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WO2003093307A3 - Mycobacterial antigens and uses thereof - Google Patents

Mycobacterial antigens and uses thereof Download PDF

Info

Publication number
WO2003093307A3
WO2003093307A3 PCT/GB2003/001815 GB0301815W WO03093307A3 WO 2003093307 A3 WO2003093307 A3 WO 2003093307A3 GB 0301815 W GB0301815 W GB 0301815W WO 03093307 A3 WO03093307 A3 WO 03093307A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptides
antigens
mycobacterium
mycobacterial antigens
derived
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2003/001815
Other languages
French (fr)
Other versions
WO2003093307A8 (en
WO2003093307A2 (en
Inventor
Paul Jason Cockle
Hanns Martin Vordermeier
Stephen Vincent Gordon
Robert Glyn Hewinson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UK Secretary of State for Environment Food and Rural Affairs
Original Assignee
UK Secretary of State for Environment Food and Rural Affairs
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0209723A external-priority patent/GB0209723D0/en
Priority claimed from GB0209724A external-priority patent/GB0209724D0/en
Application filed by UK Secretary of State for Environment Food and Rural Affairs filed Critical UK Secretary of State for Environment Food and Rural Affairs
Priority to AU2003224313A priority Critical patent/AU2003224313A1/en
Publication of WO2003093307A2 publication Critical patent/WO2003093307A2/en
Publication of WO2003093307A8 publication Critical patent/WO2003093307A8/en
Publication of WO2003093307A3 publication Critical patent/WO2003093307A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/5695—Mycobacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention relates to the use of antigens derived from the RD1 or RD2 regions of the Mycobacterium tuberculosis, Mycobacterium bovis or Mycobacterium africanum genomes, and peptides derived therefrom, as diagnostic reagents, in particular in the context of diagnostic kits. In addition, certain of these peptides, as well as other antigens and peptides derived from the RD14 region of the genome are suitable for use as vaccines. Novel fusion peptides are also part of the invention.
PCT/GB2003/001815 2002-04-27 2003-04-28 Mycobacterial antigens and uses thereof Ceased WO2003093307A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003224313A AU2003224313A1 (en) 2002-04-27 2003-04-28 Mycobacterial antigens and uses thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0209723.6 2002-04-27
GB0209723A GB0209723D0 (en) 2002-04-27 2002-04-27 Diagnostic kit
GB0209724.4 2002-04-27
GB0209724A GB0209724D0 (en) 2002-04-27 2002-04-27 Vaccine

Publications (3)

Publication Number Publication Date
WO2003093307A2 WO2003093307A2 (en) 2003-11-13
WO2003093307A8 WO2003093307A8 (en) 2004-02-12
WO2003093307A3 true WO2003093307A3 (en) 2004-03-18

Family

ID=29404286

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2003/001815 Ceased WO2003093307A2 (en) 2002-04-27 2003-04-28 Mycobacterial antigens and uses thereof

Country Status (2)

Country Link
AU (1) AU2003224313A1 (en)
WO (1) WO2003093307A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9822152B2 (en) 2007-04-04 2017-11-21 Infectious Disease Research Institute Immunogenic compositions comprising Mycobacterium tuberculosis polypeptides and fusions thereof

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1214088T3 (en) 1999-05-04 2009-08-24 Univ New Jersey Med Proteins expressed by Mycobacterium tuberculosis and not by BCG and their use as diagnostic reagents and vaccines
WO2004099771A1 (en) 2003-05-08 2004-11-18 Statens Serum Institut A new specific epitope based immunological diagnosis of tuberculosis
WO2005054851A1 (en) * 2003-11-21 2005-06-16 Institut Pasteur Recombinant adenylate cyclase of bordetella sp. for diagnostic and immunomonitoring uses, method of diagnosing or immunomonitoring using said recombinant adenylate cyclase, and kit for diagnosing or immunomonitoring comprising said recombinant adenylate cyclase
ITRM20040091A1 (en) 2004-02-19 2004-05-19 Istituto Naz Per Le Malattie QUICK IMMUNOLOGICAL TEST FOR DIAGNOSIS AND MONITORING OF TUBERCULAR INFECTION.
GB0406271D0 (en) 2004-03-19 2004-04-21 Isis Innovation Diagnostic test
CN100393876C (en) * 2004-05-11 2008-06-11 中国人民解放军第三○九医院 Mycobacterium tuberculosis proteins for tuberculosis diagnosis
CA2577597A1 (en) * 2004-08-19 2006-02-23 Proteome Systems Intellectual Property Pty Ltd. Methods of diagnosis and treatment of m. tuberculosis infection and reagents therefor
EP1674868A1 (en) * 2004-12-21 2006-06-28 Chang Gung University (a university of Taiwan) Method and device for detection of mycobacterium tuberculosis antigens in biological fluids
FR2873819B1 (en) * 2005-07-21 2009-07-10 Pasteur Institut DETECTION OF TUBERCULOSIS AND MYCOBACTERIUM TUBERCULOSIS INFECTION USING HBHA
CN101661044B (en) * 2008-08-27 2013-10-16 复旦大学附属华山医院 Diagnostic reagent of tuberculosis and kit
CN102260328B (en) * 2010-07-15 2013-09-25 华中农业大学 Antigen Protein and Application of Mycobacterium Tuberculosis
CN104628833B (en) * 2015-01-23 2016-03-23 中国疾病预防控制中心传染病预防控制所 Antigen composition for immune detection of tuberculosis infected cells and application thereof
CN116102629B (en) * 2022-09-03 2023-09-08 武汉中纪生物科技有限公司 Mycobacterium tuberculosis T cell epitope polypeptide and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000011214A1 (en) * 1998-08-25 2000-03-02 The Board Of Trustees Of The Leland Stanford Junior University Molecular differences between species of the m. tuberculosis complex
WO2000066157A1 (en) * 1999-05-04 2000-11-09 The Public Health Research Institute Of The City Of New York, Inc. Proteins expressed by mycobacterium tuberculosis and not by bcg and their use as diagnostic reagents and vaccines

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000011214A1 (en) * 1998-08-25 2000-03-02 The Board Of Trustees Of The Leland Stanford Junior University Molecular differences between species of the m. tuberculosis complex
WO2000066157A1 (en) * 1999-05-04 2000-11-09 The Public Health Research Institute Of The City Of New York, Inc. Proteins expressed by mycobacterium tuberculosis and not by bcg and their use as diagnostic reagents and vaccines

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ANDERSON P: "TB Vaccines: Progress and Problems", TRENDS IN IMMUNOLOGY, vol. 22, no. 3, March 2001 (2001-03-01), pages 160 - 168, XP002252153 *
COCKLE P J ET AL: "Identification of novel Mycobacterium tuberculosis antigens with potential as diagnostic reagents or subunit vaccine candidates by comparative genomics.", INFECTION AND IMMUNITY. UNITED STATES DEC 2002, vol. 70, no. 12, December 2002 (2002-12-01), pages 6996 - 7003, XP002252152, ISSN: 0019-9567 *
VAN PINXTEREN ET AL.,: "Diagnosis of Tuberculosis Based on the Two Specific Antigens ESAT-6 and CFP10", CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, vol. 7, no. 2, March 2000 (2000-03-01), pages 155 - 160, XP002252151 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9822152B2 (en) 2007-04-04 2017-11-21 Infectious Disease Research Institute Immunogenic compositions comprising Mycobacterium tuberculosis polypeptides and fusions thereof
US11091521B2 (en) 2007-04-04 2021-08-17 Infectious Disease Research Institute Immunogenic compositions comprising Mycobacterium tuberculosis polypeptides and fusions thereof

Also Published As

Publication number Publication date
WO2003093307A8 (en) 2004-02-12
WO2003093307A2 (en) 2003-11-13
AU2003224313A1 (en) 2003-11-17

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Free format text: IN PCT GAZETTE 46/2003 UNDER (71) REPLACE THE EXISTING ADDRESS BY "(DEFRA), NOBEL HOUSE, 17 SMITH SQUARE, LONDON SW1P 3JR, ACTING THROUGH THE VETERINARY LABORATORIES, AGENCY OF NEW HAW, ADDLESTONE, SURREY KT15 3NB (GB)."; UNDER (72, 75) REPLACE "GORDON, STEPHEN, VINCENT [DE/GB]" AND "HEWINSON, ROBERT, GLYN [DE/GB]" BY "GORDON, STEPHEN, VINCENT [IE/GB]" AND "HEWINSON, ROBERT, GLYN [GB/GB]"

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