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WO2003038107A3 - Process for the production of ascopyrone p - Google Patents

Process for the production of ascopyrone p Download PDF

Info

Publication number
WO2003038107A3
WO2003038107A3 PCT/GB2002/004895 GB0204895W WO03038107A3 WO 2003038107 A3 WO2003038107 A3 WO 2003038107A3 GB 0204895 W GB0204895 W GB 0204895W WO 03038107 A3 WO03038107 A3 WO 03038107A3
Authority
WO
WIPO (PCT)
Prior art keywords
ascopyrone
anhydro
fructose
production
dehydratase
Prior art date
Application number
PCT/GB2002/004895
Other languages
French (fr)
Other versions
WO2003038107A2 (en
Inventor
Andrew John Morgan
Shukun Yu
Original Assignee
Danisco
Andrew John Morgan
Shukun Yu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0126162A external-priority patent/GB0126162D0/en
Application filed by Danisco, Andrew John Morgan, Shukun Yu filed Critical Danisco
Priority to AU2002335992A priority Critical patent/AU2002335992A1/en
Publication of WO2003038107A2 publication Critical patent/WO2003038107A2/en
Publication of WO2003038107A3 publication Critical patent/WO2003038107A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

The present invention relates to a process for preparing ascopyrone P, or a derivative thereof, said process comprising the steps of: (I) converting a starch-type substrate to 1.5-anhydro-D-fructose with α-1,4-glucan lyase at a pH of from about 3.8 to 7.0; (II) treating said 1,5-anhydro-D-fructose with 1,5-anhydro-D-fructose dehydratase and/or pyranosone dehydratase and optionally ascopyrone P synthase at a pH of from about 5.0 to about 7.5.
PCT/GB2002/004895 2001-10-31 2002-10-30 Process for the production of ascopyrone p WO2003038107A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002335992A AU2002335992A1 (en) 2001-10-31 2002-10-30 Process for the production of ascopyrone p

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0126162A GB0126162D0 (en) 2001-10-31 2001-10-31 Process
GB0126162.7 2001-10-31
US34331601P 2001-12-21 2001-12-21
US60/343,316 2001-12-21

Publications (2)

Publication Number Publication Date
WO2003038107A2 WO2003038107A2 (en) 2003-05-08
WO2003038107A3 true WO2003038107A3 (en) 2004-10-28

Family

ID=26246721

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2002/004895 WO2003038107A2 (en) 2001-10-31 2002-10-30 Process for the production of ascopyrone p

Country Status (2)

Country Link
AU (1) AU2002335992A1 (en)
WO (1) WO2003038107A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002337341B8 (en) * 2001-10-31 2009-06-18 Dupont Nutrition Biosciences Aps Pyranosone dehydratase from Phanerochaete chrysosporium
AU2003274375A1 (en) * 2002-10-30 2004-05-25 Danisco A/S Polynucleotide encoding a pyranosone dehydratase
EP1686122B1 (en) 2003-10-28 2012-11-21 Nihon Starch Co., Ltd. Antitumor agent
JP4813903B2 (en) * 2003-11-20 2011-11-09 日本澱粉工業株式会社 Efficient production method of Ascopirone P
JP6336128B2 (en) * 2014-12-26 2018-06-06 株式会社サナス New antioxidant

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003037918A2 (en) * 2001-10-31 2003-05-08 Danisco A/S Pyranosone dehydratase from phanerochaete chrysosporium
WO2003038085A1 (en) * 2001-10-31 2003-05-08 Danisco A/S 1,5-anhydro-d-fructose dehydratase
WO2003038084A1 (en) * 2001-10-31 2003-05-08 Danisco A/S Ascopyrone p synthase

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003037918A2 (en) * 2001-10-31 2003-05-08 Danisco A/S Pyranosone dehydratase from phanerochaete chrysosporium
WO2003038085A1 (en) * 2001-10-31 2003-05-08 Danisco A/S 1,5-anhydro-d-fructose dehydratase
WO2003038084A1 (en) * 2001-10-31 2003-05-08 Danisco A/S Ascopyrone p synthase

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BAUTE M-A ET AL: "ENZYMIC ACTIVITY DEGRADING 1,4-ALPHA-D-GLUCANS TO ASCOPYRONES P AND T IN PEZIZALES AND TUBERALES", PHYTOCHEMISTRY, PERGAMON PRESS, GB, vol. 33, no. 1, 1993, pages 41 - 45, XP000925242, ISSN: 0031-9422 *
BAUTE M-A ET AL: "FUNGAL ENZYMIC ACTIVITY DEGRADING 1,4-ALPHA-D-GLUCANS TO ECHINOSPORIN (5-EPIPENTENOMYCIN I)", PHYTOCHEMISTRY, PERGAMON PRESS, GB, vol. 30, no. 5, 1991, pages 1419 - 1423, XP001147295, ISSN: 0031-9422 *
BAUTE R ET AL: "PROPOSED PATHWAY TO THE PYRONES CORTALCERONE AND MICROTHECIN IN FUNGI", PHYTOCHEMISTRY, PERGAMON PRESS, GB, vol. 26, no. 5, 1987, pages 1395 - 1397, XP009005230, ISSN: 0031-9422 *
GABRIEL J ET AL: "A convenient laboratory procedure for the preparation of cortalcerone, a fungal antibiotic beta-pyrone.", CARBOHYDRATE RESEARCH. NETHERLANDS 15 JAN 1994, vol. 252, 15 January 1994 (1994-01-15), pages 297 - 301, XP002247704, ISSN: 0008-6215 *
VOLC J ET AL: "PYRANOSE OXIDASE AND PYRANOSONE DEHYDRATASE: ENZYMES RESPONSIBLE FOR CONVERSION OF D-GLUCOSE TO CORTALCERONE BY THE BASIDIOMYCETE PHANEROCHAETE CHRYSOSPORIUM", ARCHIVES OF MICROBIOLOGY, BERLIN, DE, vol. 156, no. 4, 1991, pages 297 - 301, XP009010419, ISSN: 0302-8933 *
YU S ET AL: "alpha-1,4-Glucan lyases producing 1,5-anhydro-d-fructose from starch and glycogen have sequence similarity to alpha-glucosidases", BIOCHIMICA ET BIOPHYSICA ACTA. PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, ELSEVIER, AMSTERDAM,, NL, vol. 1433, no. 1-2, 17 August 1999 (1999-08-17), pages 1 - 15, XP004278723, ISSN: 0167-4838 *

Also Published As

Publication number Publication date
WO2003038107A2 (en) 2003-05-08
AU2002335992A1 (en) 2003-05-12

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