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WO2003018742A3 - Recombinant l-asparaginase erwinia caratovora - Google Patents

Recombinant l-asparaginase erwinia caratovora Download PDF

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Publication number
WO2003018742A3
WO2003018742A3 PCT/RU2002/000405 RU0200405W WO03018742A3 WO 2003018742 A3 WO2003018742 A3 WO 2003018742A3 RU 0200405 W RU0200405 W RU 0200405W WO 03018742 A3 WO03018742 A3 WO 03018742A3
Authority
WO
WIPO (PCT)
Prior art keywords
recombinant
erwinia caratovora
asparaginase
asparaginase erwinia
caratovora
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/RU2002/000405
Other languages
French (fr)
Russian (ru)
Other versions
WO2003018742A2 (en
Inventor
Mikhail Anatolevich Eldarov
Aleksandr Aleksandrovich Zhgun
Yury Viktorovich Gervaziev
Svetlana Serebedz Aleksandrova
Vladimir Georgievich Bogush
Konstantin Vasilevich Sidoruk
Elena Vasilevna Sveshnikova
Anna Arkadevna Borisova
Natalya Mikhailovna Omelnyuk
Aleksandr Ivanovich Archakov
Konstantin Georgievic Skryabin
Nikolai Nikolaevich Sokolov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GOSUDARSTVENNOE UCHREZHDENIE NAUCHNO-ISSLEDOVATELSKY INSTITUT BIOMEDITSINSKOY KHIMII IM OREKHOVICHA ROSSIISKOY AKADEMII MEDITSINSKIKH NAUK
GOSUDARSTVENNOE UCHREZHDENIE TSENTR "BIOINZHENERIYA" ROSSIISKOY AKADEMII NAUK
G UCHREZHDENIE NII BIOMEDITSIN
G UCHREZHDENIE TS BIOINZHENERI
Original Assignee
GOSUDARSTVENNOE UCHREZHDENIE NAUCHNO-ISSLEDOVATELSKY INSTITUT BIOMEDITSINSKOY KHIMII IM OREKHOVICHA ROSSIISKOY AKADEMII MEDITSINSKIKH NAUK
GOSUDARSTVENNOE UCHREZHDENIE TSENTR "BIOINZHENERIYA" ROSSIISKOY AKADEMII NAUK
G UCHREZHDENIE NII BIOMEDITSIN
G UCHREZHDENIE TS BIOINZHENERI
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from RU2001123442/13A external-priority patent/RU2221868C2/en
Priority claimed from RU2002108505/13A external-priority patent/RU2224797C2/en
Application filed by GOSUDARSTVENNOE UCHREZHDENIE NAUCHNO-ISSLEDOVATELSKY INSTITUT BIOMEDITSINSKOY KHIMII IM OREKHOVICHA ROSSIISKOY AKADEMII MEDITSINSKIKH NAUK, GOSUDARSTVENNOE UCHREZHDENIE TSENTR "BIOINZHENERIYA" ROSSIISKOY AKADEMII NAUK, G UCHREZHDENIE NII BIOMEDITSIN, G UCHREZHDENIE TS BIOINZHENERI filed Critical GOSUDARSTVENNOE UCHREZHDENIE NAUCHNO-ISSLEDOVATELSKY INSTITUT BIOMEDITSINSKOY KHIMII IM OREKHOVICHA ROSSIISKOY AKADEMII MEDITSINSKIKH NAUK
Priority to AU2002332371A priority Critical patent/AU2002332371A1/en
Publication of WO2003018742A2 publication Critical patent/WO2003018742A2/en
Publication of WO2003018742A3 publication Critical patent/WO2003018742A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C12N9/82—Asparaginase (3.5.1.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to the secretion of the Okazaki fragment which codes L-asparaginase of the Erwinia caratovora bacterium. Said invention makes it possible to produce a homogenous polypeptide preparation corresponding to the recombinant Erwinia caratovora L- asparaginase secreted by using a bacterial strain-producer.
PCT/RU2002/000405 2001-08-22 2002-08-21 Recombinant l-asparaginase erwinia caratovora Ceased WO2003018742A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002332371A AU2002332371A1 (en) 2001-08-22 2002-08-21 Recombinant l-asparaginase less thanigreater thanerwinia caratovoraless than/igreater than

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
RU2001123442/13A RU2221868C2 (en) 2001-08-22 2001-08-22 Gene encoding l-asparaginase in erwinia carotovora and strain escherichia coli vkpm = b-8174 as producer of erwinia caratovora l-asparaginase
RU2001123442 2001-08-22
RU2002108505/13A RU2224797C2 (en) 2002-04-04 2002-04-04 Recombinant plasmid dna pacyclans for transfer and expression gene encoding erwinia carotovora (ecar-lans) l-asparaginase in escherichia coli cells and method for preparing recombinant ecar-lans from biomass of escherichia coli producer strains
RU2002108505 2002-04-04

Publications (2)

Publication Number Publication Date
WO2003018742A2 WO2003018742A2 (en) 2003-03-06
WO2003018742A3 true WO2003018742A3 (en) 2003-08-07

Family

ID=26654092

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RU2002/000405 Ceased WO2003018742A2 (en) 2001-08-22 2002-08-21 Recombinant l-asparaginase erwinia caratovora

Country Status (2)

Country Link
AU (1) AU2002332371A1 (en)
WO (1) WO2003018742A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011003633A1 (en) 2009-07-06 2011-01-13 Alize Pharma Ii Pegylated l-asparaginase
US10174302B1 (en) 2017-06-21 2019-01-08 Xl-Protein Gmbh Modified L-asparaginase
CN110256535B (en) * 2019-06-14 2021-01-01 中国石油大学(华东) L-asparaginase XiDL and coding gene and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0226473A2 (en) * 1985-12-13 1987-06-24 THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce Process for manufacture of L-asparaginase from erwinia carotovora
EP0211639B1 (en) * 1985-08-06 1993-12-29 The Public Health Laboratory Service Board Production of L-asparaginase
US6251388B1 (en) * 1997-06-09 2001-06-26 Childrens Hospital Los Angeles Utilization of Wolinella succinogenes asparaginase to treat diseases associated with asparagine dependence

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0211639B1 (en) * 1985-08-06 1993-12-29 The Public Health Laboratory Service Board Production of L-asparaginase
EP0226473A2 (en) * 1985-12-13 1987-06-24 THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce Process for manufacture of L-asparaginase from erwinia carotovora
US6251388B1 (en) * 1997-06-09 2001-06-26 Childrens Hospital Los Angeles Utilization of Wolinella succinogenes asparaginase to treat diseases associated with asparagine dependence

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GILBERT HARRY J. ET AL.: "Cloning and expression of the Erwinia chrysanthemi asparaginase gene in escherichia coli and Erwinia carotovora", THE JOURNAL OF GENERAL MICROBIOLOGY, vol. 132, no. PART 1, 1986, pages 150 - 160 *

Also Published As

Publication number Publication date
AU2002332371A1 (en) 2003-03-10
WO2003018742A2 (en) 2003-03-06

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