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WO2003037886A3 - Heteroaromatic carboxamide derivatives for the treatment of inflammation - Google Patents

Heteroaromatic carboxamide derivatives for the treatment of inflammation Download PDF

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Publication number
WO2003037886A3
WO2003037886A3 PCT/US2002/034801 US0234801W WO03037886A3 WO 2003037886 A3 WO2003037886 A3 WO 2003037886A3 US 0234801 W US0234801 W US 0234801W WO 03037886 A3 WO03037886 A3 WO 03037886A3
Authority
WO
WIPO (PCT)
Prior art keywords
inflammation
carboxamide derivatives
treatment
heteroaromatic carboxamide
heteroaromatic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/034801
Other languages
French (fr)
Other versions
WO2003037886A2 (en
Inventor
Matthew Graneto
Cathleen E Hanau
Thao D Perry
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia LLC
Original Assignee
Pharmacia LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia LLC filed Critical Pharmacia LLC
Priority to MXPA04004064A priority Critical patent/MXPA04004064A/en
Priority to AU2002356871A priority patent/AU2002356871A1/en
Priority to JP2003540167A priority patent/JP2005509645A/en
Priority to CA002464924A priority patent/CA2464924A1/en
Priority to BR0213734-8A priority patent/BR0213734A/en
Priority to EP02802495A priority patent/EP1444010A2/en
Publication of WO2003037886A2 publication Critical patent/WO2003037886A2/en
Publication of WO2003037886A3 publication Critical patent/WO2003037886A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

The present invention relates to heteroaromatic carboxamide derivatives, compositions comprising such, intermediates, methods of making heteroaromatic carboxamide derivatives, and methods for treating cancer, inflammation, and inflammation-associated disorders, such as arthritis.
PCT/US2002/034801 2001-10-30 2002-10-30 Heteroaromatic carboxamide derivatives for the treatment of inflammation Ceased WO2003037886A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
MXPA04004064A MXPA04004064A (en) 2001-10-30 2002-10-30 Heteroaromatic carboxamide derivatives for the treatment of inflammation.
AU2002356871A AU2002356871A1 (en) 2001-10-30 2002-10-30 Heteroaromatic carboxamide derivatives for the treatment of inflammation
JP2003540167A JP2005509645A (en) 2001-10-30 2002-10-30 Heteroaromatic carboxamide derivatives for the treatment of inflammation
CA002464924A CA2464924A1 (en) 2001-10-30 2002-10-30 Heteroaromatic carboxamide derivatives for the treatment of inflammation
BR0213734-8A BR0213734A (en) 2001-10-30 2002-10-30 Heteroaromatic carboxamide derivatives for the treatment of inflammation
EP02802495A EP1444010A2 (en) 2001-10-30 2002-10-30 Heteroaromatic carboxamide derivatives for the treatment of inflammation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34081601P 2001-10-30 2001-10-30
US60/340,816 2001-10-30

Publications (2)

Publication Number Publication Date
WO2003037886A2 WO2003037886A2 (en) 2003-05-08
WO2003037886A3 true WO2003037886A3 (en) 2003-12-24

Family

ID=23335051

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/034801 Ceased WO2003037886A2 (en) 2001-10-30 2002-10-30 Heteroaromatic carboxamide derivatives for the treatment of inflammation

Country Status (7)

Country Link
EP (1) EP1444010A2 (en)
JP (1) JP2005509645A (en)
AU (1) AU2002356871A1 (en)
BR (1) BR0213734A (en)
CA (1) CA2464924A1 (en)
MX (1) MXPA04004064A (en)
WO (1) WO2003037886A2 (en)

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BRPI0417369A (en) * 2003-12-05 2007-04-10 Boehringer Ingelheim Pharma Substituted 3-amino-thieno [2,3-b] pyridine-2-carboxylic acid amide compounds as ikk inhibitors
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JP5498703B2 (en) 2006-01-23 2014-05-21 バーテックス ファーマシューティカルズ インコーポレイテッド Thiophene-carboxamides useful as inhibitors of protein kinases
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AR065804A1 (en) 2007-03-23 2009-07-01 Smithkline Beecham Corp COMPOSITE OF INDOL CARBOXAMIDE, PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS IT AND USE OF THIS COMPOUND TO PREPARE A MEDICINAL PRODUCT
US7893059B2 (en) 2007-09-24 2011-02-22 Genentech, Inc. Thiazolopyrimidine PI3K inhibitor compounds and methods of use
EP2222675B1 (en) 2007-12-19 2013-09-11 Genentech, Inc. 5-anilinoimidazopyridines and methods of use
EP2220092B1 (en) 2007-12-21 2012-06-06 Genentech, Inc. Azaindolizines and methods of use
MX368362B (en) 2009-02-05 2019-09-30 Immunogen Inc Novel benzodiazepine derivatives.
WO2010102968A1 (en) 2009-03-10 2010-09-16 Glaxo Group Limited Indole derivatives as ikk2 inhibitors
AU2010224125B2 (en) 2009-03-12 2015-05-14 Genentech, Inc. Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents for the treatment of hematopoietic malignancies
JP2012524066A (en) * 2009-04-16 2012-10-11 テリック，インコーポレイテッド Substituted 4-amino-5-benzoyl-2- (phenylamino) thiophene-3-carbonitrile and substituted 4-amino-5-benzoyl-2- (phenylamino) thiophene-3-carboxamide as tubulin polymerization inhibitors
BR112012006802A2 (en) 2009-09-28 2020-08-18 F.Hoffmann-La Roche Ag compound, pharmaceutical composition, method for treating cancer, uses of a compound, kit and invention
WO2011049625A1 (en) 2009-10-20 2011-04-28 Mansour Samadpour Method for aflatoxin screening of products
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CN102933231B (en) 2010-02-10 2015-07-29 伊缪诺金公司 CD20 antibody and its use
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Also Published As

Publication number Publication date
CA2464924A1 (en) 2003-05-08
EP1444010A2 (en) 2004-08-11
AU2002356871A1 (en) 2003-05-12
WO2003037886A2 (en) 2003-05-08
JP2005509645A (en) 2005-04-14
BR0213734A (en) 2004-10-19
MXPA04004064A (en) 2004-09-06

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