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WO2003102545A3 - Procedes de fragmentation pour spectrometrie de masse - Google Patents

Procedes de fragmentation pour spectrometrie de masse Download PDF

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Publication number
WO2003102545A3
WO2003102545A3 PCT/US2003/017436 US0317436W WO03102545A3 WO 2003102545 A3 WO2003102545 A3 WO 2003102545A3 US 0317436 W US0317436 W US 0317436W WO 03102545 A3 WO03102545 A3 WO 03102545A3
Authority
WO
WIPO (PCT)
Prior art keywords
mass spectrometry
fragmentation methods
low energy
multipole
ions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/017436
Other languages
English (en)
Other versions
WO2003102545A2 (fr
Inventor
Craig M Whitehouse
David G Welkie
Javahery Gholamreza
Lisa Cousins
Sergey Rakov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Revvity Health Sciences Inc
Original Assignee
Analytica of Branford Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Analytica of Branford Inc filed Critical Analytica of Branford Inc
Priority to CA002487135A priority Critical patent/CA2487135C/fr
Priority to EP03756376A priority patent/EP1549923B1/fr
Priority to AU2003247472A priority patent/AU2003247472A1/en
Publication of WO2003102545A2 publication Critical patent/WO2003102545A2/fr
Publication of WO2003102545A3 publication Critical patent/WO2003102545A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/062—Ion guides
    • H01J49/063—Multipole ion guides, e.g. quadrupoles, hexapoles
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H01J49/0054—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction by an electron beam, e.g. electron impact dissociation, electron capture dissociation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

L'invention concerne un appareil et des procédés qui permettent l'interaction d'électrons à faible énergie et de positrons ayant des ions d'échantillonnage qui facilitent la dissociation à capture d'électrons (ECD) et la dissociation à capture de positrons (PCD), respectivement, dans les structures de guidage d'ions multipôle. Il a été découvert récemment que la fragmentation d'ions protonés de plusieurs biomolécules par dissociation à capture d'électrons se produit le long de chemins de fragmentation auxquels d'autres procédés de dissociation n'ont pas accès. Ces chemins mènent à des informations de structure moléculaire qui ne sont pas si faciles à obtenir autrement. Cependant, de telles analyses ont été limitées aux spectromètres de masse à résonance cyclotronique ionique à haut champ et transformée de Fourrier (FTICR) onéreux. La mise en oeuvre de la dissociation de capture d'électrons (ECD) dans des structures de guidage d'ions multipôles utilisées couramment est problématique dû aux effets perturbateurs de champs RF dans ces dispositifs. L'appareil et les procédés décrits surmontent ces difficultés, et permettent d'exécuter la dissociation à capture d'électrons (et dissociation à capture de positrons) dans les guides d'ions multipôles, soit tout seuls, soit combinés aux procédés de fragmentation d'ions conventionnels. L'invention concerne donc l'exécution analytique améliorée et la fonctionnalité de spectromètres de masse qui utilisent des guides d'ions multipôles.
PCT/US2003/017436 2002-05-31 2003-05-30 Procedes de fragmentation pour spectrometrie de masse Ceased WO2003102545A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002487135A CA2487135C (fr) 2002-05-31 2003-05-30 Procedes de fragmentation pour spectrometrie de masse
EP03756376A EP1549923B1 (fr) 2002-05-31 2003-05-30 Procedes de fragmentation pour spectrometrie de masse
AU2003247472A AU2003247472A1 (en) 2002-05-31 2003-05-30 Fragmentation methods for mass spectrometry

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38511302P 2002-05-31 2002-05-31
US60/385,113 2002-05-31

Publications (2)

Publication Number Publication Date
WO2003102545A2 WO2003102545A2 (fr) 2003-12-11
WO2003102545A3 true WO2003102545A3 (fr) 2004-05-06

Family

ID=29712135

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/017436 Ceased WO2003102545A2 (fr) 2002-05-31 2003-05-30 Procedes de fragmentation pour spectrometrie de masse

Country Status (4)

Country Link
EP (1) EP1549923B1 (fr)
AU (1) AU2003247472A1 (fr)
CA (2) CA2643534C (fr)
WO (1) WO2003102545A2 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7196326B2 (en) 2004-06-11 2007-03-27 Bruker Daltonik Gmbh Mass spectrometer and reaction cell for ion-ion reactions
US7381946B2 (en) 2004-02-17 2008-06-03 Hitachi High-Technologies Corporation Mass spectrometer
US9196466B2 (en) 2002-07-24 2015-11-24 Micromass Uk Limited Mass spectrometer with bypass of a fragmentation device

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020115056A1 (en) 2000-12-26 2002-08-22 Goodlett David R. Rapid and quantitative proteome analysis and related methods
DE10325579B4 (de) 2003-06-05 2007-10-11 Bruker Daltonik Gmbh Ionenfragmentierung durch Elektroneneinfang in linearen Ionenfallen
DE10325582B4 (de) * 2003-06-05 2009-01-15 Bruker Daltonik Gmbh Ionenfragmentierung durch Elektroneneinfang in Hochfrequenz-Ionenfallen mit magnetischer Führung der Elektronen
US6800851B1 (en) * 2003-08-20 2004-10-05 Bruker Daltonik Gmbh Electron-ion fragmentation reactions in multipolar radiofrequency fields
US7026613B2 (en) 2004-01-23 2006-04-11 Thermo Finnigan Llc Confining positive and negative ions with fast oscillating electric potentials
GB0404106D0 (en) 2004-02-24 2004-03-31 Shimadzu Res Lab Europe Ltd An ion trap and a method for dissociating ions in an ion trap
EP2239574A1 (fr) 2004-03-12 2010-10-13 University Of Virginia Patent Foundation Dissociation de transfert d'électrons pour analyse de séquence biopolymère
GB2414855A (en) 2004-03-30 2005-12-07 Thermo Finnigan Llc Ion fragmentation by electron capture
GB2415541B (en) 2004-06-21 2009-09-23 Thermo Finnigan Llc RF power supply for a mass spectrometer
GB0523811D0 (en) * 2005-11-23 2006-01-04 Micromass Ltd Mass stectrometer
GB0523806D0 (en) * 2005-11-23 2006-01-04 Micromass Ltd Mass spectrometer
GB2432712B (en) 2005-11-23 2007-12-27 Micromass Ltd Mass spectrometer
GB0609253D0 (en) 2006-05-10 2006-06-21 Micromass Ltd Mass spectrometer
WO2023150866A1 (fr) * 2022-02-08 2023-08-17 Kimia Analytics Inc. Cellule de collision à cible solide pour spectrométrie de masse

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4933551A (en) * 1989-06-05 1990-06-12 The United State Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Reversal electron attachment ionizer for detection of trace species

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4731533A (en) * 1986-10-15 1988-03-15 Vestec Corporation Method and apparatus for dissociating ions by electron impact
CA1307859C (fr) 1988-12-12 1992-09-22 Donald James Douglas Spectrometre de masse a transmission amelioree d'ions
US4988869A (en) * 1989-08-21 1991-01-29 The Regents Of The University Of California Method and apparatus for electron-induced dissociation of molecular species
DE10058706C1 (de) * 2000-11-25 2002-02-28 Bruker Daltonik Gmbh Ionenfragmentierung durch Elektroneneinfang in Hochfrequenz-Ionenfallen
DE60210056T2 (de) * 2001-03-22 2006-11-16 Syddansk Universitet Massenspektrometrisches Verfahren mit Elektroneneinfang durch Ionen und Massenspektrometer zum Durchführen des Verfahrens

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4933551A (en) * 1989-06-05 1990-06-12 The United State Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Reversal electron attachment ionizer for detection of trace species

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1549923A4 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9196466B2 (en) 2002-07-24 2015-11-24 Micromass Uk Limited Mass spectrometer with bypass of a fragmentation device
US7381946B2 (en) 2004-02-17 2008-06-03 Hitachi High-Technologies Corporation Mass spectrometer
US7608819B2 (en) 2004-02-17 2009-10-27 Hitachi High-Technologies Corporation Mass spectrometer
US7196326B2 (en) 2004-06-11 2007-03-27 Bruker Daltonik Gmbh Mass spectrometer and reaction cell for ion-ion reactions

Also Published As

Publication number Publication date
CA2487135A1 (fr) 2003-12-11
AU2003247472A1 (en) 2003-12-19
EP1549923A2 (fr) 2005-07-06
CA2487135C (fr) 2009-01-27
AU2003247472A8 (en) 2003-12-19
WO2003102545A2 (fr) 2003-12-11
EP1549923B1 (fr) 2012-10-17
CA2643534A1 (fr) 2003-12-11
EP1549923A4 (fr) 2009-03-25
CA2643534C (fr) 2011-08-02

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