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WO2004050038A2 - Preparation automatique de seringues et transfert automatique du medicament dans cette seringue et caracteristiques de securite associees - Google Patents

Preparation automatique de seringues et transfert automatique du medicament dans cette seringue et caracteristiques de securite associees Download PDF

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Publication number
WO2004050038A2
WO2004050038A2 PCT/US2003/038581 US0338581W WO2004050038A2 WO 2004050038 A2 WO2004050038 A2 WO 2004050038A2 US 0338581 W US0338581 W US 0338581W WO 2004050038 A2 WO2004050038 A2 WO 2004050038A2
Authority
WO
WIPO (PCT)
Prior art keywords
syringe
automated
medication
tip cap
vial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/038581
Other languages
English (en)
Other versions
WO2004050038A3 (fr
WO2004050038A8 (fr
Inventor
Joel A. Osborne
Dennis Tribble
Jose Raul Gonzalez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ForHealth Technologies Inc
Original Assignee
ForHealth Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/426,910 external-priority patent/US7017622B2/en
Priority claimed from US10/457,066 external-priority patent/US6877530B2/en
Application filed by ForHealth Technologies Inc filed Critical ForHealth Technologies Inc
Priority to AU2003297653A priority Critical patent/AU2003297653A1/en
Priority to EP03812510A priority patent/EP1578379A4/fr
Priority to CA002505093A priority patent/CA2505093A1/fr
Publication of WO2004050038A2 publication Critical patent/WO2004050038A2/fr
Publication of WO2004050038A8 publication Critical patent/WO2004050038A8/fr
Anticipated expiration legal-status Critical
Publication of WO2004050038A3 publication Critical patent/WO2004050038A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B7/00—Closing containers or receptacles after filling
    • B65B7/16—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons
    • B65B7/28—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons by applying separate preformed closures, e.g. lids, covers
    • B65B7/2835—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons by applying separate preformed closures, e.g. lids, covers applying and rotating preformed threaded caps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2207/00—Methods of manufacture, assembly or production

Definitions

  • the present invention relates generally to medical and pharmaceutical
  • syringes are in widespread use for a number of different types of applications. For example, syringes are used not only to withdraw a fluid (e.g., blood) from a patient but also to administer a medication to a patient.
  • a fluid e.g., blood
  • each station For example, one type of exemplary automated system operates as a
  • syringe filling apparatus that receives user inputted information, such as the type of
  • the medication that is to be delivered to the patient is not limited to the medication
  • the medication includes more than one pharmaceutical substance.
  • the medication can be any suitable pharmaceutical substance.
  • the medication can be any suitable pharmaceutical substance.
  • the medication can be any suitable pharmaceutical substance.
  • the medication can be any suitable pharmaceutical substance.
  • the medication can be any suitable pharmaceutical substance.
  • the medication can be any suitable pharmaceutical substance.
  • the medication can be any suitable pharmaceutical substance.
  • the medication can be any suitable pharmaceutical substance.
  • the medication can be any suitable pharmaceutical substance.
  • the medication can be any pharmaceutical substance.
  • a trained person retrieves the correct vial from a storage
  • An instrument e.g., a needle, is then used to pierce the membrane.
  • Fig. 1 illustrates an exemplary conventional syringe 10 that includes a
  • barrel 20 having an elongated body 22 that defines a chamber 30 that receives and
  • the barrel 20 has an open
  • One end of the passageway 29 opens into the chamber 30 to provide
  • cannula (not shown) or the like that is later coupled to the barrel tip 28.
  • An outer surface of the barrel tip or luer 28 can include features to
  • luer can have threads 27 that permit a tip cap 40 to be securely and removably
  • the tip cap 40 thus has complementary fastening
  • cap 40 is constructed so that it closes off the passageway 29 to permit the syringe 10
  • the syringe 10 further includes a plunger 50 that is removably and
  • the plunger 50 is also
  • an elongated member that has a proximal end 52 that terminates in a flange 54 to permit a user to easily grip and manipulate the plunger 50 within the barrel 20.
  • the plunger flange 54 is slightly smaller than the barrel flange 25 so that
  • the user can place several fingers around, against, or near the barrel flange 25 to
  • the plunger 50 can draw a fluid (e.g., air or a
  • stopper 59 is near the proximal end 24 of the barrel 20. Conversely, the plunger 50
  • the medication to be forced into and out of the barrel tip or luer 28.
  • a drug is provided of the shelf in solid form within an
  • drug vial is typically stored in a drug cabinet or the like and is then delivered to
  • septum of the vial to permit either a diluent to be injected therein or to permit the
  • a container may have been tampered with at an earlier time.
  • a container For example, a container
  • solid medication such as pills, tablets, or capsules
  • tamper proof label that extends and is sealed across the top opening of the container
  • the system includes: (1) a first automated gripping means
  • an automated device for delivering a prescribed dosage amount of medication to the syringe by delivering the medication through the
  • the cannula unit includes a cannula extending thereaway for
  • an automated medication preparation system In another aspect, an automated medication preparation system
  • automated syringe preparation including automated syringe preparation is provided and includes: (1) an automated
  • injectable drug vial delivery assembly that identifies and transfers one drug vial
  • an automated device disposed at the fluid transfer station for delivering a prescribed dosage amount of medication to an uncapped syringe by delivering the
  • medication vials are stored after the prescribed dosage amount of the medication is
  • the vial is delivered to the multi-use medication station by means of the robotic vial gripper device and is available for later use when another syringe requiring the medication
  • orienting injectable drug vials for a robotic application includes a
  • the drug vial stores
  • means includes a robotic vial gripper device for holding and transferring one vial
  • the robotic application is an automated
  • medication preparation system that includes automated syringe preparation including
  • the detector is configured to determine whether the vial is an upright position or is in an opposite downright position relative to ground.
  • a type of detector is used in combination with a vial that includes a magnetic chip
  • the detector is capable of detecting a change in a
  • the vial can be advanced to a next station. If the vial is determined to not be in its proper orientation, the vial can be advanced to a next station. If the vial is determined to not be in its proper orientation, the vial can
  • the vial has an optical marker and is used
  • optical detector that is capable of detecting the optical
  • optical marker of the vial and generates a control signal that indicates that the vial is
  • detector is one which acts as a reader and scans and reads a scannable tag (bar code)
  • an automated medication preparation system In yet another aspect, an automated medication preparation system
  • a first automated gripper for removing a tip cap from a barrel of one
  • the tamper evident processing station is a heat-staking station and the instrument is in the form of a heated wire, rod, or
  • the bond is in the form of a
  • syringe was prepared. Moreover, a laser can be used at the tamper evident processing
  • the tamper evident processing station In yet another embodiment, the tamper evident processing station
  • the instrument includes an ultrasonic welder and the instrument is used to join the tip cap to the syringe barrel through pressure and high frequency mechanical vibrations, creating
  • Fig. 1 is a perspective view of a conventional syringe having a safety
  • Fig. 2 is a diagrammatic plan view of an automated system for
  • Fig. 3 is a local perspective view of an automated device for
  • Fig. 4 is a sectional elevation view of the automated device of Fig. 3
  • Fig. 5 is a sectional elevation view of the automated device of Fig. 3
  • Fig. 6 is a local perspective view of a device for extending a plunger
  • Fig. 7 is a sectional elevation view of the device of Fig. 6 prior to
  • Fig. 8 is a sectional elevation view of the device of Fig. 6 showing
  • Fig. 9 is a local perspective view of fluid transfer and vial
  • Fig. 10 is a side elevation view of a fluid pump system that that is located in the fluid transfer area shown in a first position for withdrawing diluent to
  • Fig. 11 is a side elevation view of the fluid pump system shown in a
  • FIG. 12 is a side elevation view of the fluid pump system shown in a
  • Fig. 13 is a side elevation view of the fluid pump system shown in a
  • Fig. 14 is a side elevation view of a fluid transfer device in a first
  • Fig. 15 is a side elevation view of the fluid transfer device in a
  • Fig. 16 is a side elevation view of the fluid transfer device in a third position in which the cannula unit and the vial gripper device are rotated to invert
  • Fig. 17 is a side elevation view of the fluid transfer device in a fourth
  • Fig. 18 is a side elevation view of the fluid transfer device in a fifth
  • Fig. 19 is a side elevation view of the fluid transfer device in a sixth
  • FIG. 20 is a side elevation view of the fluid transfer device in a
  • Fig. 21 is a side elevation view of a fluid pump system according to
  • Fig. 22 is a side elevation view of an alternative arrangement where
  • syringe plunger causes a prescribed dose amount of medication to be drawn into the
  • Fig. 23 is a side elevation view of the connector apparatus sealed
  • Fig. 24 is a local perspective view showing the mating between the
  • Fig. 25 is a sectional elevation view of an automated device for
  • Fig. 26 is a sectional elevation view of the automated device of Fig.
  • Fig. 27 is an exploded perspective view of an automated device
  • Fig. 28 is a side elevation view of the automated device of Fig. 27;
  • Fig. 29 is a front perspective view of an automated device for withdrawing a plunger of a syrmge;
  • Fig. 30 is a side elevation view of the automated device of Fig. 29;
  • Fig. 31 is an exploded perspective view of the automated device of
  • Fig. 32 is an exploded side elevation view of the automated device of
  • Fig. 33 is a local perspective of a first exemplary detector for
  • Fig. 34 is a local perspective of a second exemplary detector for
  • Fig. 35 is a side elevation of one exemplary device for providing a tamper evident syringe
  • Fig. 36 is a local elevation cut-away showing a local weld produced
  • Fig. 37 is side elevational view of a heat staking welding station
  • Fig. 38 is a top plan view of the heat staking welding station
  • Fig. 39 is a side elevation view of an exemplary tamper evident tape
  • Fig. 40 is a top plan view of a section of the tape sealing station of
  • Fig. 41 is a side elevation view of the tape sealing device in a first operating position
  • Fig. 42 is a side elevation view of the tape sealing device in a second
  • Fig. 43 is a top plan view of a secondary tamper tape wiper
  • Fig. 44 is a side elevation view of the wiper of Fig. 43 in an open condition
  • Fig. 45 is a view of a syringe with tamper evident tape attached
  • Fig. 46 is a view of a syringe disposed into a sealed plastic bag.
  • Fig. 2 is a schematic diagram illustrating one exemplary automated
  • automated system 100 is divided into a number of stations where a specific task is
  • the automated system 100 includes a station 110 where medications and other substances used in the preparation process are stored.
  • the term "medication" refers to a
  • the medication is
  • the station 110 functions as a storage unit for storing
  • medications etc. under proper storage conditions.
  • medications etc. under proper storage conditions.
  • medications etc.
  • sealed containers such as vials, that are labeled to clearly
  • a first station 120 is a syringe storage station that houses and stores a number of syringes. For example, up to 500 syringes or more can be disposed in
  • the first station 120 for storage and later use.
  • the first station 120 can be in the
  • the syringes are provided as a bandolier
  • the system 100 also includes a rotary apparatus 130 for advancing
  • the fed syringes from and to various stations of the system 100.
  • a number of the stations are arranged circumferentially around the rotary apparatus 130 so that the
  • syringe is first loaded at the first station 120 and then rotated a predetermined
  • One exemplary type of rotary apparatus 130 is a multiple station cam-
  • indexing dial that is adapted to perform material handling operations.
  • the indexer permits the rotary apparatus 130 to be advanced at specific intervals.
  • the syringes are loaded into one of the nests
  • syringe preferably includes additional mechanisms for preparing the syringe for use, such as
  • the system 100 also preferably includes a reading device (not shown)
  • the label is read using any number of suitable reader/scanner devices, such as a bar code reader, etc. , so as to confirm that the proper medication has been
  • the container is delivered to a fourth station 160
  • the vial is prepared by removing the
  • the safety cap is removed on a deck of the automated system 100 having
  • the system 100 also preferably includes a fifth station (fluid transfer
  • the prepared medication composition is withdrawn
  • a container i.e. , vial
  • cannula can be inserted into the sealed vial and the medication composition then
  • a seventh station 180 is then placed back on the syringe at a sixth station 180.
  • a seventh station 180 is then placed back on the syringe at a sixth station 180.
  • 190 prints and station 195 applies a label to the syringe and a device, such as a
  • the syringe is then unloaded from the rotary apparatus 130 at an unloading station 200 and
  • a predetermined location such as a new order bin, a conveyor, a
  • the delivery of the syringe can be accomplished
  • syringe is provided as a
  • the bandolier is cut prior at a
  • Figs. 3 through 20 illustrate parts of the third station 150 for
  • FIGs. 3-15 illustrate in more detail
  • FIG. 3 is a perspective view of an
  • syringe 10 is prepared for receiving a prescribed dose of medication as part of the
  • control unit 300 is a controllable device that is operatively connected to a control unit, such as a
  • the control unit can be a personal computer that runs one or more programs to ensure
  • the device 300 is configured to coordinate operation of all of the components of the system 100.
  • one exemplary rotary device 130 is a
  • multiple station cam-indexing dial that is adapted to perform material handling
  • the dial 130 has an upper surface 132 and first and second retaining
  • the first retaining member 134 locates the barrel 20 near the
  • notch 139 formed at a distal end thereof that is complementary in shape
  • the notch 139 is defined by a pair of opposing fingers 141, with the notch 139 being formed therebetween. The notch 139 is thus
  • the second retaining member 136 is configured to hold and retain the
  • the second retaining member 136 includes operable pivotable arms 143, 145 that pivot between an open position where the
  • a shaped surface 151 also forms a
  • the syringe 10 is disposed between the pivotable arms 143, 145 and the
  • controller directs the pivotable arms 143, 145 to either the open or closed positions.
  • a post 161 is provided for holding the tip cap 40 after its removal to
  • One exemplary post 161 has a
  • the post 161 can also be formed on the upper surface 132 of the
  • the specific shape of the post 161 can likewise vary so long as the post
  • the syringes 10 are fed to the syringes 10
  • rotary device 130 as part of a syringe bandolier i.e., multiple syringes 10 are
  • syringes 10 can be fed to the rotary device 130 in any number of other ways.
  • the syringes 10 can be fed individually into the rotary device 130 from a
  • the automated device 300 is a robotic device and preferably, the automated device 300 is a linear actuator with a gripper.
  • the device 300 has a
  • vertical base 310 which is adjustable in at least several directions.
  • the vertical base 310 which is adjustable in at least several directions.
  • vertical base 310 has an independent reach (y axis) and vertical axis (x axis) which
  • the vertical base 310 has an upper end 312 and an opposing lower end 314 which is operatively coupled to other movable components to permit the vertical
  • the upper end 312 is connected to a horizontal support member
  • the lower end 314 is disposed between two support beams that are part
  • a block member 330 is connected to the horizontal support member
  • the block member 330 is disposed on an underside of the
  • the exemplary block member 330 has a block-like shape and is connected to the
  • the device 300 has first and second positionable gripping arms 340,
  • arms 340, 350 is movable at least in a direction along the y axis which provide the
  • gripping arms 340, 350 are programmed to work together in tandem so that both
  • arms 340, 350 are driven to the same location and the same time.
  • the block member 330 can house some of the electronic components and the like that permit the gripping arms 340, 350 to move between the open and
  • Each of the gripping arms 340, 350 is a generally L-shaped member
  • the gripping section 344 has a cut-out or notch 360 formed therein for receiving and gripping a section
  • the notch 360 has a complementary shape as the shape of the tip cap 40.
  • One exemplary notch 360 has
  • the gripping arms 340, 350 can be positioned between an open position in which the opposing gripping sections 344 of the arms 340, 350 are spaced apart
  • the tip cap 40 has a base section 41 and a flange 43 that has a
  • the notches 360 define a complete circular
  • a first open position of the gripping arms 340, 350 is
  • gripping sections 344 being spaced sufficiently from one another so as to permit the tip cap 40 to be freely disposed between the gripping sections
  • control unit 370 e.g. , a programmable actuator, microprocessor,
  • the gripping arms 340, 350 are driven to the first position shown in Fig. 4.
  • the control unit 370 instructs the device 300 to perform an operation where the tip
  • cap 40 is gripped and removed by the device 300.
  • the vertical base 310 is driven inwardly toward the dial 130 and relative
  • the tip cap 40 is disposed between the gripping section 344 of the
  • the apparatus 300 can be driven in any number of different ways that can be driven.
  • the apparatus 300 can be any known and suitable for this intended use.
  • the apparatus 300 can be any known and suitable for this intended use.
  • the apparatus 300 can be any known and suitable for this intended use.
  • the apparatus 300 can be any known and suitable for this intended use.
  • the apparatus 300 can be any known and suitable for this intended use.
  • the apparatus 300 can be any known and suitable for this intended use.
  • the apparatus 300 can be any known and suitable for this intended use.
  • the apparatus 300 can
  • a number of pneumatic conduits are provided for
  • control unit 370 directs the vertical base 310 upward and this motion causes the tip cap 40 to be displaced from the barrel tip 28 as shown in phantom in Fig. 5. After the tip cap 40 is freed from the barrel tip 28, it remains held between the gripping
  • the controller 370 instructs the vertical base 310 to move downwardly so that
  • the post 161 is disposed within a hollow interior of the tip cap 40.
  • the actuator is
  • the rotary device 130 advances to deliver the uncapped syringe 10 to another station.
  • the device 300 then is returned to its initial position, the dial 130 is advanced and
  • the system 100 also includes a generic device 390 for extending the plunger 50 of one uncapped syringe 10 after it has had
  • the device 300 are described as being part of the third station 150 of the system 100.
  • the device extends the plunger 50 using an elongated member 392 that is
  • the member 392 can be controllably driven up and down a
  • the device can have any number of configurations so long as it
  • Fig. 27 is an exploded perspective view of the automated device 400
  • Fig. 27 illustrates in greater detail the working components for
  • the exemplary device 400 is
  • controller that is preferably a programmable
  • the device 400 includes a housing 410 and a tip cap gripper unit 440 that engages the tip cap 40 (Fig. 1) and removes it from syringe 10 and then securely
  • the gripper unit 400 is partially contained within the housing 410
  • the exemplary housing 410 includes a front cover plate 412, a back
  • the front cover plate 412 is a generally rectangular
  • front cover plate 412 can also include one or more slots 418 that also receive
  • the slots 418 can be formed at one edge (e.g., the bottom edge) of the
  • the back cover 414 has a substantially open front face 419 and is
  • top wall 420 formed of a top wall 420, a rear wall 421 and a pair of opposing side walls 422.
  • the top wall 420 has a cut-out 423 formed therein to accommodate movement of the
  • the top wall 420 is generally square or
  • the opposing side walls 422 are mirror images of one another and are disposed
  • fastening tabs 425 are located at the intersection between the top wall 420 and the side walls 422 and two additional fastening tabs 425 are located below the two tabs
  • the illustrated tabs 425 are generally square shaped and
  • Openings 426 are formed in the fastening tabs 425 for receiving the fasteners and
  • the base plate 416 is securely attached to the side walls 422 and the front cover plate 412.
  • the base plate 416 has a shape and is dimensioned in a
  • illustrated base plate 416 is generally rectangular shaped and is formed of a body
  • end edges 429 that includes end edges 429 and side edges 430.
  • the end edges 429 have openings 431 formed therein to receive fasteners for coupling the front cover plate
  • the side edges 430 have openings 432 that
  • body 428 also includes openings 433 formed therein for securely mounting various components
  • the gripper unit 440 is securely attached to the base plate 416.
  • the gripper unit 440 is securely attached to the base plate 416.
  • housing 410 and the shape thereof is also likely influenced by design considerations, such as the amount of available space near the dial 130.
  • housing 410 is merely exemplary in nature and not limiting of the present housing
  • the housing 410 can be formed of sheet metal, etc.
  • the gripper unit 450 is an assembled unit disposed at the third station
  • the automated gripper unit 440 is a robotic device or an automated mechanical device and preferably, one exemplary automated
  • gripper unit 440 is a pneumatically operated device; however, the gripper unit 440
  • the automated gripper unit 440 includes a vertical
  • base 442 which is adjustable in at least several directions.
  • base 442 has an independent reach (y axis) and vertical axis (x axis) which provides
  • the vertical base 442 has an upper end 443 and an opposing lower end 444 which is
  • the upper end 443 is connected to a horizontal support member 445 (e.g., a top bracket) that extends outwardly away
  • the lower end 444 is
  • a block member 448 is connected to the horizontal support member
  • the block member 448 is disposed on an underside of the
  • the exemplary block member 448 has a block-like shape and is connected to the
  • the gripper unit 440 has first and second positionable gripper arms
  • each of the gripper extend downwardly from the block member 448.
  • each of the gripper extend downwardly from the block member 448.
  • arms 450 is movable at least in a direction along the y axis to provide the flexibility
  • the gripper arms 450 are programmed to work together in tandem so that both arms 450 are driven
  • motion control devices i.e., motors, hydraulic drives, pneumatics, etc.
  • motors i.e., motors, hydraulic drives, pneumatics, etc.
  • different motion control devices are used for their defined operations.
  • the motion control devices are powered by pneumatic pressure.
  • Stations 150 and 180 each have three pneumatic motion control devices.
  • the block member 448 can house some of the electronic or
  • the gripper unit 440 is preferably a pneumatic device, a number
  • pneumatic controls are disposed near the gripper arms 450. More specifically,
  • the gripper arms 450 are pneumatic devices and therefore, a first pneumatic control
  • the first pneumatic control 451 is connected to the block member 448.
  • the first pneumatic control 451 is
  • first and second flow control valves 452 integral to block member 448 and includes first and second flow control valves 452 that are of a point locked type, with the positions set at the time of manufacture.
  • valves 452 have adjusable knobs that permit a certified field
  • the unit 440 can be a pneumatically based system since the
  • the gripper unit 440 also preferably includes a sensor assembly, generally indicated at 453, for sensing whether a tip cap 40 is present between the
  • One exemplary sensor assembly 453 includes a sensor device 454 and a reflector 455 that is spaced therefrom.
  • the sensor device 454 is formed
  • the support bracket 456 has two sections that
  • each has an L-shape and therefore the bracket 456 resembles a series of steps.
  • bottommost section 457 of the support bracket 456 is the section that holds the one
  • the support bracket 456 is disposed so that the gripper arms
  • the sensors 454 are LED type sensors or the like which emit a light beam in a predetermined direction.
  • LED sensors 454 that emit light beams in a direction
  • the light beams are targeted
  • the reflector 455 is securely attached to the vertical base 442 and is axially aligned with the sensors 453 so that when the sensors 453 are actuated, the
  • tip cap 40 lies within the path of the light beam when it is securely held between the
  • a break in the light beam generates a control signal that is delivered to the control unit to indicate that an object, such as the tip cap 40, is
  • the light beam of the sensors 483 pass completely to the reflector 485 since there is
  • control unit After a predetermined time period, the control unit will reject the
  • the gripper unit 440 to act and remove the tip cap 40. If the sensor device 453
  • control signal from the sensor device 453 is received by the control unit and the
  • gripper unit 440 is instructed to continue its process of removing, parking, or
  • the gripper unit 440 includes a number of pneumatic control devices
  • the gripper unit 440 includes a second pneumatic control
  • device 457 controls movement of the vertical base 442 in towards and out away
  • the second pneumatic control device 457 moves the vertical base 442, as well as the gripper arms 450, in a direction toward the dial
  • the second pneumatic control device 457 is similar to the previously described motion control device with its "Home" position being out, away from the dial 130.
  • the second pneumatic control device In the illustrated embodiment, the second pneumatic control device
  • pneumatic control device 457 are disposed on a support surface 459 of the support
  • the support member 446 has one or more guide
  • vertical base 442 travels a fixed distance, namely the distance between the out
  • the second pneumatic control device 457 includes a number of
  • pneumatic control device 457 can include one or more control valves 460 for controlling and adjusting the pneumatic pressure within the second pneumatic
  • control valves 460 are in the form of control knobs that can be easily adjusted by a certified field service
  • the third pneumatic control device 458 controls movement of the
  • control device 458 moves the vertical base 442, as well as the gripper arms 450, and
  • pneumatic control device 458 is similar to the previously described motion control device with its "home" position being up, keeping the gripper mechanism 450 away
  • the third pneumatic control device 458 is configured to control the third pneumatic control device 458
  • the third pneumatic control device is configured to control the third pneumatic control device
  • pneumatic control device 458 causes the selective, controlled movement of the vertical base 442 in up-down directions. As previously specified, one
  • motion controllers i.e., motors, hydraulic lines, pneumatics,
  • the up-down movement of the vertical base 442 can be any one of the vertical base 442 etc.).
  • the up-down movement of the vertical base 442 can be any one of the vertical base 442 etc.
  • vertical base 442 is raised and lowered relative to the housing 410 in a controlled
  • the vertical base 442 travels a
  • the third pneumatic control device 458 includes a number of
  • the device 458 or technician to vary the operating parameters of the device 458.
  • the device 458 or technician to vary the operating parameters of the device 458.
  • third pneumatic control device 458 can include one or more control valves 462 for
  • control valves 462 are in the form
  • the unit 450 (Fig. 27) also includes a connector module 463 that is
  • brackets 464 are spaced apart from
  • Each bracket 464 includes a planar surface 466 that has an opening 467 formed
  • the module 468 is the input/output connector block for the entire station 150.
  • an end stop 469 is provided for limiting the movement
  • the end stops 469 keep the module 468 I/O blocks from sliding off the railed tray to which the module 468 is mounted.
  • connector module 468 is located adjacent the unit 450 and more specifically, it is
  • the third pneumatic control device 458 located behind the third pneumatic control device 458 (e.g., closer to the rear wall
  • the connector module 468 is thus disposed between the unit 450 and the rear
  • the third pneumatic control device 458 is deactivated (valve is closed) so that the vertical base 442 and the gripper arms are in the raised position.
  • this orientation is referred to as a starting position which permits the dial 130 to be advanced so that one syringe 10 is delivered to a position where the
  • the syringe 10 is in axial alignment with the gripper arms 450.
  • the gripper arms 450 are in axial alignment with the gripper arms 450.
  • the first pneumatic control is in an deactivated
  • the syringe 10 likewise is in a start position.
  • the third pneumatic control device 458 is then activated so that the pressure in the valves 462 is
  • the tip cap 40 of the syringe 10 is disposed between the gripper
  • the first pneumatic control is deactivated so that the gripper arms 450 are closed and the tip cap 40 is nested within the gripper arms 450.
  • the tip cap 40 is securely held
  • the third pneumatic control device 458 is deactivated so that it moves to the raised position. Because the
  • the sensor device 453 is preferably
  • the light beam of the sensor 453 is broken when the tip cap 40
  • an object e.g., the tip cap 40, is present between the closed gripper arms 440.
  • controller is discussed as being a master
  • controller that is operatively connected to each of the working components of the
  • This controller is therefore in communication with the working data
  • each working component can have its own controller, which in turn is communicatively connected to the other working components
  • control device 458 is activated (valve is open) so that the third pneumatic control
  • pneumatic control device 458 is deactivated so that the vertical base 442 moves from
  • the system 100 includes an automated device 1400 for
  • the device 1400 is located at the fourth station. More specifically, these
  • FIG. 1 illustrates a part of the fourth station for preparing a syringe for later use
  • Fig. 29 is a front perspective view of the device 1400 and Fig. 31 is
  • the exemplary device 1400 is
  • controller that is preferably a programmable
  • the device 1400 includes a housing 1410 and a positionable, automated puller 1500 that engages the
  • plunger 50 (Fig. 1) and extends it a calculated distance based on a number of
  • the puller 1500 is substantially
  • the exemplary housing 1410 includes a front cover 1420, a back
  • the front cover 1420 has a front face 1422 that extends from an upper end 1423 to a lower end 1425 with a cut out 1426 being
  • the front face 1422 has a
  • the front cover 1420 also includes two opposing and spaced side
  • the side walls 1428 also include a rear edge
  • the rear edge 1429 that is integrally attached to the back cover 1430. Unlike the front edge 1427, which is linear in nature, the rear edge 1429 is not linear in nature but rather has an
  • the front cover 1420 also includes an upper face
  • the front cover 1420 is constructed preferably as a single
  • the base plate 1450 to be securely attached to both the front cover 1420 and the back cover 1440.
  • the gap 1432 is formed because the height of the front face 1422 is
  • the front cover 1420 has a number of features formed therein for
  • the side walls 1428 can be any suitable coupling the front cover 1420 to other parts.
  • the side walls 1428 can be any suitable coupling the front cover 1420 to other parts.
  • the side walls 1428 can be any suitable coupling the front cover 1420 to other parts.
  • the side walls 1428 can be any suitable coupling the front cover 1420 to other parts.
  • the side walls 1428 can be any suitable coupling the front cover 1420 to other parts.
  • the side walls 1428 can
  • the back cover 1440 has a shape complementary to the rear edge
  • the exemplary back cover 1440 has
  • cover 1440 also includes second and third sections 1443, 1445, respectively.
  • second section 1443 is an intermediate section that lies between the first and third
  • the first section 1442 is disposed at the upper end of the first section 1442.
  • the first section 1442 is substantially perpendicular to the ground contacting surface, as well
  • the first section 1442 has a cut out 1447 formed therein to
  • the first section 1442 also serves to permit access to the interior of the housing 1410.
  • the first section 1442 also serves to permit access to the interior of the housing 1410.
  • the second section 1443 does not lie within the same plane as the
  • the second section 1443 is generally rectangular in shape and is a beveled surface with respect to the first and third sections 1442, 1445.
  • the second section 1443 seats against a complementary shaped beveled surface that
  • openings 1444 for receiving fasteners to securely attach the second
  • the third section 1445 is substantially identical to the first section 1442. Similar to the first section 1442, the third section 1445 is substantially identical to the first section 1442.
  • first and third sections 1442, 1445 thus lie in planes that are substantially parallel to
  • the third section 1445 also includes openings 1444 for receiving fasteners to securely
  • the back cover 1440 is securely attached to the front cover 1420, an interior
  • compartment 1460 is formed and is configured to receive the puller 1500.
  • the base plate 1450 serves as the bottom of the housing 1410 and is
  • the base plate 1450 is generally square or
  • the base plate 1450 has a number of features formed therein to
  • the base plate 1450 has two
  • the fasteners extend through the openings or slots 1431 formed in the side walls 1428 and then through
  • the body 1454 has a number of openings, channels and/or
  • slots 1455 formed therethrough. For example, there are a number of thru openings 1455 that receive fasteners that threadlingly mate with complementary features
  • the base plate 1450 is disposed
  • the base plate 1450 provides a support platform for the device 1400.
  • the back cover 1440 can then be attached to the side
  • housing 1410 and the shape thereof is also likely influenced by design
  • illustrated housing 1410 is merely exemplary in nature and not limiting of the
  • the housing 1410 can be formed of sheet
  • the puller 1500 is an assembled unit that serves to engage the
  • the puller 1500 has a
  • support frame 1510 that has a first end 1512 and an opposing second end 1514 and a carrier 1550 that is controllably movable along a length of the support frame 1510
  • the carrier 1550 supports a
  • plunger gripper 1570 which serves to engage and extend the plunger 50 (Fig. 1) as
  • the support frame 1510 has a first section 1511 at or near the first
  • mounting base 1516 is also provided as part of the support frame 1510 and is
  • base 1516 receives the fasteners resulting in the unit 1500 being securely attached to
  • the support frame of the unit 1500 is fixed stationary
  • the second section 1513 acts as a support section as well as a guide
  • the second section 1513 includes two opposing end posts 1520 that are preferably in the
  • the rails 1520 have a substantially rectangular cross-
  • the rails 1520 extend between a first horizontal member 1522 and
  • each rail 1520 is spaced apart from one another so that a space is formed therebetween and an outermost edge 1525 of each rail 1520 is a smooth surface to permit the rear face of the carrier 1550 to move therealong.
  • the drive means 1560 is a device which, when actuated, drives the carrier 1550 in one of two directions vertically along the second section 1513.
  • actuation of the drive means 1560 in a first mode causes the
  • One exemplary drive means 1560 is a screw drive mechanism that includes a motor
  • the motor 1562 that is operatively connected to a screw drive type mechanism. More specifically and according to one exemplary embodiment, the motor 1562 is a servo
  • stepper motor and the screw drive mechanism includes a drive spindle or drive
  • the screw coil "migrates" in the lengthwise direction for displacing the
  • screw drive means 1560 is disposed between the two spaced rails 1520. The part
  • 1564 is also an elongated member that is disposed between the two rails 1522 in a
  • the first section 1511 is generally in the form of a U-shaped member
  • the first section 1511 has a through bore or opening
  • the first section 1511 is also attached securely to the second
  • the carrier 1550 is formed of a body that has a first end and an
  • the carrier 1550 has a front face that is
  • elongated part 1564 is operatively coupled to the first end of the carrier 1550 so that
  • the carrier 1550 also serves as a carrier or the like.
  • the puller 1500 also has an indicator feature for notifying the
  • the puller 1500 can have a first sensor 1580 at one end of the
  • sensor 1582 are of the types that have a beam that extends across a gap from one
  • each of the first and second sensors 1580, 1582 is a U-shaped bracket
  • the beam extends across the gap 1586 from one arm 1584 to the opposing arm 1584
  • sensors 1580, 1582 are in communication with the controller so that once an
  • a signal is sent to the controller to indicate the occurrence
  • the indicator feature also includes a flag or marker 1590 that is part
  • flag 1590 can be a member that is secured to the carrier 1550 at one side edge 1552.
  • the flag 1590 is L-shaped with one section being secured to the front face 1554 of the
  • the flag 1590 is disposed parallel to and spaced from the respective side edge 1552.
  • controller 470 will then take the necessary steps to stop further
  • the controller will instruct the motor 1564 to stop
  • the height of the vertical wall of the flag 1590 is approximately equal to the height of the carrier 1550 so that the flag 1590 trips the
  • 1580, 1582 is predetermined so that it correlates to the maximum up position
  • the carrier 1550 lie linearly along the second section 1513 between the two sensors
  • the sensor 1580, 1582 are thus mounted to the puller 1500 in
  • the puller 1500 includes the plunger gripper 1570 that is securely
  • gripper 1570 is a generally U-shaped member having first and second vertical walls
  • a space 1576 is thus formed between the vertical walls 1571, 1572 and this space 1576 is open at the ends of the vertical
  • Each flange member 1577 is configured and mounted to one
  • the flange members 1577 overhang respective vertical walls 1571, 1572 as best shown in Fig. xxx. The distance between the flange members
  • distance between the flange members 1577 is selected in view of the diameter of the plunger 50 such that the diameter of the plunger 50 is greater than the distance
  • syringe 10 can be introduced into the space 1576 at one end with the plunger 50 lying within the space 1576 before the flange members 1577 engage the plunger 50
  • the actuation of the drive motor 1562 causes the drive mechamsm to
  • the carrier 1550 is driven a predetermined distance and to a
  • the drive motor 1562 is preferably a conventional servo motor and therefore the actuation of the drive motor 1562 causes the drive motor
  • drive motor 1562 is preferably in communication with the main controller and control signals can be sent from the controller to the drive motor 1562 to control the
  • the number of steps of the drive motor 1562 is equated to the carrier 1550 moving a
  • the drive motor 1562 being driven through 20,000 steps causes the carrier 1550 to move 5
  • the carrier 1550 is in the up (top)
  • the master controller is preferably a programmable unit, the user
  • the device installation includes an adjustment that "teaches” it where the fully
  • the controller software determines all
  • the controller can cause all positioning to be overdrawn by 0.4 ml. This is useful in adding a slight air gap at the top of the syringe to prevent overfilling and splashing

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

Dans un mode de réalisation, l'invention concerne un système automatique de préparation de médicament, y compris la préparation automatique de la seringue consistant à reconstituer ce médicament. Ce système comprend : (1) des premiers moyens automatiques de préhension servant à retirer la coiffe du cylindre de la seringue et à placer cette coiffe dans un premier emplacement ; (2) un dispositif automatique servant à introduire une dose prescrite de médicament dans la seringue, ce qui consiste à véhiculer ce médicament à travers le cylindre dont on a retiré la coiffe, pour une administration immédiate ; (3) un contrôleur communicant avec le dispositif automatique et comprenant une base de données servant à mémoriser des informations de reconstitution pouvant être exécutées avec le dispositif automatique afin de reconstituer le médicament préalablement à son injection dans la seringue, ces informations de reconstitution comportant au moins la concentration du médicament obtenu, ainsi que la durée d'agitation d'un mélange de médicaments ; (4) des deuxièmes moyens automatiques de préhension servant à repositionner la coiffe sur le cylindre de la seringue après l'injection du médicament.
PCT/US2003/038581 2002-12-03 2003-12-03 Preparation automatique de seringues et transfert automatique du medicament dans cette seringue et caracteristiques de securite associees Ceased WO2004050038A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2003297653A AU2003297653A1 (en) 2002-12-03 2003-12-03 Automated syringe preparation and automated transfer of medication thereto and safety features associated therewith
EP03812510A EP1578379A4 (fr) 2002-12-03 2003-12-03 Preparation automatique de seringues et transfert automatique du medicament dans cette seringue et caracteristiques de securite associees
CA002505093A CA2505093A1 (fr) 2002-12-03 2003-12-03 Preparation automatique de seringues et transfert automatique du medicament dans cette seringue et caracteristiques de securite associees

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US43048102P 2002-12-03 2002-12-03
US60/430,481 2002-12-03
US10/426,910 US7017622B2 (en) 2002-12-03 2003-04-30 Automated means for removing, parking and replacing a syringe tip cap from a syringe
US10/426,910 2003-04-30
US47032803P 2003-05-13 2003-05-13
US60/470,328 2003-05-13
US10/457,066 2003-06-05
US10/457,066 US6877530B2 (en) 2002-12-03 2003-06-05 Automated means for withdrawing a syringe plunger

Publications (3)

Publication Number Publication Date
WO2004050038A2 true WO2004050038A2 (fr) 2004-06-17
WO2004050038A8 WO2004050038A8 (fr) 2004-08-12
WO2004050038A3 WO2004050038A3 (fr) 2006-04-13

Family

ID=32475707

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/038581 Ceased WO2004050038A2 (fr) 2002-12-03 2003-12-03 Preparation automatique de seringues et transfert automatique du medicament dans cette seringue et caracteristiques de securite associees

Country Status (4)

Country Link
EP (1) EP1578379A4 (fr)
AU (1) AU2003297653A1 (fr)
CA (1) CA2505093A1 (fr)
WO (1) WO2004050038A2 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7343943B2 (en) 2004-05-13 2008-03-18 Forhealth Technologies, Inc. Medication dose underfill detection system and application in an automated syringe preparing system
EP1946787A2 (fr) 2007-01-22 2008-07-23 Teva Pharmaceutical Industries Ltd Seringue et étiquette de seringue
US8293532B2 (en) 2009-03-26 2012-10-23 Dow AgroSciences, L.L.C. Method and apparatus for tissue transfer
WO2019005072A1 (fr) * 2017-06-29 2019-01-03 Regeneron Pharmaceuticals Inc. Dispositifs et procédé de sur-remplissage de récipients de médicaments
CN116215930A (zh) * 2023-02-20 2023-06-06 湖南科伦制药有限公司 一种注射器灌装加塞机
CN117342903A (zh) * 2023-10-08 2024-01-05 神华准格尔能源有限责任公司 多工位混装炸药自动加装系统及加装方法
WO2025181809A1 (fr) * 2024-02-29 2025-09-04 Equashield Medical Ltd Module de préparation de flacon automatisé

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110680995B (zh) * 2019-09-11 2024-05-07 浙江环稠机械设备制造有限公司 注射器全自动流水线生产设备
GB202107153D0 (en) * 2021-05-19 2021-06-30 UCB Biopharma SRL Method for filling vials containing liquid drug products
CN115400693B (zh) * 2022-05-06 2024-05-28 深圳瑞吉生物科技有限公司 药物合成设备和方法

Family Cites Families (4)

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GB2259081A (en) * 1991-08-16 1993-03-03 British Nuclear Fuels Plc Dispensing apparatus
US5884457A (en) * 1997-02-05 1999-03-23 Smithkline Beecham Corporation Method and apparatus for automatically producing a plurality of sterile liquid filled delivery devices
AUPP058197A0 (en) * 1997-11-27 1997-12-18 A.I. Scientific Pty Ltd Pathology sample tube distributor
AU2001290528A1 (en) * 2000-08-10 2002-02-18 Baxa Corporation Method, system, and apparatus for handling, labeling, filling, and capping syringes

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7343943B2 (en) 2004-05-13 2008-03-18 Forhealth Technologies, Inc. Medication dose underfill detection system and application in an automated syringe preparing system
EP1946787A2 (fr) 2007-01-22 2008-07-23 Teva Pharmaceutical Industries Ltd Seringue et étiquette de seringue
EP1946787A3 (fr) * 2007-01-22 2008-10-08 Teva Pharmaceutical Industries Ltd Seringue et étiquette de seringue
WO2008091623A3 (fr) * 2007-01-22 2008-11-13 Teva Pharma Seringue et étiquette de seringue
US8293532B2 (en) 2009-03-26 2012-10-23 Dow AgroSciences, L.L.C. Method and apparatus for tissue transfer
US8409860B2 (en) 2009-03-26 2013-04-02 Dow Agrosciences, Llc. Method and apparatus for tissue transfer
US8722407B2 (en) 2009-03-26 2014-05-13 Dow Agrosciences, Llc. Method and apparatus for tissue transfer
US9500570B2 (en) 2009-03-26 2016-11-22 Dow Agrosciences Llc Apparatus for tissue transfer
WO2019005072A1 (fr) * 2017-06-29 2019-01-03 Regeneron Pharmaceuticals Inc. Dispositifs et procédé de sur-remplissage de récipients de médicaments
US11577025B2 (en) 2017-06-29 2023-02-14 Regeneron Pharmaceuticals, Inc. Devices and methods for overfilling drug containers
US11918785B2 (en) 2017-06-29 2024-03-05 Regeneron Pharmaceuticals Inc. Devices and methods for overfilling drug containers
IL271434B1 (en) * 2017-06-29 2025-07-01 Regeneron Pharma Devices and methods for overfilling drug containers
US12440622B2 (en) 2017-06-29 2025-10-14 Regeneron Pharmaceuticals, Inc. Devices and methods for overfilling drug containers
IL271434B2 (en) * 2017-06-29 2025-11-01 Regeneron Pharma Devices and devices for overfilling medicine containers
CN116215930A (zh) * 2023-02-20 2023-06-06 湖南科伦制药有限公司 一种注射器灌装加塞机
CN116215930B (zh) * 2023-02-20 2024-07-23 湖南科伦制药有限公司 一种注射器灌装加塞机
CN117342903A (zh) * 2023-10-08 2024-01-05 神华准格尔能源有限责任公司 多工位混装炸药自动加装系统及加装方法
WO2025181809A1 (fr) * 2024-02-29 2025-09-04 Equashield Medical Ltd Module de préparation de flacon automatisé

Also Published As

Publication number Publication date
CA2505093A1 (fr) 2004-06-17
EP1578379A4 (fr) 2008-08-13
WO2004050038A3 (fr) 2006-04-13
EP1578379A2 (fr) 2005-09-28
AU2003297653A1 (en) 2004-06-23
AU2003297653A8 (en) 2004-06-23
WO2004050038A8 (fr) 2004-08-12

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