[go: up one dir, main page]

WO2003018690A1 - Composition containing fine particles for supporting biologically active substance thereon or having the same supported thereon and method for preparing these - Google Patents

Composition containing fine particles for supporting biologically active substance thereon or having the same supported thereon and method for preparing these Download PDF

Info

Publication number
WO2003018690A1
WO2003018690A1 PCT/JP2002/008619 JP0208619W WO03018690A1 WO 2003018690 A1 WO2003018690 A1 WO 2003018690A1 JP 0208619 W JP0208619 W JP 0208619W WO 03018690 A1 WO03018690 A1 WO 03018690A1
Authority
WO
WIPO (PCT)
Prior art keywords
active substance
biologically active
preparing
supporting
fine particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2002/008619
Other languages
English (en)
French (fr)
Inventor
Kazunori Kataoka
Yoshinori Kakizawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Todai TLO Ltd
Original Assignee
Todai TLO Ltd
Center for Advanced Science and Technology Incubation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2001560747A priority Critical patent/JP2003523544A/ja
Application filed by Todai TLO Ltd, Center for Advanced Science and Technology Incubation Ltd filed Critical Todai TLO Ltd
Priority to US10/487,713 priority patent/US7897176B2/en
Priority to EP02796357A priority patent/EP1431347B1/en
Priority to CA002458837A priority patent/CA2458837C/en
Priority to JP2003523544A priority patent/JP4641721B2/ja
Priority to DE60228742T priority patent/DE60228742D1/de
Publication of WO2003018690A1 publication Critical patent/WO2003018690A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
    • A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
    • A61K47/6935—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being obtained otherwise than by reactions involving carbon to carbon unsaturated bonds, e.g. polyesters, polyamides or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nanotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Dry Development In Electrophotography (AREA)
  • Electrophotography Configuration And Component (AREA)
PCT/JP2002/008619 2000-02-17 2002-08-27 Composition containing fine particles for supporting biologically active substance thereon or having the same supported thereon and method for preparing these Ceased WO2003018690A1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2001560747A JP2003523544A (ja) 2000-02-17 2001-02-14 導電性駆動ハブを備えたトナーカートリッジ
US10/487,713 US7897176B2 (en) 2001-08-27 2002-08-27 Composition containing fine particles for supporting biologically active substance thereon or having the same supported thereon and method for preparing these
EP02796357A EP1431347B1 (en) 2001-08-27 2002-08-27 Composition containing fine particles as carriers for biologically active substance and method for preparing these
CA002458837A CA2458837C (en) 2001-08-27 2002-08-27 Composition containing fine particles for carrying biologically active substance thereon or having the same carried thereon and method for preparing them
JP2003523544A JP4641721B2 (ja) 2001-08-27 2002-08-27 生物活性物質を担持するためのもしくは担持した微小粒子を含む組成物、ならびにそれらの調製方法
DE60228742T DE60228742D1 (de) 2001-08-27 2002-08-27 Zusammensetzung, enthaltend feine teilchen als träger von biologischen wirkstoffen, und herstellungsverfahren dafür

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001-256125 2001-08-27
JP2001256125 2001-08-27

Publications (1)

Publication Number Publication Date
WO2003018690A1 true WO2003018690A1 (en) 2003-03-06

Family

ID=19083982

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/008619 Ceased WO2003018690A1 (en) 2000-02-17 2002-08-27 Composition containing fine particles for supporting biologically active substance thereon or having the same supported thereon and method for preparing these

Country Status (7)

Country Link
US (1) US7897176B2 (ja)
EP (1) EP1431347B1 (ja)
JP (2) JP2003523544A (ja)
AT (1) ATE406917T1 (ja)
CA (1) CA2458837C (ja)
DE (1) DE60228742D1 (ja)
WO (1) WO2003018690A1 (ja)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003083478A1 (en) * 2002-04-03 2003-10-09 Japan Science And Technology Agency Biochip sensor surface carrying polyethylene glycolated nanoparticles
WO2007116965A1 (ja) * 2006-04-12 2007-10-18 Toray Industries, Inc. グラフトポリマーとカルシウム化合物とを含む微粒子
WO2008065738A1 (fr) * 2006-11-11 2008-06-05 The University Of Tokyo Charge de compensation de défauts osseux, porteur à libération contrôlée et leurs méthodes de production
WO2008068939A1 (ja) * 2006-12-07 2008-06-12 Japan Science And Technology Agency 造影剤含有有機－無機ハイブリッド型粒子
WO2009057812A1 (ja) * 2007-10-29 2009-05-07 The University Of Tokyo ポリエチレングリコールの結合した核酸のコンジュゲートとリン酸力ルシウムの有機一無機ハイブリッド型ナノ粒子
WO2009093713A1 (ja) * 2008-01-25 2009-07-30 Ebara Corporation ペグ修飾ハイドロキシアパタイト及びそれを基材とする医薬とその製造方法
JP2010524964A (ja) * 2007-04-17 2010-07-22 バクスター・インターナショナル・インコーポレイテッド 肺送達のための核酸微小粒子

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8309134B2 (en) * 2008-10-03 2012-11-13 Southwest Research Institute Modified calcium phosphate nanoparticle formation
EP2457588A1 (en) 2010-11-05 2012-05-30 UMC Utrecht Holding B.V. Microsphere comprising a lanthanide metal complex
CN113908137B (zh) * 2021-10-27 2023-04-11 高州市人民医院 一种注射用硬核软膜型纳米缓释递药系统的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0517111A (ja) * 1991-02-21 1993-01-26 Ricoh Co Ltd 水酸アパタイト超微粒子

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5368869A (en) * 1993-03-09 1994-11-29 Utah State University Foundation Compositions and methods for manufacturing a skim or lowfat milk product with increased creaminess, color, mouthfeel, and taste sensations similar to milk with a higher fat content
US6436386B1 (en) * 2000-11-14 2002-08-20 Shearwater Corporation Hydroxyapatite-targeting poly (ethylene glycol) and related polymers
US6939564B2 (en) 2001-06-08 2005-09-06 Labopharm, Inc. Water-soluble stabilized self-assembled polyelectrolytes
US7094810B2 (en) 2001-06-08 2006-08-22 Labopharm, Inc. pH-sensitive block copolymers for pharmaceutical compositions
KR100566911B1 (ko) 2001-06-25 2006-04-03 주식회사 삼양사 약물 전달체용 음이온기-함유 양친성 블록 공중합체 및 그의 양이온성 약물과의 복합체

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0517111A (ja) * 1991-02-21 1993-01-26 Ricoh Co Ltd 水酸アパタイト超微粒子

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YASUNORI KAKIZAWA ET AL.: "Block kyojugotai to DNA kara naru jiko soshikika ryushi no sosei to sono saibonai DNA donyu system eno tenkai", POLYMER PREPRINTS, JAPAN, vol. 50, no. 14, 28 August 2001 (2001-08-28), pages 3818 - 3819, XP002960225 *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003083478A1 (en) * 2002-04-03 2003-10-09 Japan Science And Technology Agency Biochip sensor surface carrying polyethylene glycolated nanoparticles
WO2007116965A1 (ja) * 2006-04-12 2007-10-18 Toray Industries, Inc. グラフトポリマーとカルシウム化合物とを含む微粒子
WO2008065738A1 (fr) * 2006-11-11 2008-06-05 The University Of Tokyo Charge de compensation de défauts osseux, porteur à libération contrôlée et leurs méthodes de production
JP5405119B2 (ja) * 2006-11-11 2014-02-05 株式会社ネクスト２１ 骨補填剤，放出制御担体，及びそれらの製造方法
WO2008068939A1 (ja) * 2006-12-07 2008-06-12 Japan Science And Technology Agency 造影剤含有有機－無機ハイブリッド型粒子
JP2008143805A (ja) * 2006-12-07 2008-06-26 Japan Science & Technology Agency 造影剤含有有機−無機ハイブリッド型粒子
US8871180B2 (en) 2006-12-07 2014-10-28 Japan Science And Technology Agency Organic-inorganic hybrid particles containing contrast agent
JP2010524964A (ja) * 2007-04-17 2010-07-22 バクスター・インターナショナル・インコーポレイテッド 肺送達のための核酸微小粒子
WO2009057812A1 (ja) * 2007-10-29 2009-05-07 The University Of Tokyo ポリエチレングリコールの結合した核酸のコンジュゲートとリン酸力ルシウムの有機一無機ハイブリッド型ナノ粒子
WO2009093713A1 (ja) * 2008-01-25 2009-07-30 Ebara Corporation ペグ修飾ハイドロキシアパタイト及びそれを基材とする医薬とその製造方法

Also Published As

Publication number Publication date
EP1431347A1 (en) 2004-06-23
US20040197360A1 (en) 2004-10-07
JP2003523544A (ja) 2003-08-05
JPWO2003018690A1 (ja) 2004-12-09
ATE406917T1 (de) 2008-09-15
CA2458837A1 (en) 2003-03-06
US7897176B2 (en) 2011-03-01
JP4641721B2 (ja) 2011-03-02
DE60228742D1 (de) 2008-10-16
EP1431347B1 (en) 2008-09-03
CA2458837C (en) 2009-12-15
EP1431347A4 (en) 2006-08-30

Similar Documents

Publication Publication Date Title
WO2002087001A3 (en) Polymer electrolyte membrane
IT1262934B (it) Componenti e catalizzatori per la polimerizzazione di olefine
WO2003018690A1 (en) Composition containing fine particles for supporting biologically active substance thereon or having the same supported thereon and method for preparing these
EP1829530A3 (en) Stabilization of active agents by formulation into nanoparticulate form
AU4950997A (en) Method for preparing malonate methylidene nanoparticles, nanoparticles optionally containing one or several biologically active molecules
AU7779900A (en) Trifluoromethyl-substituted spirocyclic ketoenols
ATE271857T1 (de) Antibiotikum-/antibiotika-polymer-kombination mit retardierender wirkstofffreisetzung
CA2335270A1 (en) Electrochromic media with concentration-enhanced stability, process for the preparation thereof and use in electrochromic devices
EP1689425B8 (fr) Formulations pharmaceutiques pour la libération prolongée de principe(s) actif(s), ainsi que leurs applications notamment therapeutiques
WO2005032511A3 (en) Nanoparticulate therapeutic biologically active agents
WO2002080883A3 (en) Method and composition for solubilising a biologically active compound with low water solubility
CA2326756A1 (en) Pharmaceutical compositions containing compounds with activity for the enhancement of absorption of active ingredients
EP1243608A3 (en) Process for producing poly(alkylene oxide) and product thereof
MXPA04004228A (es) Copolimeros utiles para acidos de gelificacion.
AU1320401A (en) A porous, molecularly imprinted polymer and a process for the preparation thereof
CA2318359A1 (en) Polymeric compounds and methods of formulating same
CA2318508A1 (en) Batch devices for the reduction of compounds from biological compositions containing cells and methods of use
WO2000069470A3 (en) Improved cellular uptake of bioactive agents
WO2001000190A3 (en) Hyaluronic acid derivatives for the prevention and treatment of cutaneous scars
EP1064909A3 (en) High internal aqueous phase water-in-oil type emulsion cosmetic composition
AU2588001A (en) A thermally stable, high surface area, modified mesoporous alluminophosphate
DE60018564D1 (de) Funktionsfähige poly-alpha-aminosäurederivate zur modifizierung von biologisch wirksamen stoffen und deren herstellung
WO2001019826A3 (en) Triazolopyrimidine derivatives
CA2452409A1 (en) Preparation of polymer particles
WO2003003828A1 (en) Material for improving living environment, and building material, laying material and spraying agent using the same

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BY BZ CA CH CN CO CR CU CZ DE DM DZ EC EE ES FI GB GD GE GH HR HU ID IL IN IS JP KE KG KR KZ LK LR LS LT LU LV MA MD MG MK MW MX MZ NO NZ OM PH PL PT RO SD SE SG SI SK SL TJ TM TN TR TT UA UG US UZ VC VN YU ZA ZM

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW MZ SD SL SZ UG ZM ZW AM AZ BY KG KZ RU TJ TM AT BE BG CH CY CZ DK EE ES FI FR GB GR IE IT LU MC PT SE SK TR BF BJ CF CG CI GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2003523544

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2458837

Country of ref document: CA

Ref document number: 10487713

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 2002796357

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2002796357

Country of ref document: EP

WWG Wipo information: grant in national office

Ref document number: 2002796357

Country of ref document: EP