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WO2003020769A1 - Pemphigus monoclonal antibody - Google Patents

Pemphigus monoclonal antibody Download PDF

Info

Publication number
WO2003020769A1
WO2003020769A1 PCT/JP2002/008987 JP0208987W WO03020769A1 WO 2003020769 A1 WO2003020769 A1 WO 2003020769A1 JP 0208987 W JP0208987 W JP 0208987W WO 03020769 A1 WO03020769 A1 WO 03020769A1
Authority
WO
WIPO (PCT)
Prior art keywords
pemphigus
monoclonal antibody
model mouse
inducing
constructed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2002/008987
Other languages
English (en)
French (fr)
Inventor
Kazuyuki Tsunoda
Masayuki Amagai
Takeji Nishikawa
Shigeo Koyasu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Keio University
Original Assignee
Keio University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Keio University filed Critical Keio University
Priority to US10/488,673 priority Critical patent/US7550562B2/en
Priority to JP2003525039A priority patent/JP3817587B2/ja
Publication of WO2003020769A1 publication Critical patent/WO2003020769A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
PCT/JP2002/008987 2001-09-04 2002-09-04 Pemphigus monoclonal antibody Ceased WO2003020769A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US10/488,673 US7550562B2 (en) 2001-09-04 2002-09-04 Pemphigus monoclonal antibody
JP2003525039A JP3817587B2 (ja) 2001-09-04 2002-09-04 天疱瘡モノクローナル抗体

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001267653 2001-09-04
JP2001-267653 2001-09-04

Publications (1)

Publication Number Publication Date
WO2003020769A1 true WO2003020769A1 (en) 2003-03-13

Family

ID=19093756

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/008987 Ceased WO2003020769A1 (en) 2001-09-04 2002-09-04 Pemphigus monoclonal antibody

Country Status (3)

Country Link
US (1) US7550562B2 (ja)
JP (1) JP3817587B2 (ja)
WO (1) WO2003020769A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008020586A1 (fr) 2006-08-14 2008-02-21 Forerunner Pharma Research Co., Ltd. diagnostic et traitement du cancer à l'aide de l'anticorps anti-desmogléine-3

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7029365B2 (en) * 2000-02-17 2006-04-18 Applied Materials Inc. Pad assembly for electrochemical mechanical processing
US8298545B2 (en) * 2007-02-07 2012-10-30 The Trustees Of The University Of Pennsylvania Anti-autoimmune antibodies for treatment of pemphigus
WO2015168613A2 (en) 2014-05-02 2015-11-05 The Trustees Of The University Of Pennsylvania Compositions and methods of chimeric autoantibody receptor t cells
RU2613718C1 (ru) * 2015-11-24 2017-03-21 Федеральное государственное бюджетное учреждение "Государственный научный центр дерматовенерологии и косметологии" Минздрава России (ФГБУ ГНЦДК Минздрава России) Способ моделирования пузырчатки у мышей методом введения иммуноглобулинов класса g
WO2021168734A1 (zh) * 2020-02-27 2021-09-02 世延生医股份有限公司 基质金属蛋白酶1的单克隆抗体、其检测试剂盒及其检测方法
RU2770444C1 (ru) * 2021-05-27 2022-04-18 Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) Рекомбинантные белки-антигены и способ определения эпитопной специфичности аутореактивных антител к отдельным фрагментам экстрацеллюлярного домена десмоглеина 3-го типа человека у больных обыкновенной пузырчаткой, тест-система на их основе
EP4223781A1 (en) * 2022-02-04 2023-08-09 Philipps-Universität Marburg Novel desmoglein 3 (dsg3)-ec5-specific monoclonal antibody 2g4

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08188540A (ja) * 1994-06-30 1996-07-23 Takeji Nishikawa 尋常性天疱瘡患者自己抗体に認識される融合蛋白質、並びに尋常性天疱瘡の治療薬、治療器具、診断剤及び診断方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08188540A (ja) * 1994-06-30 1996-07-23 Takeji Nishikawa 尋常性天疱瘡患者自己抗体に認識される融合蛋白質、並びに尋常性天疱瘡の治療薬、治療器具、診断剤及び診断方法

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
AMAGAI M. ET AL.: "Antibodies against desmoglein 3 (pemphigus vulgaris antigen) are present in sera from patients with paraneoplastic pemphigus and cause acantholysis in vivo in neonatal mice", J. CLIN. INVEST., vol. 102, no. 4, 1998, pages 775 - 782, XP002904797 *
AMAGAI M. ET AL.: "Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion", CELL, vol. 67, no. 5, 1991, pages 869 - 877, XP002904798 *
AMAGAI M. ET AL.: "Use of autoantigen-knockout mice in developing an active autoimmune disease model for pemphigus", J. CLIN. INVEST., vol. 105, no. 5, 2000, pages 625 - 631, XP002946608 *
FUTEI Y. ET AL.: "Use of domain-swapped molecules for conformational epitope mapping of desmoglein 3 in pemphigus vulgaris", J. INVEST. DERMATOL., vol. 115, no. 5, 2000, pages 829 - 834, XP002983502 *
ISHIKAWA H. ET AL.: "Molecular cloning of the mouse desmoglein 3 gene (Dsg3): genomic structure and homology with the human gene", J. INVEST. DERMATOL., vol. 106, no. 4, 1996, pages 848, XP002983501 *
OHYAMA M. ET AL.: "Immunologic and histopathologic characterization of active disease model mouse for pemphigus vulgaris", J. INVEST. DERMATOL., vol. 117, no. 2, August 2001 (2001-08-01), pages 459, XP002904800 *
TSUNODA K. ET AL.: "A pathogenic antidesmoglein 3 monoclonal antibody recognizes the N-terminal adhesive region of desmoglein 3", J. INVEST. DERMATOL., vol. 119, no. 1, July 2002 (2002-07-01), pages 228, XP002904799 *
TSUNODA K. ET AL.: "Development of anti-desmoglein 2 (Dsg3) pathogenic monoclonal antibody using active disease mouse model for pemphigus vulgaris (PV)", J. INVEST. DERMATOL., vol. 117, no. 2, August 2001 (2001-08-01), pages 394, XP002961049 *
TSUNODA K. ET AL.: "Production of anti-desmoglein 3 mouse monoclonal antibodies using active disease mouse model for pemphigus", J. INVEST. DERMATOL., vol. 114, no. 4, 2000, pages 846, XP002904796 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008020586A1 (fr) 2006-08-14 2008-02-21 Forerunner Pharma Research Co., Ltd. diagnostic et traitement du cancer à l'aide de l'anticorps anti-desmogléine-3
EP2548576A1 (en) 2006-08-14 2013-01-23 Forerunner Pharma Research Co., Ltd. Diagnosis of cancer using anti-desmoglein-3 antibodies
EP3111955A1 (en) 2006-08-14 2017-01-04 Chugai Seiyaku Kabushiki Kaisha Diagnosis and treatment of cancer using anti-desmoglein-3 antibody
US10696743B2 (en) 2006-08-14 2020-06-30 Chugai Seiyaku Kabushiki Kaisha Diagnosis and treatment of cancer using anti-desmoglein-3 antibodies

Also Published As

Publication number Publication date
US7550562B2 (en) 2009-06-23
US20050025760A1 (en) 2005-02-03
JPWO2003020769A1 (ja) 2005-02-03
JP3817587B2 (ja) 2006-09-06

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