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WO2003094694A2 - Appareil a main d'inhalotherapie et procede d'utilisation - Google Patents

Appareil a main d'inhalotherapie et procede d'utilisation Download PDF

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Publication number
WO2003094694A2
WO2003094694A2 PCT/IL2003/000359 IL0300359W WO03094694A2 WO 2003094694 A2 WO2003094694 A2 WO 2003094694A2 IL 0300359 W IL0300359 W IL 0300359W WO 03094694 A2 WO03094694 A2 WO 03094694A2
Authority
WO
WIPO (PCT)
Prior art keywords
mixture
container
gas
croup
mask
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IL2003/000359
Other languages
English (en)
Other versions
WO2003094694A3 (fr
Inventor
Nimrod Lev
Eitan Landau
Shirit Aviram
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medihale Ltd
Original Assignee
Medihale Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medihale Ltd filed Critical Medihale Ltd
Priority to AU2003223094A priority Critical patent/AU2003223094A1/en
Publication of WO2003094694A2 publication Critical patent/WO2003094694A2/fr
Publication of WO2003094694A3 publication Critical patent/WO2003094694A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/06—Respiratory or anaesthetic masks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/20—Valves specially adapted to medical respiratory devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/20—Valves specially adapted to medical respiratory devices
    • A61M16/208—Non-controlled one-way valves, e.g. exhalation, check, pop-off non-rebreathing valves
    • A61M16/209—Relief valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/02—Gases
    • A61M2202/0208—Oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/02—Gases
    • A61M2202/025—Helium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8218—Gas operated
    • A61M2205/8225—Gas operated using incorporated gas cartridges for the driving gas

Definitions

  • the present invention relates to a hand held device for inhalation therapy and method of use thereof and, more particularly, to a device which relies upon delivery of cooled gases to an airway of a patient as a means of alleviating symptoms of croup.
  • V. Madden reports (Croup. Prof Care Mother Child 1997; 7:93-4) that as many as 3 percent of children under six years of age are affected by croup, usually at two to three years of age. Symptoms include a barking cough and inspiratory stridor. The preceding infection of the larynx is usually viral; bacterial infection can complicate the condition. J.A. Rosekrans confirms that (Mayo Clin. Proc 1998 Nov; 73(1 1): 1 102-6; discussion 1 107) Viral croup manifests with noisy, labored breathing and adds that parainfluenza viruses are the most common cause of croup with epiglottises and bacterial tracheitis contributing to the overall incidence.
  • Other chemical interventions include use of nebulized racemic epinephrine and other corticosteroids.
  • use of steroids especially in young children, should be undertaken with cautiuon due to the possibility of side effects.
  • a device for symptomatic relief of croup includes: (a) a disposable compressed gas container containing a mixture including oxygen and at least one additional gas, the mixture formulated to cool upon release from the container; (b) a gas release mechanism designed and constructed to be operably connectable to the gas container, the release mechanism capable of regulating a flow of the mixture from the container to a mask and (c) the mask designed and constructed to cover a mouth and nose of a patient suffering an attack of croup.
  • Release by the release mechanism of at least a portion of the mixture from the container causes cooling of the at least a portion of the mixture and routing of the at least a portion of the mixture to the mask where the at least a portion of the mixture is in proximity to the mouth and nose and may be inhaled by the patient.
  • a method of ameliorating acute symptoms of croup includes; (a) providing a disposable compressed gas container containing a mixture including oxygen and at least one additional gas, the mixture formulated to cool upon release from the container; (b) operably attaching or connecting a gas release mechanism to the gas container, the release mechanism capable of regulating a flow of the mixture from the container to a mask capable of covering a mouth and nose of a patient suffering an attack of croup; (c) operating the release mechanism so that at least a portion of the mixture is released from the container, cooled and directed to the mask; and (d) covering the mouth and nose of the patient with the mask so that the at least a portion of the mixture which was released from the container and cooled is available for inhalation by the patient.
  • an article of manufacture which includes packaging material and a device identified for use in providing symptomatic relief of croup.
  • the article of manufacture includes a device essentially as detailed hereinabove and hereinbelow together with instructions for use of the device in providing symptomatic relief from croup.
  • the device further includes a manually operable pressure reduction mechanism designed and configured to create a flow of the at least a portion of the mixture at ambient pressure.
  • the mixture includes Helium.
  • the present invention successfully addresses the shortcomings of the presently known configurations by providing a hand held device for inhalation therapy which relies upon delivery of cooled gases to an airway of a patient and method of using same as a means of alleviating symptoms of croup.
  • FIG. 1 is an exploded view of components of one embodiment of a device according to the present invention.
  • FIG. 2 is a perspective view of the embodiment of figure 1 after assembly.
  • FIG. 3 illustrates an additional embodiment of a device according to the i present invention.
  • FIG. 4 illustrates in detail the components of one embodiment of a pressure release mechanism suited for use in the context of the present invention.
  • FIG. 5 is a simplified flow diagram of events associated with performance of a method according to the present invention.
  • the present invention is of a device for inhalation therapy which relies upon delivery of cooled gases to an airway of a patient and method of using same which can be employed as a means of alleviating symptoms of croup Specifically, the present invention can be used to provide a convenient portable (e.g. hand held) solution for an unexpected attack of croup. Methods of using the device are also claimed.
  • the device and method obviate the need for a refrigerator or cool/moist climate which is not always available. Symptomatic relief provided by the invention reduces the level of stress and anxiety of both the patient and the caregiver.
  • Figures 1, 2 and 3 illustrates a device 500 for symptomatic relief of croup according to the present invention.
  • Device 500 includes a disposable compressed gas container containing a mixture including oxygen and at least one additional gas. The mixture is formulated to cool upon release from container 1.
  • container 1 contains a Heliox mixture (20-30% oxygen, 80- 70% helium) at a pressure of 150 to 200 atmospheres or more.
  • the volume of container 1 is small, most preferably 1 liter or less so that the device 500 is portable and easily deployed.
  • Device 500 further includes a gas release mechanism 3 designed and constructed to be operably connectable to gas container 1.
  • Release mechanism 3 is capable of regulating a flow of the mixture from container 1 to a mask 4.
  • Mask 4, further included in device 500, is designed and constructed to cover a mouth and nose of a patient suffering an attack of croup. Release by of at least a portion of the mixture from container 1 by release mechanism 3 causes cooling of the released portion of the mixture and routing of the cooled portion to mask 4 where at least part of the released cooled mixture is in proximity to the mouth and nose and may be inhaled by the patient.
  • Method 600 includes providing 61 a disposable compressed gas container 1 containing a mixture including oxygen and at least one additional gas as detailed hereinabove.
  • Method 600 further includes operably attaching or connecting 62 a gas release mechanism 3 to gas container 1.
  • Release mechanism 3 is capable of regulating a flow of the mixture from container 1 to mask 4 designed and configured for covering a mouth and nose of a patient suffering an attack of croup.
  • Method 600 further includes operating 63 release mechanism 3 so that at least a portion of the mixture is released from container 1, cooled and directed to mask 4.
  • Method 600 further includes covering 64 the mouth and nose of the patient with mask 4 so that the at least a portion of the mixture which was released from container 1 and cooled is available for inhalation 65 by the patient.
  • the acute symptoms of croup are ameliorated or relieved 66 by inhalation 65 of at least a portion of the at least a portion of the mixture which has been released and cooled.
  • an article of manufacture which includes packaging material and device 500 identified for use in providing symptomatic relief of croup.
  • the article of manufacture includes device 500 essentially as detailed hereinabove and hereinbelow together with instructions for use of device 500 in providing symptomatic relief from croup.
  • device 500 further includes a manually operable pressure reduction mechanism 70 ( Figure 4) designed and configured to create a flow of the at least a portion of the mixture at ambient pressure (i.e. Approximately 1 atmosphere).
  • device 500 further includes a gas pressure indicator
  • indicator 201 indicating a pressure of the mixture in the container. Most preferably indicator 201 indicates a reduction in pressure as container 1 is emptied.
  • the mixture stored in container 1 includes Helium as this gas cools to a great degree when it is released from container 1.
  • device 500 a portable or hand held device for inhalation therapy, particularly for first aid treatment for patients with viral croup or the like.
  • Device 500 operates independently of external power sources or gas supplies.
  • pressure release mechanism 3 may be operated by an activation handle 2 rotationally translatable through at least a portion of an arc about hinge 51.
  • Container 1 may be, for example cylindrical in form, with thread 25 and removable seal 24 in one end, to facilitate connection to release mechanism 3.
  • Removable seal 24 may be, for example, a thin metal, plastic or wax seal or a metal plastic or wax ball. Seal 24 may serve to contain pressure within container 1, or may cover a closure mechanism and serve as an indicator that container 1 has not been used. Closure mechanisms may be, for example, of the type used in carbon dioxide and nitrous oxide chargers employed to prepare soda water and whipped cream respectively.
  • handle 2 is employed to facilitate opening of the valve 20 in pressure release mechanism 3.
  • solid band 5 which engages container 1 serves to retain valve 20 in an open position by preventing handle 2 from returning to its original position (figures 2 and 3).
  • pressure release mechanism 3 (shown in detail in figure 3) includes a gas inlet 30, a valve 20 which is connected to the activation handle 2, a pressure reduction mechanism 70, an expansion chamber 21, a silencer 22, a venturi system 28 with a dedicated drug capsule 50 and a gas outlet 31.
  • pressure release mechanism 3 further includes a small pressure sensor 200 and a display 201, indicating operational parameters such as mixture flow and/or pressure in container 1 during operation of device 500.
  • display 201 further indicates low gas pressure in container 1, for example by means of a visible or audible indicator (e.g. light, flag, buzzer, bell.).
  • Pressure release mechanism 3 may further include internal thread 23 in one end, which is compatible to thread 25 of gas container 1, and a sharp edged insert 26 which serves to remove or puncture seal 24 of gas container 1 when connecting container 1 to pressure release mechanism 3.
  • pressure release mechanism 3 is designed and constructed at its distal end, 29 to engage or fit inlet 35 of mask 4.
  • mask 4 is equipped with at least one ventilation passage 33, for instance, unidirectional pressure sensitive leaf- valves which permit gas to exit but prevent ambient air 100 from entering internal volume 101 of mask 4.
  • mask 4 is equipped with an internal pipe 34 with gas inlet 103 and outlet 104, attached to its internal surface 101 and surrounding it, as shown in Fig. 3 .
  • Internal pipe 34 may be connected, for example, to the mask air inlet 35 in one end, and open to internal volume 101 of mask 4 at its other end.
  • One ordinarily skilled in the manufacturing arts, whether plastic or metal or a combination thereof, will be capable of manufacturing and assembling device 500 employing known production processes, such as parts molding and machinery, and gas compressing.
  • the electronic parts may be of known components, such as LED, pressure switch, etc'. Alternately, or additionally, commercially available components may be assembled to produce device 500.
  • pressure reduction mechanism 70 may be a "first degree regulator" employed in scuba diving or a miniaturized version thereof.
  • Device 500 is employed when an attack of croup (or similar episode) occurs. Use of Device 500 provides symptomatic relief and serves to decrease anxiety/stress of the patient and/or caregiver.
  • Activation of device 500 maybe by the patient or by another person acting on their behalf.
  • Screwing 62 gas container 1 to pressure release mechanism 3 serves to operably connect these components of device 500.
  • sharp edged insert 26 may remove seal 24 from an outlet of gas container 1. Outlet of container 1 is then blocked by the valve 20.
  • Device 500 is ready to use.
  • Mask 4 should be attached now to the patient's face, in such way that it will cover its airway openings.
  • depression of handle 2 towards container 1 serves to open valve 20 of container 1.
  • This permits at least a portion of the compressed gas mixture to flow through gas inlet 30 and pressure reduction mechanism 70 where the gas pressure is reduced to a constant lower pressure (preferably approximately 1 atmosphere) and into venturi system 28 and expansion chamber 21 where it expands and cools.
  • the expanded cooled gas mixture then passes through silencer 22, which may also serve as a humidifier, and through gas outlet 31 into inlet 35 of mask 4.
  • silencer 22 which may also serve as a humidifier
  • gas outlet 31 into inlet 35 of mask 4.
  • the gas cools internal volume 101 of mask 4, allowing the patient to breath a cold oxygen mixture which is preferably also humidified.
  • Venturi system 28 allows addition of controlled amounts of a drug or medication into the 1. However, since croup is most prevalent among young children, it is often preferable to employ device 500 without adding any drug or using the venturi system option. In those cases where venturi system 28 is employed, a dedicated drug capsule 50 may be inserted so that its contents are sucked by the venturi system into the gas mixture released from container 1 as it flows past.
  • pressure sensor 200 indicates the decrease in gas pressure during operation of device 500. Below a certain pressure inside container 1, for example 30 atmospheres, an indication to the operator might appear. Such indication might be, for example a simple red LED. Unscrewing the gas container 1 from the pressure release mechanism 3 will, disconnect the electronic contact, for example, in order to save power. It is appreciated that certain features of the invention, which are, for clarity, described in the context of separate embodiments, may also be provided in combination in a single embodiment. Conversely, various features of the invention, which are, for brevity, described in the context of a single embodiment, may also be provided separately or in any. suitable sub-combination.

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  • Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Respiratory Apparatuses And Protective Means (AREA)

Abstract

L'invention concerne un appareil (500) destiné à traiter les symptômes de la laryngotrachéite aiguë, composé d'un contenant de gaz comprimé mobile (1), d'un mécanisme de libération de gaz (3) conçu de manière être connecté activement audit contenant, et d'un masque (4) destiné à couvrir la bouche et le nez d'un malade. La libération d'un mélange gazeux à partir du contenant (1) par le mécanisme de libération (3) provoque un refroidissement du gaz libéré et le transport du gaz refroidi vers le masque (4), à partir duquel ledit gaz peut être inhalé par le malade de manière à traiter les symptômes de la laryngotrachéite aiguë. Ledit gaz contient de l'oxygène et éventuellement de l'hélium. L'invention concerne également un procédé (600) d'utilisation de l'appareil (500). Ledit appareil (500) peut se présenter sous la forme d'un produit de fabrication comportant une notice d'utilisation pour le traitement des symptômes de la laryngotrachéite aiguë.
PCT/IL2003/000359 2002-05-08 2003-05-04 Appareil a main d'inhalotherapie et procede d'utilisation Ceased WO2003094694A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003223094A AU2003223094A1 (en) 2002-05-08 2003-05-04 Hand held device for inhalation therapy and method of use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37838702P 2002-05-08 2002-05-08
US60/378,387 2002-05-08

Publications (2)

Publication Number Publication Date
WO2003094694A2 true WO2003094694A2 (fr) 2003-11-20
WO2003094694A3 WO2003094694A3 (fr) 2004-03-18

Family

ID=29420393

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2003/000359 Ceased WO2003094694A2 (fr) 2002-05-08 2003-05-04 Appareil a main d'inhalotherapie et procede d'utilisation

Country Status (2)

Country Link
AU (1) AU2003223094A1 (fr)
WO (1) WO2003094694A2 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008012531A3 (fr) * 2006-07-25 2008-05-22 Optinose As Administration de gaz dans les voies nasales
EP1689474A4 (fr) * 2003-12-04 2012-09-12 Praxair Technology Inc Inhalateur portable fonctionnant au gaz
CN104640593A (zh) * 2012-08-08 2015-05-20 弗兰克·莱维 用于保存医用压缩气体的一次性气筒
CN109893729A (zh) * 2019-04-11 2019-06-18 冀新红 一种呼吸系统治疗器

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3864326A (en) * 1972-05-22 1975-02-04 Robert S Babington Spraying devices, in particular nebulizing devices
US5874029A (en) * 1996-10-09 1999-02-23 The University Of Kansas Methods for particle micronization and nanonization by recrystallization from organic solutions sprayed into a compressed antisolvent
SE9603804D0 (sv) * 1996-10-16 1996-10-16 Aga Ab Sätt och anordning för framställning av en finfördelad aerosol
US6125844A (en) * 1998-04-30 2000-10-03 Westwood Biomedical Portable oxygen based drug delivery system

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1689474A4 (fr) * 2003-12-04 2012-09-12 Praxair Technology Inc Inhalateur portable fonctionnant au gaz
WO2008012531A3 (fr) * 2006-07-25 2008-05-22 Optinose As Administration de gaz dans les voies nasales
US8910629B2 (en) 2006-07-25 2014-12-16 Optinose As Delivery of gases to the nasal airway
US10765829B2 (en) 2006-07-25 2020-09-08 Optinose As Delivery of gases to the nasal airway
US11690969B2 (en) 2006-07-25 2023-07-04 OptiNose Inc. Delivery of gases to the nasal airway
CN104640593A (zh) * 2012-08-08 2015-05-20 弗兰克·莱维 用于保存医用压缩气体的一次性气筒
CN109893729A (zh) * 2019-04-11 2019-06-18 冀新红 一种呼吸系统治疗器
CN109893729B (zh) * 2019-04-11 2021-04-06 冀新红 一种呼吸系统治疗器

Also Published As

Publication number Publication date
WO2003094694A3 (fr) 2004-03-18
AU2003223094A8 (en) 2003-11-11
AU2003223094A1 (en) 2003-11-11

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