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WO2003021230A3 - Systeme de mesure electrophysiologique de grande capacite - Google Patents

Systeme de mesure electrophysiologique de grande capacite Download PDF

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Publication number
WO2003021230A3
WO2003021230A3 PCT/US2002/028398 US0228398W WO03021230A3 WO 2003021230 A3 WO2003021230 A3 WO 2003021230A3 US 0228398 W US0228398 W US 0228398W WO 03021230 A3 WO03021230 A3 WO 03021230A3
Authority
WO
WIPO (PCT)
Prior art keywords
samples
measurement system
computer
methods
throughput
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/028398
Other languages
English (en)
Other versions
WO2003021230A2 (fr
Inventor
Kirk S Schroeder
Bradley D Neagle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Essen Instruments Inc
Original Assignee
Essen Instruments Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2002/016122 external-priority patent/WO2002095357A2/fr
Application filed by Essen Instruments Inc filed Critical Essen Instruments Inc
Priority to AU2002343338A priority Critical patent/AU2002343338A1/en
Priority to EP02780275A priority patent/EP1434850A2/fr
Publication of WO2003021230A2 publication Critical patent/WO2003021230A2/fr
Publication of WO2003021230A3 publication Critical patent/WO2003021230A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48728—Investigating individual cells, e.g. by patch clamp, voltage clamp
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1034—Transferring microquantities of liquid

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

Systèmes (dispositif et procédés) permettant d'exécuter des mesures électrophysiologiques sur des échantillons de membranes, dont des cellules vivantes et des fragments de cellule isolés (tels que des organites), et/ou sur des membranes artificielles (par exemple des vésicules). Le dispositif peut comporter un système de mesure de grande capacité et les composants qui s'y rapportent. Ce système de mesure peut comprendre, entre autres choses, (1) une tête fluidique assurant le transfert d'échantillons et/ou d'autre composés vers un substrat de mesure perforé, (2) un système de chambre à pression régulée pour le positionnement d'échantillons sur le substrat et la réalisation ultérieure d'un joint électrique à haute résistance, (3) un système d'activation (sous forme par exemple d'un module d'émission d'ultraviolets à impulsion commandé par ordinateur) activant les composés bloqués, (4) une tête électronique pour l'application et/ou la mesure d'une tension et/ou d'une intensité, et/ou (5) un système d'analyse commandé par ordinateur pour la collecte et/ou l'analyse de données. Ces procédés permettent notamment d'effectuer des mesures élecrophysiologiques à fort rendement sur des transporteurs et/ou sur des canaux ioniques dépendant de la tension ou de ligands, séquentiellement ou simultanément.
PCT/US2002/028398 2001-09-05 2002-09-05 Systeme de mesure electrophysiologique de grande capacite Ceased WO2003021230A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2002343338A AU2002343338A1 (en) 2001-09-05 2002-09-05 High-throughput electrophysiological measurement system
EP02780275A EP1434850A2 (fr) 2001-09-05 2002-09-05 Systeme de mesure electrophysiologique de grande capacite

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US31711201P 2001-09-05 2001-09-05
US60/317,112 2001-09-05
PCT/US2002/016122 WO2002095357A2 (fr) 2001-05-21 2002-05-21 Systeme d'activation chimique rapide pour mesures electrophysiologiques a fort debit
USPCT/US02/16122 2002-05-21
US38319602P 2002-05-22 2002-05-22
US60/383,196 2002-05-22

Publications (2)

Publication Number Publication Date
WO2003021230A2 WO2003021230A2 (fr) 2003-03-13
WO2003021230A3 true WO2003021230A3 (fr) 2003-10-30

Family

ID=27359127

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/028398 Ceased WO2003021230A2 (fr) 2001-09-05 2002-09-05 Systeme de mesure electrophysiologique de grande capacite

Country Status (2)

Country Link
EP (1) EP1434850A2 (fr)
WO (1) WO2003021230A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7067046B2 (en) 2000-08-04 2006-06-27 Essen Instruments, Inc. System for rapid chemical activation in high-throughput electrophysiological measurements

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7514046B2 (en) 2000-10-31 2009-04-07 Caliper Life Sciences, Inc. Methods and systems for processing microscale devices for reuse
AU2003283663A1 (en) * 2002-11-01 2004-05-25 Cellectricon Ab Computer programs,workstations, systems and methods for microfluidic substrates in cell
US20050014288A1 (en) * 2003-07-15 2005-01-20 Amphora Discovery Corporation Motion induced electrical field stimulation
JP4217739B2 (ja) * 2003-08-04 2009-02-04 カリパー・ライフ・サイエンシズ・インク． 再使用のためにマイクロスケールデバイスを処理する方法およびシステム
SE0400421D0 (sv) * 2004-02-23 2004-02-23 Astrazeneca Ab Assay
US9080999B2 (en) * 2011-09-02 2015-07-14 Molecular Devices, Llc Voltage offset correction in high-throughput electrophysiological measurement system
CN108624496B (zh) * 2017-03-23 2022-01-25 洛阳华清天木生物科技有限公司 一种微生物诱变育种仪用样品传送及收集装置
TW202405424A (zh) * 2022-04-19 2024-02-01 美商英福康公司 使用光電離進行過程污染物檢測的分壓力計元件及相關方法

Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4071315A (en) * 1976-06-02 1978-01-31 Guy Chateau Analytical tape medium
US4952518A (en) * 1984-10-01 1990-08-28 Cetus Corporation Automated assay machine and assay tray
US5169600A (en) * 1987-07-15 1992-12-08 Fuji Photo Film Co., Ltd. Biochemical analysis apparatus for incubating and analyzing test sites on a long tape test film
US5262128A (en) * 1989-10-23 1993-11-16 The United States Of America As Represented By The Department Of Health And Human Services Array-type multiple cell injector
US5508200A (en) * 1992-10-19 1996-04-16 Tiffany; Thomas Method and apparatus for conducting multiple chemical assays
US5632957A (en) * 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
US6063260A (en) * 1994-10-28 2000-05-16 Neurosearch A/S Patch clamp apparatus and technique having high throughput and low fluid volume requirements
US6132582A (en) * 1998-09-14 2000-10-17 The Perkin-Elmer Corporation Sample handling system for a multi-channel capillary electrophoresis device
US20010005774A1 (en) * 1999-12-24 2001-06-28 Hirokazu Kato Automatic electrophysiological measuring apparatus / method
US20010005489A1 (en) * 1998-07-02 2001-06-28 Roach David J. Apparatus and method for filling and cleaning channels and inlet ports in microchips used for biological analysis
US6368851B1 (en) * 1998-05-27 2002-04-09 Micronas Gmbh Method and apparatus for measuring a state variable
US6377057B1 (en) * 1999-02-18 2002-04-23 The Board Of Trustees Of The Leland Stanford Junior University Classification of biological agents according to the spectral density signature of evoked changes in cellular electric potential
US6461860B2 (en) * 2001-01-25 2002-10-08 Axon Instruments, Inc. Alignment mechanism for two-electrode voltage-clamp perfusion chamber for electrophysiological testing of oocytes
US6470226B1 (en) * 1997-05-01 2002-10-22 Sophion Bioscience A/S Automatic electrode positioning apparatus
US6488829B1 (en) * 1999-08-05 2002-12-03 Essen Instruments Inc High-throughput electrophysiological measurement apparatus

Patent Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4071315A (en) * 1976-06-02 1978-01-31 Guy Chateau Analytical tape medium
US4952518A (en) * 1984-10-01 1990-08-28 Cetus Corporation Automated assay machine and assay tray
US5169600A (en) * 1987-07-15 1992-12-08 Fuji Photo Film Co., Ltd. Biochemical analysis apparatus for incubating and analyzing test sites on a long tape test film
US5262128A (en) * 1989-10-23 1993-11-16 The United States Of America As Represented By The Department Of Health And Human Services Array-type multiple cell injector
US5508200A (en) * 1992-10-19 1996-04-16 Tiffany; Thomas Method and apparatus for conducting multiple chemical assays
US5632957A (en) * 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
US6063260A (en) * 1994-10-28 2000-05-16 Neurosearch A/S Patch clamp apparatus and technique having high throughput and low fluid volume requirements
US6470226B1 (en) * 1997-05-01 2002-10-22 Sophion Bioscience A/S Automatic electrode positioning apparatus
US6368851B1 (en) * 1998-05-27 2002-04-09 Micronas Gmbh Method and apparatus for measuring a state variable
US20010005489A1 (en) * 1998-07-02 2001-06-28 Roach David J. Apparatus and method for filling and cleaning channels and inlet ports in microchips used for biological analysis
US6132582A (en) * 1998-09-14 2000-10-17 The Perkin-Elmer Corporation Sample handling system for a multi-channel capillary electrophoresis device
US6377057B1 (en) * 1999-02-18 2002-04-23 The Board Of Trustees Of The Leland Stanford Junior University Classification of biological agents according to the spectral density signature of evoked changes in cellular electric potential
US6488829B1 (en) * 1999-08-05 2002-12-03 Essen Instruments Inc High-throughput electrophysiological measurement apparatus
US20010005774A1 (en) * 1999-12-24 2001-06-28 Hirokazu Kato Automatic electrophysiological measuring apparatus / method
US6461860B2 (en) * 2001-01-25 2002-10-08 Axon Instruments, Inc. Alignment mechanism for two-electrode voltage-clamp perfusion chamber for electrophysiological testing of oocytes

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7067046B2 (en) 2000-08-04 2006-06-27 Essen Instruments, Inc. System for rapid chemical activation in high-throughput electrophysiological measurements

Also Published As

Publication number Publication date
EP1434850A2 (fr) 2004-07-07
WO2003021230A2 (fr) 2003-03-13

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