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WO2003021267A3 - Verbesserte massenspektrometrische analyse unter verwendung von nanopartikeln - Google Patents

Verbesserte massenspektrometrische analyse unter verwendung von nanopartikeln Download PDF

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Publication number
WO2003021267A3
WO2003021267A3 PCT/EP2002/009196 EP0209196W WO03021267A3 WO 2003021267 A3 WO2003021267 A3 WO 2003021267A3 EP 0209196 W EP0209196 W EP 0209196W WO 03021267 A3 WO03021267 A3 WO 03021267A3
Authority
WO
WIPO (PCT)
Prior art keywords
nanoparticles
spectrometric analysis
mass spectrometric
improved mass
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2002/009196
Other languages
English (en)
French (fr)
Other versions
WO2003021267A2 (de
Inventor
Juergen Schmucker
Thomas Schiestel
Herwig Brunner
Guenter Tovar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fraunhofer Gesellschaft zur Foerderung der Angewandten Forschung eV
Original Assignee
Fraunhofer Gesellschaft zur Foerderung der Angewandten Forschung eV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fraunhofer Gesellschaft zur Foerderung der Angewandten Forschung eV filed Critical Fraunhofer Gesellschaft zur Foerderung der Angewandten Forschung eV
Priority to JP2003525299A priority Critical patent/JP2005502050A/ja
Priority to US10/488,061 priority patent/US7202472B2/en
Priority to EP02797583A priority patent/EP1425584A2/de
Priority to CA002457945A priority patent/CA2457945A1/en
Publication of WO2003021267A2 publication Critical patent/WO2003021267A2/de
Publication of WO2003021267A3 publication Critical patent/WO2003021267A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/15—Non-radioactive isotope labels, e.g. for detection by mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Nanotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Die vorliegende Erfindung betrifft ein verbessertes Verfahren zur massenspektrometrischen Analyse, insbesondere zur Matrix-unterstützten Laser-Desorptions/Ionisations-Flugzeit-Massenspektrometrie (MALDI-TOF-MS), unter Verwendung von Nanopartikeln, wobei ein Analyt einer Nanopartikelsuspension zugesetzt wird und die den gebundenen Analyten enthaltende Suspension dann direkt auf einem MALDI-Probenträger abgeschieden und massenspektrometrisch untersucht wird, sowie für dieses Verfahren geeignete Nanopartikel.
PCT/EP2002/009196 2001-08-31 2002-08-16 Verbesserte massenspektrometrische analyse unter verwendung von nanopartikeln Ceased WO2003021267A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2003525299A JP2005502050A (ja) 2001-08-31 2002-08-16 ナノ粒子の使用下での改善された質量スペクトル分析
US10/488,061 US7202472B2 (en) 2001-08-31 2002-08-16 Mass spectrometric analysis using nanoparticles
EP02797583A EP1425584A2 (de) 2001-08-31 2002-08-16 Verbesserte massenspektrometrische analyse unter verwendung von nanopartikeln
CA002457945A CA2457945A1 (en) 2001-08-31 2002-08-16 Improved mass spectrometric analysis using nanoparticles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10144250A DE10144250A1 (de) 2001-08-31 2001-08-31 Verbesserte massenspektrometrische Analyse unter Verwendung von Nanopartikeln
DE10144250.5 2001-08-31

Publications (2)

Publication Number Publication Date
WO2003021267A2 WO2003021267A2 (de) 2003-03-13
WO2003021267A3 true WO2003021267A3 (de) 2003-12-18

Family

ID=7698298

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/009196 Ceased WO2003021267A2 (de) 2001-08-31 2002-08-16 Verbesserte massenspektrometrische analyse unter verwendung von nanopartikeln

Country Status (6)

Country Link
US (1) US7202472B2 (de)
EP (1) EP1425584A2 (de)
JP (1) JP2005502050A (de)
CA (1) CA2457945A1 (de)
DE (1) DE10144250A1 (de)
WO (1) WO2003021267A2 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101688847B (zh) * 2007-06-27 2013-12-25 国立大学法人东京大学 Maldi质谱分析用的试样架及质谱分析方法

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10191028B1 (en) * 2003-06-06 2019-01-29 Ionwerks Inorganic nanoparticle matrices for sample analysis
WO2005065307A2 (en) * 2003-12-31 2005-07-21 Ionwerks, Inc. Maldi-im-ortho-tof mass spectrometry with simultaneaous positive and negative mode detection
DE102004007005A1 (de) * 2004-02-12 2005-09-08 Bruker Daltonik Gmbh Massenspektrometrische Häufigkeitsbestimmungen von Proteinen
EP1830184B1 (de) * 2004-10-29 2010-12-15 Japan Science and Technology Agency Substrat für maldi-tof-ms und massenspektrometrisches verfahren unter verwendung davon
JP3855171B2 (ja) * 2005-01-07 2006-12-06 独立行政法人理化学研究所 Ｍａｌｄｉ質量分析用試料の調製方法及びそのための試薬組成物
JP2008147165A (ja) * 2006-10-30 2008-06-26 National Sun Yat-Sen Univ レーザー脱離装置、マススペクトロメーター組立及び環境液体マススペクトロメトリー法
JP4984900B2 (ja) * 2007-01-12 2012-07-25 株式会社島津製作所 ポリマー被覆微粒子を用いる質量分析法
DE602008000878D1 (de) * 2008-07-15 2010-05-06 Atotech Deutschland Gmbh Lösung und Verfahren zur elektrochemischen Abscheidung eines Metalls auf ein Substrat
JP5540102B2 (ja) 2009-10-12 2014-07-02 ベンタナ メディカル システムズ， インコーポレイテッド 高められた病理学的決定のための複数モダリティコントラストおよび明視野コンテキスト表現、および組織内の複数検体検出
US8610058B2 (en) 2010-11-03 2013-12-17 University Of North Texas Silver and silver nanoparticle MALDI matrix utilizing online soft landing ion mobility
US9171710B2 (en) 2013-09-16 2015-10-27 The Board Of Trustees Of The University Of Alabama Mass spectrometric analysis using nanoparticle matrices
WO2015148721A1 (en) * 2014-03-26 2015-10-01 Li-Cor, Inc. Laser desorption ionization mass spectrometry using a particulate separation bed
US11287407B2 (en) 2015-10-19 2022-03-29 University Of North Texas Dynamic reverse gas stack model for portable chemical detection devices to locate threat and point-of-source from effluent streams
JP6685587B2 (ja) * 2015-12-07 2020-04-22 国立大学法人福島大学 質量分析用イオン化支援剤及びこれを使用した質量分析方法
WO2018151930A1 (en) * 2017-02-17 2018-08-23 The Methodist Hospital Compositions and methods of determining a level of infection in a subject
EP3631442B1 (de) * 2017-05-30 2025-05-21 Polymer Factory Sweden AB Funktionalisierte kalibriermittel für spektrometrie und chromatographie
CN109001291A (zh) * 2018-08-01 2018-12-14 清华大学 一种基于纳米金属粒子辅助低温等离子体质谱检测方法
CN111175369B (zh) * 2020-02-24 2023-02-03 陕西师范大学 一种用于小分子检测的maldi-tof ms基质及其应用
CN111380943A (zh) * 2020-03-13 2020-07-07 中国原子能科学研究院 一种核燃料后处理流程大量铀中微量镎含量的分析方法
CN114324557B (zh) * 2021-12-03 2024-05-10 融智生物科技（青岛）有限公司 一种基于MALDI-TOF MS的ζ-珠蛋白的检测方法
DE112023002587T5 (de) * 2022-06-09 2025-04-10 Elemental Scientific, Inc. Automatisierte inline-zugabe von nanopartikelstandardmaterial
CN116559269B (zh) * 2023-04-21 2025-08-12 山西医科大学 一种双官能团修饰的水溶性黑色素纳米颗粒的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996029431A2 (en) * 1995-03-17 1996-09-26 Sequenom, Inc. Dna diagnostics based on mass spectrometry
US5922537A (en) * 1996-11-08 1999-07-13 N.o slashed.AB Immunoassay, Inc. Nanoparticles biosensor
US6056877A (en) * 1997-12-05 2000-05-02 Transgenomic, Inc. Non-polar media for polynucleotide separations

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7225082B1 (en) 1999-10-01 2007-05-29 Oxonica, Inc. Colloidal rod particles as nanobar codes
WO2004001019A2 (en) * 2002-02-01 2003-12-31 Montana State University Novel nanoparticles and use thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996029431A2 (en) * 1995-03-17 1996-09-26 Sequenom, Inc. Dna diagnostics based on mass spectrometry
US6277573B1 (en) * 1995-03-17 2001-08-21 Sequenom, Inc. DNA diagnostics based on mass spectrometry
US5922537A (en) * 1996-11-08 1999-07-13 N.o slashed.AB Immunoassay, Inc. Nanoparticles biosensor
US6056877A (en) * 1997-12-05 2000-05-02 Transgenomic, Inc. Non-polar media for polynucleotide separations

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101688847B (zh) * 2007-06-27 2013-12-25 国立大学法人东京大学 Maldi质谱分析用的试样架及质谱分析方法

Also Published As

Publication number Publication date
US20050037516A1 (en) 2005-02-17
WO2003021267A2 (de) 2003-03-13
DE10144250A1 (de) 2003-04-03
US7202472B2 (en) 2007-04-10
EP1425584A2 (de) 2004-06-09
CA2457945A1 (en) 2003-03-13
JP2005502050A (ja) 2005-01-20

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