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WO2003026489A3 - Compositions de biopolymere et de biopolymere-cellule permettant de reparer un tissu nerveux - Google Patents

Compositions de biopolymere et de biopolymere-cellule permettant de reparer un tissu nerveux Download PDF

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Publication number
WO2003026489A3
WO2003026489A3 PCT/US2002/030900 US0230900W WO03026489A3 WO 2003026489 A3 WO2003026489 A3 WO 2003026489A3 US 0230900 W US0230900 W US 0230900W WO 03026489 A3 WO03026489 A3 WO 03026489A3
Authority
WO
WIPO (PCT)
Prior art keywords
mammal
biopolymer
nerve tissue
tissue
growth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/030900
Other languages
English (en)
Other versions
WO2003026489A2 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Florida
Original Assignee
University of Florida
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Florida filed Critical University of Florida
Priority to AU2002330131A priority Critical patent/AU2002330131A1/en
Publication of WO2003026489A2 publication Critical patent/WO2003026489A2/fr
Publication of WO2003026489A3 publication Critical patent/WO2003026489A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3878—Nerve tissue, brain, spinal cord, nerves, dura mater
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/32—Materials or treatment for tissue regeneration for nerve reconstruction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)

Abstract

L'invention concerne une composition implantable conçue afin de stimuler la croissance et l'orientation d'un tissu neural sur un site de lésion de tissu nerveux d'un mammifère humain ou non humain. Ladite composition comprend a) un matériau bioérodable de remplissage d'espace cellulairement compatible, permettant la croissance d'un tissu neural dans ladite composition ou sur celle-ci, et b) au moins une cellule biologiquement active, ensemencée sur ou dans le matériau, capable de produire, lors de l'implantation de la composition chez un mammifère, au moins un facteur neurotrophique, un facteur de croissance, une cytokine, une molécule matricielle extracellulaire ou un mélange de ceux-ci efficace pour fournir un support neurotrophique à un tissu nerveux de mammifère. L'invention concerne également un procédé permettant de promouvoir la régénération neuronale d'un tissu nerveux lésé ou endommagé consistant à implanter ladite composition dans le tissu du mammifère à proximité d'une lésion entre les débris d'axones proximaux et les segments distaux respectifs.
PCT/US2002/030900 2001-09-28 2002-09-30 Compositions de biopolymere et de biopolymere-cellule permettant de reparer un tissu nerveux Ceased WO2003026489A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002330131A AU2002330131A1 (en) 2001-09-28 2002-09-30 Biopolymer and biopolymer-cell compositions for nerve tissue repair

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32519001P 2001-09-28 2001-09-28
US60/325,190 2001-09-28

Publications (2)

Publication Number Publication Date
WO2003026489A2 WO2003026489A2 (fr) 2003-04-03
WO2003026489A3 true WO2003026489A3 (fr) 2003-08-21

Family

ID=23266822

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/030900 Ceased WO2003026489A2 (fr) 2001-09-28 2002-09-30 Compositions de biopolymere et de biopolymere-cellule permettant de reparer un tissu nerveux

Country Status (2)

Country Link
AU (1) AU2002330131A1 (fr)
WO (1) WO2003026489A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5174656B2 (ja) 2005-04-21 2013-04-03 マサチューセッツ インスティテュート オブ テクノロジー 同系または非同系の細胞、組織または器官を含む、外因性免疫原および内因性免疫原に対する免疫応答を改変するための材料および方法
WO2006116717A2 (fr) * 2005-04-28 2006-11-02 The Board Of Regents Of The University Of Texas System Cellules somatiques autologues du sang peripherique et leurs utilisations
US20090035346A1 (en) 2005-06-21 2009-02-05 Pervasis Therpeutics, Inc. Methods and Compositions for Enhancing Vascular Access
WO2008121331A1 (fr) * 2007-03-30 2008-10-09 Pervasis Therapeutics, Inc. Matériels et procédés de traitement de lésions nerveuses et de promotion de la réparation et de la régénération des nerfs
AU2008266019A1 (en) * 2007-06-13 2008-12-24 Fmc Corporation Peptide linked cell matrix materials for stem cells and methods of using the same
WO2009049058A1 (fr) 2007-10-10 2009-04-16 Wake Forest University Health Sciences Dispositifs et procédés de traitement d'un tissu de moelle épinière
US9700596B2 (en) 2011-03-04 2017-07-11 The Regents Of The University Of California Locally released growth factors to mediate motor recovery after stroke
CN103826646A (zh) * 2011-06-03 2014-05-28 麦瑟布莱斯特公司 治疗中风的影响的方法
CA2870052A1 (fr) * 2012-04-12 2013-10-17 Wake Forest University Health Sciences Modele de conduit pour remplacement du nerf peripherique
WO2014066724A1 (fr) 2012-10-26 2014-05-01 Wake Forest University Health Sciences Nouveau greffon à base de nanofibres pour remplacement de valvules cardiaques et procédés pour l'utiliser
CN107405428A (zh) * 2015-03-31 2017-11-28 北卡罗来纳-查佩尔山大学 干细胞的递送载体及其用途
GB2539006A (en) * 2015-06-03 2016-12-07 Ewos Innovation As Functional feed
CN107715178B (zh) * 2017-11-09 2020-10-09 李瑞锋 一种多层含有细胞因子的高强度人工硬脑膜及其制备方法
CN115531613B (zh) * 2022-10-20 2023-11-17 武汉轻工大学 一种多孔支架材料填充的神经移植物导管及制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5762926A (en) * 1988-12-15 1998-06-09 The Regents Of The University Of California Method of grafting genetically modified cells to treat defects, disease or damage of the central nervous system
US20020137706A1 (en) * 2000-07-21 2002-09-26 Evans Gregory R.D. Regulated growth factor delivery for engineered peripheral nerve
US20030027760A1 (en) * 1993-12-23 2003-02-06 Gluckman Peter David Composition and methods to improve neural outcome

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5762926A (en) * 1988-12-15 1998-06-09 The Regents Of The University Of California Method of grafting genetically modified cells to treat defects, disease or damage of the central nervous system
US20030027760A1 (en) * 1993-12-23 2003-02-06 Gluckman Peter David Composition and methods to improve neural outcome
US20020137706A1 (en) * 2000-07-21 2002-09-26 Evans Gregory R.D. Regulated growth factor delivery for engineered peripheral nerve

Also Published As

Publication number Publication date
AU2002330131A1 (en) 2003-04-07
AU2002330131A8 (en) 2003-04-07
WO2003026489A2 (fr) 2003-04-03

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