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WO2004049802A1 - Compositions d'amidon contenant des inhibiteurs de biodegradation - Google Patents

Compositions d'amidon contenant des inhibiteurs de biodegradation Download PDF

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Publication number
WO2004049802A1
WO2004049802A1 PCT/US2002/038420 US0238420W WO2004049802A1 WO 2004049802 A1 WO2004049802 A1 WO 2004049802A1 US 0238420 W US0238420 W US 0238420W WO 2004049802 A1 WO2004049802 A1 WO 2004049802A1
Authority
WO
WIPO (PCT)
Prior art keywords
group
ppm
carbon atoms
component
concentration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/038420
Other languages
English (en)
Inventor
Phillip Gerdon Sweeny
Olga Borokhov
Patrick Jay Lutz
Ahmed Mohammed Tafesh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lonza AG
Lonza LLC
Original Assignee
Lonza AG
Lonza LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza AG, Lonza LLC filed Critical Lonza AG
Priority to AU2002359562A priority Critical patent/AU2002359562A1/en
Priority to PCT/US2002/038420 priority patent/WO2004049802A1/fr
Publication of WO2004049802A1 publication Critical patent/WO2004049802A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles

Definitions

  • the present invention pertains to starch compositions containing biodegradation
  • Antimicrobial agents are useful in the
  • microorganisms is of particular interest because industrial starch slurries and pastes are utilized in a
  • starch slurries and pastes are utilized in the paper industry as dry strength
  • Starch slurries and pastes consist of complex carbohydrates dispersed in an
  • aqueous medium which provide an easily assimilated food source for bacteria, yeast and fungi.
  • Thermophilic, acid producing microorganisms are particularly troublesome
  • microorganisms also remain viable at elevated temperatures, such as 150 - 160° F.
  • compositions which control microbiological and fungal contamination in starch products such as
  • Formaldehyde in the free state, as in formalin, is effective only for short periods of
  • Alkyl parabens e.g., methyl, ethyl, and propyl
  • benzethonium chloride methyldibromo glutaronitrile, and ethylenediaminetetraacetic acid.
  • butylcarbamate are costly, so the use of large amounts of these compounds is not economical.
  • CMI 5-chloro-2-methyl-3- isothiazolin-4-one
  • MI 2-methyl-3-isothiazolin-4-one
  • a preservative system for clinical chemistry reagents comprising DMDMH and CMI/MI is
  • Patent No. 6,133,300 to Smith et al. discloses the combination of 5,5-dimethylhydantoin (DMH)
  • EP 1084 619 discloses a stable composition of at
  • At least one imidazoldine, at least one 3 -isothiazolone, a stabilizing amount of copper and a solvent at least one imidazoldine, at least one 3 -isothiazolone, a stabilizing amount of copper and a solvent.
  • compositions comprising novel low free formaldehyde formulations of formaldehyde donor
  • starch paste preparation may be used in the preservation of starch compositions.
  • Such formulations are especially beneficial in the high operating temperatures of starch paste preparation
  • This combination preferably includes a mixture of l,3-dimefhylol-5,5-
  • DDMH dimethylhydantoin
  • MDMH dimethylhydantoin
  • DH 5,5-dimethylhydantoin
  • component comprising one or more isothiazolone compounds is added to one or more of the
  • the isothiazolones are selected from the group consisting of 2-methyl-4-isothiazolin-3-
  • MI 5-chloro-2-methyl-4-isothiazolin-3-one
  • CMI 5-chloro-2-methyl-4-isothiazolin-3-one
  • BIT l,2-benbenzisothiazoin-3-one
  • the present invention provides starch compositions comprising biodegradation
  • inventions include but are not limited to pastes and slurries.
  • starch biodegradation inhibitors of the present invention comprise low free
  • formaldyhyde formulations of one or more formaldehyde donors compounds such as alkanoldialkyl
  • each R is independently hydrogen, a methyl group, an ethyl group, a propyl group, an alkyl
  • R, and R 2 are each independently hydrogen or (CH 2 )OH, with the
  • both R, and R 2 cannot be hydrogen (i.e., at least one of R, and R 2 is (CH 2 )OH)), and
  • the low free formaldehyde formulation may also include a dialkyl hydantoin having
  • R is as defined above and R] and R 2 are hydrogen.
  • the mixture preferably includes 1,3-
  • DDMH dimethylol-5,5-dimethylhydantoin
  • MDMH dimethylhydantoin
  • DH 5,5-dimethylhydantoin
  • formulation is less than 0.2% by weight based on 100% weight of the starch composition. More
  • the concentration of free formaldehyde in the low free formaldehyde formulation is less
  • the starch compositions of the present invention may include a second component
  • X is hydrogen or halogen, preferably chlorine, and R is a hydrogen, an alkyl chain of from 1
  • dialkylaminoalkyl group of up to 12 carbon atoms a haloalkyl group of up to 12 carbon atoms, an
  • alkoxyalkyl group of up to 12 carbons atoms an alkylthioalkyl group of up to 12 carbon atoms, an
  • alkenyl group of up to 12 carbon atoms an alkynyl group of up to 12 carbon atoms, an alkali metal
  • isothiazolones contain stabilizers known in the art and the presence of these stabilizers are
  • the isothiazolone compounds are preferably selected from the group consisting of
  • MI 2-methyl-4-isothiazolin-3-one
  • CMI 5-chloro-2-methyl-4-isothiazolin-3-one
  • 1,2-amino-2-methyl-4-isothiazolin-3-one 1,2-amino-2-methyl-4-isothiazolin-3-one
  • benzisothiazoin-3-one (BIT) and alkali metal salts of BIT and mixtures thereof.
  • BIT benzisothiazoin-3-one
  • alkali metal salts of BIT and mixtures thereof alkali metal salts of BIT and mixtures thereof.
  • isothiazolones of the above formula including stock solutions containing isothiazolone stabilizers
  • the inhibitors are added to the starch slurries or pastes in amounts such
  • the ratio of the first component (formaldehyde donor) to the second component (isothiazolone) ranges from about 1:1 to about 10,000:1. More preferably, the ratio of the first component to the
  • second component ranges from about 200:1 to about 500:1.
  • the first component of the system ranges from about 50 ppm to about 1000 ppm.
  • preferred range for the first component ranges from about 100 ppm to about 500 ppm.
  • a preferred range for the concentration of the second component ranges from
  • MMDMH and or DMH with MI/CMI and/or BIT such as Lonzaserve ® SG (Lonza Inc., Fairlawn
  • NJ may be used to effectively reduce microbial populations and maintain physical-chemical
  • starch biodegradation inhibitors of the present invention inhibit the production of
  • the present invention inhibits the present invention
  • the present invention is directed to starch compositions containing the formulations
  • synergistic effect is a response to a
  • Q a The quantity of Compound a acting alone, producing an endpoint.
  • Q b The quantity of Compound b acting alone, producing an endpoint.
  • Q A The quantity of Compound A in mixture, producing an endpoint.
  • Q B The quantity of Compound B in mixture, producing an endpoint.
  • test samples were sealed and stored at 20°C for 28 days of contact time. The
  • control sample contained no preservative.
  • test samples were evaluated by standard pour plate techniques. One gram of the test samples was neutralized using
  • formulation provided 2 log reductions in 14 days at 340 and 170 ppm active ingredients.
  • Lonzaserve® SG (DMDMH/MMDMH/DMH and MI/CMI blend), a
  • DMDMH/MMDMH /DMH and BIT blend DMDMH/MMDMH /DMH and BIT blend, Dantogard® 2000 (DMDMH/MMDMH/DMH) and
  • Kathon ® CG (a 1.5% CMI/MI mixture, Rohm and Haas, Philadelphia, PA) preservation efficacy was evaluated in an uncooked ethoxylated starch slurry (Ethylex 2025, Staley, Decatur LL).
  • a gram negative bacteria Pseudomonas aeruginosa ATCC 9027 was used for
  • the bacterial strain was maintained and grown on Tryptic
  • Soy Agar Soy Agar. Inoculum was prepared by washing the surface of the 18 -24 hours slants with
  • test samples The unpreserved control contained no biocide.
  • the test samples were incubated at
  • the DMDMH/MMDMH/DMH and BIT blend provided 6 log reductions in 4 hours at
  • Q a The quantity of Compound a acting alone, producing an endpoint.
  • Q b The quantity of Compound b acting alone, producing an endpoint.
  • Q A The quantity of Compound A in mixture, producing an endpoint.
  • Q B The quantity of Compound B in mixture, producing an endpoint.
  • the DMDMH/MMDMH DMH and MI/CMI blend produces a synergistic effect as demonstrated by the observed synergy index value of 0.44 for the antimicrobial results.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

La présente invention concerne des compositions d'amidon contenant des inhibiteurs de biodégradation, lesdits inhibiteurs étant des formulations à faibles teneurs en formaldéhydes libres d'un ou plusieurs composés donneurs de formaldéhydes. Les compositions d'amidon selon l'invention peuvent également contenir un inhibiteur additionnel contenant un ou plusieurs composés d'isothiazolone, qui lorsqu'ils sont combinés aux composés donneurs de formaldéhydes, forment un mélange synergique. L'invention concerne également des procédés d'inhibition de la dégradation d'amidon.
PCT/US2002/038420 2002-12-02 2002-12-02 Compositions d'amidon contenant des inhibiteurs de biodegradation Ceased WO2004049802A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2002359562A AU2002359562A1 (en) 2002-12-02 2002-12-02 Starch compositions containing biodegradation inhibitors
PCT/US2002/038420 WO2004049802A1 (fr) 2002-12-02 2002-12-02 Compositions d'amidon contenant des inhibiteurs de biodegradation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2002/038420 WO2004049802A1 (fr) 2002-12-02 2002-12-02 Compositions d'amidon contenant des inhibiteurs de biodegradation

Publications (1)

Publication Number Publication Date
WO2004049802A1 true WO2004049802A1 (fr) 2004-06-17

Family

ID=32467116

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/038420 Ceased WO2004049802A1 (fr) 2002-12-02 2002-12-02 Compositions d'amidon contenant des inhibiteurs de biodegradation

Country Status (2)

Country Link
AU (1) AU2002359562A1 (fr)
WO (1) WO2004049802A1 (fr)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999008530A1 (fr) * 1997-08-20 1999-02-25 Thor Chemie Gmbh Composition biocide synergique
US6114366A (en) * 1997-02-27 2000-09-05 Lonza Inc. Broad spectrum preservative
WO2001039721A2 (fr) * 1999-12-03 2001-06-07 Calgon Corporation Solutions a base d'amidon destinees aux soins personnels
DE10042894A1 (de) * 2000-08-31 2002-03-14 Thor Chemie Gmbh Synergistische Biozidzusammensetzung mit 2-Methylisothiazolin-3-on
WO2002067685A1 (fr) * 2001-02-26 2002-09-06 Lonza Inc. Preparations de conservateurs stables comprenant des composes halopropynyle et un solvant butoxydiglycol
US20030050280A1 (en) * 2001-06-28 2003-03-13 Lonza Inc. Starch compositions containing biodegradation inhibitors and methods for the prevention of starch biodegradation

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6114366A (en) * 1997-02-27 2000-09-05 Lonza Inc. Broad spectrum preservative
WO1999008530A1 (fr) * 1997-08-20 1999-02-25 Thor Chemie Gmbh Composition biocide synergique
WO2001039721A2 (fr) * 1999-12-03 2001-06-07 Calgon Corporation Solutions a base d'amidon destinees aux soins personnels
DE10042894A1 (de) * 2000-08-31 2002-03-14 Thor Chemie Gmbh Synergistische Biozidzusammensetzung mit 2-Methylisothiazolin-3-on
WO2002067685A1 (fr) * 2001-02-26 2002-09-06 Lonza Inc. Preparations de conservateurs stables comprenant des composes halopropynyle et un solvant butoxydiglycol
US20030050280A1 (en) * 2001-06-28 2003-03-13 Lonza Inc. Starch compositions containing biodegradation inhibitors and methods for the prevention of starch biodegradation

Also Published As

Publication number Publication date
AU2002359562A1 (en) 2004-06-23

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