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WO2003025225A3 - Liaison de genes - Google Patents

Liaison de genes Download PDF

Info

Publication number
WO2003025225A3
WO2003025225A3 PCT/GB2002/004287 GB0204287W WO03025225A3 WO 2003025225 A3 WO2003025225 A3 WO 2003025225A3 GB 0204287 W GB0204287 W GB 0204287W WO 03025225 A3 WO03025225 A3 WO 03025225A3
Authority
WO
WIPO (PCT)
Prior art keywords
pthr1
gene polymorphisms
susceptibility
subject
pthr1 gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2002/004287
Other languages
English (en)
Other versions
WO2003025225A2 (fr
Inventor
Emma L Duncan
Matthew Brown
John A H Wass
Peng Y Woon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxford University Innovation Ltd
Original Assignee
Oxford University Innovation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxford University Innovation Ltd filed Critical Oxford University Innovation Ltd
Priority to AU2002324234A priority Critical patent/AU2002324234A1/en
Publication of WO2003025225A2 publication Critical patent/WO2003025225A2/fr
Publication of WO2003025225A3 publication Critical patent/WO2003025225A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Cette invention porte sur une méthode permettant de diagnostiquer l'existence d'un trouble osseux ou la prédisposition à un tel trouble, laquelle méthode consiste à déterminer si le sujet présente un polymorphisme associé à une faible densité minérale osseuse (DMO) dans le gène récepteur-1 de la parathormone (PTHR1), ce qui permet de détecter la prédisposition du sujet à un trouble osseux.
PCT/GB2002/004287 2001-09-20 2002-09-20 Liaison de genes Ceased WO2003025225A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002324234A AU2002324234A1 (en) 2001-09-20 2002-09-20 Pthr1 gene polymorphisms

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0122730.5A GB0122730D0 (en) 2001-09-20 2001-09-20 Gene Linkakge
GB0122730.5 2001-09-20

Publications (2)

Publication Number Publication Date
WO2003025225A2 WO2003025225A2 (fr) 2003-03-27
WO2003025225A3 true WO2003025225A3 (fr) 2003-12-11

Family

ID=9922432

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2002/004287 Ceased WO2003025225A2 (fr) 2001-09-20 2002-09-20 Liaison de genes

Country Status (3)

Country Link
AU (1) AU2002324234A1 (fr)
GB (1) GB0122730D0 (fr)
WO (1) WO2003025225A2 (fr)

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "New findings for osteoporosis", INTERNET ARTICLE, 4 June 2001 (2001-06-04), pages 1 - 2, XP002252393, Retrieved from the Internet <URL:www.actionresearch.co.uk...a/press/15.45-4.6.101.press.php> [retrieved on 20030820] *
DUNCAN ET AL: "M138: Linkage mapping and mutations screening of the PTHR1 locus in osteoporosis", JOURNAL OF BONE AND MINERAL RESEARCH, vol. 15, September 2000 (2000-09-01), pages S - 491, XP008021032 *
DUNCAN ET AL: "Suggestive linkage of the parathyroid receptor type 1 to osteoporosis", JOURNAL OF BONE AND MINERAL RESEARCH, vol. 14, December 1999 (1999-12-01), pages 1993 - 1999, XP008008389, ISSN: 0884-0431 *
FUJITA: "Parathyroid hormone in the treatment of osteoporosis", BIODRUGS, vol. 15, 2001, pages 721 - 728, XP008012814, ISSN: 1173-8804 *
HOFBAUER ET AL: "Osteoprotegerin: a link between osteoporosis and arterial calcification?", LANCET, vol. 358, 28 July 2001 (2001-07-28), pages 257 - 259, XP004297345, ISSN: 0140-6736 *
MINAGAWA ET AL: "Analysis of the P3 promoter of the human parathyroid hormone (PTH)/PTH-related peptide receptor gene in pseudohypoparathyroidism type 1b*", THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 86, March 2001 (2001-03-01), pages 1394 - 1397, XP002252391 *
MINAGAWA: "Association between AAAG repeat polymorphism in the P3 promoter of the human parathyroid hormone (PTH)/PTH-related peptide receptor gene and adult height, urinary pyridinoline excretion, and promoter activity", THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 87, April 2002 (2002-04-01), pages 1791 - 1796, XP002252392 *
STEWART: "PTHrP(1-36) as a skeletal anabolic agent for the treatment of osteoporosis", BONE, vol. 19, 1996, pages 303 - 306, XP002252498 *

Also Published As

Publication number Publication date
GB0122730D0 (en) 2001-11-14
AU2002324234A1 (en) 2003-04-01
WO2003025225A2 (fr) 2003-03-27

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