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WO2004060262A3 - Modulators of notch signalling for use in immunotherpapy - Google Patents

Modulators of notch signalling for use in immunotherpapy Download PDF

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Publication number
WO2004060262A3
WO2004060262A3 PCT/GB2004/000046 GB2004000046W WO2004060262A3 WO 2004060262 A3 WO2004060262 A3 WO 2004060262A3 GB 2004000046 W GB2004000046 W GB 2004000046W WO 2004060262 A3 WO2004060262 A3 WO 2004060262A3
Authority
WO
WIPO (PCT)
Prior art keywords
modulators
notch signalling
immunotherpapy
antigen
antigenic determinant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2004/000046
Other languages
French (fr)
Other versions
WO2004060262A2 (en
Inventor
Mark William Bodmer
Emmanuel Cyrille Pascal Briend
Brian Robert Champion
Andrew Christopher Lennard
Grahame James Mckenzie
Tamara Tugal
George Albert Ward
Lesley Lynn Young
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Celldex Therapeutics Ltd
Original Assignee
Lorantis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0300234A external-priority patent/GB0300234D0/en
Priority claimed from GB0301513A external-priority patent/GB0301513D0/en
Priority claimed from GB0301518A external-priority patent/GB0301518D0/en
Priority claimed from GB0301521A external-priority patent/GB0301521D0/en
Priority claimed from GB0301524A external-priority patent/GB0301524D0/en
Priority claimed from GB0301529A external-priority patent/GB0301529D0/en
Priority claimed from GB0301526A external-priority patent/GB0301526D0/en
Priority claimed from GB0301515A external-priority patent/GB0301515D0/en
Priority claimed from GB0301522A external-priority patent/GB0301522D0/en
Priority claimed from GB0301527A external-priority patent/GB0301527D0/en
Priority claimed from GB0301512A external-priority patent/GB0301512D0/en
Priority claimed from GB0301519A external-priority patent/GB0301519D0/en
Priority claimed from GB0301510A external-priority patent/GB0301510D0/en
Priority claimed from GB0306621A external-priority patent/GB0306621D0/en
Priority claimed from PCT/GB2003/001525 external-priority patent/WO2003087159A2/en
Priority claimed from GB0312062A external-priority patent/GB0312062D0/en
Priority claimed from PCT/GB2003/003285 external-priority patent/WO2004013179A1/en
Priority claimed from GB0323130A external-priority patent/GB0323130D0/en
Application filed by Lorantis Ltd filed Critical Lorantis Ltd
Priority to JP2006500232A priority Critical patent/JP2006517533A/en
Priority to PCT/GB2004/000263 priority patent/WO2004064863A1/en
Priority to AT04722319T priority patent/ATE474593T1/en
Priority to PCT/GB2004/001252 priority patent/WO2004082710A1/en
Priority to EP04722319A priority patent/EP1646400B1/en
Publication of WO2004060262A2 publication Critical patent/WO2004060262A2/en
Publication of WO2004060262A3 publication Critical patent/WO2004060262A3/en
Anticipated expiration legal-status Critical
Priority to US11/188,417 priority patent/US20060204508A1/en
Priority to US11/231,494 priority patent/US20060205823A1/en
Priority to US12/766,738 priority patent/US20100303867A1/en
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/577—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 tolerising response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1808—Epidermal growth factor [EGF] urogastrone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A product comprises i) a pharmaceutically acceptable support matrix suitable for in vivo administration bearing a multiplicity of modulators of Notch signalling; and ii) an antigen or antigenic determinant, or a polynucleotide coding for an antigen or antigenic determinant; as a combined preparation for simultaneous, contemporaneous, separate or sequential use for modulation of the immune system.
PCT/GB2004/000046 2003-01-07 2004-01-07 Modulators of notch signalling for use in immunotherpapy Ceased WO2004060262A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
PCT/GB2004/000263 WO2004064863A1 (en) 2003-01-23 2004-01-23 Treatment of autoimmune diseases using an activator for the notch signaling pathway
JP2006500232A JP2006517533A (en) 2003-01-23 2004-01-23 Treatment of autoimmune diseases using activators of the Notch signaling pathway
EP04722319A EP1646400B1 (en) 2003-03-21 2004-03-22 Treatment of allergic diseases using a modulator of the notch signaling pathway
PCT/GB2004/001252 WO2004082710A1 (en) 2003-03-21 2004-03-22 Treatment of allergic diseases using a modulator of the notch signaling pathway
AT04722319T ATE474593T1 (en) 2003-03-21 2004-03-22 TREATMENT OF ALLERGIC DISEASES USING A MODULATOR OF THE NOTCH SIGNALING PATHWAY
US11/188,417 US20060204508A1 (en) 2003-01-23 2005-07-25 Treatment of autoimmune diseases using an activator for the notch signalling pathway
US11/231,494 US20060205823A1 (en) 2003-03-21 2005-09-21 Treatment of allergic diseases using a modulator of the Notch signaling pathway
US12/766,738 US20100303867A1 (en) 2003-03-21 2010-04-23 a composition comprising a notch ligand and an allergenb or allergen bystander antigen

Applications Claiming Priority (36)

Application Number Priority Date Filing Date Title
GB0300234A GB0300234D0 (en) 2003-01-07 2003-01-07 Medical treatment
GB0300234.2 2003-01-07
GB0301510A GB0301510D0 (en) 2003-01-23 2003-01-23 Medical treatment
GB0301515A GB0301515D0 (en) 2003-01-23 2003-01-23 Medical treatment
GB0301518.7 2003-01-23
GB0301526.0 2003-01-23
GB0301518A GB0301518D0 (en) 2003-01-23 2003-01-23 Medical treatment
GB0301510.4 2003-01-23
GB0301524A GB0301524D0 (en) 2003-01-23 2003-01-23 Medical treatment
GB0301512A GB0301512D0 (en) 2003-01-23 2003-01-23 Medical treatment
GB0301522A GB0301522D0 (en) 2003-01-23 2003-01-23 Medical treatment
GB0301512.0 2003-01-23
GB0301527.8 2003-01-23
GB0301526A GB0301526D0 (en) 2003-01-23 2003-01-23 Medical treatment
GB0301529.4 2003-01-23
GB0301521.1 2003-01-23
GB0301529A GB0301529D0 (en) 2003-01-23 2003-01-23 Medical treatment
GB0301522.9 2003-01-23
GB0301519A GB0301519D0 (en) 2003-01-23 2003-01-23 Medical treatment
GB0301513A GB0301513D0 (en) 2003-01-23 2003-01-23 Medical treatment
GB0301527A GB0301527D0 (en) 2003-01-23 2003-01-23 Medical treatment
GB0301521A GB0301521D0 (en) 2003-01-23 2003-01-23 Medical treatment
GB0301519.5 2003-01-23
GB0301524.5 2003-01-23
GB0301515.3 2003-01-23
GB0301513.8 2003-01-23
GB0306621.4 2003-03-22
GB0306621A GB0306621D0 (en) 2003-03-22 2003-03-22 Medical treatment
GBPCT/GB03/001525 2003-04-04
PCT/GB2003/001525 WO2003087159A2 (en) 2002-04-05 2003-04-04 Modulators of the notch signalling pathway and uses thereof in medical treatment
GB0312062A GB0312062D0 (en) 2003-05-24 2003-05-24 Medical treatment
GB0312062.3 2003-05-24
PCT/GB2003/003285 WO2004013179A1 (en) 2002-08-03 2003-08-01 Conjugate of notch signalling pathway modulators and their use in medical treatment
GBPCT/GB03/003285 2003-08-01
GB0323130.5 2003-10-03
GB0323130A GB0323130D0 (en) 2003-10-03 2003-10-03 Medical treatment

Publications (2)

Publication Number Publication Date
WO2004060262A2 WO2004060262A2 (en) 2004-07-22
WO2004060262A3 true WO2004060262A3 (en) 2004-12-09

Family

ID=56290518

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2004/000046 Ceased WO2004060262A2 (en) 2003-01-07 2004-01-07 Modulators of notch signalling for use in immunotherpapy

Country Status (1)

Country Link
WO (1) WO2004060262A2 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8835387B2 (en) 2012-02-16 2014-09-16 Atyr Pharma, Inc. Histidyl-tRNA synthetases for treating autoimmune and inflammatory diseases
US8986681B2 (en) 2010-04-27 2015-03-24 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of threonyl-tRNA synthetases
US9127268B2 (en) 2009-12-11 2015-09-08 Atyr Pharma, Inc. Aminoacyl tRNA synthetases for modulating inflammation
US9422539B2 (en) 2010-07-12 2016-08-23 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of histidyl-tRNA synthetases
US9587235B2 (en) 2013-03-15 2017-03-07 Atyr Pharma, Inc. Histidyl-tRNA synthetase-Fc conjugates

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2742251T3 (en) 2009-03-16 2020-02-13 Pangu Biopharma Ltd Compositions and methods comprising variants of histidyl tarn synthetase splicing that have non-canonical biological activities
US10782302B2 (en) * 2012-05-04 2020-09-22 Wayne State University Detectors of serum biomarkers for predicting ovarian cancer recurrence
US20160361240A1 (en) 2015-06-11 2016-12-15 The Procter & Gamble Company Apparatus and methods for modifying keratinous surfaces
ES2994451T3 (en) 2017-04-20 2025-01-24 Atyr Pharma Inc Compositions for treating lung inflammation

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998020142A1 (en) * 1996-11-07 1998-05-14 Lorantis Limited Notch
WO2003041735A2 (en) * 2001-11-14 2003-05-22 Lorantis Limited Composotion comprising inhibitors of the notch signalling pathway for the modulation of the immune system
WO2003087159A2 (en) * 2002-04-05 2003-10-23 Lorantis Limited Modulators of the notch signalling pathway and uses thereof in medical treatment

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998020142A1 (en) * 1996-11-07 1998-05-14 Lorantis Limited Notch
WO2003041735A2 (en) * 2001-11-14 2003-05-22 Lorantis Limited Composotion comprising inhibitors of the notch signalling pathway for the modulation of the immune system
WO2003087159A2 (en) * 2002-04-05 2003-10-23 Lorantis Limited Modulators of the notch signalling pathway and uses thereof in medical treatment

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
HICKS C ET AL: "A SECRETED DELTA1-FC FUSION PROTEIN FUNCTIONS BOTH AS AN ACTIVATOR AND INHIBITOR OF NOTCH1 SIGNALING", JOURNAL OF NEUROSCIENCE RESEARCH, WILEY-LISS, US, vol. 68, no. 6, 15 June 2002 (2002-06-15), pages 655 - 667, XP009013890, ISSN: 0360-4012 *
HOYNE G F ET AL: "SERRATE-1-INDUCED NOTCH SIGNALLING REGULATES THE DECISION BETWEEN IMMUNITY AND TOLERANCE MADE BY PERIPHERAL CD4+ T CELLS", INTERNATIONAL IMMUNOLOGY, OXFORD UNIVERSITY PRESS, GB, vol. 12, no. 2, 2000, pages 177 - 185, XP000929552, ISSN: 0953-8178 *
JANG M-S ET AL: "NOTCH SIGNALING AS A TARGET IN MULTIMODALITY CANCER THERAPY", CURRENT OPINION IN MOLECULAR THERAPEUTICS, CURRENT DRUGS, LONDON,, GB, vol. 2, no. 1, February 2000 (2000-02-01), pages 55 - 65, XP009013844, ISSN: 1464-8431 *
WONG K K ET AL: "Notch ligation by Delta1 inhibits peripheral immune responses to transplantation antigens by a CD8+ cell-dependent mechanism", JOURNAL OF CLINICAL INVESTIGATION, NEW YORK, NY, US, vol. 112, no. 11, December 2003 (2003-12-01), pages 1741 - 1750, XP002268827, ISSN: 0021-9738 *
ZLOBIN A ET AL: "TOWARD THE RATIONAL DESIGN OF CELL FATE MODIFIERS: NOTCH SIGNALING AS A TARGET FOR NOVEL BIOPHARMACEUTICALS", CURRENT PHARMACEUTICAL BIOTECHNOLOGY, BENTHAM SCIENCE PUBLISHERS, BOCA RATON,FL, US, vol. 1, no. 1, July 2000 (2000-07-01), pages 83 - 106, XP008004456, ISSN: 1389-2010 *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9127268B2 (en) 2009-12-11 2015-09-08 Atyr Pharma, Inc. Aminoacyl tRNA synthetases for modulating inflammation
US9328340B2 (en) 2009-12-11 2016-05-03 Atyr Pharma, Inc. Amino acyl tRNA synthetases for modulating inflammation
US9540628B2 (en) 2009-12-11 2017-01-10 Atyr Pharma, Inc. Aminoacyl tRNA synthetases for modulating inflammation
US8986681B2 (en) 2010-04-27 2015-03-24 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of threonyl-tRNA synthetases
US9580706B2 (en) 2010-04-27 2017-02-28 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of threonyl-tRNA synthetases
US9422539B2 (en) 2010-07-12 2016-08-23 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of histidyl-tRNA synthetases
US8835387B2 (en) 2012-02-16 2014-09-16 Atyr Pharma, Inc. Histidyl-tRNA synthetases for treating autoimmune and inflammatory diseases
US9273302B2 (en) 2012-02-16 2016-03-01 Atyr Pharma, Inc. Histidyl-tRNA synthetases for treating autoimmune and inflammatory diseases
US9587235B2 (en) 2013-03-15 2017-03-07 Atyr Pharma, Inc. Histidyl-tRNA synthetase-Fc conjugates

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