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WO2004040299A3 - Method for identifying compounds which inhibit mechanotransduction in neurons - Google Patents

Method for identifying compounds which inhibit mechanotransduction in neurons Download PDF

Info

Publication number
WO2004040299A3
WO2004040299A3 PCT/EP2003/012084 EP0312084W WO2004040299A3 WO 2004040299 A3 WO2004040299 A3 WO 2004040299A3 EP 0312084 W EP0312084 W EP 0312084W WO 2004040299 A3 WO2004040299 A3 WO 2004040299A3
Authority
WO
WIPO (PCT)
Prior art keywords
mechanotransduction
neurons
compounds
inhibit
identifying compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2003/012084
Other languages
French (fr)
Other versions
WO2004040299A2 (en
Inventor
Gary Lewin
Paul Heppenstall
Andreas Eilers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Max Delbrueck Centrum fuer Molekulare in der Helmholtz Gemeinschaft
Original Assignee
Max Delbrueck Centrum fuer Molekulare in der Helmholtz Gemeinschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Delbrueck Centrum fuer Molekulare in der Helmholtz Gemeinschaft filed Critical Max Delbrueck Centrum fuer Molekulare in der Helmholtz Gemeinschaft
Priority to EP03775263A priority Critical patent/EP1556693A2/en
Priority to AU2003283326A priority patent/AU2003283326A1/en
Publication of WO2004040299A2 publication Critical patent/WO2004040299A2/en
Publication of WO2004040299A3 publication Critical patent/WO2004040299A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5058—Neurological cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Described is a method for identifying compounds which are capable of inhibiting mechanotransduction in neurons, compounds identified by such a method, pharmaceutical compounds containing the identified compounds and methods for treating pain. Also described is the use of stomatin domain-containing proteins for the identification of compounds which are capable of inhibiting mechanotransduction.
PCT/EP2003/012084 2002-10-30 2003-10-30 Method for identifying compounds which inhibit mechanotransduction in neurons Ceased WO2004040299A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP03775263A EP1556693A2 (en) 2002-10-30 2003-10-30 Method for identifying compounds which inhibit mechanotransduction in neurons
AU2003283326A AU2003283326A1 (en) 2002-10-30 2003-10-30 Method for identifying compounds which inhibit mechanotransduction in neurons

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US42209802P 2002-10-30 2002-10-30
EP02024474.5 2002-10-30
US60/422,098 2002-10-30
EP02024474 2002-10-30

Publications (2)

Publication Number Publication Date
WO2004040299A2 WO2004040299A2 (en) 2004-05-13
WO2004040299A3 true WO2004040299A3 (en) 2004-07-15

Family

ID=56290498

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/012084 Ceased WO2004040299A2 (en) 2002-10-30 2003-10-30 Method for identifying compounds which inhibit mechanotransduction in neurons

Country Status (3)

Country Link
EP (1) EP1556693A2 (en)
AU (1) AU2003283326A1 (en)
WO (1) WO2004040299A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000026362A2 (en) * 1998-10-30 2000-05-11 Max-Delbrück-Centrum für Molekulare Medizin Proteins of the stomatin family and their use as target proteins for pain therapy
WO2003060093A2 (en) * 2002-01-10 2003-07-24 The Trustees Of Columbia University In The City Of New York METHODS AND COMPOSITIONS FOR PROPAGATING VECTORS CONTAINING TOXIC cDNAs AND ION CHANNEL ASSAY SYSTEMS

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000026362A2 (en) * 1998-10-30 2000-05-11 Max-Delbrück-Centrum für Molekulare Medizin Proteins of the stomatin family and their use as target proteins for pain therapy
WO2003060093A2 (en) * 2002-01-10 2003-07-24 The Trustees Of Columbia University In The City Of New York METHODS AND COMPOSITIONS FOR PROPAGATING VECTORS CONTAINING TOXIC cDNAs AND ION CHANNEL ASSAY SYSTEMS

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 2002, EILERS A ET AL: "MOLECULAR INTERACTIONS BETWEEN STOMATIN AND ASIC/DEG FAMILY PROTEINS.", XP002275060, Database accession no. PREV200300304347 *
GILLESPIE PETER G ET AL: "Molecular basis of mechanosensory transduction", NATURE (LONDON), vol. 413, no. 6852, 13 September 2001 (2001-09-13), pages 194 - 202, XP002275061, ISSN: 0028-0836 *
GOODMAN M B ET AL: "MEC-2 regulates C. elegans DEG/ENaC channels needed for mechanosensation", NATURE 28 FEB 2002 UNITED KINGDOM, vol. 415, no. 6875, 28 February 2002 (2002-02-28), pages 1039 - 1042, XP002275059, ISSN: 0028-0836 *
PRICE MARGARET P ET AL: "The DRASIC cation channel contributes to the detection of cutaneous touch and acid stimuli in mice", NEURON, vol. 32, no. 6, 20 December 2001 (2001-12-20), pages 1071 - 1083, XP002275062, ISSN: 0896-6273 *
SOCIETY FOR NEUROSCIENCE ABSTRACT VIEWER AND ITINERARY PLANNER, vol. 2002, 2002, 32nd Annual Meeting of the Society for Neuroscience;Orlando, Florida, USA; November 02-07, 2002, pages Abstract No. 449.7 *

Also Published As

Publication number Publication date
WO2004040299A2 (en) 2004-05-13
AU2003283326A1 (en) 2004-05-25
AU2003283326A8 (en) 2004-05-25
EP1556693A2 (en) 2005-07-27

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