THUS OBTAINED.
AU3662093A (en) * 1992-02-14 1993-09-03 Robert Lamb Phosphate derivatives of vitamin e to protect cells from effects of aging and injury
WO1995003028A1 (en) * 1993-07-23 1995-02-02 Morris Herstein Cosmetic, skin-renewal stimulating composition with long-term irritation control
CN1069320C (en) * 1995-10-17 2001-08-08 昭和电工株式会社 High-purity tocopheryl phosphate, its production method and cosmetics containing the compound
JP3950216B2 (en) * 1997-12-26 2007-07-25 日本メナード化粧品株式会社 Topical skin preparation
FR2775441B1 (en) * 1998-02-27 2000-04-28 Serobiologiques Lab Sa MATRIX FOR THE PREPARATION OF MICROPARTICLES OR NANOPARTICLES, PROCESS FOR PRODUCING SUCH PARTICLES AND PARTICLES OBTAINED
CA2332808C (en) * 1998-05-15 2010-11-23 Showa Denko K.K. Compositions of ascorbic acid derivatives for treatment of skin diseases
FI110157B (en) * 2000-10-12 2002-12-13 Duraban Oy Antimicrobial polyalphaolefin composition and its use, process for the preparation of styrene-butadiene block copolymers containing thermoplastic elastomers and their use
WO2002040033A1 (en) * 2000-11-14 2002-05-23 Vital Health Sciences Pty Ltd Formulation containing phosphate derivatives of electron transfer agents
DE60140141D1 (en) * 2000-11-14 2009-11-19 Vital Health Sciences Pty Ltd Compositions comprising complexes of tocopherol phosphate derivatives
US20050220733A1 (en) * 2002-05-09 2005-10-06 Showa Denko K.K. Skin whitening external preparation

Also Published As

Publication number Publication date
KR20050089045A (en) 2005-09-07
AU2003296454A1 (en) 2004-07-29
JP2006514047A (en) 2006-04-27
WO2004060341A2 (en) 2004-07-22
WO2004060341A3 (en) 2005-03-03
EP1583514A2 (en) 2005-10-12

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