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WO2003106624A3 - Cancer-linked gene as target for chemotherapy - Google Patents

Cancer-linked gene as target for chemotherapy Download PDF

Info

Publication number
WO2003106624A3
WO2003106624A3 PCT/US2003/018431 US0318431W WO03106624A3 WO 2003106624 A3 WO2003106624 A3 WO 2003106624A3 US 0318431 W US0318431 W US 0318431W WO 03106624 A3 WO03106624 A3 WO 03106624A3
Authority
WO
WIPO (PCT)
Prior art keywords
cancer
target
methods
chemotherapy
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/018431
Other languages
French (fr)
Other versions
WO2003106624A2 (en
Inventor
Krista Evans
Reinhard Ebner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Clinical Data Inc
Original Assignee
Avalon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avalon Pharmaceuticals Inc filed Critical Avalon Pharmaceuticals Inc
Priority to AU2003245448A priority Critical patent/AU2003245448A1/en
Publication of WO2003106624A2 publication Critical patent/WO2003106624A2/en
Publication of WO2003106624A3 publication Critical patent/WO2003106624A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention porte sur des séquences de gènes liées au cancer et sur des séquences dérivées d'amino-acides, ainsi que sur des procédés de test d'agents antitumoraux puissants sur la base de la modulation d'expression des gènes liés au cancer. L'invention porte également sur des anticorps qui réagissent aux polypeptides décrits, et sur des procédés d'utilisation de ces anticorps en vue de traiter des maladies cancéreuses, l'anticorps étant utilisé, par exemple, pour cibler des cellules cancéreuses in vivo afin d'y administrer des agents thérapeutiques. L'invention porte encore sur des méthodes de diagnostic utilisant les séquences de gènes.The invention provides cancer-related gene sequences and amino acid-derived sequences, as well as methods for testing potent anti-tumor agents based on modulation of expression of cancer-related genes. The invention also relates to antibodies which react to the polypeptides described, and to methods of using these antibodies to treat cancer diseases, the antibody being used, for example, to target cancer cells in vivo in order to '' administer therapeutic agents. The invention further relates to diagnostic methods using the gene sequences.

PCT/US2003/018431 2002-06-13 2003-06-11 Cancer-linked gene as target for chemotherapy Ceased WO2003106624A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003245448A AU2003245448A1 (en) 2002-06-13 2003-06-11 Cancer-linked gene as target for chemotherapy

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US38867202P 2002-06-13 2002-06-13
US60/388,672 2002-06-13
US39796602P 2002-07-23 2002-07-23
US60/397,966 2002-07-23

Publications (2)

Publication Number Publication Date
WO2003106624A2 WO2003106624A2 (en) 2003-12-24
WO2003106624A3 true WO2003106624A3 (en) 2004-12-09

Family

ID=29740051

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/018431 Ceased WO2003106624A2 (en) 2002-06-13 2003-06-11 Cancer-linked gene as target for chemotherapy

Country Status (2)

Country Link
AU (1) AU2003245448A1 (en)
WO (1) WO2003106624A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5876996A (en) * 1997-07-25 1999-03-02 Incyte Pharmaceuticals, Inc. Human S-adenosyl-L-methionine methyltransferase

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5876996A (en) * 1997-07-25 1999-03-02 Incyte Pharmaceuticals, Inc. Human S-adenosyl-L-methionine methyltransferase

Also Published As

Publication number Publication date
AU2003245448A1 (en) 2003-12-31
AU2003245448A8 (en) 2003-12-31
WO2003106624A2 (en) 2003-12-24

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