[go: up one dir, main page]

WO2003033729A1 - Procede de pretraitement d'echantillon pour la mesure d'une amine saccharifiee et procede de mesure d'une amine saccharifiee - Google Patents

Procede de pretraitement d'echantillon pour la mesure d'une amine saccharifiee et procede de mesure d'une amine saccharifiee Download PDF

Info

Publication number
WO2003033729A1
WO2003033729A1 PCT/JP2002/010463 JP0210463W WO03033729A1 WO 2003033729 A1 WO2003033729 A1 WO 2003033729A1 JP 0210463 W JP0210463 W JP 0210463W WO 03033729 A1 WO03033729 A1 WO 03033729A1
Authority
WO
WIPO (PCT)
Prior art keywords
faod
saccharified
amine
saccharified amine
amino acid
Prior art date
Application number
PCT/JP2002/010463
Other languages
English (en)
French (fr)
Inventor
Satoshi Yonehara
Tsuguki Komori
Original Assignee
Arkray, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arkray, Inc. filed Critical Arkray, Inc.
Priority to CN02820191.4A priority Critical patent/CN1568371B/zh
Priority to US10/492,140 priority patent/US7449305B2/en
Priority to AT02801510T priority patent/ATE469241T1/de
Priority to JP2003536452A priority patent/JP4085138B2/ja
Priority to US14/751,351 priority patent/USRE46073E1/en
Priority to EP02801510A priority patent/EP1443115B1/en
Priority to US12/903,760 priority patent/USRE43795E1/en
Priority to US13/653,024 priority patent/USRE45074E1/en
Priority to US14/326,697 priority patent/USRE45626E1/en
Priority to DE60236530T priority patent/DE60236530D1/de
Publication of WO2003033729A1 publication Critical patent/WO2003033729A1/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • G01N33/723—Glycosylated haemoglobin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/906—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
PCT/JP2002/010463 2001-10-11 2002-10-09 Procede de pretraitement d'echantillon pour la mesure d'une amine saccharifiee et procede de mesure d'une amine saccharifiee WO2003033729A1 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
CN02820191.4A CN1568371B (zh) 2001-10-11 2002-10-09 为了测定糖化胺的样品前处理方法和糖化胺的测定方法
US10/492,140 US7449305B2 (en) 2001-10-11 2002-10-09 Method of pre-treating sample for measuring saccharified amine and method of measuring saccharified amine
AT02801510T ATE469241T1 (de) 2001-10-11 2002-10-09 Verfahren zur vorbehandlung von proben zur bestimmung von verzuckerten aminen, sowie verfahren zur bestimmung von verzuckerten aminen
JP2003536452A JP4085138B2 (ja) 2001-10-11 2002-10-09 糖化アミンを測定するための試料の前処理方法および糖化アミンの測定方法
US14/751,351 USRE46073E1 (en) 2001-10-11 2002-10-09 Method of pre-treating sample for measuring saccharified amine and method of measuring saccharified amine
EP02801510A EP1443115B1 (en) 2001-10-11 2002-10-09 Method of pre-treating sample for measuring saccharified amine and method of measuring saccharified amine
US12/903,760 USRE43795E1 (en) 2001-10-11 2002-10-09 Method of pre-treating sample for measuring saccharified amine and method of measuring saccharified amine
US13/653,024 USRE45074E1 (en) 2001-10-11 2002-10-09 Method of pre-treating sample for measuring saccharified amine and method of measuring saccharified amine
US14/326,697 USRE45626E1 (en) 2001-10-11 2002-10-09 Method of pre-treating sample for measuring saccharified amine and method of measuring saccharified amine
DE60236530T DE60236530D1 (de) 2001-10-11 2002-10-09 Verfahren zur vorbehandlung von proben zur bestimmung von verzuckerten aminen, sowie verfahren zur bestimmung von verzuckerten aminen

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001314218 2001-10-11
JP2001-314218 2001-10-11

Publications (1)

Publication Number Publication Date
WO2003033729A1 true WO2003033729A1 (fr) 2003-04-24

Family

ID=19132569

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/010463 WO2003033729A1 (fr) 2001-10-11 2002-10-09 Procede de pretraitement d'echantillon pour la mesure d'une amine saccharifiee et procede de mesure d'une amine saccharifiee

Country Status (7)

Country Link
US (3) USRE46073E1 (ja)
EP (4) EP2216413B1 (ja)
JP (5) JP4085138B2 (ja)
CN (3) CN1568371B (ja)
AT (1) ATE469241T1 (ja)
DE (1) DE60236530D1 (ja)
WO (1) WO2003033729A1 (ja)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004038035A1 (ja) * 2002-10-23 2004-05-06 Daiichi Pure Chemicals Co., Ltd. フルクトシルバリンの生産方法および該生産方法により得られたフルクトシルバリンの定量方法
WO2005049857A1 (ja) * 2003-11-19 2005-06-02 Daiichi Pure Chemicals Co., Ltd. 糖化蛋白質の測定方法
WO2005056823A1 (ja) 2003-12-12 2005-06-23 Arkray, Inc. 糖化アミンの測定方法
WO2007072941A1 (ja) * 2005-12-22 2007-06-28 Kyowa Medex Co., Ltd. 糖化タンパク質の測定方法
US8105800B2 (en) 2001-01-31 2012-01-31 Asahi Kasei Pharma Corporation Composition for assaying glycated proteins
WO2013038736A1 (ja) * 2011-09-15 2013-03-21 東洋紡株式会社 糖化ヘモグロビン測定用多層試験片、およびそれを用いた測定方法
JP5204483B2 (ja) * 2005-07-19 2013-06-05 キッコーマン株式会社 糖化蛋白質の測定方法および測定キット
EP2639586A1 (en) 2012-03-15 2013-09-18 ARKRAY, Inc. Measurement method using enzymes
USRE46073E1 (en) * 2001-10-11 2016-07-19 Arkray, Inc. Method of pre-treating sample for measuring saccharified amine and method of measuring saccharified amine
WO2018221446A1 (ja) 2017-05-30 2018-12-06 協和メデックス株式会社 糖化ヘモグロビンの測定方法

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2986480B2 (ja) 1989-07-25 1999-12-06 住友石炭鉱業株式会社 放電焼結装置及びその装置を用いて放電焼結を行う方法
USRE45074E1 (en) 2001-10-11 2014-08-12 Arkray, Inc. Method of pre-treating sample for measuring saccharified amine and method of measuring saccharified amine
ATE367583T1 (de) * 2002-01-31 2007-08-15 Arkray Inc Verfahren zur quantifizierung von glykosyliertem protein unter verwendung einer redoxreaktion sowie eines quantifizierungskits
EP2354224B1 (en) * 2008-10-10 2018-02-14 Toyobo Co., Ltd. Novel protein having fructosyl valyl histidine oxidase activity and modified product thereof, and use of the protein or the modified product

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0678576A2 (en) * 1994-03-03 1995-10-25 Kyoto Daiichi Kagaku Co., Ltd. Fructosyl amino acid oxidase and process for producing the same
WO1997013872A1 (fr) * 1995-10-12 1997-04-17 Kyoto Daiichi Kagaku Co., Ltd. Procede pour doser les composes d'amadori
JP2000180439A (ja) * 1998-12-21 2000-06-30 Wako Pure Chem Ind Ltd 糖化ヘモグロビン測定用全血の前処理方法
JP2001054398A (ja) * 1999-08-18 2001-02-27 Asahi Chem Ind Co Ltd タンパク質の選択的断片化方法
JP2001215229A (ja) * 2000-02-02 2001-08-10 Wako Pure Chem Ind Ltd 糖化蛋白質測定試薬

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3416540B2 (ja) 1994-03-03 2003-06-16 アークレイ株式会社 フルクトシルアミノ酸オキシダーゼ及びその製造方法
JP2923222B2 (ja) 1994-03-03 1999-07-26 株式会社京都第一科学 フルクトシルアミノ酸オキシダーゼ及びその製造方法
US5712138A (en) 1994-10-05 1998-01-27 Kyoto Daiichi Kagaku Co., Ltd. Fructosyl amino acid oxidase
JP3850904B2 (ja) 1994-10-05 2006-11-29 アークレイ株式会社 フルクトシルアミノ酸オキシダーゼ及びその製造方法
JP4004081B2 (ja) 1995-04-11 2007-11-07 アークレイ株式会社 フルクトシルアミノ酸オキシダーゼおよびその製造方法
DE69635503T2 (de) 1995-04-11 2006-08-17 Arkray, Inc. Fructosyl-Aminosäureoxidase und Verfahren zu deren Herstellung
ATE182626T1 (de) * 1995-05-05 1999-08-15 Genzyme Ltd Bestimmung von glykierten proteinen
JP3710166B2 (ja) 1995-05-09 2005-10-26 日本化薬株式会社 Ｄ−ソルビトールの測定方法およびその測定用キット
JP3786966B2 (ja) * 1995-11-30 2006-06-21 アークレイ株式会社 フルクトシルアミノ酸オキシダーゼ、その製造方法、及び該酵素を用いたアマドリ化合物の測定方法
JP3978622B2 (ja) 1996-07-04 2007-09-19 東洋紡績株式会社 体液中の成分の測定法およびその試薬
JPH1099098A (ja) 1996-09-27 1998-04-21 Fuji Seito Kk トレハロース分析用試薬
WO1998048043A1 (fr) 1997-04-24 1998-10-29 Kyoto Daiichi Kagaku Co., Ltd. Procede de dosage enzymatique d'une proteine de saccharification
WO1999020039A1 (en) 1997-10-10 1999-04-22 Thomson Licensing S.A. Horizontal parallelogram correction combined with horizontal centering
JP3987900B2 (ja) * 1997-11-26 2007-10-10 アークレイ株式会社 糖化タンパク質の測定方法
JPH11196897A (ja) * 1998-01-09 1999-07-27 Kdk Corp 糖化タンパク質の測定方法及び測定装置
JP2000069996A (ja) * 1998-08-31 2000-03-07 Kdk Corp 糖化アミノ酸の同定または定量方法
JP2000166596A (ja) 1998-12-10 2000-06-20 Shino Test:Kk 尿素窒素の測定試薬及び測定方法
CN1510136A (zh) * 1999-02-22 2004-07-07 阿克雷株式会社 新型酶
JP2000333696A (ja) * 1999-05-26 2000-12-05 Arkray Inc 糖化アミンの測定方法
JP3949854B2 (ja) 1999-10-01 2007-07-25 キッコーマン株式会社 糖化蛋白質の測定方法
ES2502481T3 (es) 2001-01-31 2014-10-03 Asahi Kasei Pharma Corporation Composición para el análisis de proteínas glicosiladas
USRE45074E1 (en) * 2001-10-11 2014-08-12 Arkray, Inc. Method of pre-treating sample for measuring saccharified amine and method of measuring saccharified amine
USRE46073E1 (en) * 2001-10-11 2016-07-19 Arkray, Inc. Method of pre-treating sample for measuring saccharified amine and method of measuring saccharified amine
ATE458827T1 (de) * 2003-12-12 2010-03-15 Arkray Inc Verfahren zur messung von saccharifiziertem amin

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0678576A2 (en) * 1994-03-03 1995-10-25 Kyoto Daiichi Kagaku Co., Ltd. Fructosyl amino acid oxidase and process for producing the same
WO1997013872A1 (fr) * 1995-10-12 1997-04-17 Kyoto Daiichi Kagaku Co., Ltd. Procede pour doser les composes d'amadori
JP2000180439A (ja) * 1998-12-21 2000-06-30 Wako Pure Chem Ind Ltd 糖化ヘモグロビン測定用全血の前処理方法
JP2001054398A (ja) * 1999-08-18 2001-02-27 Asahi Chem Ind Co Ltd タンパク質の選択的断片化方法
JP2001215229A (ja) * 2000-02-02 2001-08-10 Wako Pure Chem Ind Ltd 糖化蛋白質測定試薬

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NOBUYUKI YOSHIDA ET AL.: "Distribution and properties of fructosyl amino acid oxidase in fungi", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 61, no. 12, December 1995 (1995-12-01), pages 4487 - 4489, XP000561863 *

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8105800B2 (en) 2001-01-31 2012-01-31 Asahi Kasei Pharma Corporation Composition for assaying glycated proteins
USRE46073E1 (en) * 2001-10-11 2016-07-19 Arkray, Inc. Method of pre-treating sample for measuring saccharified amine and method of measuring saccharified amine
WO2004038035A1 (ja) * 2002-10-23 2004-05-06 Daiichi Pure Chemicals Co., Ltd. フルクトシルバリンの生産方法および該生産方法により得られたフルクトシルバリンの定量方法
JP2011115179A (ja) * 2003-11-19 2011-06-16 Sekisui Medical Co Ltd 糖化蛋白質の測定方法
WO2005049857A1 (ja) * 2003-11-19 2005-06-02 Daiichi Pure Chemicals Co., Ltd. 糖化蛋白質の測定方法
JPWO2005049857A1 (ja) * 2003-11-19 2007-11-29 第一化学薬品株式会社 糖化蛋白質の測定方法
JP4769579B2 (ja) * 2003-11-19 2011-09-07 積水メディカル株式会社 糖化蛋白質の測定方法
US7794966B2 (en) 2003-12-12 2010-09-14 Arkray, Inc. Method of measuring glycated amine
EP1693463B2 (en) † 2003-12-12 2013-04-10 ARKRAY, Inc. Method of measuring saccharified amine
WO2005056823A1 (ja) 2003-12-12 2005-06-23 Arkray, Inc. 糖化アミンの測定方法
US8507223B2 (en) 2005-07-19 2013-08-13 Kikkoman Corporation Method for quantitative determination of glycated protein and kit for quantitative determination of the same
JP5204483B2 (ja) * 2005-07-19 2013-06-05 キッコーマン株式会社 糖化蛋白質の測定方法および測定キット
JPWO2007072941A1 (ja) * 2005-12-22 2009-06-04 協和メデックス株式会社 糖化タンパク質の測定方法
WO2007072941A1 (ja) * 2005-12-22 2007-06-28 Kyowa Medex Co., Ltd. 糖化タンパク質の測定方法
WO2013038736A1 (ja) * 2011-09-15 2013-03-21 東洋紡株式会社 糖化ヘモグロビン測定用多層試験片、およびそれを用いた測定方法
JP2013074877A (ja) * 2011-09-15 2013-04-25 Toyobo Co Ltd 糖化ヘモグロビン測定用多層試験片、およびそれを用いた測定方法
EP2639586A1 (en) 2012-03-15 2013-09-18 ARKRAY, Inc. Measurement method using enzymes
JP2013215188A (ja) * 2012-03-15 2013-10-24 Arkray Inc 酵素を用いた測定方法
US8802366B2 (en) 2012-03-15 2014-08-12 Arkray, Inc. Measurement method using enzyme
WO2018221446A1 (ja) 2017-05-30 2018-12-06 協和メデックス株式会社 糖化ヘモグロビンの測定方法

Also Published As

Publication number Publication date
JP2010263921A (ja) 2010-11-25
USRE46073E1 (en) 2016-07-19
CN102207508B (zh) 2012-12-26
JP4085138B2 (ja) 2008-05-14
EP2216413A3 (en) 2010-10-06
ATE469241T1 (de) 2010-06-15
EP2216413A2 (en) 2010-08-11
EP2270199A1 (en) 2011-01-05
DE60236530D1 (de) 2010-07-08
USRE43795E1 (en) 2012-11-06
CN102207508A (zh) 2011-10-05
EP1443115A1 (en) 2004-08-04
JP4590017B2 (ja) 2010-12-01
CN101892289A (zh) 2010-11-24
CN101892289B (zh) 2012-06-20
US20040248226A1 (en) 2004-12-09
US7449305B2 (en) 2008-11-11
EP2249163A3 (en) 2010-11-17
EP2216413B1 (en) 2013-07-10
EP1443115A4 (en) 2006-02-01
EP2249163B1 (en) 2012-06-27
JP4621812B2 (ja) 2011-01-26
JP2010104386A (ja) 2010-05-13
CN1568371A (zh) 2005-01-19
EP1443115B1 (en) 2010-05-26
CN1568371B (zh) 2014-06-04
JP2010252814A (ja) 2010-11-11
EP2249163A2 (en) 2010-11-10
JP4599486B2 (ja) 2010-12-15
JP2010110333A (ja) 2010-05-20
JPWO2003033729A1 (ja) 2005-02-03
JP5222331B2 (ja) 2013-06-26

Similar Documents

Publication Publication Date Title
WO2003033729A1 (fr) Procede de pretraitement d'echantillon pour la mesure d'une amine saccharifiee et procede de mesure d'une amine saccharifiee
WO2003040694A3 (en) Enzymatic cycling assays for homocysteine and cystathionine
WO2002066671A3 (en) Improved method for detection of atp
GB2423819A (en) Apparatus and method for analysis of molecules
MX247272B (es) Proceso para la determinacion en linea de peroxido de hidrogeno.
WO2002000006A3 (en) Nucleic acid enzyme biosensor for ions
WO2008060694A3 (en) System and/or method for determining sufficiency of pseudorange measurements
WO2003016899A3 (en) Method and system for detection of hydrocarbon species in a gas
CY1109807T1 (el) Προσδιορισμος της οξειδασης της διαμινης
EP1213358A3 (en) Method and kit for the determination of a biological component
AU2003235974A1 (en) Method of assay with sulfonic acid compound and nitro compound
EP0964249A3 (en) Method for measuring LDL-cholesterol
WO2003057905A1 (fr) Procede de colorimetrie et reactif utilise dans ce procede
ATE458827T1 (de) Verfahren zur messung von saccharifiziertem amin
DE60307836D1 (de) Durchfluss enzymassay mit einem massenspektrometrischen nachweis
EP1342791A3 (en) Reagent, method and apparatus for measuring amylase activity
EP1615029A3 (en) Reagent and method for determination of calcium
WO2001033187A3 (en) Enzymatic cycling assays for homocysteine and cystathionine
EP1515143A4 (en) PROCESS FOR REACTION TESTING OF OXIDOREDUCTION WITH FORMAZANE
WO2005029038A3 (en) Detection of potassium ions using ion-sensitive enzymes
TW200623256A (en) Method and system for treating a substrate using a supercritical fluid
EP1342790A3 (en) Reagent and method for measuring amylase activity
Himuro et al. The use of 2, 2′-thiodiethanol in the fluorimetric determination of secondary amines with o-phthalaldehyde and 2-mercaptoethanol
GB0402539D0 (en) Xerostomia treatment,composition and method
WO2001073407A3 (en) Method for the determination of an acid or a base in a non-aqueous liquid

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BY BZ CA CH CN CO CR CU CZ DE DM DZ EC EE ES FI GB GD GE GH HR HU ID IL IN IS JP KE KG KR KZ LK LR LS LT LU LV MA MD MG MK MW MX MZ NO NZ OM PH PL PT RO SD SE SG SI SK SL TJ TM TN TR TT UA UG US UZ VC VN YU ZA ZM

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW MZ SD SL SZ UG ZM ZW AM AZ BY KG KZ RU TJ TM AT BE BG CH CY CZ DK EE ES FI FR GB GR IE IT LU MC PT SE SK TR BF BJ CF CG CI GA GN GQ GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2003536452

Country of ref document: JP

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 12903760

Country of ref document: US

Ref document number: 13653024

Country of ref document: US

Ref document number: 14326697

Country of ref document: US

Ref document number: 10492140

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 20028201914

Country of ref document: CN

WWE Wipo information: entry into national phase

Ref document number: 2002801510

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2002801510

Country of ref document: EP