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WO2003035651A3 - Derives de l'artemisinine, et leurs utilisations dans le traitement du paludisme - Google Patents

Derives de l'artemisinine, et leurs utilisations dans le traitement du paludisme Download PDF

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Publication number
WO2003035651A3
WO2003035651A3 PCT/FR2002/003675 FR0203675W WO03035651A3 WO 2003035651 A3 WO2003035651 A3 WO 2003035651A3 FR 0203675 W FR0203675 W FR 0203675W WO 03035651 A3 WO03035651 A3 WO 03035651A3
Authority
WO
WIPO (PCT)
Prior art keywords
novel
group
treating malaria
compounds
artemisinine
Prior art date
Application number
PCT/FR2002/003675
Other languages
English (en)
Other versions
WO2003035651A2 (fr
Inventor
Jean-Pierre Begue
Daniele Bonnet-Delpon
Benoit Crousse
Michele Ourevitch
Fatima Chorki
Fabienne Grellepois
Guillaume Magueur
Original Assignee
Centre Nat Rech Scient
Jean-Pierre Begue
Daniele Bonnet-Delpon
Benoit Crousse
Michele Ourevitch
Fatima Chorki
Fabienne Grellepois
Guillaume Magueur
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Nat Rech Scient, Jean-Pierre Begue, Daniele Bonnet-Delpon, Benoit Crousse, Michele Ourevitch, Fatima Chorki, Fabienne Grellepois, Guillaume Magueur filed Critical Centre Nat Rech Scient
Priority to AU2002358856A priority Critical patent/AU2002358856A1/en
Priority to US10/493,576 priority patent/US7417155B2/en
Publication of WO2003035651A2 publication Critical patent/WO2003035651A2/fr
Publication of WO2003035651A3 publication Critical patent/WO2003035651A3/fr
Priority to US12/170,077 priority patent/US7696362B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

La présente invention a pour objet de nouveaux dérivés de l'artémisinine, de formule générale (I), dans laquelle : a et b représentent une simple ou une double liaison; n1 et n2 représentent 0 ou 1; R1 représente un groupe fluoroalkyle, ou un groupe fluoroaryle; R2 représente un atome d'hydrogène, ou un atome d'halogène, ou un groupe, le cas échéant ionisable, permettant de rendre lesdits composés de formule (I) solubles dans l'eau; R3 représente un groupe, le cas échéant ionisable, permettant de rendre lesdits composés de formule (I) solubles dans l'eau; R4 représente H ou OH. L'invention concerne également leur procéde d'obtention, et leurs utilisations dans des compositions pharmaceutiques destinées au traitement du paludisme.
PCT/FR2002/003675 2001-10-26 2002-10-25 Derives de l'artemisinine, et leurs utilisations dans le traitement du paludisme WO2003035651A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2002358856A AU2002358856A1 (en) 2001-10-26 2002-10-25 Novel artemisinine derivatives, and uses thereof for treating malaria
US10/493,576 US7417155B2 (en) 2001-10-26 2002-10-25 Artemisinine derivatives, and uses thereof for treating malaria
US12/170,077 US7696362B2 (en) 2001-10-26 2008-07-09 Derivatives of artemisinin, and their uses in the treatment of malaria

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0113869A FR2831538B1 (fr) 2001-10-26 2001-10-26 Nouveaux derives de l'artemisinine, et leurs utilisations dans le traitement du paludisme
FR01/13869 2001-10-26

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10493576 A-371-Of-International 2002-10-25
US12/170,077 Division US7696362B2 (en) 2001-10-26 2008-07-09 Derivatives of artemisinin, and their uses in the treatment of malaria

Publications (2)

Publication Number Publication Date
WO2003035651A2 WO2003035651A2 (fr) 2003-05-01
WO2003035651A3 true WO2003035651A3 (fr) 2003-11-27

Family

ID=8868757

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2002/003675 WO2003035651A2 (fr) 2001-10-26 2002-10-25 Derives de l'artemisinine, et leurs utilisations dans le traitement du paludisme

Country Status (5)

Country Link
US (2) US7417155B2 (fr)
AU (1) AU2002358856A1 (fr)
FR (1) FR2831538B1 (fr)
MY (1) MY139382A (fr)
WO (1) WO2003035651A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2831538B1 (fr) * 2001-10-26 2004-01-16 Centre Nat Rech Scient Nouveaux derives de l'artemisinine, et leurs utilisations dans le traitement du paludisme
WO2006002105A1 (fr) 2004-06-21 2006-01-05 University Of Mississippi Dimeres dihydroartemisinene et dihydroartemisitene anticancereux et antiprotozoaires a fonctionnalites chimiques desirees
CN1311832C (zh) * 2005-01-12 2007-04-25 四川科伦药业股份有限公司 溴代二氢青蒿素的医药用途
FR2899586B1 (fr) * 2006-04-11 2008-06-20 Sanofi Aventis Sa Dimeres de derives d'artemisinine, leur preparation et leur application en therapeutique
FR2925495B1 (fr) 2007-12-21 2010-09-10 Pf Medicament Derives dimeriques d'artemisinine et application en therapie anticancereuse
WO2010004573A1 (fr) * 2008-07-07 2010-01-14 Ipca Laboratories Limited Composition pharmaceutique synergiste antipaludique
FR2934593B1 (fr) 2008-07-29 2010-09-10 Pf Medicament Derives dimeriques d'artemisinine et application en therapie anticancereuse
CN103183682B (zh) * 2011-12-31 2015-10-14 沈阳药科大学 C-10位脲基取代的青蒿素衍生物及其制备方法和用途
WO2014070673A1 (fr) 2012-10-29 2014-05-08 University Of Rochester Dérivés d'artémisinine, leurs procédés de préparation et leur utilisation en tant qu'agents antipaludiques
CN116836176A (zh) * 2022-03-23 2023-10-03 中国科学院上海药物研究所 青蒿素类化合物、其制备方法和应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2831538B1 (fr) * 2001-10-26 2004-01-16 Centre Nat Rech Scient Nouveaux derives de l'artemisinine, et leurs utilisations dans le traitement du paludisme

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ABOUABDELLAH A ET AL: "Synthesis and in vivo Antimalarial Activity of 12alpha-Trifluoromethyl-Hydroartemisinin", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 6, no. 22, 19 November 1996 (1996-11-19), pages 2717 - 2720, XP004135882, ISSN: 0960-894X *
NGA T T T ET AL: "Synthesis and antimalarial activities of fluoroalkyl derivatives of dihydroartemisinin", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 41, 1998, pages 4101 - 4108, XP002207485, ISSN: 0022-2623 *
PU ET AL: "Synthesis and Antimalarial Activities of Several Fluorinated Artemisinin Derivatives", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 38, 1995, pages 4120 - 4124, XP002088810, ISSN: 0022-2623 *

Also Published As

Publication number Publication date
US7696362B2 (en) 2010-04-13
FR2831538B1 (fr) 2004-01-16
MY139382A (en) 2009-09-30
AU2002358856A1 (en) 2003-05-06
FR2831538A1 (fr) 2003-05-02
WO2003035651A2 (fr) 2003-05-01
US7417155B2 (en) 2008-08-26
US20080287433A1 (en) 2008-11-20
US20050038024A1 (en) 2005-02-17

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