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WO2003099198A3 - A process for the preparation of oxindole derivatives - Google Patents

A process for the preparation of oxindole derivatives Download PDF

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Publication number
WO2003099198A3
WO2003099198A3 PCT/IN2003/000198 IN0300198W WO03099198A3 WO 2003099198 A3 WO2003099198 A3 WO 2003099198A3 IN 0300198 W IN0300198 W IN 0300198W WO 03099198 A3 WO03099198 A3 WO 03099198A3
Authority
WO
WIPO (PCT)
Prior art keywords
formula
compound
preparation
coor1
branched
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2003/000198
Other languages
French (fr)
Other versions
WO2003099198A2 (en
Inventor
Nagarajan Periyandi
Srinivasu Kilaru
Rajamannar Thennati
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sun Pharmaceutical Industries Ltd
Original Assignee
Sun Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sun Pharmaceutical Industries Ltd filed Critical Sun Pharmaceutical Industries Ltd
Priority to AU2003260942A priority Critical patent/AU2003260942A1/en
Publication of WO2003099198A2 publication Critical patent/WO2003099198A2/en
Publication of WO2003099198A3 publication Critical patent/WO2003099198A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)

Abstract

A process for the preparation of oxindole derivative of formula (I) comprising reacting compound of formula (II) with dialkyl malonate, COOR1-COOR1, in the presence of a mild base to give compound of formula (III); and wherein R is selected from hydrogen, linear, branched or cyclic alkyl, aryl, substituted aryl, heteroaryl, haloalkyl like CF3, alkoxy, haloalkoxy, thioalkyl and halogen.; R1 is selected from linear, branched and cyclic alkyl (C1 to C4 groups); and X is selected from chloro, bromo, fluoro and iodo groups;further converting compound of formula (III) to compound of formula (I).
PCT/IN2003/000198 2002-05-24 2003-05-26 A process for the preparation of oxindole derivatives Ceased WO2003099198A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003260942A AU2003260942A1 (en) 2002-05-24 2003-05-26 A process for the preparation of oxindole derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN464MU2002 2002-05-24
IN464/MUM/2002 2002-05-24

Publications (2)

Publication Number Publication Date
WO2003099198A2 WO2003099198A2 (en) 2003-12-04
WO2003099198A3 true WO2003099198A3 (en) 2004-04-08

Family

ID=29560491

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2003/000198 Ceased WO2003099198A2 (en) 2002-05-24 2003-05-26 A process for the preparation of oxindole derivatives

Country Status (2)

Country Link
AU (1) AU2003260942A1 (en)
WO (1) WO2003099198A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2250001B1 (en) * 2004-09-29 2007-06-01 Medichem, S.A. PROCESS FOR THE PURIFICATION OF ZIPRASIDONA.
ES2250000B1 (en) * 2004-09-29 2007-06-01 Medichem, S.A. PROCEDURE FOR PREPARATION OF ZIPRASIDONE.
US20090163513A1 (en) * 2005-01-27 2009-06-25 Hetero Drugs Limited Process for ziprasidone using novel intermediates
WO2012020424A1 (en) 2010-08-12 2012-02-16 Arch Pharmalabs Limited A short process for the preparation of ziprasidone and intermediates thereof
WO2013093928A1 (en) 2011-12-20 2013-06-27 Arch Pharmalabs Limited An improved process for preparing 2-oxindoles of formula i, a key raw material for making pharmaceutical drugs and intermediates thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995000510A1 (en) * 1993-06-28 1995-01-05 Pfizer Inc. Processes and intermediates for the preparation of 5-[2-(4-(benzoisothiazol-3-yl)-piperazin-1-yl)ethyl]-6-chloro-1,3-dihydro-indol-2-one

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995000510A1 (en) * 1993-06-28 1995-01-05 Pfizer Inc. Processes and intermediates for the preparation of 5-[2-(4-(benzoisothiazol-3-yl)-piperazin-1-yl)ethyl]-6-chloro-1,3-dihydro-indol-2-one

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 118, no. 21, 24 May 1993, Columbus, Ohio, US; abstract no. 212810U, QUALLICH G.J., MORRISSEY P.M.: "A general oxindole synthesis" page 890; *
SYNTHESIS, no. 1, 1993, pages 51 - 53 *

Also Published As

Publication number Publication date
AU2003260942A1 (en) 2003-12-12
WO2003099198A2 (en) 2003-12-04
AU2003260942A8 (en) 2003-12-12

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