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WO2003025162A3 - Regulation of human prolyl 4-hydroxylase alpha subunit precursor - Google Patents

Regulation of human prolyl 4-hydroxylase alpha subunit precursor Download PDF

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Publication number
WO2003025162A3
WO2003025162A3 PCT/EP2002/010515 EP0210515W WO03025162A3 WO 2003025162 A3 WO2003025162 A3 WO 2003025162A3 EP 0210515 W EP0210515 W EP 0210515W WO 03025162 A3 WO03025162 A3 WO 03025162A3
Authority
WO
WIPO (PCT)
Prior art keywords
alpha subunit
subunit precursor
human prolyl
regulation
hydroxylase alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2002/010515
Other languages
French (fr)
Other versions
WO2003025162A2 (en
Inventor
Alex Smolyar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to AU2002333862A priority Critical patent/AU2002333862A1/en
Publication of WO2003025162A2 publication Critical patent/WO2003025162A2/en
Publication of WO2003025162A3 publication Critical patent/WO2003025162A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Reagents that regulate human prolyl 4-hydroxylase alpha subunit precursor and reagents which bind to human prolyl 4-hydroxylase alpha subunit precursor gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, cancer, cardiovascular disorders or COPD.
PCT/EP2002/010515 2001-09-20 2002-09-19 Regulation of human prolyl 4-hydroxylase alpha subunit precursor Ceased WO2003025162A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002333862A AU2002333862A1 (en) 2001-09-20 2002-09-19 Regulation of human prolyl 4-hydroxylase alpha subunit precursor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32330701P 2001-09-20 2001-09-20
US60/323,307 2001-09-20

Publications (2)

Publication Number Publication Date
WO2003025162A2 WO2003025162A2 (en) 2003-03-27
WO2003025162A3 true WO2003025162A3 (en) 2003-09-04

Family

ID=23258624

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/010515 Ceased WO2003025162A2 (en) 2001-09-20 2002-09-19 Regulation of human prolyl 4-hydroxylase alpha subunit precursor

Country Status (2)

Country Link
AU (1) AU2002333862A1 (en)
WO (1) WO2003025162A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112566927A (en) * 2018-08-17 2021-03-26 现代牧场股份有限公司 Fusion proteins and products for hydroxylated amino acids

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999014328A2 (en) * 1997-09-17 1999-03-25 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2001004311A1 (en) * 1999-07-07 2001-01-18 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2001068848A2 (en) * 2000-03-01 2001-09-20 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999014328A2 (en) * 1997-09-17 1999-03-25 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2001004311A1 (en) * 1999-07-07 2001-01-18 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2001068848A2 (en) * 2000-03-01 2001-09-20 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
ANNUNEN PIA ET AL: "Cloning of the human prolyl 4-hydroxylase alpha subunit isoform alpha(II) and characterization of the type II enzyme tetramer: The alpha(I) and alpha(II) subunit do not form a mixed alpha(I) and alpha(II) beta-2 tetramer", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 272, no. 28, 11 July 1997 (1997-07-11), pages 17342 - 17348, XP002172825, ISSN: 0021-9258 *
DATABASE EMBL [online] 12 December 2002 (2002-12-12), XP002232959, retrieved from HOMO SAPIENS Database accession no. AAH35813 *
DATABASE EMBL [online] 20 August 2002 (2002-08-20), XP002232953, Database accession no. BD526596 *
DATABASE EMBL [online] 20 February 2003 (2003-02-20), XP002232954, Database accession no. BD173139 *
DATABASE EMBL [online] 20 February 2003 (2003-02-20), XP002232956, Database accession no. BD173458 *
DATABASE EMBL [online] 20 February 2003 (2003-02-20), XP002232957, Database accession no. BD172501 *
DATABASE EMBL [online] 20 February 2003 (2003-02-20), XP002232958, Database accession no. BD172820 *
DATABASE EMBL [online] 4 September 2002 (2002-09-04), XP002232955, Database accession no. BD075641 *
IVAN MIRCEA ET AL: "Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 99, no. 21, 15 October 2002 (2002-10-15), http://www.pnas.org October 15, 2002, pages 13459 - 13464, XP002232952, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
AU2002333862A1 (en) 2003-04-01
WO2003025162A2 (en) 2003-03-27

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