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WO2003015703A3 - Compositions et procedes relatifs a de nouveaux composes de benzodiazepine et leurs cibles - Google Patents

Compositions et procedes relatifs a de nouveaux composes de benzodiazepine et leurs cibles Download PDF

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Publication number
WO2003015703A3
WO2003015703A3 PCT/US2002/026171 US0226171W WO03015703A3 WO 2003015703 A3 WO2003015703 A3 WO 2003015703A3 US 0226171 W US0226171 W US 0226171W WO 03015703 A3 WO03015703 A3 WO 03015703A3
Authority
WO
WIPO (PCT)
Prior art keywords
targets
compositions
methods relating
benzodiazepine compounds
novel benzodiazepine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/026171
Other languages
English (en)
Other versions
WO2003015703A2 (fr
Inventor
Gary D Glick
Anthony W Opipari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Michigan System
University of Michigan Ann Arbor
Original Assignee
University of Michigan System
University of Michigan Ann Arbor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/217,878 external-priority patent/US20030119029A1/en
Priority to CA002457405A priority Critical patent/CA2457405A1/fr
Priority to NZ531117A priority patent/NZ531117A/xx
Priority to EP02794914A priority patent/EP1423122A4/fr
Priority to JP2003520664A priority patent/JP2005502652A/ja
Priority to MXPA04001421A priority patent/MXPA04001421A/es
Application filed by University of Michigan System, University of Michigan Ann Arbor filed Critical University of Michigan System
Priority to AU2002332560A priority patent/AU2002332560B2/en
Publication of WO2003015703A2 publication Critical patent/WO2003015703A2/fr
Publication of WO2003015703A3 publication Critical patent/WO2003015703A3/fr
Anticipated expiration legal-status Critical
Priority to NO20041058A priority patent/NO20041058L/no
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention porte sur de nouveaux composés chimiques, sur leurs méthodes de recherche et leur utilisation thérapeutique. L'invention porte notamment sur des dérivés de benzodiazépine et sur leurs procédés d'utilisation comme agents thérapeutiques afin de traiter plusieurs états associés à une mauvaise régulation des processus de la mort cellulaire programmée, l'auto-immunité, l'inflammation, l'hyperprolifération et autre.
PCT/US2002/026171 2001-08-15 2002-08-15 Compositions et procedes relatifs a de nouveaux composes de benzodiazepine et leurs cibles Ceased WO2003015703A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
AU2002332560A AU2002332560B2 (en) 2001-08-15 2002-08-15 Compositions and methods relating to novel benzodiazepine compounds and targets thereof
NZ531117A NZ531117A (en) 2001-08-15 2002-08-15 Compositions and methods relating to novel benzodiazepine compounds and targets thereof
EP02794914A EP1423122A4 (fr) 2001-08-15 2002-08-15 Compositions et procedes relatifs a de nouveaux composes de benzodiazepine et leurs cibles
JP2003520664A JP2005502652A (ja) 2001-08-15 2002-08-15 新規ベンゾジアゼピン化合物に関連した組成物および方法、ならびにそれらの標的
MXPA04001421A MXPA04001421A (es) 2001-08-15 2002-08-15 Composiciones y metodos que se relacionan con compuestos novedosos de benzodiazepina y sus destinos.
CA002457405A CA2457405A1 (fr) 2001-08-15 2002-08-15 Compositions et methodes relatives a des benzodiazepines
NO20041058A NO20041058L (no) 2001-08-15 2004-03-12 Preparater og fremgangsmater relatert til nye benzodiazepinforbindelser og mal derav

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US31256001P 2001-08-15 2001-08-15
US60/312,560 2001-08-15
US31368901P 2001-08-20 2001-08-20
US60/313,689 2001-08-20
US39667002P 2002-07-18 2002-07-18
US60/396,670 2002-07-18
US10/217,878 2002-08-13
US10/217,878 US20030119029A1 (en) 1999-04-30 2002-08-13 Compositions and methods relating to novel benzodiazepine compounds and targets thereof

Publications (2)

Publication Number Publication Date
WO2003015703A2 WO2003015703A2 (fr) 2003-02-27
WO2003015703A3 true WO2003015703A3 (fr) 2003-11-13

Family

ID=27499087

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/026171 Ceased WO2003015703A2 (fr) 2001-08-15 2002-08-15 Compositions et procedes relatifs a de nouveaux composes de benzodiazepine et leurs cibles

Country Status (8)

Country Link
EP (1) EP1423122A4 (fr)
JP (1) JP2005502652A (fr)
AU (1) AU2002332560B2 (fr)
CA (1) CA2457405A1 (fr)
MX (1) MXPA04001421A (fr)
NO (1) NO20041058L (fr)
NZ (1) NZ531117A (fr)
WO (1) WO2003015703A2 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7572788B2 (en) 1999-04-30 2009-08-11 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
US7994313B2 (en) 2005-06-01 2011-08-09 The Regents Of The University Of Michigan Unsolvated benzodiazepine compositions and methods
US9126978B2 (en) 2009-11-17 2015-09-08 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050113460A1 (en) * 1999-04-30 2005-05-26 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
US20060025388A1 (en) * 1999-04-30 2006-02-02 Glick Gary D Compositions and methods relating to novel compounds and targets thereof
DE60007960T2 (de) 1999-04-30 2004-10-21 Univ Michigan Ann Arbor Therapeutische Anwendungen von pro-apoptotischen Benzodiazepinen
US7276348B2 (en) 1999-04-30 2007-10-02 Regents Of The University Of Michigan Compositions and methods relating to F1F0-ATPase inhibitors and targets thereof
CA2524394C (fr) * 2003-05-01 2011-07-12 The Regents Of The University Of Michigan Nouvelles benzodiazepines, compositions de celles-ci et leurs utilisations
US20050272723A1 (en) * 2004-04-27 2005-12-08 The Regents Of The University Of Michigan Methods and compositions for treating diseases and conditions associated with mitochondrial function
WO2006074358A1 (fr) 2005-01-03 2006-07-13 The Regents Of The University Of Michigan Compositions et procedes concernant de nouveaux composes et leurs cibles
CN101267825B (zh) * 2005-09-19 2011-12-28 阿罗治疗有限公司 治疗丙型肝炎感染的苯并二氮杂*衍生物
NZ568254A (en) * 2005-11-01 2011-06-30 Univ Michigan 1,4-Benzodiazepine-2,5-diones for regulating cell death and treating autoimmune diseases
US7759338B2 (en) 2006-04-27 2010-07-20 The Regents Of The University Of Michigan Soluble 1,4 benzodiazepine compounds and stable salts thereof
MX2008015488A (es) 2006-06-09 2009-02-12 Univ Michigan Composiciones y metodos relacionados con compuestos novedosos y objetivos de los mismos.
WO2008112553A1 (fr) 2007-03-09 2008-09-18 The Regents Of The University Of Michigan Compositions et procédés en rapport avec de nouveaux composés et cibles de ceux-ci
MX2010002732A (es) 2007-09-14 2010-06-02 Univ Michigan Inhibidores de f1f0-atpasa y metodos relacionados.
AU2008323945B2 (en) 2007-11-06 2013-11-28 The Regents Of The University Of Michigan Benzodiazepinone compounds useful in the treatment of skin conditions
EP2352724B1 (fr) 2008-09-11 2015-04-22 The Regents of the University of Michigan Aryle guanidines comme inhibiteurs de la f1f0-atpase et leur utilisation medicale
WO2010121164A2 (fr) 2009-04-17 2010-10-21 The Regents Of The University Of Michigan Composés de 1,4-benzodiazépinone et leur utilisation dans le traitement du cancer
EP2470020A4 (fr) 2009-09-18 2013-03-13 Univ Michigan Composés de benzodiazépinone et méthodes de traitement les utilisant
AU2010322287B2 (en) 2009-11-17 2014-04-03 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6277844B1 (en) * 1998-09-14 2001-08-21 Sydney Spector Compound for selective treatment of malignant cells by inhibiting cell cycle progression, decreasing Bcl2, and increasing apoptosis

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4898861A (en) * 1987-03-26 1990-02-06 Hoffmann-La Roche Inc. Method for inhibiting the proliferation of tumor cells
US5776946A (en) * 1995-08-28 1998-07-07 Mcgeer; Patrick L. Peripheral benzodiazepine receptor ligands as antiinflammatory agents
WO1999058117A1 (fr) * 1998-05-13 1999-11-18 Sanofi-Synthelabo Utilisation de composes reduisant l'apoptose
FR2779963A1 (fr) * 1998-06-22 1999-12-24 Centre Nat Rech Scient Utilisation d'un compose possedant une affinite pour le recepteur mitochondrial des benzodiazepines en therapie du cancer
DE60007960T2 (de) * 1999-04-30 2004-10-21 Univ Michigan Ann Arbor Therapeutische Anwendungen von pro-apoptotischen Benzodiazepinen
EP1210596A2 (fr) * 1999-06-22 2002-06-05 Mitokor Compositions et procedes d'analyse de conditions infracellulaires et traitement par transert d'energie
US7005274B1 (en) * 1999-09-15 2006-02-28 Migenix Corp. Methods and compositions for diagnosing and treating arthritic disorders and regulating bone mass
WO2001051922A2 (fr) * 2000-01-14 2001-07-19 Mitokor Procedes pour identifier les agents liant le recepteur de benzodiazepine peripherique

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6277844B1 (en) * 1998-09-14 2001-08-21 Sydney Spector Compound for selective treatment of malignant cells by inhibiting cell cycle progression, decreasing Bcl2, and increasing apoptosis

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JONES G.B.: "The non-covalent interaction of pyrrolo(2,1-c)(1,4)benzodiazepine-5,11-diones with DNA", ANTI-CANCER DRUG DESIGN, vol. 5, 1990, pages 249 - 264, XP002966651 *
See also references of EP1423122A4 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7572788B2 (en) 1999-04-30 2009-08-11 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
US8415343B2 (en) 1999-04-30 2013-04-09 The Regents Of The University Of Michigan Compositions and methods for inhibiting the proliferation of cells
US8722667B2 (en) 1999-04-30 2014-05-13 The Regents Of The University Of Michigan Compositions and methods for inhibiting the proliferation of cells
US7994313B2 (en) 2005-06-01 2011-08-09 The Regents Of The University Of Michigan Unsolvated benzodiazepine compositions and methods
US9126978B2 (en) 2009-11-17 2015-09-08 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties

Also Published As

Publication number Publication date
NO20041058L (no) 2004-05-14
NZ531117A (en) 2006-03-31
AU2002332560B2 (en) 2006-01-19
MXPA04001421A (es) 2004-06-03
WO2003015703A2 (fr) 2003-02-27
JP2005502652A (ja) 2005-01-27
CA2457405A1 (fr) 2003-02-27
EP1423122A2 (fr) 2004-06-02
EP1423122A4 (fr) 2008-12-10

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