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WO2003104489A3 - VARIANT OF MCHR1 ASSOCIATED WITH HUMAN OBESITY - Google Patents

VARIANT OF MCHR1 ASSOCIATED WITH HUMAN OBESITY Download PDF

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Publication number
WO2003104489A3
WO2003104489A3 PCT/EP2003/005917 EP0305917W WO03104489A3 WO 2003104489 A3 WO2003104489 A3 WO 2003104489A3 EP 0305917 W EP0305917 W EP 0305917W WO 03104489 A3 WO03104489 A3 WO 03104489A3
Authority
WO
WIPO (PCT)
Prior art keywords
variant
mchr1
human obesity
relates
obesity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2003/005917
Other languages
French (fr)
Other versions
WO2003104489A2 (en
Inventor
Matthias Platzer
Cornelia Platzer
Thomas Gudermann
Johannes Hebebrand
Anke Hinney
Kathrin Reichwald
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Philipps Universitaet Marburg
Original Assignee
Philipps Universitaet Marburg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Philipps Universitaet Marburg filed Critical Philipps Universitaet Marburg
Priority to AU2003236700A priority Critical patent/AU2003236700A1/en
Publication of WO2003104489A2 publication Critical patent/WO2003104489A2/en
Publication of WO2003104489A3 publication Critical patent/WO2003104489A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention concerne un nouveau marqueur associé à l'obésité humaine, une variante du récepteur MCHR1 (Melanin-Concentrating Hormone Receptor), ainsi que des polynucléotides codant ce nucléotide. L'invention concerne également des utilisations en diagnostic et en thérapie reposant sur le fait que cette variante du MCHR1 est associée à l'obésité humaine.The present invention relates to a new marker associated with human obesity, a variant of the MCHR1 receptor (Melanin-Concentrating Hormone Receptor), as well as polynucleotides encoding this nucleotide. The invention also relates to uses in diagnosis and therapy based on the fact that this variant of MCHR1 is associated with human obesity.

PCT/EP2003/005917 2002-06-05 2003-06-05 Mchr1 variant associated with human obesity Ceased WO2003104489A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003236700A AU2003236700A1 (en) 2002-06-05 2003-06-05 Mchr1 variant associated with human obesity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02012569 2002-06-05
EP02012569.6 2002-06-05

Publications (2)

Publication Number Publication Date
WO2003104489A2 WO2003104489A2 (en) 2003-12-18
WO2003104489A3 true WO2003104489A3 (en) 2004-03-11

Family

ID=29724376

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/005917 Ceased WO2003104489A2 (en) 2002-06-05 2003-06-05 Mchr1 variant associated with human obesity

Country Status (2)

Country Link
AU (1) AU2003236700A1 (en)
WO (1) WO2003104489A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006246116A1 (en) * 2005-05-11 2006-11-16 Aarhus Universitet Method for diagnosis and treatment of a mental disease

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000075166A1 (en) * 1999-06-08 2000-12-14 The Regents Of The University Of California Melanin concentrating hormone receptor
EP1288310A1 (en) * 2001-08-31 2003-03-05 Aventis Pharma Deutschland GmbH Use of SNPs of MCH-R for identifying genetic disorders in maintaining the normal body weight

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000075166A1 (en) * 1999-06-08 2000-12-14 The Regents Of The University Of California Melanin concentrating hormone receptor
EP1288310A1 (en) * 2001-08-31 2003-03-05 Aventis Pharma Deutschland GmbH Use of SNPs of MCH-R for identifying genetic disorders in maintaining the normal body weight

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BOUTIN JEAN A ET AL: "Melanin-concentrating hormone and its receptors: State of the art", CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, vol. 80, no. 5, May 2002 (2002-05-01), pages 388 - 395, XP001155641, ISSN: 0008-4212 *
DATABASE OMIM [online] XP002257865, accession no. OMIM Database accession no. OMIM 601751 *
DATABASE SNP [online] 6 December 2000 (2000-12-06), XP002257864, accession no. SNP Database accession no. rs133072 *

Also Published As

Publication number Publication date
AU2003236700A1 (en) 2003-12-22
WO2003104489A2 (en) 2003-12-18

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