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WO2003035695A3 - Agents that activate or inhibit toll-like receptor 9 - Google Patents

Agents that activate or inhibit toll-like receptor 9 Download PDF

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Publication number
WO2003035695A3
WO2003035695A3 PCT/US2002/023645 US0223645W WO03035695A3 WO 2003035695 A3 WO2003035695 A3 WO 2003035695A3 US 0223645 W US0223645 W US 0223645W WO 03035695 A3 WO03035695 A3 WO 03035695A3
Authority
WO
WIPO (PCT)
Prior art keywords
molecules
tlr9
bind
present
mimic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/023645
Other languages
French (fr)
Other versions
WO2003035695A2 (en
Inventor
Ling-Ling An
Herren Wu
Michael S C Fung
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanox Inc
Original Assignee
Tanox Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanox Inc filed Critical Tanox Inc
Priority to EP02795487A priority Critical patent/EP1412390A2/en
Priority to AU2002360243A priority patent/AU2002360243A1/en
Publication of WO2003035695A2 publication Critical patent/WO2003035695A2/en
Publication of WO2003035695A3 publication Critical patent/WO2003035695A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention includes molecules that bind to a peptidic segment on TLR9 and mimic the effects of the CpG motif. The CpG mimicking agents include, but are not limited to, antibodies, small-molecule compounds, peptides, peptide mimetics, and nucleic acids, including compositions comprising molecules that bind to a peptidic segment on TLR9 and mimic the effects of the CpG motif suitable for administering to a patient in need of treatment, optionally in combination with, for example, an excipient, diluant, or carrier. In addition, the present invention includes those molecules which bind to the TLR9's CXXC motifs at 255Cys-Arg-Arg 258Cys (as CRRC) or at 265Cys-Met-GIu 268Cys (as CMEC). The present invention includes methods for modulating the immune response by inducing a Th1-type response comprising administering molecules that bind to TLR9 and mimic CpG function. These molecules also shift the host cellular response away from a Th2-type response toward the Th1-type response. Thus, administering the molecules of the present invention that bind to TLR9 may avoid the risk of Th2-mediated, immunization-induced anaphylaxis, making this method useful in immunotherapy and asthma treatment. The molecules of the present invention may be administered in combination with a particular allergen.
PCT/US2002/023645 2001-07-26 2002-07-25 Agents that activate or inhibit toll-like receptor 9 Ceased WO2003035695A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP02795487A EP1412390A2 (en) 2001-07-26 2002-07-25 Agents that activate or inhibit toll-like receptor 9
AU2002360243A AU2002360243A1 (en) 2001-07-26 2002-07-25 Agents that activate or inhibit toll-like receptor 9

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30806801P 2001-07-26 2001-07-26
US60/308,068 2001-07-26

Publications (2)

Publication Number Publication Date
WO2003035695A2 WO2003035695A2 (en) 2003-05-01
WO2003035695A3 true WO2003035695A3 (en) 2003-11-13

Family

ID=23192407

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/023645 Ceased WO2003035695A2 (en) 2001-07-26 2002-07-25 Agents that activate or inhibit toll-like receptor 9

Country Status (4)

Country Link
EP (1) EP1412390A2 (en)
CN (1) CN1642982A (en)
AU (1) AU2002360243A1 (en)
WO (1) WO2003035695A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8883174B2 (en) 2009-03-25 2014-11-11 The Board Of Regents, The University Of Texas System Compositions for stimulation of mammalian innate immune resistance to pathogens

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6943240B2 (en) 2000-09-15 2005-09-13 Coley Pharmaceuticals Gmbh Nucleic acids for high throughput screening of CpG-based immuno-agonist/antagonist
BR0212366A (en) 2001-09-07 2004-07-27 Univ Boston Method and composition for treating disorders associated with the immune complex
KR20060016817A (en) * 2003-06-20 2006-02-22 콜리 파마슈티칼 게엠베하 Small molecule toll-like receptor (TLL) antagonists
US20050255451A1 (en) * 2003-12-16 2005-11-17 Eicke Latz Toll-like receptor 9 modulators
CA2574176A1 (en) * 2004-07-20 2006-02-09 Schering Corporation Induction of apoptosis in toll-like receptor expressing tumor cells
US9636415B2 (en) 2006-03-03 2017-05-02 S-Target Therapeutics Gmbh Bispecific molecule binding TLR9 and CD32 and comprising a T cell epitope for treatment of allergies
EP1829895A1 (en) * 2006-03-03 2007-09-05 f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. Bispecific molecule binding TLR9 and CD32 and comprising a T cell epitope for treatment of allergies
CN102851295B (en) * 2006-08-28 2015-01-07 长春华普生物技术有限公司 Toll-like receptor regulatory oligonucleotide and application thereof
CN101134046B (en) * 2006-09-01 2011-10-05 中国医学科学院药物研究所 Application of TLR4 and TLR9 agonist compound in inhibiting tumor metastasis
US20110105383A1 (en) * 2008-09-10 2011-05-05 Magnus Hook Methods and compositions for stimulation of mammalian innate immune resistance to pathogens
CN102803500B (en) 2009-06-05 2014-11-19 13治疗有限公司 Immunoregulatory peptides and methods of use
US20120282276A1 (en) * 2009-11-05 2012-11-08 The Regents Of The University Of Michigan Biomarkers predictive of progression of fibrosis
CN101712957B (en) * 2009-11-25 2011-11-23 中国人民解放军第三军医大学第一附属医院 Toll-like receptor 9 blocker and application
FR2975600B1 (en) 2011-05-24 2013-07-05 Assist Publ Hopitaux De Paris AGENTS FOR THE TREATMENT OF TUMORS
AR095882A1 (en) 2013-04-22 2015-11-18 Hoffmann La Roche ANTIBODY COMBINATION THERAPY AGAINST HUMAN CSF-1R WITH A TLR9 AGONIST
EP3702369A1 (en) 2014-05-16 2020-09-02 Ablynx NV Immunoglobulin variable domains
CA2948945C (en) 2014-05-16 2023-08-08 Ablynx Nv Methods for detecting and/or measuring anti-drug antibodies, in particular treatment-emergent anti-drug antibodies
WO2016044839A2 (en) 2014-09-19 2016-03-24 The Board Of Regents Of The University Of Texas System Compositions and methods for treating viral infections through stimulated innate immunity in combination with antiviral compounds
WO2019066571A2 (en) 2017-09-28 2019-04-04 연세대학교 산학협력단 Method for producing myeloid-derived suppressor cells, myeloid-derived suppressor cells produced thereby, and uses thereof
WO2021207653A1 (en) * 2020-04-10 2021-10-14 Idera Pharmaceuticals, Inc. Use of a tlr9 agonist in methods for treating covid-19
TWI827057B (en) * 2021-05-18 2023-12-21 中國醫藥大學 Vaccine, use thereof and cancer vaccine cocktail

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001055386A1 (en) * 2000-01-25 2001-08-02 Glaxosmithkline Toll-like receptor
WO2001093905A1 (en) * 2000-06-08 2001-12-13 Intercell Biomedizinische Forschungs- Und Entwicklungs Ag Immunostimulatory oligodeoxynucleotides
WO2002006482A1 (en) * 2000-07-19 2002-01-24 Japan Science And Technology Corporation Receptor protein specifically recognizing bacterial dna

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001055386A1 (en) * 2000-01-25 2001-08-02 Glaxosmithkline Toll-like receptor
WO2001093905A1 (en) * 2000-06-08 2001-12-13 Intercell Biomedizinische Forschungs- Und Entwicklungs Ag Immunostimulatory oligodeoxynucleotides
WO2002006482A1 (en) * 2000-07-19 2002-01-24 Japan Science And Technology Corporation Receptor protein specifically recognizing bacterial dna

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HEMMI HIROAKI ET AL: "A Toll-like receptor recognizes bacterial DNA", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 408, no. 6813, 7 December 2000 (2000-12-07), pages 740 - 745, XP002168474, ISSN: 0028-0836 *
KRIEG A M ET AL: "CpG motifs in bacterial DNA trigger direct B-cell activation.", NATURE. ENGLAND 6 APR 1995, vol. 374, no. 6522, 6 April 1995 (1995-04-06), pages 546 - 549, XP002910391, ISSN: 0028-0836 *
WAGNER H: "Bacterial CpG DNA activates immune cells to signal infectious danger.", ADVANCES IN IMMUNOLOGY. UNITED STATES 1999, vol. 73, 1999, pages 329 - 368, XP009015569, ISSN: 0065-2776 *
WAGNER HERMANN: "Toll meets bacterial CpG-DNA.", IMMUNITY, vol. 14, no. 5, May 2001 (2001-05-01), pages 499 - 502, XP002250852, ISSN: 1074-7613 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8883174B2 (en) 2009-03-25 2014-11-11 The Board Of Regents, The University Of Texas System Compositions for stimulation of mammalian innate immune resistance to pathogens
US9186400B2 (en) 2009-03-25 2015-11-17 The Board Of Regents, The University Of Texas System Compositions for stimulation of mammalian innate immune resistance to pathogens
US9504742B2 (en) 2009-03-25 2016-11-29 The Board Of Regents, The University Of Texas System Compositions for stimulation of mammalian innate immune resistance to pathogens

Also Published As

Publication number Publication date
EP1412390A2 (en) 2004-04-28
CN1642982A (en) 2005-07-20
AU2002360243A1 (en) 2003-05-06
WO2003035695A2 (en) 2003-05-01

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