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WO2004044613A3 - Scintillateur a halogenure de lanthane pour tomographie par emission de positons en 3d et a temps de vol - Google Patents

Scintillateur a halogenure de lanthane pour tomographie par emission de positons en 3d et a temps de vol Download PDF

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Publication number
WO2004044613A3
WO2004044613A3 PCT/US2003/035922 US0335922W WO2004044613A3 WO 2004044613 A3 WO2004044613 A3 WO 2004044613A3 US 0335922 W US0335922 W US 0335922W WO 2004044613 A3 WO2004044613 A3 WO 2004044613A3
Authority
WO
WIPO (PCT)
Prior art keywords
pet
time
cavity
flight
tof
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/035922
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English (en)
Other versions
WO2004044613A2 (fr
Inventor
Joel S Karp
Suleman Surti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pennsylvania Penn
Original Assignee
University of Pennsylvania Penn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Pennsylvania Penn filed Critical University of Pennsylvania Penn
Priority to AU2003291467A priority Critical patent/AU2003291467A1/en
Publication of WO2004044613A2 publication Critical patent/WO2004044613A2/fr
Publication of WO2004044613A3 publication Critical patent/WO2004044613A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01T—MEASUREMENT OF NUCLEAR OR X-RADIATION
    • G01T1/00—Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation
    • G01T1/29—Measurement performed on radiation beams, e.g. position or section of the beam; Measurement of spatial distribution of radiation
    • G01T1/2914—Measurement of spatial distribution of radiation
    • G01T1/2985—In depth localisation, e.g. using positron emitters; Tomographic imaging (longitudinal and transverse section imaging; apparatus for radiation diagnosis sequentially in different planes, steroscopic radiation diagnosis)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03—Computed tomography [CT]
    • A61B6/037—Emission tomography

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Molecular Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Nuclear Medicine (AREA)
  • Measurement Of Radiation (AREA)

Abstract

L'invention concerne un scintillateur à halogénure de lanthane (par exemple LaCl3 and LaBr3) présentant un temps de descente rapide et une bonne résolution temporelle, ainsi qu'une émission lumineuse légère et une bonne résolution d'énergie. Ledit scintillateur est utilisé dans la conception d'un scanner TEP. Ledit scanner TEP comprend une cavité destinée à recevoir un patient et une pluralité de modules détecteurs TEP disposés dans une configuration cylindrique, approximativement autour de la cavité. Chaque détecteur TEP comprend un scintillateur à halogénure de lanthane présentant une pluralité de cristaux d'halogénure de lanthane, un guide lumineux, et une pluralité de tubes photomultiplicateurs disposés, respectivement, à la périphérie de la cavité. La bonne résolution temporelle permet de développer un scanner TEP à temps de vol (TOF) qui présente une réduction de la propagation du bruit lors de la reconstruction d'images et un gain dans le rapport signal sur bruit. Ledit scanner TEP comprend un circuit de marque d'horodatage qui enregistre l'heure de réception des rayons gamma par les détecteurs TEP et fournit des sorties de données temporelles qui sont transmises à un processeur, qui, à son tour, calcule le temps de vol (TOF) des rayons gamma passant à travers un patient placé dans la cavité et il utilise le temps de vol des rayons gamma dans la reconstruction des images du patient.
PCT/US2003/035922 2002-11-12 2003-11-12 Scintillateur a halogenure de lanthane pour tomographie par emission de positons en 3d et a temps de vol Ceased WO2004044613A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003291467A AU2003291467A1 (en) 2002-11-12 2003-11-12 Lanthanum halide scintillators for time-of-flight 3-d pet

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42551102P 2002-11-12 2002-11-12
US60/425,511 2002-11-12

Publications (2)

Publication Number Publication Date
WO2004044613A2 WO2004044613A2 (fr) 2004-05-27
WO2004044613A3 true WO2004044613A3 (fr) 2004-07-01

Family

ID=32313001

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/035922 Ceased WO2004044613A2 (fr) 2002-11-12 2003-11-12 Scintillateur a halogenure de lanthane pour tomographie par emission de positons en 3d et a temps de vol

Country Status (3)

Country Link
US (1) US7381958B2 (fr)
AU (1) AU2003291467A1 (fr)
WO (1) WO2004044613A2 (fr)

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US7381958B2 (en) * 2002-11-12 2008-06-03 The Trustees Of The University Of Pennsylvania Lanthanum halide scintillators for time-of-flight 3-D pet
WO2005044311A2 (fr) * 2003-11-11 2005-05-19 Philips Intellectual Property & Standards Gmbh Dispositif et procede pour determiner la concentration d'un traceur dans le sang
US7649176B2 (en) * 2003-11-14 2010-01-19 Siemens Medical Solutions Usa, Inc. Method for improving clinical data quality in positron emission tomography
US7252789B2 (en) 2005-03-31 2007-08-07 General Electric Company High-density scintillators for imaging system and method of making same
JP5345383B2 (ja) 2005-04-22 2013-11-20 コーニンクレッカ フィリップス エヌ ヴェ 検出器画素、放射線検出器および方法、陽電子放出断層撮影システム、撮像検出器およびその較正方法、検出器セルの無効化方法
US8395127B1 (en) 2005-04-22 2013-03-12 Koninklijke Philips Electronics N.V. Digital silicon photomultiplier for TOF PET
US7335891B2 (en) * 2005-06-27 2008-02-26 General Electric Company Gamma and neutron radiation detector
CN101365963B (zh) * 2006-01-09 2012-02-01 皇家飞利浦电子股份有限公司 构建飞行时间pet图像的方法
JP5103879B2 (ja) 2006-09-20 2012-12-19 日立化成工業株式会社 シンチレータ用結晶及び放射線検出器
US7767975B2 (en) 2007-12-04 2010-08-03 Saint-Gobain Cristaux Et Detecteurs Ionizing radiation detector
FR2929296B1 (fr) * 2008-03-31 2011-01-21 Saint Gobain Cristaux Detecteurs Recuit de monocristaux
US8476599B2 (en) * 2008-05-30 2013-07-02 Saint-Gobain Ceramics & Plastics, Inc. Curved scintillation crystal array
EP2376942B1 (fr) * 2008-12-15 2013-03-27 Koninklijke Philips Electronics N.V. Circuit de compensation de température pour des photomultiplicateurs électroniques et autres compteurs monophotoniques
CN102094628B (zh) * 2011-03-22 2014-01-08 东华理工大学 基于LaBr3(Ce)晶体的多道γ能谱测井仪
US9962136B2 (en) * 2014-06-04 2018-05-08 The Board Of Trustees Of The Leland Stanford Junior University Reconstructing time-varying position of individual radioactive cells directly from positron emission tomography (PET) measurements
US9606245B1 (en) 2015-03-24 2017-03-28 The Research Foundation For The State University Of New York Autonomous gamma, X-ray, and particle detector
US12298454B2 (en) 2015-08-10 2025-05-13 Shanghai United Imaging Healthcare Co., Ltd. Apparatus and method for PET detector
US9696439B2 (en) 2015-08-10 2017-07-04 Shanghai United Imaging Healthcare Co., Ltd. Apparatus and method for PET detector

Citations (3)

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Publication number Priority date Publication date Assignee Title
US5015860A (en) * 1990-04-03 1991-05-14 University Of California Scintillator materials containing lanthanum fluorides
US6285028B1 (en) * 1998-06-02 2001-09-04 Kabushiki Kaisha Toshiba Semiconductor radiation detector and nuclear medicine diagnostic apparatus
US20040017224A1 (en) * 2002-03-05 2004-01-29 Nova R & D, Inc. Integrated circuit and sensor for imaging

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US4743764A (en) * 1984-12-04 1988-05-10 Computer Technology And Imaging, Inc. Two dimensional photon counting position encoder system and process
US4980552A (en) * 1989-06-20 1990-12-25 The Regents Of The University Of California High resolution PET scanner using rotating ring array of enlarged detectors having successively offset collimation apertures
US5210420A (en) * 1991-12-19 1993-05-11 Positron Corporation Positron emission tomography scanner
US5453623A (en) * 1992-05-13 1995-09-26 Board Of Regents, The University Of Texas System Positron emission tomography camera with quadrant-sharing photomultipliers and cross-coupled scintillating crystals
US6362479B1 (en) * 1998-03-25 2002-03-26 Cti Pet Systems, Inc. Scintillation detector array for encoding the energy, position, and time coordinates of gamma ray interactions
US6552348B2 (en) * 1999-12-14 2003-04-22 Regents Of The University Of California Apparatus and method for breast cancer imaging
NL1014401C2 (nl) * 2000-02-17 2001-09-04 Stichting Tech Wetenschapp Ceriumhoudend anorganisch scintillatormateriaal.
US6297506B1 (en) * 2000-03-23 2001-10-02 John W. Young System and method for reducing pile-up errors in multi-crystal gamma ray detector applications
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US7381958B2 (en) * 2002-11-12 2008-06-03 The Trustees Of The University Of Pennsylvania Lanthanum halide scintillators for time-of-flight 3-D pet
US7238946B2 (en) * 2003-06-27 2007-07-03 Siemens Medical Solutions Usa, Inc. Nuclear imaging system using scintillation bar detectors and method for event position calculation using the same
US7129494B2 (en) * 2003-09-24 2006-10-31 Radiation Monitoring Devices, Inc. Very fast doped LaBr3 scintillators and time-of-flight PET
US7084403B2 (en) * 2003-10-17 2006-08-01 General Electric Company Scintillator compositions, and related processes and articles of manufacture

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5015860A (en) * 1990-04-03 1991-05-14 University Of California Scintillator materials containing lanthanum fluorides
US6285028B1 (en) * 1998-06-02 2001-09-04 Kabushiki Kaisha Toshiba Semiconductor radiation detector and nuclear medicine diagnostic apparatus
US20040017224A1 (en) * 2002-03-05 2004-01-29 Nova R & D, Inc. Integrated circuit and sensor for imaging

Also Published As

Publication number Publication date
US20080099685A1 (en) 2008-05-01
US7381958B2 (en) 2008-06-03
AU2003291467A1 (en) 2004-06-03
WO2004044613A2 (fr) 2004-05-27

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