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WO2003016272A3 - Improving bioavailability of carbapewem salts by nanofiltration - Google Patents

Improving bioavailability of carbapewem salts by nanofiltration Download PDF

Info

Publication number
WO2003016272A3
WO2003016272A3 PCT/US2002/025566 US0225566W WO03016272A3 WO 2003016272 A3 WO2003016272 A3 WO 2003016272A3 US 0225566 W US0225566 W US 0225566W WO 03016272 A3 WO03016272 A3 WO 03016272A3
Authority
WO
WIPO (PCT)
Prior art keywords
salts
nanofiltration
carbapewem
improving bioavailability
carbapenem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/025566
Other languages
French (fr)
Other versions
WO2003016272A2 (en
Inventor
Erik A Dienemann
Ross A Miller
Diane R Yen
Vincent Antonucci
Orn Almarsson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Priority to AU2002324678A priority Critical patent/AU2002324678A1/en
Publication of WO2003016272A2 publication Critical patent/WO2003016272A2/en
Publication of WO2003016272A3 publication Critical patent/WO2003016272A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C07D477/08—Modification of a carboxyl group directly attached in position 2, e.g. esterification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

This invention relates to a formulation 'through process' for making carbapanem compounds, particularly on a manufacturing scale. More specifically, this invention relates to a formulation 'through process' for making bioavailable carbapenem salts by from stable, non-soluble carbapenem salts using nanofiltration.
PCT/US2002/025566 2001-08-16 2002-08-12 Improving bioavailability of carbapewem salts by nanofiltration Ceased WO2003016272A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002324678A AU2002324678A1 (en) 2001-08-16 2002-08-12 Improving bioavailability of carbapewem salts by nanofiltration

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31295701P 2001-08-16 2001-08-16
US60/312,957 2001-08-16

Publications (2)

Publication Number Publication Date
WO2003016272A2 WO2003016272A2 (en) 2003-02-27
WO2003016272A3 true WO2003016272A3 (en) 2003-05-22

Family

ID=23213755

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/025566 Ceased WO2003016272A2 (en) 2001-08-16 2002-08-12 Improving bioavailability of carbapewem salts by nanofiltration

Country Status (2)

Country Link
AU (1) AU2002324678A1 (en)
WO (1) WO2003016272A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103537192A (en) * 2013-10-25 2014-01-29 上海珺领生化科技有限公司 Membrane integration device for purifying and concentrating Ertapenem aqueous solution

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6180783B1 (en) * 1997-06-16 2001-01-30 Merck & Co., Inc. Stabilized carbapenem intermediates and improved process for carbapenem synthesis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6180783B1 (en) * 1997-06-16 2001-01-30 Merck & Co., Inc. Stabilized carbapenem intermediates and improved process for carbapenem synthesis

Also Published As

Publication number Publication date
AU2002324678A1 (en) 2003-03-03
WO2003016272A2 (en) 2003-02-27

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