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WO2003020699A3 - Tyrosine kinase inhibitors - Google Patents

Tyrosine kinase inhibitors Download PDF

Info

Publication number
WO2003020699A3
WO2003020699A3 PCT/US2002/027114 US0227114W WO03020699A3 WO 2003020699 A3 WO2003020699 A3 WO 2003020699A3 US 0227114 W US0227114 W US 0227114W WO 03020699 A3 WO03020699 A3 WO 03020699A3
Authority
WO
WIPO (PCT)
Prior art keywords
tyrosine kinase
kinase inhibitors
compounds
angiogenesis
atherosclerosis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/027114
Other languages
French (fr)
Other versions
WO2003020699A2 (en
Inventor
Jennifer P Peckham
William F Hoffman
Kenneth L Arrington
Mark E Fraley
George D Hartman
Yuntae Kim
Barbara Hanney
Keith L Spencer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Priority to AU2002323406A priority Critical patent/AU2002323406A1/en
Priority to US10/487,589 priority patent/US7186723B2/en
Publication of WO2003020699A2 publication Critical patent/WO2003020699A2/en
Publication of WO2003020699A3 publication Critical patent/WO2003020699A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.
PCT/US2002/027114 2001-08-30 2002-08-26 Tyrosine kinase inhibitors Ceased WO2003020699A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2002323406A AU2002323406A1 (en) 2001-08-30 2002-08-26 Tyrosine kinase inhibitors
US10/487,589 US7186723B2 (en) 2001-08-30 2002-08-26 Tyrosine kinase inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31612301P 2001-08-30 2001-08-30
US60/316,123 2001-08-30

Publications (2)

Publication Number Publication Date
WO2003020699A2 WO2003020699A2 (en) 2003-03-13
WO2003020699A3 true WO2003020699A3 (en) 2003-05-22

Family

ID=23227566

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/027114 Ceased WO2003020699A2 (en) 2001-08-30 2002-08-26 Tyrosine kinase inhibitors

Country Status (3)

Country Link
US (1) US7186723B2 (en)
AU (1) AU2002323406A1 (en)
WO (1) WO2003020699A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2365588C2 (en) 2002-02-01 2009-08-27 Астразенека Аб Quinazoline compounds
CL2004001120A1 (en) * 2003-05-19 2005-04-15 Irm Llc COMPOUNDS DERIVED FROM AMINA REPLACED WITH HETEROCICLES, IMMUNOSUPPRESSORS; PHARMACEUTICAL COMPOSITION; AND USE TO TREAT DISEASES MEDIATED BY LYMPHOCYTE INTERACTIONS, SUCH AS AUTOIMMUNE, INFLAMMATORY, INFECTIOUS, CANCER DISEASES.
JP2005306839A (en) * 2003-08-29 2005-11-04 Takeda Chem Ind Ltd Bicyclic piperazine compound and its use
EP1661898A4 (en) 2003-08-29 2009-04-15 Takeda Pharmaceutical BICYCLIC PIPERAZINE COMPOUND AND USE THEREOF
CA2595290C (en) * 2005-01-19 2013-06-25 Mgi Gp, Inc. Diazabenzo[de]anthracen-3-one compounds and methods for inhibiting parp
US20090215857A1 (en) * 2005-09-13 2009-08-27 Pfizer Products Inc. Therapeutic Pyrrolidines
US20080051380A1 (en) 2006-08-25 2008-02-28 Auerbach Alan H Methods and compositions for treating cancer
US8642067B2 (en) 2007-04-02 2014-02-04 Allergen, Inc. Methods and compositions for intraocular administration to treat ocular conditions
CA2738929A1 (en) * 2008-10-17 2010-04-22 Boehringer Ingelheim International Gmbh Heteroaryl substituted indole compounds useful as mmp-13 inhibitors
CA2756870A1 (en) 2009-03-31 2010-10-07 Arqule, Inc. Substituted indolo-pyridinone compounds
LT3490560T (en) 2016-07-29 2025-02-25 Janssen Pharmaceutica, N.V. A METHOD FOR TREATING PROSTATE CANCER USING NIRAPARIB
TW201927777A (en) * 2017-12-19 2019-07-16 大陸商基石藥業（蘇州）有限公司 IDO inhibitor
CN114805204B (en) * 2022-04-01 2023-09-15 云南师范大学 A method for preparing 4-iodoisoquinoline-1(2H)-one compounds
CN115160211B (en) * 2022-06-23 2023-11-03 温州大学 Green synthesis method of isoindolinone compound

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001029025A2 (en) * 1999-10-19 2001-04-26 Merck & Co., Inc. Tyrosine kinase inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001029025A2 (en) * 1999-10-19 2001-04-26 Merck & Co., Inc. Tyrosine kinase inhibitors

Also Published As

Publication number Publication date
AU2002323406A1 (en) 2003-03-18
US7186723B2 (en) 2007-03-06
US20040235826A1 (en) 2004-11-25
WO2003020699A2 (en) 2003-03-13

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