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WO2004045570A1 - Concentre de protection contre la lumiere contenant des polymeres solubles dans l'eau - Google Patents

Concentre de protection contre la lumiere contenant des polymeres solubles dans l'eau Download PDF

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Publication number
WO2004045570A1
WO2004045570A1 PCT/EP2003/050831 EP0350831W WO2004045570A1 WO 2004045570 A1 WO2004045570 A1 WO 2004045570A1 EP 0350831 W EP0350831 W EP 0350831W WO 2004045570 A1 WO2004045570 A1 WO 2004045570A1
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Prior art keywords
acid
emulsion
weight
advantageous
preparation
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German (de)
English (en)
Inventor
Sabine Koopmann
Jens Schulz
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Beiersdorf AG
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Beiersdorf AG
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Priority to EP03796021A priority Critical patent/EP1565156A1/fr
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Anticipated expiration legal-status Critical
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/731—Cellulose; Quaternized cellulose derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
    • A61K8/8176—Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/54—Polymers characterized by specific structures/properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms

Definitions

  • the present invention relates to a process for producing an O / W emulsion, characterized in that an O / W emulsion containing a) a lipid phase in a concentration of 20 to 95% by weight, b) one or more water-soluble polymers in one Total concentration of 1 to 80% by weight, based in each case on the total weight of the preparation, and c) one or more UV light protection filters and d) an aqueous phase, in addition to any other cosmetic and / or dermatological active ingredients, auxiliaries and additives, by spray drying and / or freeze drying.
  • the skin is the largest organ in humans. Among its many functions (for example for heat regulation and as a sensory organ), the barrier function that prevents the skin (and ultimately the entire organism) from drying out is probably the most important. At the same time, the skin acts as a protective device against the penetration and absorption of external substances and UV radiation. This barrier function is brought about by the epidermis, which as the outermost layer forms the actual protective cover against the environment. At around a tenth of the total thickness, it is also the thinnest layer of the skin.
  • Emulsions are generally understood to mean heterogeneous systems which consist of two immiscible or only to a limited extent miscible liquids, which are usually referred to as phases and in which one of the two liquids is dispersed in the form of very fine droplets in the other liquid. When viewed externally and with the naked eye, emulsions appear homogeneous.
  • the two liquids are water and oil and oil droplets are finely distributed in water, then it is an oil-in-water emulsion (O / W emulsion, e.g. milk).
  • O / W emulsion oil-in-water emulsion
  • the basic character of an O / W emulsion is characterized by the water.
  • a water-in-oil emulsion (W / O emulsion, e.g. butter) is the opposite principle, whereby the basic character is determined by the oil.
  • UVB range wavelength: 280-320 nm
  • UVB and UVA radiation wavelength: 320-400 nm
  • UVA and UVB filters summarized in most industrialized countries in the form of positive lists such as Appendix 7 of the Cosmetics Regulation.
  • the application concentrations of the ingredients are already predetermined for the consumer. An individual adaptation to the conditions at the application site is no longer possible.
  • the object is surprisingly achieved by a process for producing an O / W emulsion, characterized in that an O / W emulsion containing a) a lipid phase in a concentration of 20 to 95% by weight, 'b) one or more water-soluble Polymers in a total concentration of 1 to 80% by weight, based in each case on the total weight of the preparation, and c) one or more UV light protection filters and d) an aqueous phase, in addition to any other cosmetic and / or dermatological active ingredients, auxiliaries and additives, is dried by spray drying and / or freeze drying.
  • the lipid phase in a concentration of 25 to 90% by weight and particularly preferably in a concentration of 35 to 80 % By weight, based in each case on the total weight of the preparation, is present in the emulsion according to the invention.
  • one or more water-soluble polymers are contained in a total concentration of 5 to 70% by weight and particularly preferably in a concentration of 10 to 60% by weight, in each case based on the total weight of the emulsion.
  • the water content in the preparation after the spray and / or freeze drying is less than 8% by weight and particularly preferably less than 5% by weight, in each case based on the total weight of the dried emulsion.
  • O / W emulsions produced by such a method are also in accordance with the invention.
  • dry emulsions can be “re-emulsified” by simply adding water, that is to say that an O / W emulsion is formed again, which is usually not the case with “dried” emulsions.
  • the emulsions according to the invention have a particularly pleasant feeling on the skin and can be combined with a large number of cosmetic active ingredients, auxiliaries and additives.
  • the emulsions according to the invention contain UV light protection filters which could not previously be incorporated into re-emulsifiable emulsions.
  • the oil phase of the emulsion according to the invention ie the lipophilic organic constituents, are advantageously chosen from the group of polar oils, for example from the group of lecithins and fatty acid triglycerides, namely the triglycerol esters of saturated and / or unsaturated, branched and / or unbranched alkane carboxylic acids Chain length of 8 to 24, especially 12 to 18 carbon atoms.
  • the fatty acid triglycerides can for example be advantageously selected from the group of synthetic, semi-synthetic and natural oils, such as. B.
  • cocoglyceride olive oil, sunflower oil, soybean oil, peanut oil, rapeseed oil, almond oil, palm oil, coconut oil, castor oil, wheat germ oil, grape seed oil, safflower oil, evening primrose oil, macadamia nut oil and the like.
  • z. B natural waxes of animal and vegetable origin, such as beeswax and other insect waxes and berry wax, shea butter and / or lanolin (wool wax).
  • further advantageous polar oil components can also be selected from the group of esters from saturated and / or unsaturated, branched and / or unbranched alkane carboxylic acids with a chain length of 3 to 30 carbon atoms and saturated and / or unsaturated, branched and / or unbranched alcohols with a chain length of 3 to 30 C atoms and from the group of esters from aromatic carboxylic acids and saturated and / or unsaturated, branched and / or unbranched alcohols with a chain length of 3 to 30 C atoms.
  • the oil phase can advantageously be selected from the group of dialkyl ethers and dialkyl carbonates.
  • pentylglykoldiheptanoat the one or more oil components from the group consisting of isoeicosane, neopentyl, propylene glycol dicaprylate / dicaprate, caprylic / capric / Diglyceryl- succinate, butylene glycol dicaprylate / dicaprate, cocoglycerides (z. B.
  • Myritol® 331 by Henkel C ⁇ 2 - 13 -Alkyllactate, Di-C ⁇ 2 - 13 -alkyl tartrate, triisostearin, dipentaerythrityl hexacaprylate / hexacaprate, propylene glycol monoisostearate, tricaprylin, dimethyl isosorbide. It is particularly advantageous if the oil phase of the formulations according to the invention has a content of C 12 -is alkyl benzoate or consists entirely of this.
  • Advantageous oil components are also e.g. B. butyl octyl salicylate (for example that available under the trade name Hallbrite BHB from CP Hall), hexadecyl benzoate and butyl octyl benzoate and mixtures thereof (Hallstar AB) and / or diethyl hexyl naphthalate (Corapan®TQ from Haarmann & Reimer).
  • B. butyl octyl salicylate for example that available under the trade name Hallbrite BHB from CP Hall
  • hexadecyl benzoate and butyl octyl benzoate and mixtures thereof Hallstar AB
  • Diethyl hexyl naphthalate Corapan®TQ from Haarmann & Reimer
  • the lipid phase can contain the polar oil components in a concentration of up to 80% by weight based on the total weight of the lipid phase.
  • the weight given relates to the composition of the preparation before drying by means of freeze and / or spray drying.
  • the oil phase can also advantageously also contain non-polar oils, for example those selected from the group of branched and unbranched hydrocarbons and waxes, in particular mineral oil, petroleum jelly (petrolatum), paraffin oil, squalane and squalene, polyolefins, hydrogenated polyisobutenes and isohexa- decane.
  • non-polar oils for example those selected from the group of branched and unbranched hydrocarbons and waxes, in particular mineral oil, petroleum jelly (petrolatum), paraffin oil, squalane and squalene, polyolefins, hydrogenated polyisobutenes and isohexa- decane.
  • non-polar oils for example those selected from the group of branched and unbranched hydrocarbons and waxes, in particular mineral oil, petroleum jelly (petrolatum), paraffin oil, squalane and squalene, polyolefins, hydrogenated polyisobutenes and isohex
  • the non-polar oil components can advantageously be present in the emulsions according to the invention in a concentration of up to 80% by weight, based on the total weight of the lipid phase.
  • the weight specification refers to the Composition of the preparation before drying by freeze and / or spray drying.
  • the oil phase can advantageously also have a content of cyclic or linear silicone oils or consist entirely of such oils, although it is preferred to use an additional content of other oil phase components in addition to the silicone oil or the silicone oils.
  • Silicone oils are high-molecular synthetic polymeric compounds in which silicon atoms are linked in a chain and / or network-like manner via oxygen atoms and the remaining valences of silicon by hydrocarbon residues (mostly methyl, more rarely ethyl, propyl, phenyl groups, etc.) are saturated.
  • the silicone oils are systematically referred to as polyorganosiloxanes.
  • the methyl-substituted polyorganosiloxanes which are the most important compounds of this group in terms of quantity and are characterized by the following structural formula
  • Dimethicone is available in different chain lengths or with different molecular weights.
  • Particularly advantageous polyorganosiloxanes for the purposes of the present invention are, for example, dimethylpolysiloxanes [polydimethylsiloxane)], which are available, for example, under the trade names Abil 10 to 10,000 from Th. Goldschmidt.
  • Phenylmethylpolysiloxanes INCI: phenyl dimethicone, phenyl trimethicone
  • cyclic silicones octamethylcyclotetrasiloxane or decamethylcyclopentasiloxane
  • cyclomethicones are also advantageous, amino-modified silicones (INCI: amodimethicone and silicone wax).
  • polysiloxane-polyalkylene copolymers (INCI: stearyl dimethicone and cetyl dimethicone) and dialkoxydimethyl polysiloxanes (stearoxy dimethicone and behenoxy stearyl dimethicone), which are available as different Abil-Wax types from Th. Goldschmidt.
  • other silicone oils can also be used advantageously for the purposes of the present invention, for example Cetyldimethicone, hexamethylcyclotrisiloxane, polydimethylsiloxane, poly (methylphenylsiloxane).
  • Silicones which are particularly preferred according to the invention are dimethicone and cyclomethicone.
  • the silicone oil content of the lipid phase can advantageously be 20 to 100% by weight and particularly preferably 30 to 60% by weight, in each case based on the total weight of the lipid phase.
  • Water-soluble polymers which are advantageous according to the invention can advantageously be inventively selected from the group of water-soluble or dispersible film-formers (for example polyurethanes, dimethicone copolyol polyacrylates, polyvinylpyrrolidone-vinyl acetates PVP / VA, polyvinylpyrrolidones (PVP), see below) and from the group of hydrocolloids (for example Agar-agar, carrageenan, tragacanth, gum arabic, alginates, pectins, polyoses, guar flour, locust bean gum, starch, dextrins, polysaccharide-N-alkyl urethanes, inulin carbamates, gelatin, casein, cellulose ethers, hydroxyethyl and - propyl cellulose derivatives, polysaccharide derivatives , Polyacrylic and polymethacrylic compounds, ammonium acryloyldimethyl taurates / vinyl
  • Hydrocolloids preferred according to the invention are, for example, methyl celluloses, as the methyl ethers of cellulose are referred to. They are characterized by the following structure
  • R can represent a hydrogen or a methyl group.
  • cellulose mixed ethers which are generally also referred to as methyl celluloses and which, in addition to a dominant content of methyl, also contain 2-hydroxyethyl, 2-hydroxypropyl or 2-hy- contain droxybutyl groups.
  • Particularly preferred hydroxypropylmethyl celluloses (HPMC) have an average molar mass M m ⁇ 50,000 g mol "1 and are, for example, under the name Pharmacoat 603, Pharmacoat 606 and Pharmacoat 645 or under the name Metolose 65 SH 50 or Metolose 60 SH 50 from FA Shin Etsu available.
  • (hydroxypropyl) methyl celluloses for example those sold under the trade name Methocel E4M by Dow Chemical Comp. available.
  • sodium carboxymethyl cellulose the sodium salt of the glycolic acid ether of cellulose, for which R in structural formula I can be a hydrogen and / or CH2-COONa.
  • R in structural formula I can be a hydrogen and / or CH2-COONa.
  • Particularly preferred is the sodium carboxymethyl cellulose available under the trade name Natrosol Plus 330 CS from Aqualon, also referred to as cellulose gum.
  • O / W emulsion according to the invention contains water-soluble cosmetic and / or dermatological active ingredients, auxiliaries and / or additives.
  • an O / W emulsion according to the invention is the process for producing an O / W emulsion according to the invention, which is characterized in that an O / W emulsion according to the invention dried by spray drying and / or freeze drying in a mixing device with water-soluble and / or volatile active, auxiliary and / or additives are mixed.
  • volatile means that these compounds have a boiling point of at most 30 ° C.
  • the emulsion according to the invention can thus contain water-soluble and / or water-dispersible ingredients according to the invention. These are advantageously added to the preparation according to the invention after freeze or spray drying.
  • the emulsion according to the invention can contain water-soluble ingredients according to the invention, for example alcohols, diols or polyols of low C number, and their ethers, preferably ethanol, isopropanol, propylene glycol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or mono butyl ether, diethylene glycol monomethyl or monoethyl ether and analog products.
  • water-soluble ingredients according to the invention for example alcohols, diols or polyols of low C number, and their ethers, preferably ethanol, isopropanol, propylene glycol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol
  • the emulsions can contain one or more polyols selected from the group sorbitol, propylene glycol and butylene glycol.
  • the polyols which are particularly preferred according to the invention are sorbitol and mannitol.
  • the cosmetic and / or dermatological emulsion according to the invention has a total amount of polyols of 5.0 to 40.0% by weight, preferably 7.5 to 35.0% by weight and very particularly preferably from 10.0 to 25.0% by weight, based in each case on the total weight of the preparation.
  • the weight data relate to the composition of the preparation before drying by means of freeze and / or spray drying.
  • the emulsion according to the invention is advantageously used as a sunscreen. It is also advantageous for the purposes of the present invention to produce cosmetic and dermatological preparations, the main purpose of which is not protection from sunlight, but which nevertheless contain UV protection substances. So z.
  • UV-A or UV-B filter substances are usually incorporated into day creams or makeup products. UV protection substances, like antioxidants and, if desired, preservatives, also provide effective protection of the preparations themselves against spoilage.
  • cosmetic and dermatological preparations which are in the form of a sunscreen are favorable.
  • the preparations in the sense of the present invention preferably contain at least one UV-A and / or UV-B filter substance.
  • the formulations can, although not necessary, optionally also contain one or more organic and / or inorganic pigments as UV filter substances.
  • Preferred inorganic pigments are metal oxides and / or other metal compounds which are sparingly soluble or insoluble in water, in particular oxides of titanium (Ti0 2 ), zinc (ZnO), iron (e.g. Fe 2 0 3 ), zirconium (Zr0 2 ), silicon ( Si0 2 ), manganese (e.g. MnO), aluminum (Al 2 0 3 ), cerium (e.g. Ce 2 0 3 ), mixed oxides of the corresponding metals and mixtures of such oxides, as well as the sulfate of barium (BaS0 ).
  • the titanium dioxide pigments can be present both in the rutile and anatase crystal modification and, for the purposes of the present invention, can advantageously be surface-treated (“gecoatef”), for example forming or maintaining a hydrophilic, amphiphilic or hydrophobic character.
  • This surface treatment can consist in that the pigments are provided with a thin hydrophilic and / or hydrophobic inorganic and / or organic layer by methods known per se.
  • the various surface coatings can also contain water.
  • Coated and uncoated titanium dioxides described can also be used in the form of the present invention in the form of commercially available oily or aqueous predispersions. Dispersing aids and / or solubilizing agents can advantageously be added to these predispersions.
  • the titanium dioxides according to the invention are distinguished by a primary particle size between 10 nm to 150 nm.
  • titanium dioxides are the MT-100 Z and MT-100 TV from Tayca Corporation, Eusolex T-2000 and Eusolex TS from Merck and the titanium dioxide T 805 from Degussa.
  • zinc oxides can also be used in the form of commercially available oily or aqueous predispersions.
  • Draw suitable zinc oxide particles and predispersions of zinc oxide particles according to the invention are characterized by a primary particle size of ⁇ 300 nm and are available under the following trade names from the companies listed:
  • Z-Cote HP1 from BASF and zinc oxide NDM from Haarmann & Reimer are particularly preferred zinc oxides for the purposes of the invention.
  • the total amount of one or more inorganic pigments in the finished cosmetic preparation is advantageously selected from the range 0.1% by weight to 25% by weight, preferably 0.5% by weight to 18% by weight.
  • An advantageous organic pigment for the purposes of the present invention is 2,2'-methylene-bis- (6- (2H-benzotriazol-2-yl) -4- (1,1,3,3-tetramethylbutyl) phenol) [INCI: bisoctyl-triazole], which is available under the trade name Tinosorb® M from CIBA-Chemicals GmbH.
  • UV-A filter substances for the purposes of the present invention are dibenzoyl methane derivatives, in particular 4- (tert-butylH'-red n ° xydibenzoyl methane (CAS No. 70356-09-1), which is available from Givaudan under the Parsol brand ® 1789 and is sold by Merck under the trade name Eusolex® 9020.
  • 4- tert-butylH'-red n ° xydibenzoyl methane
  • UV-A filter substances are the phenylene-1,4-bis (2-benzimidazyl) -3,3'-5,5'-tetrasulfonic acid and its salts, especially the corresponding sodium, potassium or triethanolammonium salts , in particular the phenylene-1,4-bis- (2-benzimidazyl) -3,3'-5,5'-tetrasulfonic acid bis-sodium salt with the INCI name bisimidazylate, which is available, for example, under the trade name Neo Heliopan AP from Haarmann & Reimer is available.
  • 1,4-di (2-oxo-10-sulfo-3-bornylidenemethyl) benzene and its salts especially the corresponding 10-sulfato compounds, especially the corresponding sodium, potassium or triethanolammonium salt
  • benzene-1,4-di (2-oxo-3-bornylidenemethyl-10-surfonic acid especially the corresponding sodium, potassium or triethanolammonium salt
  • UV-A filter substances are hydroxybenzophenones, which are characterized by the following structural formula:
  • R 1 and R 2 independently of one another are hydrogen, -CC-C2o-alkyl, C 3 -C -o-cycloalkyl or C 3 -C- 0 -cycloalkenyl, the substituents R 1 and R 2 together with the nitrogen atom to which they are bound , can form a 5- or 6-ring and
  • R 3 is a C 1 -C 2 o-alkyl radical.
  • a particularly advantageous hydroxybenzophenone in the sense of the present invention is 2- (4'-diethylamino-2'-hydoxybenzoyl) benzoic acid hexyl ester (also: aminobenzophenone), which is characterized by the following structure:
  • UV filter substances in the sense of the present invention are also so-called broadband filters, ie filter substances that absorb both UV-A and UV-B radiation.
  • Advantageous broadband filters or UV-B filter substances are, for example, bis-resorcinyltriazine derivatives with the following structure:
  • R 1 , R 2 and R 3 are independently selected from the group of branched and unbranched alkyl groups having 1 to 10 carbon atoms or represent a single hydrogen atom. Particularly preferred are the 2,4-bis - ⁇ [4- (2-ethylhexyloxy) -2-hydroxy] phenyl ⁇ -6- (4-methoxyphenyl) -1,3,5-triazine (INCI: Aniso triazine ), which is available under the trade name Tinosorb® S from CIBA-Chemicals GmbH.
  • Particularly advantageous preparations within the meaning of the present invention which are distinguished by a high or very high UV-A protection, preferably contain a plurality of UV-A and / or broadband filters, in particular dibenzoylmethane derivatives [for example 4- (tert-butyl) -4 , -methoxydibenzoylmethane], benzotriazole derivatives [for example 2,2'-methylene-bis- (6- (2H-benzotriazol-2-yl) -4- (1, 1, 3,3-tetramethylbutyl) phenol )], Phenylene-1,4-bis (2-benzimidazyl) -3 > 3'-5,5'-tetrasulfonic acid and / or its salts, the 1,4-di (2-oxo-10-sulfo-3 -bomylidene-methyl) -benzene and / or its salts and / or the 2,4-bis - ⁇ [4- (2-ethylhexy
  • UV filter substances which the structural motif
  • R is a branched or unbranched CC 18 alkyl, C 5 -C 12 cycloalkyl radical optionally substituted with one or more C 4 - alkyl groups ⁇ represents,
  • X represents an oxygen atom or an NH group
  • t is a branched or unbranched CC ⁇ alkyl radical, a C 5 -C 12 cycloalkyl radical, optionally substituted with one or more dC 4 alkyl groups, or a hydrogen atom, an alkali metal atom Ammonium group or a 'group of formula means in which
  • A represents a branched or unbranched CrC 18 alkyl radical, a C 5 -C 2 cycloalkyl or aryl radical, optionally substituted by one or more CC 4 alkyl groups
  • R 3 represents a hydrogen atom or a methyl group
  • n is a number 1 to 10 represents a branched or unbranched C 1 -C 8 alkyl radical, a C 5 -Ci2 cycloalkyl radical, optionally substituted with one or more dC - alkyl groups, when X represents the NH group, and a branched or unbranched CC 18 alkyl radical, a C 5 -C 2 cycloalkyl radical, optionally substituted with one or more CC 4 alkyl groups, or a hydrogen atom, an alkali metal atom, an ammonium group or a group of the formula
  • A represents a branched or unbranched Ci-C-i ⁇ -alkyl radical, a Cs-C ⁇ - 2 cycloalkyl or aryl radical, optionally substituted with one or more C 1 -C 4 alkyl groups,
  • R 3 represents a hydrogen atom or a methyl group
  • n represents a number from 1 to 10 when X represents an oxygen atom.
  • a particularly preferred UV filter substance in the sense of the present invention is also an asymmetrically substituted s-triazine, the chemical structure of which is represented by the formula
  • dioctylbutylamidotriazon (INCI: dioctylbutamidotriazone) and is available under the trade name UVASORB HEB from Sigma 3V.
  • Also advantageous in the sense of the present invention is a symmetrically substituted s-triazine, the 4,4 ', 4 "- (1,3,5-triazine-2,4,6-triyltriimino) -t'is-benzoic acid tris ( 2-ethylhexyl ester), synonymous: 2,4,6-tris [anilino- (p-carbo-2'-ethyl-1'-hexyloxy)] - 1,3,5-triazine (INCI: octyl triazone) , which is sold by BASF Aktiengesellschaft under the trade name UVINUL® T 150.
  • European laid-open specification 775698 also describes bis-resorcinyltriazine derivatives which are preferably to be used and whose chemical structure is represented by the generic formula
  • Ri, R 2 and Ai represent a wide variety of organic radicals.
  • An advantageous broadband filter in the sense of the present invention is the 2,2'-methylene-bis- (6- (2H-benzotriazol-2-yl) -4- (1,1,3,3-tetramethylbutyl) phenol), which is available under the trade name Tinosorb® M from CIBA-Chemicals GmbH.
  • Another advantageous broadband filter for the purposes of the present invention is 2- (2H-benzotriazol-2-yl) -4-methyl-6- [2-methyl-3- [1,3,3,3-tetramethyl-1 - [( trimethylsilyl) oxy] disiloxanyl] propyl] phenol (CAS No .: 155633-54-8) with the INCI name Drometrizole Trisiloxane.
  • the UV-B and / or broadband filters can be oil-soluble or water-soluble.
  • Advantageous oil-soluble UV-B and / or broadband filter substances are e.g. B .:
  • 3-benzylidene camphor derivatives preferably 3- (4-methylbenzylidene) camphor, 3-benzylidene camphor;
  • 4-aminobenzoic acid derivatives preferably 4- (dimethylamino) benzoic acid (2-ethylhexyl) ester, 4- (dimethylamino) benzoic acid amyl ester;
  • esters of benzalmalonic acid preferably 4-methoxybenzalmalonic acid di (2-ethylhexyl) este ⁇
  • esters of cinnamic acid preferably 4-methoxycinnamic acid (2-ethylhexyl) ester, 4-methoxycinnamic acid isopentyl ester;
  • benzophenone preferably 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone
  • Advantageous water-soluble UV-B and / or broadband filter substances are e.g. B .:
  • a further light protection filter substance according to the invention to be used advantageously is ethylhexyl-2-cyano-3,3-diphenylacrylate, obtainable (octocrylene) from BASF under the name Uvinul ® N 539th
  • a particularly preferred benzoxazole derivative according to the invention is 2,4-bis- [5-1 (dimethylpropyl) benzoxazol-2-yl- (4-phenyl) -imino] -6- (2-ethylhexyl) -imino-1 , 3,5-triazine with CAS No. 288254-16-0, which is characterized by the structural formula
  • the preparations according to the invention advantageously contain the substances which absorb UV radiation in the UV-A and / or UV-B range in a total amount of, for. B. 0.1 wt .-% to 80 wt .-%, preferably 0.5 to 70 wt .-%, in particular 1.0 to 60 wt .-%, each based on the total weight of the preparations to cosmetic preparations To provide that protect the hair or skin from the entire range of ultraviolet radiation. They can also serve as sunscreens for the hair or skin.
  • the weight data relate to the composition of the preparation before drying by means of freeze and / or spray drying.
  • the weight data relate to the composition of the preparation before drying by means of freeze and / or spray drying.
  • Particularly preferred embodiments of the present invention contain one or more triazine derivatives, dibenzoylmethane derivatives, UV filters which are liquid at room temperature and / or inorganic pigments, in particular titanium dioxide, as UV filters.
  • film formers may also be advantageous to incorporate film formers into the emulsion according to the invention, for example in order to improve the water resistance of the preparations or to increase the UV protection performance (UV-A and / or UV-B boosting).
  • Both water-soluble or dispersible and fat-soluble film formers are suitable, in each case individually or in combination with one another.
  • Advantageous water-soluble film formers are e.g. B., the film formers from the group of polymers based on polyvinylpyrrolidone (PVP)
  • copoly of polyvinylpyrrolidone for example the PVP hexadecene copolymer and the PVP eicosen copolymer, which are available under the trade names Antaron V216 and Antaron V220 from GAF Chemicals Cooperation, as well as the Tricontayl PVP and the like.
  • the usual antioxidants can be used in the emulsion.
  • the antioxidants are advantageously selected from the group consisting of amino acids (eg glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (eg urocanic acid) and their derivatives, peptides such as D, L-carnosine, D-camosine, L- Camosin and its derivatives (e.g. anserine), carotenoids, carotenes (e.g. ⁇ -carotene, ⁇ -carotene, lycopene) and their derivatives, aurothioglucose, propylthiouracil and other thiols (e.g.
  • amino acids eg glycine, histidine, tyrosine, tryptophan
  • imidazoles eg urocanic acid
  • peptides such as D, L-carnosine, D-camosine, L- Camosin and its derivatives (e.g. anserine)
  • ⁇ -hydroxy fatty acids palmitic acid, phytin acid, lactoferrin
  • ⁇ -hydroxy acids e.g. citric acid, lactic acid, malic acid
  • humic acid e.g. citric acid, lactic acid, malic acid
  • bile acid e.g. bile extracts
  • bilirubin biliverdin
  • EDTA EDTA
  • EGTA unsaturated fatty acids and their derivatives
  • the amount of the antioxidants (one or more compounds) in the preparations is preferably 0.001 to 30% by weight, particularly preferably 0.025-6.0% by weight, in particular 0.05-3.0% by weight, based on the total weight of the preparation.
  • the weight data relate to the composition of the preparation before drying by means of freeze and / or spray drying.
  • vitamin A or vitamin A derivatives or carotenes or their derivatives represent the antioxidant or antioxidants
  • the weight data relate to the composition of the preparation before drying by means of freeze and / or spray drying.
  • vitamin E and / or its derivatives represent the antioxidant or antioxidants, it is advantageous to choose their respective concentrations from the range from 0.001 to 30% by weight, based on the total weight of the formulation.
  • the weights relate to the composition of the preparation before drying by means of freeze and / or spray drying.
  • active ingredients in the sense of the present invention are natural active ingredients and / or their derivatives, such as. B. alpha-lipoic acid, phytoene, D-biotin, coenzyme Q10, alpha-glucosyl rutin, carnitine, carnosine, natural and / or synthetic isoflavonoids, creatine, fumaric acid ester, ectoine and its derivatives, taurine, and / or ß-alanine.
  • active ingredients can be contained in a concentration of 0.001 to 30% by weight, based on the total weight of the emulsion.
  • the weight data relate to the composition of the preparation before drying by means of freeze and / or spray drying.
  • Recipes according to the invention which, for. B. known anti-wrinkle active ingredients such as flavone glycosides (especially ⁇ -glycosylrutin), coenzyme Q10, vitamin E and / or derivatives and the like are particularly suitable for the prophylaxis and treatment of cosmetic or dermatological skin changes, such as z. B. occur with skin aging (such as dryness, roughness and formation of dry lines, itching, reduced re-greasing (e.g. after washing), visible vasodilation (telangiectasia, cuperosis), flaccidity and formation of wrinkles and fine lines, local hyper- , Hypo and incorrect pigmentation (e.g. age spots), increased susceptibility to mechanical stress (e.g. cracking) and the like). They are also advantageous against the appearance of dry or rough skin.
  • compositions according to the invention include, for example, panthenol, allantoin, tannin, antihistamines (e.g. loratadine, cetirizine, dimetionden, clemastine, capsaicin, HR antagonists, tannin preparations), local anesthetics, opiate antagonists (e.g. naltrexone, naloxone), anti-inflammatory drugs, e.g.
  • Plant active ingredients such as azulene and bisabolol, glycyrrhizin, hamamelin and plant extracts such as chamomile, aloe vera, hamazelis, licorice root.
  • the vitamin D 3 analogues tacalcitol, calcipotriol, tacalcitol, colecalciferol and calcitrol (vitamin D 3 ) and / or fumaric acid esters can also be successful be incorporated into the preparations.
  • These active ingredients can be contained in a concentration of 0.001 to 30% by weight, based on the total weight of the emulsion.
  • the weight data relate to the composition of the preparation before drying by means of freeze and / or spray drying.
  • moisturizers for the purposes of the present invention are, for example, glycerol, lactic acid and / or lactates, in particular sodium lactate, butylene glycol, propylene glycol, biosaccaride Gum-1, glycine soybean, ethylhexyloxyglycerol, pyrrolidonecarboxylic acid and urea. Furthermore, it is particularly advantageous to use polymeric moisturizers from the group of water-soluble and / or water-swellable and / or water-gelable polysaccharides.
  • the preparations according to the invention can advantageously contain solid carriers in the form of microfine solid particles. According to the invention, these can advantageously be surface-repellent treated (“gecoatef”), an amphiphilic character of these solid particles being formed or to be retained.
  • the surface treatment can consist in that the solid particles are provided with a thin hydrophobic or hydrophilic layer by methods known per se.
  • the average particle diameter of the microfine solid carrier used as stabilizer is preferably chosen to be less than 100 ⁇ m, particularly advantageously less than 50 ⁇ m. It is essentially irrelevant in which form (platelets, rods, beads, etc.) or modification the solid particles used are present.
  • the microfine solid supports are preferably selected from the group of amphiphilic metal oxide pigments.
  • the following are particularly advantageous: • Titanium dioxides (coated and uncoated): e.g. B. Eusolex T-2000 from Merck, titanium dioxide MT-100 Z from Tayca Corporation
  • microfine solid carriers are selected from the following group: boron nitrides, starch derivatives (Tapioca Starch, Sodium Com Starch octynyl succinate etc.), talc, latex particles.
  • the microfine solid particles are advantageously used in a concentration of 0.5 to 60% by weight, preferably in a concentration of 1 to 50% by weight and particularly preferably in a concentration of 3 to 30% by weight, in each case based on the total weight of the Preparation used.
  • the weight data relate to the composition of the preparation before drying by means of freeze and / or spray drying.
  • the cosmetic or dermatological preparations according to the invention can furthermore advantageously, although not necessarily, contain fillers which, for. B. further improve the sensory and cosmetic properties of the formulations and, for example, cause or intensify a velvety or silky feeling on the skin.
  • Advantageous fillers for the purposes of the present invention are starch and starch derivatives (such as tapioca starch, distarch phosphate, aluminum or sodium starch, octenyl succinate and the like), pigments which have neither mainly UV filter nor coloring effects (such as e.g. B. boron nitride etc.) and / or Aerosile ® (CAS No. 7631-86-9).
  • compositions according to the invention optionally contain the additives customary in cosmetics, for example perfume, colorants, antimicrobial substances, refatting agents, complexing and sequestering agents, pearlescent agents, plant extracts, vitamins, active ingredients, preservatives, bactericides, repellents, Self-tanners (e.g. DHA), depigmenting agents (e.g.
  • 8-hexadecen-1,16-dicarboxylic acid (dioic acid, CAS number 20701-68-2; provisional INCI name Octadecendioic acid)), pigments that have a coloring effect, softening, moisturizing and / or moisturizing substances, or other usual components of a cosmetic or dermatological formulation such as emulsifiers, polymers, foam stabilizers, peeling substances (abrasives, e.g. polymer beads or powder made of polyethylene, polypropylene etc. inorganic oxides, silicates etc.), antiperspirant salts (e.g. acidic aluminum and / or aluminum / zirconium salts such as aluminum chlorohydrate and / or aluminum / zirconium chlorohydrate) and electrolytes.
  • emulsifiers emulsifiers, polymers, foam stabilizers, peeling substances (abrasives, e.g. polymer beads or powder made of polyethylene, polypropylene etc. inorgan
  • repellent active ingredients listed below are preferred:
  • repellent active ingredients for the purposes of the present invention are the active ingredients N, N-diethyl-3-methylbenzamide, 3- (N-n-butyl-N-acetylamino) propionic acid ethyl ester and dimethyl phthalate.
  • the repellent is very particularly preferably ethyl 3- (N-n-butyl-N-acetylamino) propionate.
  • Embodiments of the emulsion according to the invention which are advantageous according to the invention contain one or more repellent active ingredients in a concentration of 1-50% by weight, based on the total weight of the formulation.
  • the weight data relate to the composition of the preparation before drying by means of freeze and / or spray drying.
  • the following can advantageously be used as self-tanners: Glycerol aldehyde, hydroxymethylglyoxal, ⁇ -dialdehyde, erythrulose, 6-aldo-D-fructose, ninhydrin, 5-hydroxy-1,4-naphthoquinone (juglone), 2-hydroxy-1,4-naphthoquinone (Lawson) and particularly preferably 1, 3-dihydroxyacetone.
  • Embodiments which are advantageous according to the invention and have at least one self-tanning substance contain these in a total concentration of 0.1 to 30% by weight, based on the total weight of the emulsion.
  • the weight data relate to the composition of the preparation before drying by means of freeze and / or spray drying.
  • the emulsion according to the invention can advantageously contain one or more preservatives according to the invention.
  • Advantageous preservatives for the purposes of the present invention are, for example, formaldehyde releasers (such as, for example, DMDM hydantoin, which is available, for example, from Lonza under the trade name Glydant TM), iodopropyl butyl carbamates (for example those under the trade names Glycacil-L, Glycacil -S available from Lonza and / or Dekaben LMB from Jan Dekker), parabens (ie alkyl p-hydroxybenzoate such as methyl, ethyl, propyl and / or butyl paraben), phenoxyethanol, ethanol, benzoic acid and the like.
  • formaldehyde releasers such as, for example, DMDM hydantoin, which is available, for example, from Lonza under the trade name Glydant
  • the preservation system according to the invention also advantageously includes preservation aids, such as, for example, octoxyglycerol, glycine soya, etc.
  • preservation aids such as, for example, octoxyglycerol, glycine soya, etc.
  • preservatives or preservation aids such as dibromodicyanobutane (2-bromo-2-bromomethylglutarodinitrile), phenoxyethanol, 3-iodo-2-propynylbutylcarbamate, 2-bromo-2-nitro-propane-1,3-diol and imidazolidinyl - urea, 5-chloro-2-methyl-4-isothiazolin-3-one, 2-chloroacetamide, benzalkonium chloride, benzyl alcohol, salicylic acid and salicylates.
  • dibromodicyanobutane (2-bromo-2-bromomethylglutarodinitrile)
  • phenoxyethanol 3-iodo-2-propynylbutylcarbamate
  • 2-bromo-2-nitro-propane-1,3-diol and imidazolidinyl - urea 2-chloro-2-methyl-4-isothiazolin-3-one
  • iodopropyl butyl carbamates parabens (methyl, ethyl, propyl and / or butyl paraben) and / or phenoxyethanol are used as preservatives.
  • one or more preservatives are advantageous in a concentration of 2% by weight or less than 2% by weight, preferably 1.5% by weight or less than 1.5% by weight and particularly preferably 1% by weight or less than 1% by weight , each based on the total weight of the preparation.
  • the weight data relate to the composition of the preparation before drying by means of freeze and / or spray drying.
  • the emulsion according to the invention advantageously contains one or more conditioners.
  • Preferred conditioners according to the invention are, for example, all compounds which are described in Section 4 below in the International Cosmetic Ingredient Dictionary and Handbook (Volume 4, publisher: RC Pepe, JA Wenninger, GN McEwen, The Cosmetic, Toiletry, and Fragrance Association, 9th edition, 2002) the keywords Hair Conditioning Agents, Humectants, Skin-Condftioning Agents, Skin-Conditioning Agents-Emollient, Skin-Conditioning Agents-Humactant, Skin-Conditioning Agents-Miscellaneous, Skin-Conditioning Agents-Occlusive and Skin Protectans are all listed in the EP 0934956 (p.11-13) under water soluble conditioning agent and oil soluble conditioning agent.
  • the emulsion according to the invention can contain glitter substances and / or other effect substances.
  • hydrocolloids which are advantageous according to the invention and which can be used as water-soluble polymers according to the invention are agar agar, carrageenan, tragacanth, gum arabic, alginates, pectins, polyoses, guar flour, locust bean gum, starch, dextrins, polysaccharide-N-alkyl urethanes, inulin carbamates, gelatin, casein, cellulose ethers, hydroxyethyl and propyl cellulose derivatives, polysaccharides, polyacrylic and polymethacrylic compounds, Ammoniumacryloyldime- thyltaurate / vinyl pyrrolidone copolymers and Ammoniumpolyacryl-dimethyltauramide, vinyl polymers, polycarboxylic acids, polyethers, polyimines, polyamides, polysilicic acids, clay minerals, zeolites, silicas used.
  • xanthan (CAS No. 11138-66-2), also called xanthan gum, which is an anionic heteropolysaccharide which is generally formed from corn sugar by fermentation and is isolated as the potassium salt.
  • An advantageous hydrocolloid in the sense of the present invention is he carrageenan, a gel-forming and similar to agar extract from north Atlantic, belonging to the florida red algae (Chondrus crispus and Gigartina stellata).
  • Polyacrylates are also advantageous hydrocolloids to be used in the sense of the present invention.
  • Polyacrylates which are advantageous according to the invention are acrylate-alkyl acrylate copolymers, in particular those which are selected from the group of the so-called carbomers or carbopols (Carbopol® is actually a registered trademark of NOVEON Inc.).
  • the acrylate-alkyl acrylate copolymers which are advantageous according to the invention are distinguished by the following structure:
  • R ' represents a long-chain alkyl radical and x and y numbers, which symbolize the respective stoichiometric proportion of the respective comonomers.
  • acrylate copolymers and / or acrylate-alkyl acrylate copolymers which are marketed under the trade names Carbopol® 1382, Carbopol® 981 and Carbopol® 5984, Aqua SF-1 by NOVEON Inc. or as Aculyn® 33 by International Specialty Products Corp. are available.
  • the carbomers Carbopol EDT 2001, ETD 2020 and ETD 2050 are also preferred.
  • neutralized or partially neutralized polyacrylates e.g. Carbopole from Noveon.
  • the cosmetic and / or dermatological emulsions according to the invention can contain a number of pigments.
  • the dyes and pigments can be selected from the corresponding positive list in the Cosmetics Ordinance or the EC list of cosmetic colorants. In most cases, they are identical to the colorants approved for food.
  • Advantageous color pigments are, for example, titanium dioxide, mica, iron oxides (e.g. Fe 0 3 , F ⁇ 3 ⁇ , FeO (OH)) and / or tin oxide.
  • Advantageous dyes are, for example, carmine, Berlin blue, chrome oxide green, ultramarine blue and / or manganese violet. It is particularly advantageous to choose the dyes and / or color pigments from the list below.
  • the Color Index Numbers (CIN) are taken from the Rowe Color Index, 3rd edition, Society of Dyers and Colorists, Bradford, England, 1971.
  • 2,4-dihydroxyazobenzene 1- (2'-chloro-4'-nitro-1'-phenylazo) -2-hydroxynaphthalene, ceres red
  • 2- (4-sulfo-1-naphthylazo) -1 -naphthol-4-sulfonic acid calcium salt of 2-hydroxy-1,2 "azonaphthalene-1 '-'ulfonic acid
  • aluminum salt of 1- (4-sulfo-1-phenylazo) -2-naphthol-6-sulfonic acid aluminum salt of 1- (4-sulfo-1-naphthylazo
  • Emulsions according to the invention can contain titanium dioxides, which can be present both in the rutile and anatase crystal modification and, for the purposes of the present invention, are advantageously surface-treated (“gecoatef”), for example a hydrophilic, amphiphilic or hydrophobic character is to be formed or retained.
  • This surface treatment can consist in that the pigments are provided with a thin hydrophilic and / or hydrophobic inorganic and / or organic layer by methods known per se.
  • the various surface coatings can also contain water.
  • Inorganic surface coatings in the sense of the present invention can consist of aluminum oxide (Al 2 0 3 ), aluminum hydroxide Al (OH) 3 , or aluminum oxide hydrate (also: alumina, CAS no .: 1333-84-2), sodium hexametaphosphate (NaP0 3 ) 6 , sodium metaphosphate (NaP0 3 ) n , silicon dioxide (Si0 2 ) (also: silica, CAS No .: 7631-86-9), zirconium oxide (Zr0 2 ) or iron oxide (F ⁇ 2 ⁇ 3 ).
  • These inorganic surface coatings can occur alone, in combination and / or in combination with organic coating materials.
  • oxides, oxide hydrates or phosphates for example of the elements Al, Si, Zr, are struck in dense layers on the pigment surface.
  • the inorganic aftertreatment generally takes place in an aqueous suspension of the pigment by adding soluble aftertreatment chemicals, such as, for example, aluminum sulfate, and then precipitating the hydroxide, which is sparingly soluble in the neutral range, by specifically adjusting the pH with sodium hydroxide solution.
  • soluble aftertreatment chemicals such as, for example, aluminum sulfate
  • the coated pigments are separated from the suspension by filtration and washed carefully to remove the dissolved salts, and then the isolated pigments are dried.
  • titanium dioxides to which aluminum hydroxide has been applied to the surface, such as, for example, titanium dioxide types C47-051 and C47- 5175 available from Sun Chemical.
  • Further preferred pigments are titanium dioxides containing aluminum and / or silicon oxides are coated, such as from Krosnos Titan: Kronos 1071 and 1075 or from Kingfisher: A310.03 Mathematics Aspen.
  • Organic surface coatings in the sense of the present invention can consist of vegetable or animal aluminum stearate, vegetable or animal stearic acid, lauric acid, dimethylpolysiloxane (also: dimethicone), methylpolysiloxane (methicone), simethicone (a mixture of dimethylpolysiloxane with an average chain length of 200 to 350 dimethylsiloxane Units and silica gel) or alginic acid.
  • dimethylpolysiloxane also: dimethicone
  • methicone methylpolysiloxane
  • simethicone a mixture of dimethylpolysiloxane with an average chain length of 200 to 350 dimethylsiloxane Units and silica gel
  • alginic acid can consist of vegetable or animal aluminum stearate, vegetable or animal stearic acid, lauric acid, dimethylpolysiloxane (also: dimethicone), methylpolysiloxan
  • pearlescent pigments according to the invention include natural pearlescent pigments such as B.
  • monocrystalline pearlescent pigments such as B. bismuth oxychloride (BiOCI), layer-substrate pigments: e.g. B. mica / metal oxide
  • Pearlescent pigments are based, for example, on powdered pigments or castor oil dispersions of bismuth oxychloride and / or titanium dioxide and bismuth oxychloride and / or titanium dioxide on mica. Particularly advantageous is e.g. B. the gloss pigment listed under CIN 77163.
  • pearlescent pigment types based on mica / metal oxide are also advantageous:
  • the pearlescent pigments available from Merck under the trade names Timiron, Colorona or Dichrona are particularly preferred.
  • pearlescent pigments which are advantageous in the sense of the present invention can be obtained in numerous ways known per se.
  • other substrates besides mica can be coated with other metal oxides, such as. B. silica and the like.
  • Z are advantageous.
  • Pearlescent pigments which are produced using SiO 2 are particularly preferred. Such pigments, which can also have gonichromatic effects, are e.g. B. available under the trade name Sicopearl Fantastico from BASF.
  • the dyes and pigments can be present both individually and in a mixture and can be mutually coated, different color effects generally being produced by different coating thicknesses.
  • the total amount of dyes and coloring pigments is advantageously from the range of z. B. 0.1 wt .-% to 30 wt .-%, preferably from 0.5 to 15 wt .-%, in particular from 1.0 to 10 wt .-%, each based on the total weight of the preparations.
  • the weight data relate to the composition of the preparation before drying by means of freeze and / or spray drying.
  • the O / W emulsion according to the invention advantageously contains one or more tablet auxiliaries. According to the invention, these can advantageously be in a concentration of 0.1 to 60% by weight, preferably in a concentration of 1 to 50% by weight and very particularly preferably in a concentration of 3 to 35% by weight, in each case based on the total weight of the preparation be used.
  • the weight data relate to the composition of the preparation, the preparation being considered to be the emulsion after freeze and / or spray drying, together with any other water-soluble and / or volatile compounds and tableting materials (including hydrogen carbonates and acids which are solid at room temperature).
  • fillers and compacting aids e.g. starch and / or cellulose derivatives
  • flow agents e.g. highly disperse silicon dioxide
  • flow control agents e.g. highly disperse silicon dioxide
  • all substances can be used that are in the H.P. Fiedler, Lexicon of auxiliaries for pharmacy, cosmetics and related areas, 5th edition, Editio Cantor Verlag, Aulendorf, 2002, under the keywords tablet binders, tablet fillers, tablet lubricants, tablet auxiliaries, tablet disintegrants, tablet Coatings are listed.
  • the preparation according to the invention contains a combination of carbonates and / or hydrogen carbonates and acids which are solid at room temperature (for example citric acid, ascorbic acid, lactic acid, tartaric acid, etc.). Strongly swelling polymers such as crosslinked polyvinylpyrrolidone can also be used advantageously according to the invention.
  • one or more hydrogen carbonates for example sodium hydrogen carbonate, potassium hydrogen carbonate
  • other water-soluble and / or and / or volatile compounds and tableting materials including hydrogen carbonates and acids solid at room temperature
  • one or more acids which are solid at room temperature are advantageous in an amount of 0.1 to 30% by weight, preferably in an amount of 0.5 to 20% by weight and particularly preferably in an amount of 0, 5 to 15% by weight, based in each case on the total weight of the preparation, the emulsion being used after the freeze and / or spray drying together with any further water-soluble and / or volatile compounds and tableting materials (including hydrogen carbonates and solid at room temperature) Acids) is considered.
  • Such an embodiment is particularly advantageous in the sense of the present invention if the emulsion according to the invention is in the form of a tablet (e.g. an effervescent tablet), since the emulsion according to the invention in this embodiment is particularly easy to re-emulsify by adding water.
  • a tablet e.g. an effervescent tablet
  • the invention is also the method for producing such a preparation, which is characterized in that the O / W emulsion according to the invention are mixed with one or more tablet auxiliaries in a mixing device.
  • According to the invention is also a method for producing tablets and / or granules, which is characterized in that an inventive Preparation is pressed or granulated in a press to form one or more tablets, and preparations which are produced by this process.
  • the process for producing a cosmetic is according to the invention, which is characterized in that a preparation according to the invention (an O / W emulsion dried by spray drying and / or freeze drying, optionally with water-soluble and / or volatile active ingredients, auxiliary additives and / or tablet auxiliaries are added and, if appropriate, was tableted or granulated) is mixed with water or emulsified in water.
  • a preparation according to the invention an O / W emulsion dried by spray drying and / or freeze drying, optionally with water-soluble and / or volatile active ingredients, auxiliary additives and / or tablet auxiliaries are added and, if appropriate, was tableted or granulated
  • Cosmetics which are produced by this method are also according to the invention.
  • Such a cosmetic according to the invention is then in the form of an ointment, cream, lotion or an emulsion foam (French mousse) or a sprayable form.
  • a cosmetic according to the invention it can advantageously be used for the treatment and care of the skin, hair and nails.
  • use as a sunscreen is preferred.
  • the examples from Table 1 are mixed homogeneously with mixtures of the water-soluble and dispersible additives (Table 2).
  • the substance mixtures (Tables 1 + 2) can be mixed with tableting and granulating aids (Table 3) and granules and / or tablets according to the invention can be produced by suitable processes.
  • Tablets 1 + 2 can be mixed with tableting and granulating aids (Table 3) and granules and / or tablets according to the invention can be produced by suitable processes.

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Abstract

L'invention concerne un procédé de production d'une émulsion huile dans eau, caractérisé en ce qu'une émulsion huile dans eau contienne a) une phase lipide dans une concentration comprise entre 20 et 95% en poids, b) un ou plusieurs polymères solubles dans l'eau dans une concentration totale comprise entre 1 et 80% en poids, chacun se rapportant au poids total de la composition, ainsi que c) un ou plusieurs filtres de protection U.V. et d) une phase aqueuse. Ladite émulsion peut éventuellement contenir des additifs, des agents auxiliaires et des matières actives cosmétiques et/ou dermatologiques. Ladite émulsion est séchée par séchage par pulvérisation et/ou par lyophilisation.
PCT/EP2003/050831 2002-11-21 2003-11-14 Concentre de protection contre la lumiere contenant des polymeres solubles dans l'eau Ceased WO2004045570A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP03796021A EP1565156A1 (fr) 2002-11-21 2003-11-14 Concentre de protection contre la lumiere contenant des polymeres solubles dans l'eau

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2002154335 DE10254335A1 (de) 2002-11-21 2002-11-21 Lichtschutzkonzentrat mit wasserlöslichen Polymeren
DE10254335.6 2002-11-21

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WO2004045570A1 true WO2004045570A1 (fr) 2004-06-03

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EP (1) EP1565156A1 (fr)
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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005025521A3 (fr) * 2003-09-15 2005-08-11 Basf Ag Preparations pulverulentes contenant un melange de 2,4,6-trianilino-p-(carbo-2'-ethylhexyl-1'-oxi)-1,3,5-triazine et de diethylamino-hydroxybenzoyl-hexyl-benzoate
EP1604644A1 (fr) * 2004-05-19 2005-12-14 Beiersdorf AG Concentrés d'émulsion comprenant des polymères solubles dans l'eau et des polymères soluble dans l'huile
WO2006034982A1 (fr) * 2004-09-27 2006-04-06 Beiersdorf Ag Concentre photoprotecteur a micropigments organiques
EP1923044A1 (fr) * 2006-11-14 2008-05-21 Beiersdorf AG Préparation cosmétique et son concentré à propriétés améliorées
CN100393298C (zh) * 2003-06-24 2008-06-11 巴斯福股份公司 由uv-a和uv-b过滤剂组成的混合物
FR2938767A1 (fr) * 2008-11-25 2010-05-28 Oreal Composition photoprotectrice contenant un amidon gelifiant et des particules de polyamide
EP3554461B1 (fr) 2016-12-16 2021-03-24 L'oreal Composition cosmétique comprenant des corps gras solides et un polymère gélifiant

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DE102005024967A1 (de) * 2005-05-30 2006-12-07 Beiersdorf Ag Polypeptidgebundene UV-Lichtschutzfilter in kosmetischen Zubereitungen

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Cited By (12)

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Publication number Priority date Publication date Assignee Title
CN100393298C (zh) * 2003-06-24 2008-06-11 巴斯福股份公司 由uv-a和uv-b过滤剂组成的混合物
WO2005025521A3 (fr) * 2003-09-15 2005-08-11 Basf Ag Preparations pulverulentes contenant un melange de 2,4,6-trianilino-p-(carbo-2'-ethylhexyl-1'-oxi)-1,3,5-triazine et de diethylamino-hydroxybenzoyl-hexyl-benzoate
EP1604644A1 (fr) * 2004-05-19 2005-12-14 Beiersdorf AG Concentrés d'émulsion comprenant des polymères solubles dans l'eau et des polymères soluble dans l'huile
WO2006034982A1 (fr) * 2004-09-27 2006-04-06 Beiersdorf Ag Concentre photoprotecteur a micropigments organiques
EP1923044A1 (fr) * 2006-11-14 2008-05-21 Beiersdorf AG Préparation cosmétique et son concentré à propriétés améliorées
FR2938767A1 (fr) * 2008-11-25 2010-05-28 Oreal Composition photoprotectrice contenant un amidon gelifiant et des particules de polyamide
WO2010060776A1 (fr) * 2008-11-25 2010-06-03 L'oreal Composition photoprotectrice contenant un amidon gélifiant non modifié et des particules de polyamide
US20110256192A1 (en) * 2008-11-25 2011-10-20 Cyril Chevalier Photoprotective composition containing an unmodified gelling starch and polyamide particles
RU2466708C1 (ru) * 2008-11-25 2012-11-20 Л'Ореаль Фотозащитная композиция, содержащая немодифицированный гелеобразующий крахмал и полиамидные частицы
US20140287005A1 (en) * 2008-11-25 2014-09-25 L'oreal Photoprotective composition containing an unmodified gelling starch and polyamide particles
CN102223924B (zh) * 2008-11-25 2015-03-11 莱雅公司 含有非改性胶凝淀粉和聚酰胺粒子的光防护组合物
EP3554461B1 (fr) 2016-12-16 2021-03-24 L'oreal Composition cosmétique comprenant des corps gras solides et un polymère gélifiant

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