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WO2003037903A8 - Dihydrate-ii d'olanzapine: son procede de preparation et son utilisation - Google Patents

Dihydrate-ii d'olanzapine: son procede de preparation et son utilisation

Info

Publication number
WO2003037903A8
WO2003037903A8 PCT/US2002/034701 US0234701W WO03037903A8 WO 2003037903 A8 WO2003037903 A8 WO 2003037903A8 US 0234701 W US0234701 W US 0234701W WO 03037903 A8 WO03037903 A8 WO 03037903A8
Authority
WO
WIPO (PCT)
Prior art keywords
dihydrate
olanzapine
preparation
olanzapine dihydrate
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/034701
Other languages
English (en)
Other versions
WO2003037903A1 (fr
Inventor
Reguri Buchi Reddy
Chakka Ramesh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dr Reddys Laboratories Ltd
Original Assignee
Dr Reddys Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Reddys Laboratories Ltd filed Critical Dr Reddys Laboratories Ltd
Priority to AU2002340328A priority Critical patent/AU2002340328A1/en
Priority to CA002464306A priority patent/CA2464306A1/fr
Priority to EP02778677A priority patent/EP1440074A1/fr
Publication of WO2003037903A1 publication Critical patent/WO2003037903A1/fr
Publication of WO2003037903A8 publication Critical patent/WO2003037903A8/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne une nouvelle forme de dihydrate 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5 benzodiazepine (appelé dihydrate-II d'olanzapine), son procédé de préparation et sa conversion en olanzapine de forme II. L'invention concerne également des compositions contenant le dihydrate-II d'olanzapine, l'utilisation dudit dihydrate-II d'olanzapine et des compositions contenant le dihydrate-II d'olanzapine permettant de traiter des troubles du système nerveux central.
PCT/US2002/034701 2001-10-29 2002-10-29 Dihydrate-ii d'olanzapine: son procede de preparation et son utilisation Ceased WO2003037903A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2002340328A AU2002340328A1 (en) 2001-10-29 2002-10-29 Olanzapine dihydrate-ii a process for its preparation and use thereof
CA002464306A CA2464306A1 (fr) 2001-10-29 2002-10-29 Dihydrate-ii d'olanzapine: son procede de preparation et son utilisation
EP02778677A EP1440074A1 (fr) 2001-10-29 2002-10-29 Dihydrate-ii d'olanzapine: son procede de preparation et son utilisation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN877CH2001 2001-10-29
IN877/MAS/2001 2001-10-29

Publications (2)

Publication Number Publication Date
WO2003037903A1 WO2003037903A1 (fr) 2003-05-08
WO2003037903A8 true WO2003037903A8 (fr) 2004-02-12

Family

ID=11097012

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/034701 Ceased WO2003037903A1 (fr) 2001-10-29 2002-10-29 Dihydrate-ii d'olanzapine: son procede de preparation et son utilisation

Country Status (4)

Country Link
EP (1) EP1440074A1 (fr)
AU (1) AU2002340328A1 (fr)
CA (1) CA2464306A1 (fr)
WO (1) WO2003037903A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1513846T1 (sl) 2002-05-31 2011-11-30 Sandoz Ag Postopek za pripravo olanzapina form I
US7323459B2 (en) 2002-12-24 2008-01-29 Teva Pharmaceutical Industries Ltd. Crystal forms, methods for their preparation and method for preparation of olanzapine
US20080009481A1 (en) * 2004-07-14 2008-01-10 Shasun Chemicals And Drugs Limited Process For Making Form I Of Olanzapine
PT1838716E (pt) 2005-01-05 2011-07-15 Lilly Co Eli Di-hidrato de pamoato de olanzapina
CN103185759A (zh) * 2011-12-27 2013-07-03 天津药物研究院 奥氮平中溶剂残留的检测方法及其应用
CN103848847B (zh) * 2012-12-04 2018-02-06 广东东阳光药业有限公司 一种改进制备奥氮平及其晶型ii的方法
JP6008734B2 (ja) * 2012-12-20 2016-10-19 株式会社トクヤマ オランザピンｉｉ型結晶の製造方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5229382A (en) * 1990-04-25 1993-07-20 Lilly Industries Limited 2-methyl-thieno-benzodiazepine
EG23659A (en) * 1995-03-24 2007-03-26 Lilly Co Eli Process and crystal forms of methyl-thieno-benzodiazepine
ZA978515B (en) * 1996-09-23 1999-03-23 Lilly Co Eli Intermediates and process for preparing olanzapine
WO1998011893A1 (fr) * 1996-09-23 1998-03-26 Eli Lilly And Company Dihydrate d d'olanzapine
BR0114031A (pt) * 2000-08-31 2003-09-09 Reddy S Lab Ltd Processo para a preparação de hidratos de olanzapina e sua conversão em formas cristalinas de olanzapina

Also Published As

Publication number Publication date
WO2003037903A1 (fr) 2003-05-08
CA2464306A1 (fr) 2003-05-08
AU2002340328A1 (en) 2003-05-12
EP1440074A1 (fr) 2004-07-28

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