WO2003003984A8 - Novel proteins and nucleic acids encoding same - Google Patents
Novel proteins and nucleic acids encoding same Download PDFInfo
- Publication number
- WO2003003984A8 WO2003003984A8 PCT/US2002/021268 US0221268W WO03003984A8 WO 2003003984 A8 WO2003003984 A8 WO 2003003984A8 US 0221268 W US0221268 W US 0221268W WO 03003984 A8 WO03003984 A8 WO 03003984A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- nucleic acids
- acids encoding
- encoding same
- novel proteins
- proteins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2002327198A AU2002327198A1 (en) | 2001-07-05 | 2002-07-03 | Novel proteins and nucleic acids encoding same |
Applications Claiming Priority (22)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30324101P | 2001-07-05 | 2001-07-05 | |
| US30316801P | 2001-07-05 | 2001-07-05 | |
| US60/303,241 | 2001-07-05 | ||
| US60/303,168 | 2001-07-05 | ||
| US09/966,545 | 2001-09-26 | ||
| US09/966,545 US20020172999A1 (en) | 1999-04-09 | 2001-09-26 | Novel KIAA1061-like cell adhesion molecule-like proteins and polynucleotides encoding them |
| US09/965,212 | 2001-09-26 | ||
| US09/966,546 | 2001-09-26 | ||
| US09/965,212 US20030003462A1 (en) | 1999-04-09 | 2001-09-26 | Novel human interleukin-like proteins and polynucleotides encoding them |
| US09/966,546 US20020168716A1 (en) | 1999-04-09 | 2001-09-26 | Novel amino acid sequences for human microfibril glycoprotein 4-like polypeptides |
| US36906502P | 2002-04-01 | 2002-04-01 | |
| US36899602P | 2002-04-01 | 2002-04-01 | |
| US60/369,065 | 2002-04-01 | ||
| US60/368,996 | 2002-04-01 | ||
| US37873002P | 2002-05-08 | 2002-05-08 | |
| US60/378,730 | 2002-05-08 | ||
| US38432702P | 2002-05-30 | 2002-05-30 | |
| US60/384,327 | 2002-05-30 | ||
| US38681602P | 2002-06-07 | 2002-06-07 | |
| US60/386,816 | 2002-06-07 | ||
| US17437202A | 2002-06-17 | 2002-06-17 | |
| US10/174,372 | 2002-06-17 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| WO2003003984A2 WO2003003984A2 (en) | 2003-01-16 |
| WO2003003984A9 WO2003003984A9 (en) | 2009-05-22 |
| WO2003003984A8 true WO2003003984A8 (en) | 2009-08-13 |
Family
ID=27581222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2002/021268 Ceased WO2003003984A2 (en) | 2001-07-05 | 2002-07-03 | Novel proteins and nucleic acids encoding same |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2003003984A2 (en) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003085096A2 (en) * | 2002-04-01 | 2003-10-16 | Curagen Corporation | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
| DK1725249T3 (en) | 2003-11-06 | 2014-03-17 | Seattle Genetics Inc | Monomethylvaline compounds capable of conjugating to ligands. |
| KR101200133B1 (en) | 2004-06-01 | 2012-11-13 | 제넨테크, 인크. | Antibody drug conjugates and methods |
| ES2579805T3 (en) | 2004-09-23 | 2016-08-16 | Genentech, Inc. | Antibodies and conjugates engineered with cysteine |
| US20100111856A1 (en) | 2004-09-23 | 2010-05-06 | Herman Gill | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
| WO2011031870A1 (en) | 2009-09-09 | 2011-03-17 | Centrose, Llc | Extracellular targeted drug conjugates |
| MA34277B1 (en) | 2010-04-15 | 2013-06-01 | Spirogen Developments Sarl | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF |
| MX336540B (en) | 2010-06-08 | 2016-01-22 | Genentech Inc | Cysteine engineered antibodies and conjugates. |
| ES2544608T3 (en) | 2010-11-17 | 2015-09-02 | Genentech, Inc. | Antibody and alaninyl-maitansinol conjugates |
| KR101992502B1 (en) | 2011-05-12 | 2019-06-24 | 제넨테크, 인크. | Multiple reaction monitoring lc-ms/ms method to detect therapeutic antibodies in animal samples using framework signature peptides |
| SI2750713T1 (en) | 2011-10-14 | 2016-01-29 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
| WO2013130093A1 (en) | 2012-03-02 | 2013-09-06 | Genentech, Inc. | Biomarkers for treatment with anti-tubulin chemotherapeutic compounds |
| EP2766048B1 (en) | 2012-10-12 | 2014-12-10 | Spirogen Sàrl | Pyrrolobenzodiazepines and conjugates thereof |
| DK2906251T3 (en) | 2012-10-12 | 2017-11-20 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-anti-CD22-antibody conjugates |
| BR112015008174B1 (en) | 2012-10-12 | 2022-12-27 | Medimmune Limited | PYROLOBENZODIAZEPINE-ANTIBOD CONJUGATES, PHARMACEUTICAL COMPOSITION COMPRISING SAID CONJUGATES AND USES THEREOF TO TREAT PROLIFERATIVE DISEASE AND CANCER |
| HUE039329T2 (en) | 2012-10-12 | 2018-12-28 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
| KR101986404B1 (en) | 2012-10-12 | 2019-06-07 | 에이디씨 테라퓨틱스 에스에이 | Pyrrolobenzodiazepine - anti-psma antibody conjugates |
| WO2014057114A1 (en) | 2012-10-12 | 2014-04-17 | Adc Therapeutics Sàrl | Pyrrolobenzodiazepine-anti-psma antibody conjugates |
| ES2660029T3 (en) | 2012-10-12 | 2018-03-20 | Medimmune Limited | Antibody-pyrrolobenzodiazepine conjugates |
| CA2894961C (en) | 2012-12-21 | 2020-09-15 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
| CN110627797A (en) | 2012-12-21 | 2019-12-31 | 麦迪穆有限责任公司 | Asymmetric pyrrolobenzodiazepine dimers for the treatment of proliferative and autoimmune diseases |
| JP6444902B2 (en) | 2013-03-13 | 2018-12-26 | メドイミューン・リミテッドMedImmune Limited | Pyrrolobenzodiazepine and its conjugates |
| JP6340019B2 (en) | 2013-03-13 | 2018-06-06 | メドイミューン・リミテッドMedImmune Limited | Pyrrolobenzodiazepine and its conjugates |
| JP6445519B2 (en) | 2013-03-13 | 2018-12-26 | メドイミューン・リミテッドMedImmune Limited | Pyrrolobenzodiazepine and its conjugates |
| WO2015023355A1 (en) | 2013-08-12 | 2015-02-19 | Genentech, Inc. | 1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment |
| GB201317982D0 (en) | 2013-10-11 | 2013-11-27 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
| US9950078B2 (en) | 2013-10-11 | 2018-04-24 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
| WO2015052535A1 (en) | 2013-10-11 | 2015-04-16 | Spirogen Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
| EP3054983B1 (en) | 2013-10-11 | 2019-03-20 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
| BR112016013258A2 (en) | 2013-12-16 | 2018-01-16 | Genentech Inc | antibody-drug conjugate, pharmaceutical composition, method for treating cancer and kit |
| CN105873614B (en) | 2013-12-16 | 2020-10-30 | 基因泰克公司 | Peptidomimetic compounds and antibody-drug conjugates thereof |
| MX2016007826A (en) | 2013-12-16 | 2017-03-31 | Genentech Inc | Peptidomimetic compounds and antibody-drug conjugates thereof. |
| CN106687141A (en) | 2014-09-10 | 2017-05-17 | 麦迪穆有限责任公司 | Pyrrolobenzodiazepines and conjugates thereof |
| WO2016040825A1 (en) | 2014-09-12 | 2016-03-17 | Genentech, Inc. | Anthracycline disulfide intermediates, antibody-drug conjugates and methods |
| GB201416112D0 (en) | 2014-09-12 | 2014-10-29 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| EP3191521A2 (en) | 2014-09-12 | 2017-07-19 | F. Hoffmann-La Roche AG | Cysteine engineered antibodies and conjugates |
| SG11201702079UA (en) | 2014-09-17 | 2017-04-27 | Genentech Inc | Pyrrolobenzodiazepines and antibody disulfide conjugates thereof |
| NZ731782A (en) | 2014-11-25 | 2023-04-28 | Medimmune Ltd | Pyrrolobenzodiazepine-antibody conjugates |
| CN107206101B (en) | 2014-12-03 | 2021-06-25 | 基因泰克公司 | Quaternary ammonium compounds and antibody-drug conjugates thereof |
| GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
| GB201506402D0 (en) | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
| MA43345A (en) | 2015-10-02 | 2018-08-08 | Hoffmann La Roche | PYRROLOBENZODIAZEPINE ANTIBODY-DRUG CONJUGATES AND METHODS OF USE |
| MA43354A (en) | 2015-10-16 | 2018-08-22 | Genentech Inc | CONJUGATE DRUG CONJUGATES WITH CLOUDY DISULPHIDE |
| MA45326A (en) | 2015-10-20 | 2018-08-29 | Genentech Inc | CALICHEAMICIN-ANTIBODY-DRUG CONJUGATES AND METHODS OF USE |
| GB201601431D0 (en) | 2016-01-26 | 2016-03-09 | Medimmune Ltd | Pyrrolobenzodiazepines |
| GB201602356D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| GB201602359D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| JP6943872B2 (en) | 2016-03-25 | 2021-10-06 | ジェネンテック, インコーポレイテッド | Multiple whole antibody and antibody complex drug quantification assay |
| GB201607478D0 (en) | 2016-04-29 | 2016-06-15 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| EP3458101B1 (en) | 2016-05-20 | 2020-12-30 | H. Hoffnabb-La Roche Ag | Protac antibody conjugates and methods of use |
| CN109313200B (en) | 2016-05-27 | 2022-10-04 | 豪夫迈·罗氏有限公司 | Bioanalytical methods for characterizing site-specific antibody-drug conjugates |
| CN109476648B (en) | 2016-06-06 | 2022-09-13 | 豪夫迈·罗氏有限公司 | Sevelamer antibody-drug conjugates and methods of use |
| EP3496763A1 (en) | 2016-08-11 | 2019-06-19 | Genentech, Inc. | Pyrrolobenzodiazepine prodrugs and antibody conjugates thereof |
| JP7050770B2 (en) | 2016-10-05 | 2022-04-08 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | Method for preparing antibody drug conjugate |
| GB201617466D0 (en) | 2016-10-14 | 2016-11-30 | Medimmune Ltd | Pyrrolobenzodiazepine conjugates |
| GB201702031D0 (en) | 2017-02-08 | 2017-03-22 | Medlmmune Ltd | Pyrrolobenzodiazepine-antibody conjugates |
| RS61795B1 (en) | 2017-02-08 | 2021-06-30 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
| LT3612537T (en) | 2017-04-18 | 2022-10-10 | Medimmune Limited | Pyrrolobenzodiazepine conjugates |
| ES2977788T3 (en) | 2017-04-20 | 2024-08-30 | Adc Therapeutics Sa | Combination therapy with an anti-AXL antibody-drug conjugate |
| KR102442736B1 (en) | 2017-06-14 | 2022-09-16 | 에이디씨 테라퓨틱스 에스에이 | Dosage regime for administration of anti-CD19 ADCs |
| WO2019034764A1 (en) | 2017-08-18 | 2019-02-21 | Medimmune Limited | Pyrrolobenzodiazepine conjugates |
| KR20200055065A (en) | 2017-09-20 | 2020-05-20 | 주식회사 피에이치파마 | Tylanstatin analogs |
| GB201803342D0 (en) | 2018-03-01 | 2018-04-18 | Medimmune Ltd | Methods |
| GB201806022D0 (en) | 2018-04-12 | 2018-05-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| GB201814281D0 (en) | 2018-09-03 | 2018-10-17 | Femtogenix Ltd | Cytotoxic agents |
| IL282441B2 (en) | 2018-10-24 | 2025-07-01 | Hoffmann La Roche | Combined chemical influencing factors of decomposition and methods of use |
| EP3894427A1 (en) | 2018-12-10 | 2021-10-20 | Genentech, Inc. | Photocrosslinking peptides for site specific conjugation to fc-containing proteins |
| GB201901197D0 (en) | 2019-01-29 | 2019-03-20 | Femtogenix Ltd | G-A Crosslinking cytotoxic agents |
| ES2967878T3 (en) | 2019-03-15 | 2024-05-06 | Medimmune Ltd | Azetidobenzodiazepine dimers and conjugates comprising them for use in the treatment of cancer |
| GB2597532A (en) | 2020-07-28 | 2022-02-02 | Femtogenix Ltd | Cytotoxic compounds |
| WO2022078524A2 (en) | 2021-11-03 | 2022-04-21 | Hangzhou Dac Biotech Co., Ltd. | Specific conjugation of an antibody |
| EP4637833A2 (en) | 2022-12-23 | 2025-10-29 | Genentech, Inc. | Cereblon degrader conjugates, and uses thereof |
| AU2024257248A1 (en) | 2023-04-17 | 2025-11-06 | Peak Bio, Inc. | Antibodies and antibody-drug conjugates and methods of use and synthetic processes and intermediates |
-
2002
- 2002-07-03 WO PCT/US2002/021268 patent/WO2003003984A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003003984A9 (en) | 2009-05-22 |
| WO2003003984A2 (en) | 2003-01-16 |
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