[go: up one dir, main page]

WO2003014110A1 - Benzazepine derivative, process for producing the same, and use - Google Patents

Benzazepine derivative, process for producing the same, and use Download PDF

Info

Publication number
WO2003014110A1
WO2003014110A1 PCT/JP2002/008045 JP0208045W WO03014110A1 WO 2003014110 A1 WO2003014110 A1 WO 2003014110A1 JP 0208045 W JP0208045 W JP 0208045W WO 03014110 A1 WO03014110 A1 WO 03014110A1
Authority
WO
WIPO (PCT)
Prior art keywords
producing
same
benzazepine derivative
optionally substituted
aromatic ring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2002/008045
Other languages
English (en)
French (fr)
Inventor
Mitsuru Shiraishi
Masanori Baba
Masaki Seto
Yoshio Aramaki
Naoyuki Kanzaki
Naoki Miyamoto
Yuji Iizawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to EP02762752A priority Critical patent/EP1422228A1/en
Priority to CA002456754A priority patent/CA2456754A1/en
Priority to US10/486,002 priority patent/US7262185B2/en
Publication of WO2003014110A1 publication Critical patent/WO2003014110A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PCT/JP2002/008045 2001-08-08 2002-08-07 Benzazepine derivative, process for producing the same, and use Ceased WO2003014110A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP02762752A EP1422228A1 (en) 2001-08-08 2002-08-07 BENZAZEPINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE
CA002456754A CA2456754A1 (en) 2001-08-08 2002-08-07 Benzazepine derivative, process for producing the same, and use
US10/486,002 US7262185B2 (en) 2001-08-08 2002-08-07 Benzazepine derivative, process for producing the same, and use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001240718 2001-08-08
JP2001-240718 2001-08-08

Publications (1)

Publication Number Publication Date
WO2003014110A1 true WO2003014110A1 (en) 2003-02-20

Family

ID=19071283

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/008045 Ceased WO2003014110A1 (en) 2001-08-08 2002-08-07 Benzazepine derivative, process for producing the same, and use

Country Status (4)

Country Link
US (1) US7262185B2 (ja)
EP (1) EP1422228A1 (ja)
CA (1) CA2456754A1 (ja)
WO (1) WO2003014110A1 (ja)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005090320A3 (en) * 2004-03-12 2006-04-27 Wyeth Corp Triazole derivatives and method of using the same to treat hiv infections
US8480868B2 (en) 2005-08-05 2013-07-09 Bayer Healthcare Llc Method for distinguishing electrochemical sensors
US8993577B2 (en) 2009-02-20 2015-03-31 Astrazeneca Ab Cyclopropyl amide derivatives
US9012452B2 (en) 2010-02-18 2015-04-21 Astrazeneca Ab Processes for making cyclopropyl amide derivatives and intermediates associated therewith
US9029381B2 (en) 2007-08-22 2015-05-12 Astrazeneca Ab Cyclopropyl amide derivatives

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003235097A1 (en) * 2002-04-24 2003-11-10 Takeda Pharmaceutical Company Limited Use of compounds having ccr antagonism
US20060178359A1 (en) * 2003-02-07 2006-08-10 Mitsuru Shiraishi Tricyclic compound, process for producing the same, and use
EP2592075B1 (en) * 2004-11-02 2015-04-29 Northwestern University Pyridazine compounds for the treatment of inflammatory diseases
BRPI0518829A2 (pt) * 2004-12-06 2008-12-09 Avigen Inc mÉtodo para o tratamento de dor neuropÁtica e sÍndromes associadas
WO2007127474A2 (en) * 2006-04-28 2007-11-08 Northwestern University Compositions and treatments using pyridazine compounds and cholinesterase inhibitors
TW200824693A (en) * 2006-08-28 2008-06-16 Jazz Pharmaceuticals Inc Pharmaceutical compositions of clonazepam and methods of use thereof
AU2007318922C1 (en) * 2006-11-07 2013-09-12 Proteologics Ltd. Pyrimidine derivatives as POSH and POSH-AP inhibitors
US7638541B2 (en) 2006-12-28 2009-12-29 Metabolex Inc. 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
US20080181876A1 (en) * 2007-01-30 2008-07-31 Johnson Kirk W Methods for treating acute and subchronic pain
US20080287402A1 (en) * 2007-05-03 2008-11-20 Johnson Kirk W Use of a glial attenuator to prevent amplified pain responses caused by glial priming
CA2693169C (en) 2007-07-19 2016-01-12 Metabolex, Inc. N-linked heterocyclic receptor agonists for the treatment of diabetes and metabolic disorders
CA2775840C (en) 2009-10-01 2018-02-06 Metabolex, Inc. Substituted tetrazol-1-yl-phenoxymethyl-thiazol-2-yl-piperidinyl-pyrimidine salts
ES2676209T3 (es) 2010-06-23 2018-07-17 Metabolex Inc. Composiciones de 5-etil-2-{4-[4-(4-tetrazol-1-il-fenoximetil)-tiazol-2-il]-piperidin-1-il}-pirimidina
CN107899012A (zh) 2011-01-11 2018-04-13 戴麦里克斯生物科学有限公司 联合疗法
EP3493807A1 (en) 2016-08-03 2019-06-12 CymaBay Therapeutics, Inc. Oxymethylene aryl compounds for treating inflammatory gastrointestinal diseases or gastrointestinal conditions
ES2906992T3 (es) * 2016-12-09 2022-04-21 Medshine Discovery Inc Compuesto de bifenilo como antagonista del receptor CCR2/CCR5
JP7292588B2 (ja) * 2019-06-24 2023-06-19 无錫▲りん▼方生物医薬科技有限公司 Ｃｃｒ２／ｃｃｒ５アンタゴニストとしてのヘテロシクロアルキル系化合物
US11629196B2 (en) 2020-04-27 2023-04-18 Incelldx, Inc. Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions
WO2021233349A1 (zh) 2020-05-22 2021-11-25 南京明德新药研发有限公司 吡啶类衍生物及其应用
WO2023143112A1 (zh) * 2022-01-26 2023-08-03 无锡瓴方生物医药科技有限公司 氮杂苯并八元环化合物的盐型、晶型及其应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999032468A1 (en) * 1997-12-19 1999-07-01 Takeda Chemical Industries, Ltd. Anilide derivative, production and use thereof
WO1999032100A2 (en) * 1997-12-19 1999-07-01 Takeda Chemical Industries, Ltd. Pharmaceutical composition for antagonizing ccr5 comprising anilide derivative
WO2000037455A1 (en) * 1998-12-21 2000-06-29 Takeda Chemical Industries, Ltd. Benzothiepin-anilide derivatives, their production and their use for antagonizing ccr-5
WO2000076993A1 (en) * 1999-06-16 2000-12-21 Takeda Chemical Industries, Ltd. Benzazepine derivatives, process for the preparation of the same and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6096780A (en) 1998-08-20 2000-08-01 Takeda Chemical Industries, Ltd. Quaternary ammonium salts and their use

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999032468A1 (en) * 1997-12-19 1999-07-01 Takeda Chemical Industries, Ltd. Anilide derivative, production and use thereof
WO1999032100A2 (en) * 1997-12-19 1999-07-01 Takeda Chemical Industries, Ltd. Pharmaceutical composition for antagonizing ccr5 comprising anilide derivative
WO2000037455A1 (en) * 1998-12-21 2000-06-29 Takeda Chemical Industries, Ltd. Benzothiepin-anilide derivatives, their production and their use for antagonizing ccr-5
WO2000076993A1 (en) * 1999-06-16 2000-12-21 Takeda Chemical Industries, Ltd. Benzazepine derivatives, process for the preparation of the same and uses thereof

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005090320A3 (en) * 2004-03-12 2006-04-27 Wyeth Corp Triazole derivatives and method of using the same to treat hiv infections
US7563905B2 (en) 2004-03-12 2009-07-21 Wyeth Triazole derivatives and method of using the same to treat HIV infections
US8480868B2 (en) 2005-08-05 2013-07-09 Bayer Healthcare Llc Method for distinguishing electrochemical sensors
US9029381B2 (en) 2007-08-22 2015-05-12 Astrazeneca Ab Cyclopropyl amide derivatives
US8993577B2 (en) 2009-02-20 2015-03-31 Astrazeneca Ab Cyclopropyl amide derivatives
US9012452B2 (en) 2010-02-18 2015-04-21 Astrazeneca Ab Processes for making cyclopropyl amide derivatives and intermediates associated therewith

Also Published As

Publication number Publication date
EP1422228A1 (en) 2004-05-26
CA2456754A1 (en) 2003-02-20
US7262185B2 (en) 2007-08-28
US20040235822A1 (en) 2004-11-25

Similar Documents

Publication Publication Date Title
WO2003014110A1 (en) Benzazepine derivative, process for producing the same, and use
WO2003041664A1 (fr) Cosmetiques contenant un mineral argileux
MXPA03011329A (es) Antiinfecciosos novedosos.
CA2379747A1 (en) Novel succinate derivative compounds useful as cysteine protease inhibitors
CA2229183A1 (en) Endothelin antagonist
GB0128996D0 (en) Organic compounds
MY138525A (en) Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
CA2167382A1 (en) Novel Fused Indan Derivative and Pharmaceutically Acceptable Salt thereof
SI1975164T1 (sl) Oktahidrobenzimidazolonske spojine kot analgetiki
SE0004245D0 (sv) Novel compounds and their use
EP1295867A4 (en) BIPHENYL COMPOUND
EP1043312A4 (en) HETEROCYCLIC COMPOUNDS HAVING NOS-INHIBITING ACTIVITIES
WO2002026714A1 (en) Spiro compounds
WO2000046210A3 (en) New process for preparing pesticidal intermediates
WO2001009122A3 (en) Serotonergic benzofurans
MXPA04004937A (es) Proceso para preparar 3,3??,3,6??,-tetraalquil-2,2??-bifenoles y 3,??,6,??-tetraalquil-5,??-dihalo-2,??-bifenoles.
CA2419764A1 (en) Process for preparing a substituted imidazopyridine compound
WO2001010861A3 (de) Substituierte heterocyclyl-2h-chromene
WO2002046152A3 (de) Coniosetin und derivate davon, verfahren zur herstellung und verwendung derselben
WO2001010849A3 (de) Substituierte arylalkylamino-1,3,5-triazine als herbizide
WO2003004464A3 (de) Heterozyklische amidderivate und deren verwendung als schädlingsbekämpfungsmittel
HK1049836A1 (zh) 新的偶合方法
WO2001012597A3 (fr) Procede de preparation de quinoleine-5,8-diones
WO2002062758A1 (en) Indoline derivative and process for producing the same
WO2002012155A3 (en) Process for the preparation of chiral 1,4-diaryl-2-fluoro-2-butenes

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BY BZ CA CH CN CO CR CU CZ DE DM DZ EC EE ES FI GB GD GE GH HR HU ID IL IN IS JP KE KG KR KZ LK LR LS LT LU LV MA MD MG MK MW MX MZ NO NZ OM PH PL PT RO SD SE SG SI SK SL TJ TM TN TR TT UA UG US UZ VC VN YU ZA ZM

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW MZ SD SL SZ UG ZM ZW AM AZ BY KG KZ RU TJ TM AT BE BG CH CY CZ DK EE ES FI FR GB GR IE IT LU MC PT SE SK TR BF BJ CF CG CI GA GN GQ GW ML MR NE SN TD TG

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2456754

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 10486002

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 2002762752

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2002762752

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

NENP Non-entry into the national phase

Ref country code: JP