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WO2003096020A3 - Diagnostics and therapeutics for diseases associated with chemokine receptor 8 (ccr8) - Google Patents

Diagnostics and therapeutics for diseases associated with chemokine receptor 8 (ccr8) Download PDF

Info

Publication number
WO2003096020A3
WO2003096020A3 PCT/EP2003/004496 EP0304496W WO03096020A3 WO 2003096020 A3 WO2003096020 A3 WO 2003096020A3 EP 0304496 W EP0304496 W EP 0304496W WO 03096020 A3 WO03096020 A3 WO 03096020A3
Authority
WO
WIPO (PCT)
Prior art keywords
ccr8
diseases
therapeutics
diagnostics
diseases associated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2003/004496
Other languages
French (fr)
Other versions
WO2003096020A2 (en
Inventor
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer Healthcare AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare AG filed Critical Bayer Healthcare AG
Priority to AU2003229753A priority Critical patent/AU2003229753A1/en
Publication of WO2003096020A2 publication Critical patent/WO2003096020A2/en
Publication of WO2003096020A3 publication Critical patent/WO2003096020A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention provides a human CCR8 which is associated with the disorders of the peripheral and central nervous system, cardio-vascular diseases, gastro-intestinal diseases, cancer and hematological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of disorders of the peripheral and central nervous system, cardio-vascular diseases, gastro-intestinal diseases, cancer and hematological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of CCR8 as well as pharmaceutical compositions comprising such compounds.
PCT/EP2003/004496 2002-05-13 2003-04-30 Diagnostics and therapeutics for diseases associated with chemokine receptor 8 (ccr8) Ceased WO2003096020A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003229753A AU2003229753A1 (en) 2002-05-13 2003-04-30 Diagnostics and therapeutics for diseases associated with chemokine receptor 8 (ccr8)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02010147 2002-05-13
EP02010147.3 2002-05-13

Publications (2)

Publication Number Publication Date
WO2003096020A2 WO2003096020A2 (en) 2003-11-20
WO2003096020A3 true WO2003096020A3 (en) 2004-02-26

Family

ID=29414670

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/004496 Ceased WO2003096020A2 (en) 2002-05-13 2003-04-30 Diagnostics and therapeutics for diseases associated with chemokine receptor 8 (ccr8)

Country Status (2)

Country Link
AU (1) AU2003229753A1 (en)
WO (1) WO2003096020A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202216771A (en) 2020-06-26 2022-05-01 德商拜耳廠股份有限公司 Ccr8 antibodies for therapeutic applications
EP4186926A4 (en) * 2020-08-28 2024-06-05 Harbour Biomed US, Inc. Ccr8 antibody and application thereof
CN114891117B (en) * 2022-04-26 2023-09-05 深圳市体内生物医药科技有限公司 Chimeric antigen receptor T cell targeting CCR8 and preparation method and application thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5776729A (en) * 1995-06-05 1998-07-07 Human Genome Sciences, Inc. Human G-protein receptor HGBER32
WO1999006561A2 (en) * 1997-07-29 1999-02-11 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services, National Institutes Of Health Chemokine receptor ccr8 dna and uses thereof
WO1999025734A2 (en) * 1997-11-13 1999-05-27 Schering Corporation Th2 CELL DEPLETION; COMPOSITIONS; METHODS
WO2001058484A2 (en) * 2000-02-10 2001-08-16 Schering Corporation Novel uses of mammalian ccr8 receptors and related reagents

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5776729A (en) * 1995-06-05 1998-07-07 Human Genome Sciences, Inc. Human G-protein receptor HGBER32
WO1999006561A2 (en) * 1997-07-29 1999-02-11 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services, National Institutes Of Health Chemokine receptor ccr8 dna and uses thereof
WO1999025734A2 (en) * 1997-11-13 1999-05-27 Schering Corporation Th2 CELL DEPLETION; COMPOSITIONS; METHODS
WO2001058484A2 (en) * 2000-02-10 2001-08-16 Schering Corporation Novel uses of mammalian ccr8 receptors and related reagents

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BERNARDINI ET AL: "Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor", EUROPEAN JOURNAL OF IMMUNOLOGY, WEINHEIM, DE, vol. 28, no. 2, 1 February 1998 (1998-02-01), pages 582 - 588, XP002092743, ISSN: 0014-2980 *
HAQUE N S ET AL: "The chemokine receptor CCR8 mediates human endothelial cell chemotaxis induced by I-309 and Kaposi sarcoma herpesvirus-encoded vMIP-I and by lipoprotein(a)-stimulated endothelial cell conditioned medium.", BLOOD. UNITED STATES 1 JAN 2001, vol. 97, no. 1, 1 January 2001 (2001-01-01), pages 39 - 45, XP002264851, ISSN: 0006-4971 *
RUCKES T ET AL: "Autocrine antiapoptotic stimulation of cultured adult T-cell leukemia cells by overexpression of the chemokine I-309.", BLOOD. UNITED STATES 15 AUG 2001, vol. 98, no. 4, 15 August 2001 (2001-08-15), pages 1150 - 1159, XP002264850, ISSN: 0006-4971 *
TIFFANY ET AL: "Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309", JOURNAL OF EXPERIMENTAL MEDICINE, TOKYO, JP, vol. 186, no. 1, 7 July 1997 (1997-07-07), pages 165 - 170, XP002092538, ISSN: 0022-1007 *
TREBST CORINNA ET AL: "CC chemokine receptor 8 in the central nervous system is associated with phagocytic macrophages.", AMERICAN JOURNAL OF PATHOLOGY, vol. 162, no. 2, February 2003 (2003-02-01), pages 427 - 438, XP009023102, ISSN: 0002-9440 (ISSN print) *

Also Published As

Publication number Publication date
WO2003096020A2 (en) 2003-11-20
AU2003229753A1 (en) 2003-11-11

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