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WO2003010324A3 - Methode de preparation de simvastatine - Google Patents

Methode de preparation de simvastatine Download PDF

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Publication number
WO2003010324A3
WO2003010324A3 PCT/IN2002/000157 IN0200157W WO03010324A3 WO 2003010324 A3 WO2003010324 A3 WO 2003010324A3 IN 0200157 W IN0200157 W IN 0200157W WO 03010324 A3 WO03010324 A3 WO 03010324A3
Authority
WO
WIPO (PCT)
Prior art keywords
simvastatin
preparation
analogs
host
derivatives
Prior art date
Application number
PCT/IN2002/000157
Other languages
English (en)
Other versions
WO2003010324A2 (fr
Inventor
Anand Ranganathan
Original Assignee
Icgeb
Anand Ranganathan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icgeb, Anand Ranganathan filed Critical Icgeb
Priority to AU2002337601A priority Critical patent/AU2002337601A1/en
Publication of WO2003010324A2 publication Critical patent/WO2003010324A2/fr
Publication of WO2003010324A3 publication Critical patent/WO2003010324A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pyrane Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Cette invention concerne une méthode de préparation de simvastatine, ou des analogues ou dérivés de simvastatine, par expression biologique. La méthode consiste à: a) mettre en oeuvre un hôte présentant un gène personnalisé codant pour une polycétide synthase; b) fermenter ledit hôte afin d'obtenir simvastatine ou des analogues ou dérivés de simvastatine.
PCT/IN2002/000157 2001-07-25 2002-07-25 Methode de preparation de simvastatine WO2003010324A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002337601A AU2002337601A1 (en) 2001-07-25 2002-07-25 Process for the preparation of simvastatin

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN796/DEL/01 2001-07-25
IN796DE2001 2001-07-25

Publications (2)

Publication Number Publication Date
WO2003010324A2 WO2003010324A2 (fr) 2003-02-06
WO2003010324A3 true WO2003010324A3 (fr) 2003-08-21

Family

ID=11097092

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2002/000157 WO2003010324A2 (fr) 2001-07-25 2002-07-25 Methode de preparation de simvastatine

Country Status (2)

Country Link
AU (1) AU2002337601A1 (fr)
WO (1) WO2003010324A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4731489B2 (ja) * 2003-10-21 2011-07-27 ヴェレニウム コーポレイション シンバスタチン及び中間体の製造方法
KR101455794B1 (ko) 2006-05-24 2014-11-03 더 리전츠 오브 더 유니버시티 오브 캘리포니아 심바스타틴 및 관련 화합물의 제조를 위한 방법 및 재료
EP2029760A1 (fr) * 2006-06-20 2009-03-04 DSMIP Assets B.V. Procédé de production de la simvastatine
WO2009056539A1 (fr) * 2007-10-30 2009-05-07 Dsm Ip Assets B.V. Production de la simvastatine par fermentation
US9499803B2 (en) 2009-10-08 2016-11-22 The Regents Of The University Of California Variant LovD polypeptide
IN2012DN03403A (fr) 2009-10-08 2015-10-23 Univ California

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000037629A2 (fr) * 1998-12-18 2000-06-29 Wisconsin Alumni Research Foundation Methode pour produire des agents antihypercholesterolemiques

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000037629A2 (fr) * 1998-12-18 2000-06-29 Wisconsin Alumni Research Foundation Methode pour produire des agents antihypercholesterolemiques

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
KENNEDY J ET AL: "Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis.", SCIENCE. UNITED STATES 21 MAY 1999, vol. 284, no. 5418, 21 May 1999 (1999-05-21), pages 1368 - 1372, XP002243924, ISSN: 0036-8075 *
MOLNAR I ET AL: "THE BIOSYNTHETIC GENE CLUSTER FOR THE MICROTUBULE-STABILIZING AGENTS EPOTHILONES A AND B FROM SORANGIUM CELLULOSUM SO CE90", CHEMISTRY AND BIOLOGY, CURRENT BIOLOGY, LONDON, GB, vol. 7, no. 7, February 2000 (2000-02-01), pages 97 - 109, XP000904734, ISSN: 1074-5521 *
OLIYNYK M ET AL: "A hybrid modular polyketide synthase obtained by domain swapping", CHEMISTRY AND BIOLOGY, CURRENT BIOLOGY, LONDON, GB, vol. 3, no. 10, 1996, pages 833 - 839, XP002045171, ISSN: 1074-5521 *
RANGANATHAN A ET AL: "KNOWLEDGE-BASED DESIGN OF BIMODULAR AND TRIMODULAR POLYKETIDE SYNTHASES BASED ON DOMAIN AND MODULE SWAPS: A ROUTE TO SIMPLE STATIN ANALOGUES", CHEMISTRY AND BIOLOGY, CURRENT BIOLOGY, LONDON, GB, vol. 6, no. 10, October 1999 (1999-10-01), pages 731 - 741, XP000879061, ISSN: 1074-5521 *
SUTHERLAND A ET AL: "Recent advances in the biosynthetic studies of lovastatin.", CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT. ENGLAND MAR 2001, vol. 4, no. 2, March 2001 (2001-03-01), pages 229 - 236, XP008018200, ISSN: 1367-6733 *

Also Published As

Publication number Publication date
AU2002337601A1 (en) 2003-02-17
WO2003010324A2 (fr) 2003-02-06

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