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WO2003006017A3 - Use of certain castanospermine esters in the treatment of influenza virus infections - Google Patents

Use of certain castanospermine esters in the treatment of influenza virus infections Download PDF

Info

Publication number
WO2003006017A3
WO2003006017A3 PCT/EP2002/007632 EP0207632W WO03006017A3 WO 2003006017 A3 WO2003006017 A3 WO 2003006017A3 EP 0207632 W EP0207632 W EP 0207632W WO 03006017 A3 WO03006017 A3 WO 03006017A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
influenza virus
virus infections
esters
castanospermine esters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2002/007632
Other languages
French (fr)
Other versions
WO2003006017A2 (en
Inventor
Albert Stanley Tyms
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Virogen Ltd
Original Assignee
Virogen Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virogen Ltd filed Critical Virogen Ltd
Priority to AU2002325312A priority Critical patent/AU2002325312A1/en
Publication of WO2003006017A2 publication Critical patent/WO2003006017A2/en
Publication of WO2003006017A3 publication Critical patent/WO2003006017A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Use of certain castanospermine esters in the treatment of influenza virus infection and compositions containing said esters in combination with adjunctive therapeutic agents.
PCT/EP2002/007632 2001-07-09 2002-07-08 Use of certain castanospermine esters in the treatment of influenza virus infections Ceased WO2003006017A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002325312A AU2002325312A1 (en) 2001-07-09 2002-07-08 Use of certain castanospermine esters in the treatment of influenza virus infections

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0116643.8 2001-07-09
GBGB0116643.8A GB0116643D0 (en) 2001-07-09 2001-07-09 Antiviral compounds

Publications (2)

Publication Number Publication Date
WO2003006017A2 WO2003006017A2 (en) 2003-01-23
WO2003006017A3 true WO2003006017A3 (en) 2003-08-28

Family

ID=9918105

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/007632 Ceased WO2003006017A2 (en) 2001-07-09 2002-07-08 Use of certain castanospermine esters in the treatment of influenza virus infections

Country Status (3)

Country Link
AU (1) AU2002325312A1 (en)
GB (1) GB0116643D0 (en)
WO (1) WO2003006017A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017192599A1 (en) 2016-05-02 2017-11-09 Florida State University Research Foundation, Inc. Treatment of zika virus infections using alpha-glucosidase inhibitors
WO2020185675A1 (en) * 2019-03-08 2020-09-17 University Of Virginia Patent Foundation Compositions and methods for modulating viral infections by regulating glucosylceramides
AU2021332085B2 (en) * 2020-08-26 2022-12-08 COVIRIX Medical Pty Ltd Glucosidase inhibitors for the treatment and prevention of pulmonary infections

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5385911A (en) * 1990-12-18 1995-01-31 Merrell Dow Pharmaceuticals Inc. Anti-herpes castanospermine esters
WO2002089780A2 (en) * 2001-05-03 2002-11-14 Virogen Ltd Antiviral compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5385911A (en) * 1990-12-18 1995-01-31 Merrell Dow Pharmaceuticals Inc. Anti-herpes castanospermine esters
WO2002089780A2 (en) * 2001-05-03 2002-11-14 Virogen Ltd Antiviral compounds

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
HAMMOND C ET AL: "ROLE OF N-LINKED OLIGOSACCHARIDE RECOGNITION, GLUCOSE TRIMMING, AND CALNEXIN IN GLYCOPROTEIN FOLDING AND QUALITY CONTROL", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 91, no. 3, 1 February 1994 (1994-02-01), pages 913 - 917, XP002035740, ISSN: 0027-8424 *
MEHTA A ET AL: "alpha-Glucosidase inhibitors as potential broad based anti-viral agents", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 430, no. 1-2, 23 June 1998 (1998-06-23), pages 17 - 22, XP004259130, ISSN: 0014-5793 *
MIST (MANAGEMENT OF INFLUENZA IN THE SOUTHERN HEMISPHERE TRIALISTS) STUDY GROUP T: "Randomised trial of efficacy and safety of inhaled zanamivir in treatment of influenza A and B virus infections", LANCET, XX, XX, vol. 352, no. 9144, 12 December 1998 (1998-12-12), pages 1877 - 1881, XP004265783, ISSN: 0140-6736 *
NICHOL K L: "Complications of influenza and benefits of vaccination", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 17, 30 July 1999 (1999-07-30), pages S47 - S52, XP004173584, ISSN: 0264-410X *
NICHOLSON K G ET AL: "Efficacy and safety of oseltamivir in treatment of acute influenza: a randomised controlled trial", LANCET, XX, XX, vol. 355, no. 9218, 27 May 2000 (2000-05-27), pages 1845 - 1850, XP004263555, ISSN: 0140-6736 *
SAITO TAKEHIKO ET AL: "Effect of glycosylation and glucose trimming inhibitors on the influenza A virus glycoproteins.", JOURNAL OF VETERINARY MEDICAL SCIENCE, vol. 62, no. 6, June 2000 (2000-06-01), pages 575 - 581, XP001135294, ISSN: 0916-7250 *
TAYLOR D L ET AL: "Synergistic inhibition of human immunodeficiency virus type 1 in vitro by 6-O-butanoylcastanospermine (MDL 28 574) in combination with inhibitors of the virus-encoded reverse transcriptase and proteinase.", ANTIVIRAL CHEMISTRY & CHEMOTHERAPY, vol. 6, no. 3, 1995, pages 143 - 152, XP001119625, ISSN: 0956-3202 *

Also Published As

Publication number Publication date
WO2003006017A2 (en) 2003-01-23
AU2002325312A1 (en) 2003-01-29
GB0116643D0 (en) 2001-08-29

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