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WO2003027060A1 - Diphenylbutane amide derivatives - Google Patents

Diphenylbutane amide derivatives Download PDF

Info

Publication number
WO2003027060A1
WO2003027060A1 PCT/JP2002/009424 JP0209424W WO03027060A1 WO 2003027060 A1 WO2003027060 A1 WO 2003027060A1 JP 0209424 W JP0209424 W JP 0209424W WO 03027060 A1 WO03027060 A1 WO 03027060A1
Authority
WO
WIPO (PCT)
Prior art keywords
diphenylbutane
amide derivatives
deoxy
muscarinic receptor
represents hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2002/009424
Other languages
French (fr)
Japanese (ja)
Inventor
Ichiro Araya
Takeshi Tsubuki
Makoto Numata
Tatsuhiro Saito
Hiroyuki Miyachi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyorin Pharmaceutical Co Ltd
Original Assignee
Kyorin Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Pharmaceutical Co Ltd filed Critical Kyorin Pharmaceutical Co Ltd
Priority to JP2003530651A priority Critical patent/JPWO2003027060A1/en
Publication of WO2003027060A1 publication Critical patent/WO2003027060A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

It is intended to provide compounds represented by the following general formula (1), which show a higher selectivity for muscarinic receptor in smooth muscle than for muscarinic receptor in heart and have a potent antagonism, salts thereof and hydrates of the same: (1) wherein X represents hydrogen or hydroxy; R1 represents hydrogen or 1-deoxy-D-glucopyranuronate; and R2 represents 4,5-dioxo-2-methylimidazolidinyl, 1-(2-methyl-1-imidazolio)-1-deoxy-β-D-puranuronate, etc.
PCT/JP2002/009424 2001-09-20 2002-09-13 Diphenylbutane amide derivatives Ceased WO2003027060A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2003530651A JPWO2003027060A1 (en) 2001-09-20 2002-09-13 Diphenylbutanamide derivative

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001-287712 2001-09-20
JP2001287712 2001-09-20

Publications (1)

Publication Number Publication Date
WO2003027060A1 true WO2003027060A1 (en) 2003-04-03

Family

ID=19110478

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/009424 Ceased WO2003027060A1 (en) 2001-09-20 2002-09-13 Diphenylbutane amide derivatives

Country Status (2)

Country Link
JP (1) JPWO2003027060A1 (en)
WO (1) WO2003027060A1 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007013421A1 (en) * 2005-07-25 2007-02-01 Mitsubishi Tanabe Pharma Corporation Novel nitrogenated heterocyclic compound
WO2007077510A2 (en) 2005-12-30 2007-07-12 Ranbaxy Laboratories Limited Muscarinic receptor antagonists
EP2130830A1 (en) 2008-06-03 2009-12-09 Ranbaxy Laboratories Limited Muscarinic receptor antagonists
CN103242230A (en) * 2013-05-02 2013-08-14 陕西步长高新制药有限公司 Quinolinone derivative and preparation method thereof
CN103242214A (en) * 2013-05-02 2013-08-14 陕西步长高新制药有限公司 Indole derivative and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995015951A1 (en) * 1993-12-10 1995-06-15 Kyorin Pharmaceutical Co. Ltd. Novel imidazole derivative and process for producing the same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995015951A1 (en) * 1993-12-10 1995-06-15 Kyorin Pharmaceutical Co. Ltd. Novel imidazole derivative and process for producing the same

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007013421A1 (en) * 2005-07-25 2007-02-01 Mitsubishi Tanabe Pharma Corporation Novel nitrogenated heterocyclic compound
WO2007077510A2 (en) 2005-12-30 2007-07-12 Ranbaxy Laboratories Limited Muscarinic receptor antagonists
EP2130830A1 (en) 2008-06-03 2009-12-09 Ranbaxy Laboratories Limited Muscarinic receptor antagonists
CN103242230A (en) * 2013-05-02 2013-08-14 陕西步长高新制药有限公司 Quinolinone derivative and preparation method thereof
CN103242214A (en) * 2013-05-02 2013-08-14 陕西步长高新制药有限公司 Indole derivative and preparation method thereof
CN103242230B (en) * 2013-05-02 2015-02-18 陕西步长高新制药有限公司 Quinolinone derivative and preparation method thereof
CN103242214B (en) * 2013-05-02 2016-04-06 陕西步长高新制药有限公司 A kind of indole derivatives and preparation method thereof

Also Published As

Publication number Publication date
JPWO2003027060A1 (en) 2005-05-12

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