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WO2003027274A3 - Purified polypeptides from pseudomonas aeruginosa - Google Patents

Purified polypeptides from pseudomonas aeruginosa Download PDF

Info

Publication number
WO2003027274A3
WO2003027274A3 PCT/CA2002/001453 CA0201453W WO03027274A3 WO 2003027274 A3 WO2003027274 A3 WO 2003027274A3 CA 0201453 W CA0201453 W CA 0201453W WO 03027274 A3 WO03027274 A3 WO 03027274A3
Authority
WO
WIPO (PCT)
Prior art keywords
pseudomonas aeruginosa
purified polypeptides
polypeptides
provides
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CA2002/001453
Other languages
French (fr)
Other versions
WO2003027274A2 (en
Inventor
Aled Edwards
Akil Dharamsi
Masoud Vedadi
Muhammad Zahoor Alam
Donald Awrey
Bryan Beattie
Simon Houston
Matthew Kimber
Robert Lam
Kathleen Nethery
Qin Li
Sasha Necakov
Francois Vallee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Affinium Pharmaceuticals Inc
Original Assignee
Affinium Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affinium Pharmaceuticals Inc filed Critical Affinium Pharmaceuticals Inc
Priority to AU2002331473A priority Critical patent/AU2002331473A1/en
Publication of WO2003027274A2 publication Critical patent/WO2003027274A2/en
Publication of WO2003027274A3 publication Critical patent/WO2003027274A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

The present invention relates to drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 4. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.
PCT/CA2002/001453 2001-09-25 2002-09-25 Purified polypeptides from pseudomonas aeruginosa Ceased WO2003027274A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002331473A AU2002331473A1 (en) 2001-09-25 2002-09-25 Purified polypeptides from pseudomonas aeruginosa

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US32473901P 2001-09-25 2001-09-25
US60/324,739 2001-09-25
US37691702P 2002-05-01 2002-05-01
US60/376,917 2002-05-01

Publications (2)

Publication Number Publication Date
WO2003027274A2 WO2003027274A2 (en) 2003-04-03
WO2003027274A3 true WO2003027274A3 (en) 2003-10-02

Family

ID=26984610

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2002/001453 Ceased WO2003027274A2 (en) 2001-09-25 2002-09-25 Purified polypeptides from pseudomonas aeruginosa

Country Status (2)

Country Link
AU (1) AU2002331473A1 (en)
WO (1) WO2003027274A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107632105A (en) * 2017-08-31 2018-01-26 中国农业科学院农业质量标准与检测技术研究所 Ornidazole purity rubric material and preparation method and application

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001070955A2 (en) * 2000-03-21 2001-09-27 Elitra Pharmaceuticals, Inc. Identification of essential genes in prokaryotes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001070955A2 (en) * 2000-03-21 2001-09-27 Elitra Pharmaceuticals, Inc. Identification of essential genes in prokaryotes

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BRENNER STEVEN E: "A tour of structural genomics.", NATURE REVIEWS GENETICS, vol. 2, no. 10, October 2001 (2001-10-01), pages 801 - 809, XP002250126, ISSN: 1471-0056 *
FLEISCHMANN WOLFGANG ET AL: "A novel method for automatic functional annotation of proteins.", BIOINFORMATICS (OXFORD), vol. 15, no. 3, March 1999 (1999-03-01), pages 228 - 233, XP002250093, ISSN: 1367-4803 *
GSCHWEND D A ET AL: "MOLECULAR DOCKING TOWARDS DRUG DISCOVERY", JOURNAL OF MOLECULAR RECOGNITION, HEYDEN & SON LTD., LONDON, GB, vol. 9, 1996, pages 175 - 186, XP000882526, ISSN: 0952-3499 *
JOUBERT F ET AL: "Structure-based inhibitor screening: A family of sulfonated dye inhibitors for malaria parasite triosephosphate isomerase.", PROTEINS, vol. 45, no. 2, 1 November 2001 (2001-11-01), pages 136 - 143, XP009015107, ISSN: 0887-3585 *
NIENABER VICKI L ET AL: "Discovering novel ligands for macromolecules using X-ray crystallographic screening.", NATURE BIOTECHNOLOGY, vol. 18, no. 10, October 2000 (2000-10-01), pages 1105 - 1108, XP002250092, ISSN: 1087-0156 *
STOVER C K ET AL: "COMPLETE GENOME SEQUENCE OF PSEUDOMONAS AERUGINOSA PA01, AN OPPORTUNISTIC PATHOGEN", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 406, no. 6799, 31 August 2000 (2000-08-31), pages 959 - 964, XP000996980, ISSN: 0028-0836 *
VELANKER SAMEER S ET AL: "Triosephosphate isomerase from Plasmodium falciparum: The crystal structure provides insights into antimalarial drug design.", STRUCTURE (LONDON), vol. 5, no. 6, 1997, pages 751 - 761, XP009015082, ISSN: 0969-2126 *
WIERENGA R K ET AL: "COMPARISON OF THE REFINED CRYSTAL STRUCTURES OF LIGANDED AND UNLIGANDED CHICKEN YEAST AND TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE", JOURNAL OF MOLECULAR BIOLOGY, vol. 224, no. 4, 1992, pages 1115 - 1126, XP009015108, ISSN: 0022-2836 *
WILLIAMS JOHN C ET AL: "Structural and mutagenesis studies of leishmania triosephosphate isomerase: A point mutation can convert a mesophilic enzyme into a superstable enzyme without losing catalytic power.", PROTEIN ENGINEERING, vol. 12, no. 3, March 1999 (1999-03-01), pages 243 - 250, XP002250090, ISSN: 0269-2139 *

Also Published As

Publication number Publication date
AU2002331473A1 (en) 2003-04-07
WO2003027274A2 (en) 2003-04-03

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