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WO2003101377A3 - Association of snps in the dgcr2 locus and neighboring loci with schizophrenia - Google Patents

Association of snps in the dgcr2 locus and neighboring loci with schizophrenia Download PDF

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Publication number
WO2003101377A3
WO2003101377A3 PCT/IL2003/000464 IL0300464W WO03101377A3 WO 2003101377 A3 WO2003101377 A3 WO 2003101377A3 IL 0300464 W IL0300464 W IL 0300464W WO 03101377 A3 WO03101377 A3 WO 03101377A3
Authority
WO
WIPO (PCT)
Prior art keywords
schizophrenia
dgcr2
locus
snps
association
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IL2003/000464
Other languages
French (fr)
Other versions
WO2003101377A2 (en
Inventor
Ariel Darvasi
Naomi Zak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IDGENE PHARMACEUTICALS Ltd
Original Assignee
IDGENE PHARMACEUTICALS Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IDGENE PHARMACEUTICALS Ltd filed Critical IDGENE PHARMACEUTICALS Ltd
Priority to AU2003231897A priority Critical patent/AU2003231897A1/en
Publication of WO2003101377A2 publication Critical patent/WO2003101377A2/en
Anticipated expiration legal-status Critical
Publication of WO2003101377A3 publication Critical patent/WO2003101377A3/en
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Methods and kits used for determining predisposition and/or diagnosis of schizophrenia, using genotypes in the DGCR2 locus are disclosed. Also disclosed are methods and drugs for treating schizophrenia. Further disclosed are methods and kits useful for prediction of drug responsiveness towards mental disorders drugs, and more specifically towards schizophrenia drugs.
PCT/IL2003/000464 2002-06-03 2003-06-03 Association of snps in the dgcr2 locus and neighboring loci with schizophrenia Ceased WO2003101377A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003231897A AU2003231897A1 (en) 2002-06-03 2003-06-03 Association of snps in the dgcr2 locus and neighboring loci with schizophrenia

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38441302P 2002-06-03 2002-06-03
US60/384,413 2002-06-03

Publications (2)

Publication Number Publication Date
WO2003101377A2 WO2003101377A2 (en) 2003-12-11
WO2003101377A3 true WO2003101377A3 (en) 2005-01-27

Family

ID=29712028

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2003/000464 Ceased WO2003101377A2 (en) 2002-06-03 2003-06-03 Association of snps in the dgcr2 locus and neighboring loci with schizophrenia

Country Status (2)

Country Link
AU (1) AU2003231897A1 (en)
WO (1) WO2003101377A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1756314A1 (en) * 2004-06-04 2007-02-28 Novartis AG Biomarkers for the prediction of responsiveness to clozapine treatment
EP2514840B1 (en) * 2008-01-02 2014-10-22 Suregene Llc Genetic markers of mental illness, in particular in the ASTN2 gene
EP2581459A3 (en) * 2008-01-17 2013-07-17 Suregene LLC Genetic markers of mental illness
US7932042B1 (en) 2010-10-13 2011-04-26 Suregene, Llc Methods and compositions for the treatment of psychotic disorders through the identification of the olanzapine poor response predictor genetic signature

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE SNP [online] 9 June 2004 (2004-06-09), accession no. NCBI Database accession no. rs807759 *

Also Published As

Publication number Publication date
AU2003231897A8 (en) 2003-12-19
WO2003101377A2 (en) 2003-12-11
AU2003231897A1 (en) 2003-12-19

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