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WO2003102164A3 - Cancer-linked gene as target for chemotherapy - Google Patents

Cancer-linked gene as target for chemotherapy

Info

Publication number
WO2003102164A3
WO2003102164A3 PCT/US2003/017920 US0317920W WO03102164A3 WO 2003102164 A3 WO2003102164 A3 WO 2003102164A3 US 0317920 W US0317920 W US 0317920W WO 03102164 A3 WO03102164 A3 WO 03102164A3
Authority
WO
WIPO (PCT)
Prior art keywords
cancer
target
disclosed
chemotherapy
linked gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/017920
Other languages
French (fr)
Other versions
WO2003102164A2 (en
Inventor
Martin Shea
Reinhard Ebner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Clinical Data Inc
Original Assignee
Avalon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avalon Pharmaceuticals Inc filed Critical Avalon Pharmaceuticals Inc
Priority to AU2003240572A priority Critical patent/AU2003240572A1/en
Publication of WO2003102164A2 publication Critical patent/WO2003102164A2/en
Anticipated expiration legal-status Critical
Publication of WO2003102164A3 publication Critical patent/WO2003102164A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Cancer-linked gene sequences, and derived amino acid sequences, are disclosed along with processes for assaying potential antitumor agents based on their modulation of the expression of these cancer-linked genes. Also disclosed are antibodies that react with the disclosed polypeptides and methods of using the antibodies to treat cancerous conditions, such as by using the antibody to target cancerous cells in vivo for purposes of delivering therapeutic agents thereto. Also described are methods of diagnosing using the gene sequences.
PCT/US2003/017920 2002-05-30 2003-05-29 Cancer-linked gene as target for chemotherapy Ceased WO2003102164A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003240572A AU2003240572A1 (en) 2002-05-30 2003-05-29 Cancer-linked gene as target for chemotherapy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38436702P 2002-05-30 2002-05-30
US60/384,367 2002-05-30

Publications (2)

Publication Number Publication Date
WO2003102164A2 WO2003102164A2 (en) 2003-12-11
WO2003102164A3 true WO2003102164A3 (en) 2005-04-21

Family

ID=29712020

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/017920 Ceased WO2003102164A2 (en) 2002-05-30 2003-05-29 Cancer-linked gene as target for chemotherapy

Country Status (2)

Country Link
AU (1) AU2003240572A1 (en)
WO (1) WO2003102164A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000058473A2 (en) * 1999-03-31 2000-10-05 Curagen Corporation Nucleic acids including open reading frames encoding polypeptides; 'orfx'

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000058473A2 (en) * 1999-03-31 2000-10-05 Curagen Corporation Nucleic acids including open reading frames encoding polypeptides; 'orfx'

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE GENBANK [online] 29 January 2002 (2002-01-29), KIKUNO R. ET AL: "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro", XP002903261, Database accession no. (AB028982) *
DATABASE GENBANK [online] 8 February 2001 (2001-02-08), SHIMKETS RA ET AL: "Novel nucleic acids and peptides derived from open reading frame X, useful for treating e.g. cancers, proliferative disorders, neurodegenerative disorders and cardiovascular disease", XP002903260, Database accession no. (AAC76569) *
DNA RES., vol. 6, no. 3, 1999, pages 197 - 205 *
HAMPE ET AL: "The genes for the human VPS10 domain-containing receptors are large and contain many small exons", HUMAN GENETICS, vol. 108, no. 6, 2001, pages 529 - 536, XP002294173 *
KIKUNO R. ET AL: "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro", DNA RESEARCH, vol. 6, no. 3, 1999, pages 197 - 205, XP002952960 *

Also Published As

Publication number Publication date
AU2003240572A1 (en) 2003-12-19
AU2003240572A8 (en) 2003-12-19
WO2003102164A2 (en) 2003-12-11

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